• Title/Summary/Keyword: miR-25

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Mediating Effect of Social Support on the Relation between the Stress and Mental Health of Female College Students (여대생의 스트레스와 정신건강과의 관계에서 사회적 지지의 매개효과 -일부 전문대학 여대생을 중심으로-)

  • So, Mi-Hyun
    • The Journal of Korean Society for School & Community Health Education
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    • v.16 no.1
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    • pp.15-25
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    • 2015
  • Objectives: The purpose of this study was to identify the mediated effect of social support in relationship of stress and mental health of woman college students. Methods: Data were collected by distributing self recording type questionnaire to 336 woman students in three universities placed in Gyeonggi-do, who agreed attending to the research, and then were re-collected. The statistical methods used for data analysis were the descriptive statistics, frequency analysis, One-way ANOVA test, Pearson correlation coefficient, hierarchial regression analysis. Results: 1. According to the research, it appeared that social support differed depending on the grade the one is in(F=10.643, p<0.05), and mental health(F=3.446, p<0.05) and social support(F=2.444, p<0.05) differed depending on the family's economical level. 2. As the result of analysis of relationship of objects' mental health, stress, and social support, it appeared that mental health and stress(r=-0.605, p<0.01), mental health and social support(r=0.276, p<0.01) have relationship to each other. 3. As the result of hierarchial regression analysis for verifying the mediated effect of social support in relationship of research objects' stress and mental health, it showed that social support partially mediate in relationship of stress and mental health. Conclusion: The program which can intensify woman college students' social support and decrease stress needs to be developed and provided, in order to arrange solution of promoting woman students' mental health.

Effects of a mixture of essential oils and organic acid supplementation on growth performance, blood profiles, leg bone length, and intestinal morphology in broilers

  • Liu, Shu Dong;Song, Min Ho;Yun, Won;Lee, Ji Hwan;Cho, Seung Yeol;Kim, Gok Mi;Kim, Hyeun Bum;Cho, Jin Ho
    • Korean Journal of Agricultural Science
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    • v.46 no.2
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    • pp.285-292
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    • 2019
  • This study was done to evaluate the effects of a mixture of essential oils and organic acid supplementation on growth performance, blood profiles, leg bone length and intestinal morphology in Ross broilers. A total of 40 Ross 308 broilers ($1140{\pm}80g$) were randomly allocated to 2 groups, a basal diet (CON) and a basal diet + 0.05% $Avi-protect^{(R)}$ (AVI, Mixture of 25% citric, 16.7 sorbic, 1.7% thymol, and 1.0% vanillin), with 20 replicates for every group and 1 chicken per replicate per cage. The broilers were raised in a temperature-controlled room maintained at $24{\pm}1^{\circ}C$ and $50{\pm}5%$ humidity. The body weight (p < 0.05) and weight gain (p < 0.05) of the broilers were increased in the AVI group compared with the CON group. The triglyceride (p < 0.05) and low density lipoprotein (LDL) (p < 0.05) contents were significantly decreased in the AVI group compared with the CON group. There was no significant difference in the leg bone length between the AVI and CON groups (p > 0.05). The villi height (p < 0.05) and goblet cell count (p < 0.05) were significantly increased in the AVI group compared with the CON group. In conclusion, $Avi-protect^{(R)}$ as a feed additive improved the growth performance and lipid metabolism and promoted the development of the intestinal morphology of broilers.

Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement

  • Hong, Bok Sil;Baek, Suji;Kim, Myoung-Ryu;Park, Sun Mi;Kim, Bom Sahn;Kim, Jisu;Lee, Kang Pa
    • Korean Journal of Exercise Nutrition
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    • v.25 no.4
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    • pp.38-44
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    • 2021
  • [Purpose] Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person's exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement. [Methods] The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software. [Results] Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function. [Conclusion] According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.

Occurrence of Virus Diseases on Major Crops in 2008 (2008년 우리나라 주요 작물 바이러스병 발생 상황)

  • Kim, Jeong-Soo;Lee, Su-Heon;Choi, Hong-Soo;Kim, Mi-Kyeong;Kwak, Hae-Ryun;Cho, Jeom-Deog;Choi, Gug-Seoun;Kim, Jin-Young
    • Research in Plant Disease
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    • v.15 no.1
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    • pp.1-7
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    • 2009
  • Viruses diagnosed on crops including rice plants from farmers or agricultural extension agencies cover the country were 11 species including Broad bean wilt virus 2 (BBWV2) in 2008. Tomato spotted wilt virus (TSWV) was the most important virus having the detection rate of 22.9%. Two viruses of Tomato yellow leaf curl virus (TYLCV) and Tobacco leaf curl virus (TLCV) inducing leaf yellow and curl diseases on tomatoes were occurred newly with the detection rate of 12.2% and 4.0%, respectively, in 2008. Rice stripe virus (RSV) was occurred on 869.5 ha mainly at Jindo and Haenam areas in Jeollanamdo province. At Jindo area, 12 plots were damaged severely with the infected hill rate of 83.8%. At the main production area of oriental melon at Seongju, almost all fruits from whole sale market at Seongju were infected with Cucumber green mottle mosaic virus (CGMMV) as the detection rate of 87%. The areas occurred TSWV in Korea were 25 totally from 2003 including 7 areas newly reported in 2008 including Naju in Jeoallanamdo. TSWV could be reduced as 0.1 % from 5.3% by covering insect proof net in vinyl house after chemical soil sterilization. Tomato yellow leaf curl disease was occurred on April in 2008 at Tongyoung area in Kyeongsangnamdo, and detected continuously at 13 areas, 7 in Kyeongsangnamdo, 4 in Jeollabukdo and 2 in Jejudo. Potato spindle tuber viroid (PSTVd) was occurred abruptly in a confined space of a civil breeding greenhouse and a cultivar evaluation field followed by disuse 17.4 M/T of potato tubers. No PSTVd was detected at 17 fields cultivated the related potatoes to the bred company by RT-PCR.

A Seroepidemiological survey of scrub typhus and murine typhus among residents and rodents in Kyodongmyeon, Kanghwagun (강화 교동면 주민과 들쥐의 쯔쯔가무시병 및 발진열에 대한 혈청역학 조사)

  • Choi, Eun-Jeong;Hur, Myoung-Jei;Oh, Bo-Young;Park, Jin-Su;Lee, Mi-Yeon;Lee, Jea-Man;Go, Jong-Myoung;Kim, Yong-Hee
    • Korean Journal of Veterinary Service
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    • v.26 no.3
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    • pp.203-214
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    • 2003
  • Scrub typhus and murine typhus are common endemic febrile illness in the fall in Korea. Scrub typhus is caused by Orientia tsutsugomushi, murine typhus is caused by Rickettsia typhi. Trombiculid mites are known as both the vector and the reservoir host of O tsutsugamushi, the mites which transmit O tsutsugomushi have been reported to be Leptotrombidium pallidum and L scutellare. The author carried out an epidemiological study of scrub typhus and murine typhus in Kyodong-Myeon, Kanghwa-Gun, Incheon in relation to the residents and the host rodents, such as their distribution, seroepidemiology, and population density of chigger mites. 1. Out of 900 residents, 33(3.7%) showed positive reaction to O tsutsugamushi, 24(2.7%) to R typhi. 2. In the seropositives to O tsutsugamushi or R typhi, between the sixties and the seventies of the age were dominant. 3. In the seropositives to O tsutsugamushi serotypically Gilliam was dominant. 4. Among the total 42 field rodents trapped by the sherman traps, 18 rodents were Apodemus agrarius(42.9%), 13 rodents were Crocidura lasiura(31.0%), 5 rodents were Musmusculus(11.9%), 2 rodents(4.8%) were Crocidura suaveolens, Rattus norvegicus, Tscherskia triton, respectively. 5. Out of 42 field rodents, 25 were parasitized by 4,419 chigger mites, showing 59.5% of the infestation rate and 98.8 of the chigger index. L pallidum parasitized in A agrarius, C lasiura, M musculus, R norvegicus and T triton, and L scutellare parasitized only C lasiura. 6. Antibodies in the sera of field rodents against O tsutsugamushi and R typhi were investigated by indirect immunofluorescent antibody technique. Positive rate of antibody against O tsutsugamushi were 11.9(5 of 42) and all of the positive is A agrarius. Antibody against R typhi was not detected. These results might provide the basic information for the management of scrub typhus and murine typhus in Kyodong-myeon, where the epidemiological studies on scrub typhus and murine typhus was not carried out enough.

Age and Growth of Purple whelk, Rapana venosa (Gastropoda: Muricidae) in the West Sea of Korea (한국 서해산 피뿔고둥, Rapana venosa (Valenciennes, 1846) 의 연령과 성장)

  • Choi, Jong-Duk;Ryu, Dong-Ki
    • The Korean Journal of Malacology
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    • v.25 no.3
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    • pp.189-196
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    • 2009
  • Based on 1,260 samples, the age and growth of purple whelk, Rapana venosa (Valenciennes) (Gastropoda:Muricidae) have been investigated. The samples were collected monthly during one year time (from February, 2004 to January, 2005) from the West Sea of Korea. The age of R. venosa was determined by the ring of the operculum analysis. The relationship between whelk's shell height and ring radius in each ring group was expressed as an equation of linear regression and later a correspondence in each ring formation was determined. Based on the monthly variations in the marginal index (MI) of the operculum, it was assumed that the ring of this species has been formed once a year during the period from July to August. The relationship between shell height and shell width was expressed by the equation SW = 0.7867 SH - 6.3988 ($R^2$=0.8604); and between shell height and total weight by the equation $TW=0.0000626{\times}SH^{3.206}$ ($R^2$=0.8324). The purple whelk's spawning period was estimated through the fatness analysis and has occurred during the period from May to July. Obtained results suggests that the ring formation occurs once a year (in July) and the length of time period since the first ring has been formed on the operculum is approximately 13 months (1.08 year). The purple whelk's growth curves for shell height and total weight fitted to the von Bertalanffy's equation and were expressed as follows: $SH_t=199.653(1-e^{-0.104(t+2.478)}$ $TW_t=1484.105(1-e^{0.104(t+2.478)})^{3.206}$.

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Development of Agenda for Pharmaceutical Care Service Research and Development using the Analytical Hierarchy Process (약료서비스 R&D 고도화를 위한 우선순위 기반 전략과제 설정)

  • Han, Nayoung;Jeong, Chae-Reen;Song, Yun-Kyoung;Yoon, Jeong-Hyun;Jang, Sunmee;Lee, Eui-Kyung;Shin, Hyun Taek;Lee, Young Sook;Sohn, Hyun Soon;Ji, Eunhee;Suh, Dong Chul;Kim, Daekyung;Oh, Jung Mi
    • Korean Journal of Clinical Pharmacy
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    • v.29 no.1
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    • pp.45-55
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    • 2019
  • Background: Although the importance of pharmaceutical care service has been growing to meet the needs of customers with the improvement of clinical and humanistic outcomes, there was not a systematic strategy to promote research in Korea. The aim of this study was to suggest the core agendas for pharmaceutical care services research and development (R&D) considering priorities. Methods: Based on desk researches, we developed R&D agendas for the needs of improving pharmaceutical care services in the area of institution, community, and public health. To determine the priority of agendas in developing pharmaceutical care service, analytic hierarchy process (AHP) analysis was performed by the 14 experts. Criteria and subcriteria were assessed for significance by pairwise comparisons. Then, agendas were evaluated for importance according to each subcriteria, and rank ordered considering the weight calculated by multiplying the importance scores of the criteria and the subcriteria. Results: We derived 25 agendas including 13 for institutional pharmaceutical care service, 8 for community pharmaceutical care service, and 4 for public-health related pharmaceutical care service. AHP model was constructed based on 4 criteria and 8 subcriteria by a hierarchical structure. From the AHP survey, the 'Development of pharmaceutical care service for metabolic and chronic disease' agenda accounted for the highest priority. Conclusion: We have developed the R&D agendas of the pharmaceutical care service which should be promoted. The results should be utilized by the government to nationally support the development of the standards and relevant regulations related to pharmaceutical care services in Korea.

Anti-Inflammatory and Anti-Allergic Effects of Adenophora triphylla var. japonica Extract (잔대 추출물의 항염 및 항천식 효과)

  • Jang, Hwan Hee;Kim, Mi Ju;Cho, Su Yeon;Kim, Jung Bong;Lee, Sung Hyeon;Lee, Young Min
    • Journal of the East Asian Society of Dietary Life
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    • v.25 no.5
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    • pp.813-821
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    • 2015
  • Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The purpose of the present study was to evaluate the anti-inflammatory and anti-asthma effects of Adenophora triphylla var. japonica extracts. We investigated the molecular mechanism underlying the effects of 80% ethanol extracts (AE) of A. triphylla on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. AE treatment inhibited pro-inflammatory cytokines such as TNF-${\alpha}$ and IL-6 as well as nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. In particular, NO and pro-inflammatory cytokine production was suppressed more effectively by aerial parts (AE-A) than roots (AE-R) of A. triphylla. Quantitative RT-PCR assay showed that AE reduced mRNA levels of iNOS and COX-2. We also evaluated the anti-asthmatic effects of AE-A in an ovalbumin (OVA)-induced BALB/c mouse model. AE-A supplementation significantly reduced the amounts of airway eosinophils, IL-4 and IL-13 levels in BALF, and IgE levels in serum as compared with untreated, OVA-induced mice. These results suggest that AE-A can be considered as a therapeutic agent to potentially relieve asthma.

Effect of Planting Date on Freezing Tolerance and Winter Survival of Canola (Brassica napus L.) (파종시기가 케놀라의 내동성과 월동율에 미치는 영향)

  • Moon-Tae Song
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.2
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    • pp.150-156
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    • 1995
  • Planting date is the most important factor in determining winter survival of Crop plants. The objective of this study was to explore the effect of planting date on the development of freezing tolerance and winter survival of canola. Six winter cultivars were planted at three different dates during the fall on the Michigan State University Research Farm at East Lansing, MI. Freezing tolerance was determined by ion leakage tests every 15 days after planting until middle of November. Winter survival was evaluated by counting the live plants in the fall and next spring. Planting date as well as cultivar treatment had a significant effect on freezing tolerance and winter survival A different pattern in development of freezing tolerance was observed for different planting dates. There was a high correlation between freezing tolerance and winter survival suggesting that freezing tolerance could be a useful predictor for winter survival.

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Relationships between Cell Bio-volume and Growth Rate of Dominant Red Tide Organisms in the Coastal Water (연안내만해역에서 우점하는 주요적조생물의 성장과 세포체적의 관계)

  • Baek, Seung-Ho;Joo, Hae-Mi
    • Korean Journal of Environmental Biology
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    • v.30 no.1
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    • pp.1-8
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    • 2012
  • To understand growth characteristics of eight dominant red tide species ($Prorocentrum$ $minimum$, $Heterocapsa$ $triquetra$, $Scrippsiella$ $trochoidea$, $Akashiwo$ $sanguinea$, $Chattonella$ $marina$, $Heterosigma$ $akashiwo$, $Amphidinium$ $carterae$ and $Rhodomonas$ $salina$) in the Korean coastal water, the growth rates were examined in relation with the impacts of water temperature and bio-volume. Of these, $P.$ $minimum$, $C.$ $marina$, $H.$ $akashiwo$, $A.$ $carterae$ and $R.$ $salina$ were eurythermal species with relatively high growth rates in a borad ranges (15 to $25^{\circ}C$) of water temperature. On the other hand, the growth rate of $H.$ $triquetra$, $S.$ $trochoidea$ and $A.$ $sanguinea$ were high in relatively mid temperature (optimum: $25^{\circ}C$) condition. In particular, $H.$ $triquetra$ was well adapted in low temperature of 5 to $15^{\circ}C$, implying that the species can survive and grows even at very low temperature. Based on results of our experiment, the growth characterestics of five eurythermal species and three mid temperature species may have dominated in Korean coastal water during summer season and fall season, respectively. Contrastively, the growth characteristics of $H.$ $triquetra$ make a consistently dominant during the cold winter season. In addition, the growth rates of large bio-volume species were lower than those of small bio-volume species, indicates that growth of single cells of several flagellates might be depended on the cells sizes.