Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.355.1-355.1
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- 2002
Design. Synthesis and Biological Activities of Novel Vanilloid Receptor (VR) Agonists and Antagonists
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Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Lee, Bo-Young (Pacific R＆D Cente) ;
- Kim, Jin-Kwan (Pacific R＆D Cente) ;
- Min, Kyung-Hoon (Pacific R＆D Cente) ;
- Park, Ok-Hui (Pacific R＆D Cente) ;
- Lee, Young-Sil (Pacific R＆D Cente) ;
- Oh, Uh-Taek (Pacific R＆D Cente) ;
- Park, Young-Ho (Pacific R＆D Cente) ;
- Joo, Yung-Hyup (Pacific R＆D Center) ;
- Choi, Jin-Kyu (Pacific R＆D Center) ;
- Jeong, Yeon-Su (Pacific R＆D Center) ;
- Koh, Hyun-Ju (Pacific R＆D Center)
- Published : 2002.10.01
Abstract
Recently. we have reported that several lipoxygenases products directly activate the capsaicin-activated channel as intracellular messengers in neuron. In particular, 12-(S)-hydroperoxyeicosatetraenoic acid turned out to be the most potent endogenous VR activator. This finding prompted us to search for a novel non-vaniloid VR agonists and antagonists. We have designed and synthesized a series of non-vanilloid VR binding ligands based on the structural simllarity between 12-HPETE and capsaicin, the natural VR agonist. Our recent studies on the development of selective vanilloid receptor agonists and antagonists will be presented.
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