Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Anti-Inflammatory and Anti-Allergic Effects of Adenophora triphylla var. japonica Extract

잔대 추출물의 항염 및 항천식 효과

  • Jang, Hwan Hee (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science, RDA) ;
  • Kim, Mi Ju (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science, RDA) ;
  • Cho, Su Yeon (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science, RDA) ;
  • Kim, Jung Bong (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science, RDA) ;
  • Lee, Sung Hyeon (Functional Food & Nutrition Division, Department of Agrofood Resources, National Institute of Agricultural Science, RDA) ;
  • Lee, Young Min (Dept. of Food and Nutrition, Seoul Women's University)
  • 장환희 (국립농업과학원 기능성식품과) ;
  • 김미주 (국립농업과학원 기능성식품과) ;
  • 조수연 (국립농업과학원 기능성식품과) ;
  • 김정봉 (국립농업과학원 기능성식품과) ;
  • 이성현 (국립농업과학원 기능성식품과) ;
  • 이영민 (서울여자대학교 식품영양학과)
  • Received : 2015.09.21
  • Accepted : 2015.10.20
  • Published : 2015.10.30
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Abstract

Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The purpose of the present study was to evaluate the anti-inflammatory and anti-asthma effects of Adenophora triphylla var. japonica extracts. We investigated the molecular mechanism underlying the effects of 80% ethanol extracts (AE) of A. triphylla on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. AE treatment inhibited pro-inflammatory cytokines such as TNF-${\alpha}$ and IL-6 as well as nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. In particular, NO and pro-inflammatory cytokine production was suppressed more effectively by aerial parts (AE-A) than roots (AE-R) of A. triphylla. Quantitative RT-PCR assay showed that AE reduced mRNA levels of iNOS and COX-2. We also evaluated the anti-asthmatic effects of AE-A in an ovalbumin (OVA)-induced BALB/c mouse model. AE-A supplementation significantly reduced the amounts of airway eosinophils, IL-4 and IL-13 levels in BALF, and IgE levels in serum as compared with untreated, OVA-induced mice. These results suggest that AE-A can be considered as a therapeutic agent to potentially relieve asthma.

Keywords

References

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