• Korean Journal of Plant Resources
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• v.27 no.6
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• pp.714-719
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• 2014

This study investigated DNA damage protection and anti-inflammatory activity of different solvent fractions from Aruncus dioicus var. kamtschaticus (A. dioicus) aerial parts water extract. As for DNA damage protection, distilled water ($H_2O$) fraction displayed the most powerful protection for DNA damage at a concentration of 1 mg/ml. As for anti-inflammatory activity, dichloromethane ($CH_2Cl_2$) fraction exhibited the highest NO inhibition activity, ranging from 61% to 19% ($10-40{\mu}g/ml$). Furthermore, the levels of pro-inflammatory cytokines mRNA expressions and intracellular reactive oxygen species (ROS) were employed to verify the anti-inflammatory activity of the $CH_2Cl_2$ fraction on further researches. It could be concluded that A. dioicus had a significantly effect of DNA damage protection and anti-inflammatory activity which also as an essential edible vegetable and medicinal species.

• Journal of Korean Academy of Nursing Administration
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• v.12 no.2
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• pp.305-310
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• 2006

Purpose: This study was to identify affecting factors on job satisfaction, nursing professional attitudes of new nurses according to transformational leadership of preceptors. Method: The subjects were 101 new nurses who were working for the 4 of university hospitals in Seoul, Daejeon and Kyong Ki. This study was conducted from Aug to Oct 2005. The data was collected by questionnaires and were analyzed using descriptive statistics, pearson correlation coefficient, stepwise multiple regression. Result: Transformational leadership of preceptors were significantly correlated between Job satisfaction, nursing professional attitudes of the new nurses. The stepwise multiple regression analysis for job satisfaction, nursing professional attitudes revealed that the most powerful predictor was charisma. Conclusion: The findings indicated that the transformational leadership of preceptors is important for improving job satisfaction, nursing professional attitudes of the new nurses. Therefore it may be necessary further to develop of the leadership training program for effective preceptorship.

• Journal of Korean Academy of Nursing
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• v.33 no.4
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• pp.471-477
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• 2003

Purpose. This cross-sectional survey research was undertaken to examine the degree of depression in post-menopausal women and to analyze the factors affecting that depression. Method. 325 people from public health center in Inchon were surveyed as the subject of this study. Data collection was conducted through the use of questionnaires. Results. The above half of these sampled people were in depressed state (64.0%) and the mean score of depression was 12.71. There were significant differences in the depression state according to presence of spouse, economic level, exercise, and smoking. A positive correlation was found between depression and climacteric symptoms. Stepwise multiple regression analysis revealed that the most powerful predictor was climacteric symptom. Climacteric symptom, presence of spouse, smoking, and exercise accounted for 45 % of the variance in postmenopausal women's depression. Conclusion. Nurses are able to use these results to plan and implement nursing interventions for decreasing depression and consequent the improved quality of life in Korean postmenopausal women. Also, the nurses have to be more aware of the following groups; solitary women, low-income group and smokers, that they have higher mean score of depression.

• Korean Journal of Child Studies
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• v.17 no.2
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• pp.141-161
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• 1996

The purpose of this study was to investigate the effects of self-regulated learning components, such as metacognition, motivation, and learning strategies, on academic achievement in normally achieving children and learning disabled(LD) children. The subjects were 345 normally achieving children, 12 LD children, and a group of 12 normally achieving children to match the LD children. Data was analyzed by Pearson's product moment correlation coefficient, stepwise multiple regression analysis, and t-test. Results showed that metacognition, motivation and learning strategy are important components of successful academic achievement and self-regulated learning in normally achieving children. Among the self-regulated learning components, metacognition was the most powerful predictor of academic achievement. For the LD children, the results showed that they have metacognitive deficits and motivational problems. Implications for intervention to improve academic achievement of low achievers and LD children were discussed.

• 보존과학연구
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• s.28
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• pp.75-90
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• 2007

The ancient biomolecular remains are the potential source for paleobiology and paleoanthropology. Especially, ancient human specimens such as bone, teeth, and hair are powerful materials to identify historical origin and migration of ancestor population from the past. However, most excavated human specimens in archaeological sites have commonly problems as natural damage and exogenous contamination. We carried out histological and molecular analyses of excavated bone from the historic sites in South Korea from the recently discovered in tumulus of Seochun and Naju. Biological deterioration of bone was observed anatomically by optical and scanning electron microscope (SEM). We extracted degraded DNA, and amplified hyper variable region (HVR) of mitochondrial DNA (mtDNA) and amelogenin of nucleus DNA. This study applied and examined the relationships between histological preservation and DNA survival in excavated bone.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.30 no.4
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• pp.1-12
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• 2007

Motorola developed the framework of six sigma in 1987. In these days, many companies adapt this powerful tool. In 1996, six sigma was introduced to the Korean companies as a management innovation tool. This study shows case study of 'Champion Project' which was adopted on one Korean company. The champion project is directed by the leader who has a champion belt. The project focus on the processes optimization problem or resource concentration problem to solve critical issues inside of the process. This case study shows the result of champion project. The effect was encouraging in the aspect of effectiveness and efficiency. The most important point of this study is an introduction of the third generation six sigma which was successively adopted on the Korean company.

• International Journal of Naval Architecture and Ocean Engineering
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• v.4 no.3
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• pp.228-240
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• 2012

Morphing is a geometric interpolation technique that is often used by the animation industry to transform one form into another seemingly seamlessly. It does this by producing a large number of 'intermediate' forms between the two 'extreme' or 'parent' forms. It has already been shown that morphing technique can be a powerful tool for form design and as such can be a useful addition to the armoury of product designers. Morphing procedure itself is simple and consists of straightforward linear interpolation. However, establishing the correspondence between vertices of the parent models is one of the most difficult and important tasks during a morphing process. This paper discusses the mesh-merging method employed for this process as against the already established mesh-regularising method. It has been found that the merging method minimises the need for manual manipulation, allowing automation to a large extent.

• YAKHAK HOEJI
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• v.54 no.1
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• pp.62-66
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• 2010

Benzopyrene is known to be one of the most powerful carcinogens which can build intercalated motif between base pairs in damaged DNA. The dimension of benzopyrene itself is much bigger than any of the DNA bases and thus the question whether the lesion of some base pair by insertion of benzopyrene can happen with or without a dramatic distortion of the helical structure is a highly interesting theme. In this work we used a molecular mechanics simulation using AMBER program package to go into the conformational characteristics. The condition of the insertion process of the benzopyrene motif from minor groove of the starting structure between the base pairs in the internal area of double helix was investigated using the molecular dynamics simulation at elevated temperature.

• Molecules and Cells
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• v.40 no.8
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• pp.533-541
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• 2017

Engineered DNA-binding domains provide a powerful technology for numerous biomedical studies due to their ability to recognize specific DNA sequences. Zinc fingers (ZF) are one of the most common DNA-binding domains and have been extensively studied for a variety of applications, such as gene regulation, genome engineering and diagnostics. Another novel DNA-binding domain known as a transcriptional activator-like effector (TALE) has been more recently discovered, which has a previously undescribed DNA-binding mode. Due to their modular architecture and flexibility, TALEs have been rapidly developed into artificial gene targeting reagents. Here, we describe the methods used to design these DNA-binding proteins and their key applications in biomedical research.

• Journal of muscle and joint health
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• v.18 no.1
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• pp.5-15
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• 2011

Purpose: Osteoporosis is often considered as a women's disease, but men's osteoporosis is also increasingly recognized as an important public health problem. This study was carried out to identify the important modifiable risk factors for osteoporosis in men. Methods: Two hundred and fourteen men were selected among those who checked bone mineral density by dual energy x-ray absorptiometry in lumbar vertebrae from June to September, 2009 at 3 general hospitals in Busan. Self-administrated questionnaires and BMD results of lumbar vertebrae were used for data. Collected data were analyzed by using SPSS 14.0 program. Results: The sports activity level in 30's, body weight, and fracture history of mother were the most powerful influencing factors on the bone mineral density of lumbar vertebrae. Conclusion: These results highlight the need to participate vigorously in sports activity during 30s as a means of increasing peak bone mass in lumbar vertebrae in order to prevent osteoporosis and fracture in men.