• 운동영양학회지
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• 제23권1호
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• pp.28-35
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• 2019

[Purpose] The purpose of this study was to investigate the effects of treadmill exercise on oxidative stress in the hippocampal tissue and mitochondrial dynamic-related proteins in rats fed a long-term high-fat diet (HFD). [Methods] Obesity was induced in experimental animals using high fat feed, and the experimental groups were divided into a normal diet-control (ND-CON; n=12), a high fat diet-control (HFD-CON; n=12) and a high fat diet-treadmill exercise (HFD-TE; n=12) group. The rats were subsequently subjected to treadmill exercise (progressively increasing load intensity) for 8 weeks (5 min at 8 m/min, then 5 min at 11 m/min, and finally 20 min at 14 m/min). We assessed weight, triglyceride (TG) concentration, total cholesterol (TC), area under the curve, homeostatic model assessment of insulin resistance, and AVF/body weight. Western blotting was used to examine expression of proteins related to oxidative stress and mitochondrial dynamics, and immunohistochemistry was performed to examine the immunoreactivity of gp91phox. [Results] Treadmill exercise effectively improved the oxidative stress in the hippocampal tissue, expression of mitochondrial dynamic-related proteins, and activation of NADPH oxidase (gp91phox) and induced weight, blood profile, and abdominal fat loss. [Conclusion] Twenty weeks of high fat diet induced obesity, which was shown to inhibit normal mitochondria fusion and fission functions in hippocampal tissues. However, treadmill exercise was shown to have positive effects on these pathophysiological phenomena. Therefore, treadmill exercise should be considered during prevention and treatment of obesity-induced metabolic diseases.

• Asian-Australasian Journal of Animal Sciences
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• 제22권5호
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• pp.667-673
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• 2009

Ninety six intact male sheep (12 months old with mean live weight of about 35 kg) were used to assess the effects of restricted feeding on intake, digestion, nitrogen balance and metabolizable energy (ME). The animals were selected from two known Iranian small and large body size breeds: 48 Sangsari (S) and 48 Afshari (A), and were divided into two equal groups: restricted (R) and a control (C). Each group had 48 sheep (24 each breed). The experiment had a duration of 15 and 75 days adaptation and treatment periods, respectively. The animals were individually placed in metabolism cages and fed a diet based on pelleted concentrate mixture consisting of alfalfa, barley grain, cottonseed meal and barley straw. The animals in group C were fed ad libitum, while animals in group R were fed at maintenance level and maintained a relatively constant live weight. During the experiment, the average daily weight gain (ADG) of S and A animals in R group was 0.34 and -0.25 g/d (0.02 and -0.02 $g/kg^{0.75}/d$), respectively. While that of S and A animals in C group was 174.4 and 194.4 g/d (10.16 and 11.48 $g/kg^{0.75}/d$), respectively. Nitrogen (N) was determined by both measured and regression methods. Animals of R group stayed at about zero N balance (0.01 and -0.00 g $N/kg^{0.75}/d$ for S and A animals, respectively). The N retention of animals of both S and A breeds in C group were similar (0.45 and 0.46 g $N/kg^{0.75}/d$, respectively). Digestible organic matter intake (DOMI) and ME requirement for maintenance (MEm) were measured by both constant weight technique and regression method by regressing N balance on DOMI and ME intake on ADG. The measured DOMI during constant weight was 24.61 and 24.27 g $DOMI/kg^{0.75}/d$ and the calculated DOMI from regression equation was 24.24 and 24.22 g $DOMI/kg^{0.75}/d$, for S and A animals, respectively. The measured MEm was 402 and 401 kJ $ME/kg^{0.75}/d$ and the calculated MEm from regression analysis was 398 and 400 kJ $ME/kg^{0.75}/d$ for S and A breeds, respectively. There were no significant differences between both measured and regression techniques. There was no significant difference between S and A breeds for DOMI, N retention, MEm, digestibility and metabolizability values. Digestibility values for OM, GE and CP and metabolizability were significantly (p<0.05) higher in restricted feeding sheep compared with that of sheep fed ad libitum.

• 대한한방내과학회지
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• 제38권6호
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• pp.955-970
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• 2017

Objectives: The aim of this observational study was to identify and analyze the patterns to compare the characteristics of asthma patients. Methods: The subjects were 40 asthma patients who had satisfied the inclusion and exclusion criteria. They were divided into deficiency syndrome and excess syndrome groups, and cold syndrome and heat syndrome groups. Their quality of life was measured by the quality of life questionnaire for adult Korean asthmatics (QLQAKA) and VAS. Heart rate variability (HRV) was measured, and the degree of obesity was evaluated by body mass index (BMI). Hematological, biochemical, and immunoglobulin (Ig) E laboratory tests were included. Results: Based on pattern identification, the 40 asthma patients could be divided into two categories of groups: 1) the deficiency syndrome (N=18) and the excess syndrome (N=22) groups: 2) the cold syndrome (N=35) and the heat syndrome (N=5) groups. The mean value of HF differed significantly between the deficiency and excess syndrome groups. The mean value of IgE in blood tests of asthmatics was greater than four times the reference value. For BMI, the subjects were classified into three groups: normal weight (N=12), overweight (N=12), and obese (N=16). Conclusions: Development of a more accurate asthma-specific pattern identification tool could play a crucial role in asthma control. In addition, good control of asthma can improve the quality of life. Obesity is one of the factors associated with asthma exacerbation.

• Asian-Australasian Journal of Animal Sciences
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• 제31권2호
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• pp.225-229
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• 2018

Objective: This experiment was designed to evaluate the effect of supplementation with soybean or canola oil on milk production and the composition of long chain fatty acids as well as weight changes in the goats and their kids. Methods: Thirty nine mulitparous crossed Alpine${\times}$Nubian goats (initial body weight [BW] $43.5{\pm}1.7kg$) from the day of parturition were assigned to the treatments: grazing control (n = 15); grazing plus 20 mL/goat/d of supplemental soybean oil (n = 12); and grazing plus 20 mL/goat/d of supplemental canola oil (n = 12) from November 26, 2014 to March 7, 2015. The planned contrasts were: CI (control vs supplemented with oils); CII (soybean vs canola oil) to compare the treatment effects. Results: The vegetable oil supplementation reduced weight losses in lactating goats (CI: -0.060 vs 0.090 kg/d; p = 0.03) but did not improve milk production or affect kids' growth. The content of C4, C6, C8, C10, C11, C14, and C18:1n9t in the milk was increased (p<0.05) with respect to control. However, C12, C14, C16, C18, C18:1n9c, C18:2n6c, and C18:3n3 were reduced (p<0.05) in supplemented goats. Conjugated linoleic acid (CLA) was increased (p<0.05) in goats supplemented with oils compared to the control group. Conclusion: Supplementation with 20 mL/d of soybean or canola oil did not affect milk production or kids' performance; however, it increased CLA concentration and reduced the reduced weight losses in lactating goats.

• 한방비만학회지
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• 제5권1호
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• pp.75-85
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• 2005

Objectives : This study examined the association between body mass index(BMI) and psychological factors; self-esteem, depression, restraint eating, disinhibition, and hunger. The difference of TFEQ(restraint eating, disinhibition and hunger) was analyzed in variety of current diet situations. Methods : The research was based on a sample of people who visited our website and submit the result of self test(self-esteem n=3183; TFEQ n=5167; BDI n=2457). Results : Self-esteem and BDI was slightly correlated with BMI. There is negative correlation between restraint eating and BMI and positive correlations were observed between hunger and BMI, and disinhibition and BMI. We studied diet situation and eating habits. We divided the sample into 4 groups in accordance with self-submitted result: non-diet group(n=2806), diet-failed group within 3 months group(n=371), maintaining group after successful-diet(n=233), on-going diet group(n=1757) As to restraint eating, non-diet group showed the lowest score in restraint eating and maintaining group after successful-diet showed the highest. The score in disinhibition and hunger was significantly lower in maintaining group after successful-diet group than one in diet-failed group. Conclusion : These results suggest that it would be essential to treat these psychological factors such as depression and self-esteem in weight loss program. Considering the result in diet-situation and TFEQ, we insist that restraint-eating and disinhibition should be controlled. If these psychological factors were not treated in place, even the successful diet might turn out to be a worse situation like binge-eating

• 한방재활의학과학회지
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• 제24권2호
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• pp.115-130
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• 2014

Objectives The objective of this study is to interpretate Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou" in a modern kineologic approach Methods Based on the interpretation of "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou" and implementation of its kinesiology, this study presents similar kineologies and their purposes, with the reference to various documents on modern kinesiology. Results 1) Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou" is similar to stretching, active exercise and resistance exercise. 2) Exercises in Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou", which are similar to resistance exercise, can be used for isometic exercise of cervical extensor. 3) Exercises in Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou", which are similar to Stretching exercise, has its purpose to stretch quadratus Lumborum, lateral side of body, gluteus Maximus, quadriceps femoris, shoulder extensor, hamstrings, hip joint, ankle dorsi flexor, thoracic rotator,inferior shoulder joint. 4) Exercises in Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou", which are similar to active exercise, can be used for strengthen exteral oblique. 5) Doctors can make various applications of Yansaeng-Doinbub. For example, it can be used to correct improper low back and neck exercise patterns. 6) Yangsaeng-Doinbub also describes breathing methods, which help normalization of breathing exercises and increase the efficiency of spine exercises. Conclusions The modern interpretation on kinesiology of Yangsaeng-Doinbub presented in "Zhu-Bing-Yuan-Hou-Lun Yao-Bei-Bing-Zhu-Hou" leads to a conclusion that Yangsaeng-Doinbub consists of numourous exercises for various body parts. In particular, breathing methods increase efficiency of such exercises. Plus, the exercises in Yangsaeng-Doinbub can be applied to various uses by doctors.

• 한국지하수토양환경학회지:지하수토양환경
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• 제14권6호
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• pp.35-44
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• 2009

나프탈렌과 TNT는 미국 환경청(U.S. EPA)에서 규정한 발암가능성 물질로(Group C), 환경으로 방출될 경우 수생태계와 인체에 심각한 영향을 주는 것으로 알려져 있다. 그러나 지하수 내 두 물질의 미량 분석법에 대한 기존연구는 매우 미비한 실정이다. 이에 본 연구에서는 HPLC-FLD(Fluorescence etector)와 MSD(Mass detector)를 이용한 지하수 내 나프탈렌 및 TNT의 미량분석법을 개발하여, MDL과 LOQ 및 이온영향을 조사하고, 현재 사용되고 있는 HPLC-UV 분석법과 비교 평가하였다. 나프탈렌의 경우, 3D-Fluorescence를 통하여 확인된 최고의 파장(Ex: 270 nM, Em: 330 nM)이 HPLC-FLD에 적용되었고, $0.3\;{\mu}g/L$의 MDL과 $2.0\;{\mu}g/L$의 LOQ가 획득되었다. 이는 현재 방법(HPLC-UV; MDL: $23.3\;{\mu}g/L$, LOQ: $163.1\;{\mu}g/L$)보다 약 80배 우수한 결과이며, U.S. EPA의 음용수 권고기준($700\;{\mu}g/L$)의 약 350배 이하까지 정량분석이 가능한 수치이다. TNT의 경우, 새롭게 제시된 HPLC-MSD로 측정한 방법(MDL: $0.13\;{\mu}g/L$, LOQ: $0.88\;{\mu}g/L$)이 HPLC-UV(MDL: $16.8\;{\mu}g/L$, LOQ: $117.5\;{\mu}g/L$ at 230 nM)보다 약 130 배 우수한 것으로 조사되었고, U.S. EPA의 음용수 권고기준($20\;{\mu}g/L$)보다 약 23배 낮은 농도까지 정량분석이 가능한 것을 확인하였다. 또한 HPLC-UV(230 nM)의 분석법은 ${NO_3}^-$ 농도가 증가할수록(특히 21 mg/L 이상) 크로마토그램의 기준선이 증가하여 정량에 방해를 주었으나, HPLC-MSD 분석법은 국내 지하수 평균 농도보다 약 3.5배인 63.7 mg/L에서도 분석의 영향 없이 안정한 크로마토그램을 보여주었다. 따라서 새롭게 제시된 HPLC-FLD와 MSD에의한 나프탈렌과 TNT 분석법은 지하수 및 음용수 미량분석에 적합하며, 관련분야 연구에 크게 도움이 될 것이다.

• 생물정신의학
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• 제19권2호
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• pp.84-90
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• 2012

Objectives : The purpose of this study was to examine the changes in metabolic parameters and Positive and Negative Syndrome Scale (PANSS) scores of patients previously treated with atypical antipsychotic drugs other than paliperidone, after 8 weeks of treatment with paliperidone. Methods : Changes in body weight, body mass index, leptin, lipid levels, fasting glucose, and PANSS scores of patients who switched from other atypical antipsychotic drugs to paliperidone were measured after 8 weeks of treatment with paliperidone. We compared these results with those of patients who had not been treated with antipsychotic drugs for at least 2 weeks prior to treatment with paliperidone (antipsychotic drug-free patients). Results : The antipsychotic drug-free group (n = 9) did not show significant changes in metabolic parameters, but showed a significant improvement in total and subscale scores of PANSS. In the group that switched from other atypical antipsychotic drugs to paliperidone (n = 13), body weight, body mass index and fasting glucose level significantly increased, while total and subscale scores of PANSS significantly improved. Conclusions : Paliperidone treatment will benefit patients with schizophrenia who have been antipsychotic drug-free or who have had difficulty with other atypical antipsychotic drugs, with regard to their psychopathological state. However, if patients have been treated with other atypical antipsychotic drugs before switching to paliperidone, they could gain body weight or their fasting glucose level could increase over a short period because of a change in receptor number and sensitivity caused by the previously prescribed antipsychotic drugs, and hence, paliperidone should be prescribed with caution for these patients.

• Journal of the Korean Data and Information Science Society
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• 제24권6호
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• pp.1241-1251
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• 2013

이 논문의 연구목적은 운동형태에 따라 중년여성의 신체구성과 혈중지질에 미치는 영향을 규명하기 위한 것이다. 연구대상은 40 50대 중년여성으로 유산소운동집단 8명, 복합트레이닝집단 8명 두 그룹으로 나누었으며, 12주간의 운동프로그램을 실시하였다. 운동강도는 주4회, 1회 70~90분, HRmax 60%~75%, 1RM 60%~80%로 점진적으로 증가시켰다. 자료처리는 Windows 용 SPSS ver. 21.0 통계 프로그램을 사용하여 평균과 표준편차 등을 산출하고, 비모수통계분석 방법인 윌콕슨 부호순위검정과 윌콕슨 순위합검정을 통해 그룹별 사전-사후 평균차와 변화량에 대한 그룹간 차이를 검정하였다. 연구결과를 살펴보면, 먼저 각 집단별 사전-사후 평균차에서는 복합운동 집단의 BMI, 체지방량, 그리고 중성지방에서만 통계적으로 유의한 차이가 나타났다. 또한 변인별 사전-사후 변화량에 대한 두 집단간의 차이 검정에서는 체지방량에서만 통계적으로 유의한 차이가 나타났다. 부가적으로 통계적 유의성은 검증되지 않았지만 각 별인별 사전-사후 평균 변화에 대한 기술통계를 살펴보면 복합운동이 유산소운동에 비해 상대적으로 더 효과적일 수 있다는 것을 알 수 있다.

• 대한물리의학회지
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• 제19권1호
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• pp.81-94
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• 2024

PURPOSE: This study aimed to investigate the effect of a progressive balance training program with whole-body vibration stimulation on knee joint pain, dysfunction, psychosocial status, and balance ability in individuals aged ≥ 65 years with knee osteoarthritis. METHODS: A total of 40 individuals aged ≥ 65 years with osteoarthritis of the knees participated in the study. Using a randomization program, participants were assigned to an experimental group (n = 20) or a control group (n = 20). Both groups were assigned a knee strength training program, and a progressive balance training program with whole-body vibration stimulation was assigned to the experimental group. All interventions were conducted three times a week for four weeks. Participants were evaluated for the following: pain (numeric rating scale, NRS), knee dysfunction (Korean version of the Western Ontario and McMaster Universities Arthritis Index, K-WOMAC), fall efficacy (Korean Version Falls Efficacy Scale, K-FES), quality of life (Euro Quality of life 5 Dimension, EQ-5D), and advanced balance scale score (Fullerton advanced balance scale, FAB) before and after the intervention, and the effects of the intervention were compared accordingly between groups. RESULTS: Both groups showed significant differences in the results of the NRS, K-WOMAC, K-FES, and EQ-5D assessments before and after the intervention, and there was a significant difference in the amount of change between the two groups (p < .05). There was a significant improvement in FAB in all but items FAB 8 and FAB 9 after the intervention in the experimental group. In the control group, there was a significant improvement in FAB 1, FAB 2, FAB 7, and FAB total after the intervention (p < .05). In addition, there was a significant difference in the amount of change between the two groups in all items except FAB 8 and FAB 9 (p < .05). CONCLUSION: The progressive balance training program with whole body vibration stimulation is an effective intervention method with clinical significance in improving knee joint pain, knee disability index, psychosocial level, and balance ability in adults aged ≥ 65 with osteoarthritis of the knees.