• 한국자기학회:학술대회 개요집
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• 한국자기학회 2005년도 동계학술연구발표회 및 2차 아시안포럼
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• pp.2-2
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• 2005

• 한국광학회:학술대회논문집
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• 한국광학회 2000년도 하계학술발표회
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• pp.166-169
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• 2000

This paper briefly reviews magneto-optic spatial light modulators (MOSLMs) developed so far and discusses the design concepts, issues concerning its fabrication, and performances of a new MOSLM based on one-dimensional magnetophotonic crystal (1D-MPC). (omitted)

• 한국광학회:학술대회논문집
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• 한국광학회 2002년도 제13회 정기총회 및 2002년도 동계학술발표회
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• pp.174-175
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• 2002

We generate short optical pulses of ∼ 6 picoseconds at 10 GHz by chirped pulse compression based on phase modulation and chirp compensation. In the suggested method, sinusoidally driven intensity and phase modulators generate chirped pulses which are subsequently suppressed by chirp compensation using a single mode fiber.

• 대한기계학회논문집A
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• 제28권12호
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• pp.1990-1996
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• 2004

This paper presents a nonlinearly modulated digital actuator (NMDA) for producing nano-precision digital stroke. The NMDA, composed of a digital microactuator and a nonlinear micromechanical modulator, purifies the stroke of the digital actuator in order to generate the high-precision displacement output required for nano-positioning devices. The function and concept of the nonlinear micromechanical modulator are equivalent to those of the nonlinear electrical limiters. The linear and nonlinear modulators, having an identical input and output strokes of 15.2${\mu}{\textrm}{m}$ and 5.4${\mu}{\textrm}{m}$, are designed, fabricated and tested, respectively. The linear and nonlinear modulators are linked to identical digital actuators in order to compare the characteristics of the linearly modulated microactuator (LMDA) and NMDA. In addition, an identical linear modulator is attached to the output ports of LMDA and NMDA. The NMDA shows the repeatability of 12.3$\pm$2.9nm, superior to that of 27.8$\pm$2.9nm achieved by LMDA. When the identical linear modulator is connected to LMDA and NMDA, the final modulated output from NMDA shows the repeatability of 10.3$\pm$7.2nm, superior to that of 15.7$\pm$7.7nm from LMDA. We experimentally verify the displacement purifying capability of the nonlinear mechanical modulator, applicable to nano-precision positioning devices and systems.

• Biomolecules & Therapeutics
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• 제25권1호
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• pp.80-90
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• 2017

Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, $S1P_{1-5}$. The molecular identification of S1P receptors opened up a new avenue for pathophysiological research on this lipid mediator. Cellular and molecular in vitro studies and in vivo studies on gene deficient mice have elucidated cellular signaling pathways and the pathophysiological meanings of S1P receptors. Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials. In addition, more selective S1P receptor modulators with better pharmacokinetic profiles and fewer side effects are under development. Some of them are being clinically tested in the contexts of multiple sclerosis and other autoimmune and inflammatory disorders, such as, psoriasis, Crohn's disease, ulcerative colitis, polymyositis, dermatomyositis, liver failure, renal failure, acute stroke, and transplant rejection. In this review, the authors discuss the state of the art regarding the status of drug discovery efforts targeting S1P receptors and place emphasis on potential clinical applications.

• 조명전기설비학회논문지
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• 제20권9호
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• pp.11-17
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• 2006

We have theoretically investigated the effects of the interplay between the driving voltage of Mach-Zehnder(MZ) modulators and the bandwidth of low-pass filters(LPF) in 10[Gb/s] duobinary modulation systems. For the change of driving voltage ratios(driving voltage/switching voltage), the transmission performance has been evaluated over 200[km] of single-mode fiber(SMF) systems. For driving voltage ratios with smaller than 100[%], the transmission performance has been maintained and greatly affected by the bandwidth of LPFs than the driving voltage. For driving voltage ratios with larger than 100[%], the transmission performance has been degraded and is not sensitive to the bandwidth of LPFs. To see the limitation of driving voltage, we have reduced the driving voltage ratio to 50[%]. Our results suggest that 10[Gb/s] duobinary signals with driving voltage ratio with smaller than 100[%] have been transmitted over 200[km] SMF within 2[dB] power penalty without dispersion compensation. For the driving voltage ratio with 50[%], we have verified that the transmission performance was maintained.

• Toxicological Research
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• 제11권2호
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• pp.273-277
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• 1995

Several metabolic modulators on the generation of carbon monoxide (CO)from dichloromethane (DCM) was examined in adult female rats. It has been known that DCM is converted to CO by cytochrome P-450 or to carbon dioxide $(CO_2)$ by glutathione-dependent metabolic reaction. In rats treated with DCM (3 mmol/kg, ip) only, the carboxyhemoglobin (COHb) level reached a peak of approximately 10% 2 or 3 hr following the treatment. Disulfiram (300 mg/kg, ip) or allylsulfide (200 mg/kg, po), both known as a selective inhibitior for cytochrome P-450 2E1, blocked the increase in COHb concentratlons almost completely suggesting that the metabolic conversion of DCM to CO is mediated by the activity of this specific type of isozyme. YH439 (125 or 250 mg/kg, po), a potential hepatoprotective agent, decreased the COHb elevation as well indicating that this chemical is a potent inhibitor for 2E1. In rats treated with pyrazine (200 mg/kg, ip) 18 hr prior to DCM the peak COHb concentration was decreased by approximately 3 or 4%. However, pretreatment of rats with pyrazine either 24 or 48 hr before DCM increased the peak COHb concentration significantly compared to the rats treated with DCM only. The results in the present study strongly suggest that the generation of CO from DCM depends on the 2E1 activity and that the pharmacological and/or toxicological action of YH439 or pyrazine in animals or human is associated with its effect on this isozyme.

• 생약학회지
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• 제26권4호
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• pp.344-348
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• 1995

Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.

• 한국식품위생안전성학회지
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• 제11권4호
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• pp.291-297
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• 1996

The role of cytochrome P-450 2E1 (P450 2E1) in the early phase of alcoholic fatty liver was examined. Female rats were pretreated with either allyl sulfide (200 mg/kg, po), disulfiram (500 mg/kg, po), YH 439 (250 mg/kg, po) or pyrazine (200 mg/kg/day$\times$2 days, ip). Marked changes in carbon tetrachloride-induced hepatotoxicity and caboxyhemoglobin (COHb) elevation due to dichloromethane administration were observed in rats treated with one of the P450 2E1 modulators. A single dose of ethanol (6 g/kg, po) increased the hepatic triglyceride contents approximately 2 fold, which was inhibited completely by YH 439 pretreatment. However, the other P450 2E1 modulators failed to alter the ethanol-induced hepatic triglyceride accumulation. In vitro hepatic microsomal enzyme activity was determined in 4 week old premature and 12 week old adult rats. Aminopyrine-N demethylation was not different, but p-nitrophenol hydroxylation and p-nitroanisole O-demethylation were significantly higher in premature rats. However, no difference in the triglyceride accumulation induced by an intraperitoneal dose of ethanol (3 g/kg) was noted between premature and adult rats. The results suggest that the P450 2E1 activity dose not play an important role in the induction of acute alcoholic fatty liver.

• 한국통신학회논문지
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• 제19권9호
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• pp.1782-1792
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• 1994

$Ti:LiNbO_3$채널형 광도파로와 Asymmetric Coplanar Strip(ACPS) 전극구조를 이용해서, $1.3{\mu}m$에서 동작하는 진형파형 위상 광변조기를 설계, 제작한 다음 변조특성을 관찰하였다. 위상정합이 개선되도록 ACPS 진행파형 전극을 설계하기 위해서 전극과 완충박막의 두께를 포함하여, 전극제원의 해석적 함수로 특성저항, 변조파의 유효굴절률 및 전극손실 등을 고려하였다. Ti 확산방법으로 저손실 채널형 광도파로 제작하였으며, double-spin image reversal 공정을 이용해서 $2.5{\mu}m$ 두께의 전극을 형성하였다. 9GHz 부근에서의 전극구조 공진형상 때문에 변조특성이 제한 되었지만, 2.5GHz 까지는 큰 왜곡없이 변조특성이 관찰되었다.