• 수산해양교육연구
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• 제28권5호
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• pp.1266-1272
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• 2016

Phospholipase C is a key enzyme of signaling pathways hydrolyzed phosphatidylinositol 4,5-bisphosphate to generate 2 second messengers. Among the PLC, $PLC-{\beta}$ subfamily consisted of 4 isoforms, $PLC-{\beta}$ 1~4. Here, we studied the tissue specific expression of $PLC-{\beta}3$ in olive flounder (Paralichthys olivaceus) following external stimulation like lipopolysaccharide (LPS), concanavalin A (ConA) and environmental stress compared with the inflammatory cytokines IL-1b. $PoPLC-{\beta}3$ gene transcripts has the effect in stimulated tissue compared to control. These results provide what we sure to be a important role for $PLC-{\beta}3$ activity in tissue and verify $PLC-{\beta}3$ as potential immune enzyme for signal transduction.

• 한국동물학회지
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• 제37권1호
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• pp.130-136
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• 1994

Although alteration in protein phosphorylation by specific protein kinases is of importance in transducing cellular signals in a variety of neural/endocrine systems, little is known about protein phosphorylation in the hvpothalamus. The present study aims to explore whether activation of the second messenger-dependent protein kinases affects phosphorylation of specific proteins using a cell free phosphorylation system followed by SDS-polvacrylamide gel electrophoresis. Cytoplasmic fractions derived from hvpothalami of immature rats were used as substrates and several activators and/or inhibitors of CAMP-, phosphatidylinositol- and Ca2+-calmodulin-dependent protein kinases were assessed. Many endogenous proteins were extensively phosphorylated and depending on the signal transduction pathways, phosphorvlation profiles were markedly different. The present data indicate that extracellular signals may affect cellular events through protein phosphorylation by second messengers-protein kinases in the rat hypothalamus.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2014년도 추계학술발표대회
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• pp.466-469
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• 2014

기존 Window8 Style 에 대한 디지털 포렌식 연구는 윈도우 기본 애플리케이션에 대해서만 진행되어 있는 상황이고, 다른 3rd party Style App 들에 대해서만 진행되어있는 상황이다. 본 논문에서는 Window8 Style UI 의 Instant Messengers 에 대해 디지털 포렌식 분석하고 이를 통해 범인의 행동 흐름 파악 및 증거확보 매커니즘을 제시하고자 한다. 본 논문은 기존의 Window8 의 접근방법을 토대로 하여, Style App 의 사용흔적이나 내용에 대해 확인하며, 시간정보, 이미지 등 각종 애플리케이션들을 다각적으로 분석한다. 본 논문에서 제안한 접근법은 개별 App 들에 대한 정보를 효율적이고 빠르게 분석하고 사건에 대한 정보를 제공함으로써 범죄수사과정에 도움이 될 것으로 기대된다.

• Toxicological Research
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• 제9권2호
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• pp.195-206
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• 1993

The expression of proenkephalin (proENK) mRNA and Met-enkephalin (ME) secretion in C6 rat glioma cells and bovine adrenal medullary chromaffin (BAMC) cells were elucidated in the present study. The levels of proENK mRNA and ME secreted into the media in BAMC cells were measured in the presence of cycloheximide and 12-tetrade-canoylphorbol-13-acetate (TPA). Cycloheximide (20 nM) abolished the induction of proENK mRNA expression, protein synthesis and ME secretion by TPA (1nM), indicating that de novo protein synthesis was necessary for proENK gene expression and ME secretion.

• Molecules and Cells
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• 제39권1호
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• pp.72-76
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• 2016

Cell death pathways such as apoptosis can be activated in response to oxidative stress, enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are proposed to be a significant event during apoptosis signaling, regardless of the initiating stimulus. In this scenario oxidants act as second messengers, mediating the post-translational modification of specific regulatory proteins. The exact mechanism of this signaling is unclear, but increased understanding offers the potential to promote or inhibit apoptosis through modulating the redox environment of cells. Peroxiredoxins are thiol peroxidases that remove hydroperoxides, and are also emerging as important players in cellular redox signaling. This review discusses the potential role of peroxiredoxins in the regulation of apoptosis, and also their ability to act as biomarkers of redox changes during the initiation and progression of cell death.

• 융합보안논문지
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• 제18권2호
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• pp.25-32
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• 2018

스마트폰 사용이 보편화되면서 자연스럽게 서로간의 소통이 메신저를 통하여 이뤄지게 되었다. 하지만 서로간의 대화공간이 범죄를 공모하는 공간으로도 활용되고 있는 실정이다. 이에 따른 범죄와 관련된 증거들이 스마트폰에 저장된다. 스마트폰의 특성상 저장정보의 삭제를 손쉽게 할 수 있기 때문에 증거를 신속히 확보 하는 것이 중요하다. 따라서 본 논문에서는 국 내외에서 대표적으로 사용 중인 모바일 메신저에 대하여 데이터 파일의 아키텍처 분석을 수행하였다. 사용자가 메시지 삭제를 위해 이용할 수 있는 방법에 대한 시나리오를 설정하고 실험을 통해 메시지 복원가능 여부에 대하여 비교 분석한다.

• Journal of Information Processing Systems
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• 제17권2호
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• pp.318-333
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• 2021

Smartphones are one of the most widely used mobile devices allowing users to communicate with each other. With the development of mobile apps, many companies now provide various services for their customers by studying interactive systems in the form of mobile messengers for business marketing and commercial promotion. Such interactive systems are called "chatbots." In this paper, we propose a method of avoiding the redundant responses of chatbots, according to the utterances entered by the user. In addition, the redundant patterns of chatbot responses are classified into three categories for the first time. In order to verify the proposed method, a chatbot is implemented using Telegram, an open source messenger. By comparing the proposed method with an existent method for each pattern, it is confirmed that the proposed method significantly improves the redundancy avoidance rate. Furthermore, response performance and variation analysis of the proposed method are investigated in our experiment.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.355.1-355.1
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• 2002

Recently. we have reported that several lipoxygenases products directly activate the capsaicin-activated channel as intracellular messengers in neuron. In particular, 12-(S)-hydroperoxyeicosatetraenoic acid turned out to be the most potent endogenous VR activator. This finding prompted us to search for a novel non-vaniloid VR agonists and antagonists. We have designed and synthesized a series of non-vanilloid VR binding ligands based on the structural simllarity between 12-HPETE and capsaicin, the natural VR agonist. Our recent studies on the development of selective vanilloid receptor agonists and antagonists will be presented.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.260.1-260.1
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• 2002

Green tea contains several antioxidants including polyphenols of the catechin. which have been shown to act in vitro and in vivo as anti-inflammatory. anti-viral and anti-tumor drugs. Prostaglandins (PGs) are a family of intercellular and intracellular messengers derived from arachidonic acid(AA) by phospholipase(PL) and cyclooxygenase(COX). These mediators exert a wide range of effects on processes such as smooth muscle tone. vascular permeability, cellular proliferation. and inflammatory/immune function. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.258.1-258.1
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• 2002

Piperine (piperinoyl-piperidine) is a nitrogenous pungent substance contained in black pepper. the well know spice obtained from Piper nigrum L. (Piperaceae). Pharmacological studies have shown that piperine reduces inflammation and pain. possesses anticonvulsant and antiulcer activity. protects the liver and has deleterious effects on testis function. Prostaglandins(PGs) are a family of intercellular and intracellular messengers derived from arachidonic acid(AA) by phospholipase(PL) and cyclooxygenase(COX). (omitted)