• 제목/요약/키워드: miR-20a

검색결과 547건 처리시간 0.022초

Objective and Subjective Quality Characteristics of Pork Longissimus Muscle as a Function of the Ultimate pH

  • Cho, Byung-Wook;Oliveros, Maria Cynthia;Park, Kyoung-Mi;Do, Kyoung-Tag;Lee, Ki-Hwan;Seo, Kang-Seok;Choi, Jae-Gwan;Lee, Moon-Jun;Cho, In-Kyung;Choi, Byoung-Chul;Ryu, Kyeong-Seon;Hwang, In-Ho
    • 한국축산식품학회지
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    • 제29권6호
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    • pp.685-694
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    • 2009
  • The aim of the present study was to evaluate the variation in ultimate pH of commercial populations of pure-breed (Landrace, Duroc and Yorkshire) pig's longissimus muscles and their effect on objective meat quality traits and sensory characteristics. Fifty boars were sampled from 184 pigs, which were reared at three breeding farms and slaughtered at a commercial abattoir. The selection was determined based on ultimate pH, and animals were segregated into three groups: low pH (pH $\leq$ 5.5, n=13), medium pH (pH 5.5 to 5.6, n=18) and high pH (pH $\geq$ 5.6, n=16). The breeds had no significant effects; however, pigs with a higher ultimate pH had significantly (p<0.05) higher intramuscular fat content, lower level of polyunsaturated fatty acids, lower level of lipid oxidation and higher eating quality compared to those with lower ultimate pH. As the ultimate pH increased, the relative proportion of C14:0, C16:0 and C18:1 increased while C18:2n6 and C20:4n6 decreased. The present study demonstrates that the economic value of pigs can be characterized by the ultimate pH and/or intramuscular fat content. However, these results do not necessarily indicate that a high ultimate pH directly corresponds to high intramuscular fat content and vice versa.

일 지역사회 노인의 건강증진 생활양식, 자아존중감 및 사회적지지 관계연구 (A Study on Self-esteem and Social Support, Health-promoting Lifestyle of the Elderly)

  • 박순옥;백훈정;김춘미;문진하;최순영;김정숙;김애정
    • 지역사회간호학회지
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    • 제14권1호
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    • pp.144-156
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    • 2003
  • This study was conducted to investigate the relationship between the self-esteem, social support and health promoting lifestyle of the elderly in a community. The sample consisted of 147 elderly, and data were collected from September 1 to October 15, 2001. The instrument of this study was a structured questionnaire including Health Promoting Lifestyle (47 items), Social Support(18 items), Self-Esteem(10 items), Socio-demographic Characteristics. Analysis of the data was done by use of descriptive statistics, ANOVA, Pearson Correlation Coefficient. The results of this study are as follows: 1. The degrees of self-esteem of the elderly were mean score $25{\pm}2.98$ points, socio-demographic characteristics containing meaningful difference with self-esteem was not significant. 2. The degrees of social support by elderly were mean score $55.03{\pm}9.60$ points and social support according to the socio-demographic characteristics showed meaning difference in family structure $\ulcorner$with off spring$\lrcorner$ (F=8.50, p=.000), health status $\ulcorner$good$\lrcorner$ (t=2.19, p=.030), smoking $\ulcorner$below 1 packet daily$\lrcorner$ (F=4.88 p=.009). 3. The degrees of health enhancing lifestyle by elderly were mean score $113.61{\pm}20.12$ points and health enhancing lifestyle according to the socio-demographic characteristics showed meaning difference in education level $\ulcorner$middle school and above$\lrcorner$ (F=6.37 p=.002), occupation before retirement $\ulcorner$profession, technician, employee of company, education$\lrcorner$ (F=5.00, p=.003), health status $\ulcorner$good$\lrcorner$ (t=3.14, p=0.002), exercise $\ulcorner$weekly 2-3$\lrcorner$ (F=4.31, p=.006), drinking $\ulcorner$weekly 1$\lrcorner$ (F=2.74, p= .046). 4. The item mean score of personal relationship support field in health enhancing lifestyle were $2.90{\pm}.60$ points. item mean scores of exercise and nutrition were $2.26{\pm}.39$ points, item mean scores of stress managing field were $2.25{\pm}.49$ points, item mean scores of health responsible field were $2.14{\pm}.61$ points. 5. The relationship between self-esteem and health enhancing lifestyle revealed a significant correlation(r=.169. p=.041), but self-esteem and social support, showed no significant correlation, and health enhancing lifestyle and social support, revealed a significant correlation(r=.654, p=.001).

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A Role for Leu247 Residue within Transmembrane Domain 2 in Ginsenoside-Mediated α7 Nicotinic Acetylcholine Receptor Regulation

  • Lee, Byung-Hwan;Choi, Sun-Hye;Pyo, Mi Kyung;Shin, Tae-Joon;Hwang, Sung-Hee;Kim, Bo-Ra;Lee, Sang-MoK;Lee, Jun-Ho;Lee, Joon-Hee;Lee, Hui Sun;Choe, Han;Han, Kyou-Hoon;Kim, Hyoung-Chun;Rhim, Hyewhon;Yong, Joon-Hwan;Nah, Seung-Yeol
    • Molecules and Cells
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    • 제27권5호
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    • pp.591-599
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    • 2009
  • Nicotinic acetylcholine receptors (nAChRs) play important roles in nervous system functions and are involved in a variety of diseases. We previously demonstrated that ginsenosides, the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not ${\alpha}7$, expressed in Xenopus laevis oocytes. Mutation of the highly conserved Leu247 to Thr247 in the transmembrane domain 2 (TM2) channel pore region of ${\alpha}7$ nAChR induces alterations in channel gating properties and converts ${\alpha}7$ nAChR antagonists into agonists. In the present study, we assessed how point mutations in the Leu247 residue leading to various amino acids affect 20(S)-ginsenoside $Rg_3$ ($Rg_3$) activity against the ${\alpha}7$ nAChR. Mutation of L247 to L247A, L247D, L247E, L247I, L247S, and L247T, but not L247K, rendered mutant receptors sensitive to $Rg_3$. We further characterized $Rg_3$ regulation of L247T receptors. We found that $Rg_3$ inhibition of mutant ${\alpha}7$ nAChR channel currents was reversible and concentration-dependent. $Rg_3$ inhibition was strongly voltage-dependent and noncompetitive manner. These results indicate that the interaction between $Rg_3$ and mutant receptors might differ from its interaction with the wild-type receptor. To identify differences in $Rg_3$ interactions between wild-type and L247T receptors, we utilized docked modeling. This modeling revealed that $Rg_3$ forms hydrogen bonds with amino acids, such as Ser240 of subunit I and Thr244 of subunit II and V at the channel pore, whereas $Rg_3$ localizes at the interface of the two wild-type receptor subunits. These results indicate that mutation of Leu247 to Thr247 induces conformational changes in the wild-type receptor and provides a binding pocket for $Rg_3$ at the channel pore.

아동감각처리척도(Sensory Processing Scale for Children; SPS-C)의 검사-재검사 신뢰도와 검사자간 신뢰도 연구 (A Study of Test-Retest Reliability and Interrater Reliability of the Sensory Processing Scale for Children (SPS-C))

  • 김경미;김가연;이승진
    • 대한감각통합치료학회지
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    • 제20권2호
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    • pp.11-21
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    • 2022
  • 목적 : 본 연구의 목적은 국내에서 개발된 아동감각처리척도(Sensory Processing Scale-Children; SPS-C)의 안정성 확립을 위해 감각처리에 어려움을 가진 만 3~5세 아동의 보호자를 대상으로 검사-재검사 신뢰도와 검사자간 신뢰도를 검증하는 것이다. 연구방법 : 본 연구의 대상자는 감각처리에 어려움을 가진 3~5세 아동 70명이었다. 검사-재검사 신뢰도 검증은 감각처리에 어려움을 가진 아동의 주 양육자 20명이 대상이었다. 초기평가 후 7~14일 내로 재평가를 실시하였고, 두 시점 간 관련성은 피어슨 상관계수를, 일치도는 급내상관계수를 사용하였다. 검사자 간 신뢰도 검증은 감각처리에 어려움을 가진 아동의 주 양육자, 부 양육자 각각 18명을 대상으로 하였다. 두 검사자 간의 일치도 확인은 급내상관계수를 사용하였다. 결과 : 검사-재검사 신뢰도는 피어슨 상관계수 r=.914, 급내상관계수 ICC=.939로 높은 수준의 관련성과 일치도를 나타냈다. 검사자간 신뢰도는 급내상관계수 ICC=.727로 좋은 일치도를 나타냈으나 촉각 영역(ICC=.455)과 고유감각 영역(ICC=.439)은 통계적으로 유의하지 않았지만, 보통의 일치도를 보였다. 결론 : 본 연구를 통해 아동감각처리척도(SPS-C)는 검사-재검사 신뢰도와 검사자간 신뢰도가 검증되어 안정성 있는 평가도구임을 확인하였으며, 추후 임상적 사용을 위한 표준화 연구에 도움을 제공할 수 있을 것이다.

일부 종합병원 간호사들이 경험한 간병인에 대한 연구 (A Study on Occupational Care Diver Though Nurse's Experiences in General Hospitals)

  • 김혜순;김숙영;박미성
    • 지역사회간호학회지
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    • 제5권2호
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    • pp.216-226
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    • 1994
  • This study attempted to analize nurse's experiences about care giver including nurse's recognition of occupational care giver's existence, the helping part of occupational care giver's activities, problems between occupational care giver and nurse, and correlations between reasons of problems and each variable. The subjects of the study are 218 nurses who are working at general hospitals. The study informations gathered by using structured questionnaire which consisted of 38 items. The reliability of the instrument was cronhach's 0.8310. The collected data was analized by spss program for the statistics of percent, t-test, ANOVA, and Pearson's correlation. The study results were as follows : 1. For the nurse's recognition of occupational care giver's existence 70.2% of nurses(153 nurses) who felt occupaitional care giver's existence was helpful. The result showed 2.20 when transfered to score. 2. Occupational care giver's activities which were helpful to nurses were in order of following : simple serving, personal hygiene, companion of talking, room arrangement, and saftey management. 3. Among 10 items of the problems which nurses having experiences with occupational care givers, 4 items were related with nurses directly. 88.4% of the reasons of the problems were due to lack of occupational care giver's eduction. 4. For the relationships of general characteristics and nurse's reason of problems there was the significant difference in the nurse's status and education. There was the significant difference showed in the group of over status of charge nurse and over college education(T=-2.08, P<0.05, T=-2.13, P<0.01) 5. Correlation between nurse's recognition of occupational care giver's existence and the problems between care giver and the nurse revealed weak relationship (r=0.2002, P<0.01). However, correlation between nurse's recognition of occupational care giver's existence and degree of occupational care giver's helping and also relationship of degree of care giver's helping and problems between these two groups were not statistically significant.

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Bacillus licheniformis Isolated from Korean Traditional Food Sources Enhances the Resistance of Caenorhabditis elegans to Infection by Staphylococcus aureus

  • Yun, Hyun Sun;Heo, Ju Hee;Son, Seok Jun;Park, Mi Ri;Oh, Sangnam;Song, Min-Ho;Kim, Jong Nam;Go, Gwang-Woong;Cho, Ho-Seong;Choi, Nag-Jin;Jo, Seung-Wha;Jeong, Do-Youn;Kim, Younghoon
    • Journal of Microbiology and Biotechnology
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    • 제24권8호
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    • pp.1105-1108
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    • 2014
  • We investigated whether Bacillus spp., newly isolated from Korean traditional food resources, influence the resistance of hosts to foodborne pathogens, by using Caenorhabditis elegans as a surrogate host model. Initially, we selected 20 Bacillus spp. that possess antimicrobial activity against various foodborne pathogens, including Staphylococcus aureus. Among the selected strains, six strains of Bacillus spp. used in preconditioning significantly prolonged the survival of nematodes exposed to S. aureus. Based on 16S rRNA gene sequencing, all six strains were identified as B. licheniformis. Our findings suggest that preconditioning with B. licheniformis may modulate the host defense response against S. aureus.

기혼 여성의 유방조영술 검진 행위에 대한 영향요인 (Factors Related to the Stage of Mammography Screening in Married Korean Women)

  • 허혜경;박소미;김기연
    • 성인간호학회지
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    • 제16권1호
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    • pp.72-81
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    • 2004
  • Purpose: The purpose of this study was to examine factors related to different stages of mammography screening based on the transtheoretical model (TTM) and health belief model (HBM). Method: 143 women were recruited from community centers in W city. The mean age was 44.08 (SD=7.78) and 74 (51.7%) had experienced education on preventative behavior related to breast cancer. The Decisional Balance Scale (Pros and Cons of mammography) and Stages of Adoption of Mammography Scale by Rakowski et al. (1992) and the revised Health Belief Model Scale (Perceived Seriousness, Perceived Susceptibility and Health Motivation) by Champion (1993) were used. Result: According to the stage of adoption of mammography, 17.4% of the women were In pre-contemplation, 45.5% in contemplation, 24.5% in action, and 12.6% in maintenance. The mean differences for pros, and the decisional balances between the stages of mammography adoption were significant (F=8.84, p=.000; F=7.20, p=.000). Education related to prevention of breast cancer was the most important variable. Prevention education, history of breast disease and pros of mammography explained the stages of mammography adoption ($R^{2}=26%$). Conclusion: Findings support TTM as a useful tool for improving mammography adherence. Behavioral interventions that target decisional balance and health belief can effectively promote adherence to mammography.

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일부 여성 미용종사자들의 근골격계 증상의 위험요인 (A Study on Risk Factors of Musculoskeletal Disorders among Selected Female Hair Dressers)

  • 송미라;한성현
    • 한국산업보건학회지
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    • 제15권3호
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    • pp.250-260
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    • 2005
  • This study was designed to find the symptom prevalence rates of musculoskeletal disorders and the risk factors of musculoskeletal disorders among selected hair dressers. Methods; The survey were conducted from July 1 to 30, 2004 for 459 hair dressers working in Seoul and Gwangju using self-administration questionnaire. The risk factors on musculoskeletal disorders have analysed by multiple linear regression analysis. The results of this study are summarized as follows: The experience rate of musculoskeletal disorders symptom in the last one year was 56.4%. The experience rates of each body parts were 36.4% on the shoulders, 30.5% on the legs and the feet, 28.5% on the low back, 27.0% on the hand and the fingers, 23.3% on the neck and 17.0% on the arms and the elbows. The prevalence rate of musculoskeletal disorders symptom in the last one week was 40.5%, those of each body parts were 24.0% on the legs and the feet, 21.4% on the shoulders, 20.7% on the low back, 15.7% on the hand and the wrists, 15.0% on the neck, 9.4% on the arms. The risk factors on musculoskeletal disorders were working posture(${\beta}=0.32$), perceived stress(${\beta}=0.19$), working period(${\beta}=0.16$), standing working over 10 hour(${\beta}=0.16$), hard working(${\beta}=0.11$). The adjusted determinant coefficient($R^2$) of this regression model was 0.267. Based on the results, in order to prevent musculoskeletal disorders of hair dressers, working posture shall be improved and leisure opportunities to relieve stress, and health management program shall be provided.

정부주도형 및 민간주도형 푸드뱅크(Food Bank) 사업의 기탁 특성 분석 (Analysis on the Donators' Characteristics of Government-dominant and Non-governmental Food Bank Programs)

  • 조미나;홍민아;강혜승;양일선
    • 대한지역사회영양학회지
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    • 제11권5호
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    • pp.618-628
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    • 2006
  • The purpose of this study was to examine the donators' characteristics and donative foods of both government-dominant and non-governmental food bank program, to understand the problems and benefits of food bank program, and to find the solutions to activate food bank program. The questionnaires were distributed to 120 food bank operators and 3 donators were selected from each food bank for the survey from April 2002 to May 2002. 118 sheets (32.8%) from government-dominant food bank and 53 sheets (20.1%) from non-governmental food bank were collected. The main results of this study were as follows: The largest donators to either government-dominant or non-governmental food bank programs were bakery and confectionery companies 31.4% and 45.3% respectively. The majority of donated foods were 'goods in stock' (55.6%) and frequency of donation were largely on a daily basis (27.1% for government-dominant and 22.6% for non-governmental). Some of the donators who had more donative food did not donate, and the reasons were closeness to expiration date of food (67.3%), lack of legal protection in the event of food poisoning (54.5%), and poor public image of food related accidents (52.3%).

Comparative Study of White and Steamed Black Panax ginseng, P. quinquefolium, and P. notoginseng on Cholinesterase Inhibitory and Antioxidative Activity

  • Lee, Mi-Ra;Yun, Beom-Sik;Sung, Chang-Keun
    • Journal of Ginseng Research
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    • 제36권1호
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    • pp.93-101
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    • 2012
  • This study evaluated the anti-cholinesterases (ChEs) and antioxidant activities of white ginseng (WG) and black ginseng (BG) roots of Panax ginseng (PG), P. quinquefolium (PQ), and P. notoginseng (PN). Ginsenosides $Rg_1$, Re, Rf, $Rb_1$, Rc, $Rb_2$, and Rd were found in white PG, whereas Rf was not found in white PQ and Rf, Rc, and $Rb_2$ were not detected in white PN. The major ginsenoside content in steamed BG including $RK_3$, $Rh_4$, and 20(S)/(R)-$Rg_3$ was equivalent to approximately 70% of the total ginsenoside content. The WG and BG inhibited acetylcholinesteras (AChE) and butyrylcholinesterase (BChE) in a dose dependent manner. The efficacy of BG roots of PG, PQ, and PN on AChE and BChE inhibition was greater than that of the respective WG roots. The total phenolic contents and 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) scavenging activity were increased by heat treatment. Among the three WG and BG, white PG and steamed black PQ have significantly higher contents of phenolic compounds. The best results for the DPPH scavenging activity were obtained with the WG and BG from PG. These results demonstrate that the steamed BG roots of the three studied ginseng species have both high ChEs inhibition capacity and antioxidant activity.