• 제목/요약/키워드: miR-25

검색결과 441건 처리시간 0.038초

심장이식 수혜자의 삶의 질 관련 요인에 대한 메타분석 (A Meta-Analysis on Factors Related to Quality of Life in Heart Transplant Recipients)

  • 장미라;임세라;최모나
    • 임상간호연구
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    • 제25권3호
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    • pp.251-264
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    • 2019
  • Purpose: This study was a systematic review and meta-analysis to explore the factors related to quality of life in heart transplant recipients. Methods: To identify studies that suggested the factors related to the quality of life in heart transplant recipients, we searched the articles published from 1974 to November 2018 using Six databases, PubMed, CINAHL, EMBASE, Cochrane, KMBASE and RISS. A total of 22 studies were selected out of 5,234 for the systematic review and meta-analysis on the basis of the PRISMA flow. The quality of study was assessed by assessment tool form the NIH and meta-analysis was performed using the 'R 3.5.2' version to analyze the correlated effect sizes. Results: Factors related to quality of life in heart transplant recipients were categorized into six domains based on the health-related quality of life model introduced by Ferrans: individual, environmental, biological function, symptoms, functional status, and general health perception. In the meta-analysis, 34 factors were used and 17 factors having significant effect sizes were as follows: self-efficacy, demoralization, perceived control, current occupational status, age, marital status, health promotion life style in the individual characteristics; stress in environmental characteristics; physical function status, creatinine level, left ventricular ejection fraction (LVEF) in biological function; anxiety, depression, symptom frequency and distress in symptoms domain; coping, self-care compliance in functional status. Conclusion: The findings indicate that the multi-dimensional factors influencing the quality of life in heart transplant recipients and provide the evidence for developing effective interventions for improving the quality of life of recipients.

Aging effects on the diurnal patterns of gut microbial composition in male and female mice

  • Kim, Hyun-Jung;Moon, Chang Mo;Kang, Jihee Lee;Park, Eun-Mi
    • The Korean Journal of Physiology and Pharmacology
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    • 제25권6호
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    • pp.575-583
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    • 2021
  • Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the day, and the disruption of their diurnal rhythm results in gut dysbiosis leading to metabolic and immune dysfunctions. It is well documented that circadian rhythm changes with age in several biological functions such as sleep, body temperature, and hormone secretion. However, it is not defined whether the diurnal pattern of gut microbial composition is affected by aging. To evaluate aging effects on the diurnal pattern of the gut microbiome, we evaluated the taxa profiles of cecal contents obtained from young and aged mice of both sexes at daytime and nighttime points by 16S rRNA gene sequencing. At the phylum level, the ratio of Firmicutes to Bacteroidetes and the relative abundances of Verrucomicrobia and Cyanobacteria were increased in aged male mice at night compared with that of young male mice. Meanwhile, the relative abundances of Sutterellaceae, Alloprevotella, Lachnospiraceae UCG-001, and Parasutterella increased in aged female mice at night compared with that of young female mice. The Lachnospiraceae NK4A136 group relative abundance increased in aged mice of both sexes but at opposite time points. These results showed the changes in diurnal patterns of gut microbial composition with aging, which varied depending on the sex of the host. We suggest that disturbed diurnal patterns of the gut microbiome can be a factor for the underlying mechanism of age-associated gut dysbiosis.

텍스트 네크워크 분석을 이용한 임상간호연구 게재논문의 연구동향 분석: 2000년부터 2017년까지 (Research Trends of Articles Published in the Journal of Korean Clinical Nursing Research from 2000 to 2017: Text Network Analysis of Keywords)

  • 김연희;문성미;권인각;김광성;정금희;신은숙;오향순;김수현
    • 임상간호연구
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    • 제25권1호
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    • pp.80-90
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    • 2019
  • Purpose: The aim of this study was to identify the research trends of articles published in the Journal of Korean Clinical Nursing Research from 2000 to 2017 by a text network analysis using keywords. Methods: This study analyzed 600 articles. The R program was used for text mining that extracted frequency, centrality rank, and keyword network. Results: From 2000 to 2009, keywords with high-frequency were 'nurse', 'pain', 'anxiety', 'knowledge', 'attitude', and so on. 'Pain', 'nurse', and 'knowledge' showed a high centrality. 'Fatigue' showed no high frequency but a high centrality. Keywords such as 'nurse', 'knowledge', and 'pain' also showed high frequency and centrality between 2010 and 2017. 'Hemodialysis' and 'intensive care unit' were added to keywords with high frequency and centrality during the period. Conclusion: The frequency and centrality of keywords such as 'nurse', 'pain', 'knowledge', 'hemodialysis', and 'intensive care unit' reflect the research trends in clinical nursing between 2000 and 2017. Further studies need to expand the keyword networks by connecting the main keywords.

간호대학생의 비판적 사고성향, 메타인지에 대한 상황모듈학습 프로그램 적용 효과 (Effect of a Situational Module Learning Course on Critical Thinking Disposition and Metacognition in Nursing Students: A Quasi-experimental Study)

  • 박광옥;유미
    • 한국간호교육학회지
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    • 제25권2호
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    • pp.251-262
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    • 2019
  • Purpose: This study aimed to identify the effect of a situational module learning course on critical thinking disposition and metacognition in sophomore nursing students. Methods: This study was a non-equivalent control-group pretest-posttest quasi-experimental design; the participants included 64 nursing students (32 in the experimental and 32 in the control group) from two Korean universities. Critical thinking disposition and metacognition between the control and intervention groups were measured before and after program participation. Data collection was conducted between September 1 and December 15, 2016. An independent t-test was used to determine differences in critical thinking disposition and metacognition between the groups and Pearson's correlations were measured for correlation with critical thinking disposition and metacognition. Results: The intervention group showed higher critical thinking disposition (t=3.16, p=.002); intellectual integrity (t=2.85, p=.006); and open-mindedness (t=3.30, p=.002) relative to those of the control group. However, there were no statistical differences in metacognition between the two groups (t=-0.14, p=.888). A significant positive correlation between metacognition and critical thinking disposition was found. (r=.62, p<.001). Conclusion: The situational module learning course developed in this study could be used to promote critical thinking disposition in nursing students.

간호대학생의 MBTI성격유형, 감성지능, 스트레스 대처방식이 대학생활적응에 미치는 영향 (Effect of Myers-Briggs Type Indicator(MBTI) Personality Type, Emotional Intelligence, Sress Coping Strategies on Nursing student's Adjustment to College Life)

  • 한영미;김선희
    • 한국산학기술학회논문지
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    • 제18권8호
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    • pp.124-134
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    • 2017
  • 본 연구의 목적은 간호대학생의 MBTI성격유형, 감성지능, 스트레스 대처방식, 대학생활적응 수준을 파악하고 간호대학생들의 대학생활적응에 미치는 영향 요인을 파악하기 위한 것이다. 연구대상자는 C시에 소재하는 간호학과 학생 267명이다. 자료수집은 2017년 3월 6일부터 3월 31일까지 실시되었다. 연구결과, 간호대학생의 대학생활적응은 감성지능(r=.29, p<.001)과 스트레스 대처방식(r=.27, p<.001)으로 양의 상관관계를 나타내었고, MBTI 성격유형의 심리기능유형(F=0.36, p=.781)과 심리기질유형(F=0.43, p=.730)과는 유의하지 않았다. 대학생활적응에 영향을 미치는 요인은 학년(${\beta}=.22$, p<.001), 입학동기 중 적성(${\beta}=.17$, p=.024), 전공만족도 중 만족(${\beta}=.24$, p=.025), 감성지능(${\beta}=.14$, p=.028) 및 스트레스 대처방식(${\beta}=.15$, p=.013)으로 설명력은 총 17.5%(F=8.03, p<.001)이었다. 대학생활적응의 각 하부영역에 유의한 영향을 미친 변수를 살펴보면 다음과 같다. 학업활동에 영향을 미친 변수는 학년(${\beta}=.12$, p=.045), 성적(${\beta}=.36$, p<.001), 전공만족도 중 만족(${\beta}=.21$, p=.047), 감성지능(${\beta}=.12$, p=.055), 스트레스 대처방식(${\beta}=.12$, p=.055)으로 설명력($R^2$)이 22.0% 이었으며, 진로준비에 영향을 미친 변수는 학년(${\beta}=.14$, p=.026), 입학동기 중 적성(${\beta}=.18$, p=.018), 입학동기 중 취업(${\beta}=.18$, p=.016), 감성지능(${\beta}=.15$, p=.023)으로 설명력($R^2$)은 10.0%이었다. 또한 개인심리에 영향을 미친 변수는 연령(${\beta}=.13$, p=.016), 입학동기 중 적성(${\beta}=.19$, p=.010), 감성지능(${\beta}=.30$, p<.001), 스트레스 대처방식(${\beta}=.18$, p=.003)으로 설명력($R^2$)은 26.5% 이었으며, 대인관계와 사회체험에 영향을 미친 변수는 학년(${\beta}=.25$, p<.001 & ${\beta}=.25$, p<.001)으로 설명력($R^2$)은 각각 8.4%, 6.1%였다. 따라서 간호대학생의 대학생활적응을 위해 감성지능과 스트레스 대처전략을 향상시킬 수 있는 교육 커리큘럼과 함께 교과 외 활동을 통합하는 체계적인 교육프로그램 개발이 필요할 것이다. 또한 간호대학생의 대학생활적응에 영향을 미치지 않은 것으로 확인된 MBTI 성격유형의 심리기능유형과 심리기질유형은 대규모 표본을 대상으로 추후연구가 필요할 것으로 사료된다.

국내·외 리그별 프로축구 유니폼의 색채 특성과 이미지 비교 연구 (A Comparative Study on the Color Features and Images of Professional Football Uniforms in Korea and Foreign Leagues)

  • 이미숙;임송미
    • 복식
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    • 제64권3호
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    • pp.108-125
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    • 2014
  • The purpose of this study is to provide the basic information necessary to develop sports uniform design by comparing and analyzing the color features and images of professional football uniforms in Korea and foreign countries. The subjects of this study were limited to 5 top leagues in Europe (Premier League, Primera Liga, Bundesliga, Serie A, and Ligue 1) as well as J-League, and K-League. This study was done using the 2012/2013 season home and away uniforms for European leagues and 2013 season home and away uniforms for Korean and Japan leagues. Using the Adobe photoshop CS2 eyedropper tool, color chips and RGB values were extracted from digital images and converted into HV/C of Munsell Conversion. Finally, a total of 735 colors were used for the analysis. The color image scale by Shigenobu Kobayashi was used to position the color images. The results are as follows. First, the color analysis of professional football uniforms in leagues suggested that chromatic color (53.7%) was more prevalent than achromatic color (46.3%). The two most common colors of the ten chromatic colors were R(19.7%) and PB(18.0%), followed by Y(5.4%), RP(2.0%), G(1.9), GY(1.8%), B(1.6%), YR(1.5%), P(1.1%), and BG(0.7%). Second, for the color tone comparison and analysis of professional football uniforms in leagues, the most commonly used color tone was W(28.4%), followed by v(25.5%), Bk(16.3%), s(5.8%), dk(5.2%), b/lt(5.2%), dp(3.0%), sf(2.0%), ltGy(1.0%), p(0.5%), G/dkGy(0.4%), and ltg/mGy (0.1%). Third, for the comparison and analysis of color and color tone of professional football uniforms in leagues, W(28.4%), R(v)(17.7%), and Bk(16.3%) were commonly used. Finally, for the comparison and analysis of color images of professional football uniforms in leagues, the most commonly used color image was a casual image(31.8%), followed by modern image(26.5%), dynamic12.8%), cool casual(12.0%), gorgeous(9.3%), clear(6.6%), chic(3.5%), and elegant images. Dandy, classical, romantic and pretty images(0.4% respectively) were also used.

플라즈마 화장품 용기 적합성 (Plasma Cosmetic Container Suitability)

  • 조하현;천유연;허효진;이상훈;;김예지;곽병문;이미기;빈범호
    • 대한화장품학회지
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    • 제50권1호
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    • pp.59-65
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    • 2024
  • 플라즈마 화장품은, 플라즈마의 제형 내 장기 안정성을 확보하는 것이 중요하다. 이번 연구는 효율적인 플라즈마 화장품 개발을 위하여 용기 적합성을 검토하였다. 플라즈마가 닿는 표면적을 달리하여, 4 cm2, 25 cm2, 75 cm2, 175 cm2 용기 별로 화장품 제조용 플라즈마를 주입 후, 질소 플라즈마 주요 활성 종인 nitric oxide (NO)의 양을 추적 분석 하였다. 그 결과, 플라즈마에 노출된 표면적과 안정도는 반비례 경향을 나타내었고, 4 cm2 용기에서 가장 효과적이었다. 추가적으로, 25 mm, 40 mm, 50 mm 바이알 병에 플라즈마를 처리하였고, 그 결과 공기에 노출된 용기의 표면 면적이 작은 25 mm에서 NO의 상대적 장기 안정성이 확보되었다. 화장품 제형으로 수상 미스트(water mist)와 층 분리 미스트(stratified mist)를 선택하여 수상층 부분에 NO 플라즈마를 주입 후 제형의 성상 및 주입한 NO 플라즈마의 상태 변화를 관찰하였다. 두 제형에서 NO 플라즈마의 주입량은 수상 미스트가 층 분리 미스트보다 약 1.5 배 가량 높았으며, 층 분리 미스트는 시간에 따라 점차 감소하여 3 주 후, 소실되는 것이 확인되었다. 저온(4 ℃), 실온(25 ℃), 고온(37 ℃, 50 ℃)에서 질소 플라즈마의 안정도를 진행하였다. 그 결과 수상 미스트는 안정도에 영향을 미치지 않는 것을 확인하였지만, 층 분리 미스트는 유상층에서 색 변화를 관찰하였다. 종합적으로, 본 연구는 질소 플라즈마의 용기 적합성을 제시하고 있으며 화장품 제형 내 주입된 질소 플라즈마의 안정성 확보의 중요성을 시사하고 있다.

한국에서 이매패류 5종의 이성생식세포 발현 (Intersexuality of Five Bivalves Species in Korea)

  • 김혜진;전미애;주선미;강승완;김재원;이연규;이정식
    • 한국패류학회지
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    • 제32권3호
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    • pp.197-202
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    • 2016
  • 본 연구에서는 한국 연안의 생태학적 건강도를 조사하는 과정에서 이매패류 5종 (굴, 지중해담치, 바지락, 대복, 둥글레조개) 에서 발견된 이성생식세포 발현현상을 보고한다. 암컷에서 이성생식세포 발현 현상은 반대 성의 생식세포들이 난자형성소낭 내부와 소낭 사이에서 단독 또는 무리지어 나타나는 형태였다. 이성생식세포 발현 현상이 관찰된 정소에서 난모세포들은 대부분 난황형성전기 또는 난황형성개시기 단계였다. 이들은 단독으로 산재되어 있거나 또는 정자형성소낭의 내부와 소낭 사이에 무리지어 존재하고 있었다. 굴에서 이성생식세포 발현율은 약 10.4% (n = 19/183) 로 수컷 (9.7%, n = 13/134) 보다 암컷 (12.2%, n = 6/49) 에서 높게 나타났다. 지중해담치에서 이성생식세포 발현율은 약 31.7% (n = 19/60) 였으며, 수컷 (25.9%, n = 7/27) 보다 암컷 (36.4%, n = 12/33)에서 높게 나타났다. 바지락 이성생식세포 발현율은 11.2% (n = 11/98) 였는데, 암컷 (7.1%, n = 4/56) 보다 수컷 (16.7%, n = 7/42) 에서 높았다. 대복의 이성생식세포 발현율은 약 28% (n = 30/107) 로 암컷 (24.5%, n = 13/53) 보다 수컷 (31.5%, n = 17/54) 에서 높았다. 둥글레조개에서 이성생식세포 발현율은 약 18.4% (n = 7/38) 였는데, 수컷 (8.3%, n = 2/24) 에 비해 암컷 (35.7%, n = 5/14) 에서 높았다.

질소시비수준이 콩의 생육 및 isoflavone 함량에 미치는 영향 (Effect of Nitrogen Fertilization levels on Growth and Isoflavone Content in Soybean)

  • 이미자;박종철;오영진;김경호;김형순;이상복;김정곤
    • 한국작물학회지
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    • 제51권5호
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    • pp.445-450
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    • 2006
  • 본 연구에서는 질소 시비수준이 생육시기별 식물체 및 종실에서 isoflavone함량에 미치는 영향을 구명하기 위하여 고속액체크로마토그래피(HPLC)를 이용하여 생육시기에 따른 식물체에서 isoflavone을 분석한 결과를 요약하면 다음과 같다. 1. 질소시비 수준에 따른 일반생육은 50%증비구가 다른 처리에 비하여 가장 좋았는데, 엽수 및 엽면적이 표준비의 72.7개, $619.7cm^{2}$에 비하여 81.9개와 $723cm^{2}$으로 증가하였다. 2. 수량 관련 형질 중에서 협수 및 종실수는 50%증비에서 개체당 31.9개와 72.3개로 가장 많았으며, 수량도 246 kg/10a로 다른 시비구에 비하여 가장 높았다. 무비와 N무비구에서는 협수가 24.9개/개체와 25.1개/개체, 립수는 60.3개/개체과 51.1개/개체, 수량은 181.0 kg/10a과 178.0 kg/10a으로 낮았다. 3. 생육시기에 따른 isoflavone 함량은 잎, 줄기, 뿌리에서 개화이후부터 립비대기(R5)까지는 감소하다가 이후 수확기(R7)까지 다시 증가하였다. 4. 식물체 부위별 isoflavone 함량은 뿌리에서 가장 높은 값을 나타내었다. 5. 시비수준에 따른 종실의 isoflavone 함량은 무비, N무비 및 50% 감비의 경우가 표준비나 증비보다 다소 높은 함량을 나타내었다.

교정환자의 자아존중감과 구강건강영향지수(OHIP)에 영향을 미치는 요인 (Maincause of influencing oral health impact profile(OHIP) and self-esteem of orthodontic patients)

  • 박영남;이미라
    • 한국치위생학회지
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    • 제10권3호
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    • pp.513-522
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    • 2010
  • Objectives : This study aimed to determine self-esteem and oral health impact profile (OHIP) of orthodontic patients to get data necessary for the process of consultation, education, and treatment for those patients who hoped to get orthodontic therapy in order to see effects of orthodontic therapy on personal life in consideration of general characteristics of those patients under orthodontic therapy. methods : A self-administered questionnaire was used among 232 outpatients under orthodontic therapy from October to November 2009, obtaining the following results. Results : 1. As for general characteristics of respondents, those under 19 years of age constituted 46.6%; the unmarried comprised 85.8%; and students constituted 53.4%. 2. Most respondents were getting orthodontic therapy for beauty (41.8%) and dental health (40.5%). Family (54.3%) contributed to their decision to get orthodontic therapy; parents or siblings (62.5%) were bearing the treatment expenses. 3. Females were getting orthodontic therapy for an aesthetic purpose (50.3%), and male for the purpose of dental health (44.6%) (P<0.01). 4. OHIP was slightly higher among males ($4.10{\pm}0.61$) than among female ($4.00{\pm}0.78$), and was highest among those 19 years old and under ($4.17{\pm}0.67$); the older they were, the lower it was significantly (P<0.05). Most of them were earning 3 to 4 million won ($4.22{\pm}0.72$); the married ($4.05{\pm}0.74$) constituted higher percentage. As for occupation, students ($4.13{\pm}0.66$) comprised the highest percentage. 5. Self-esteem was higher among males ($3.83{\pm}0.47$) than among females ($3.80{\pm}0.50$), and was highest among those 25 to 29 years old ($3.92{\pm}0.46$). Most of them were earning more than 5 million won ($3.91{\pm}0.42$), which was statistically significant (P<0.01). The married ($3.91{\pm}0.54$) constituted higher percentage than the unmarried ($3.80{\pm}0.48$); office managers ($3.95{\pm}0.55$) comprised the highest percentage. 6. As for correlation between variables effecting OHIP of orthodontic patients, there was negative correlation in age (r=-0.225) and positive correlation in occupation (r=0.122). As for correlation between variables effecting self-esteem of orthodontic patients, there was negative correlation in occupation (r=-0.130) and positive correlation n income (0.126), while there was positive correlation (r=0.202) between OHIP and self-esteem of orthodontic patients. Conclusions : Younger orthodontic patients who were students showed higher OHIP, and professionals earning more showed higher self-esteem. Orthodontic patients with higher OHIP showed higher self-esteem. Therefore, it is necessary to develop a program based on OHIP and self-esteem in consulting and treating orthodontic patients; since it is considered that orthodontic therapy will improve appearance, enhance self-confidence, and have positive effects on interpersonal relationships and quality of living, researches are necessary on constant changes in psychological properties.