• Toxicological Research
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• v.31 no.4
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• pp.347-354
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• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• Journal of the Semiconductor & Display Technology
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• v.18 no.2
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• pp.82-86
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• 2019

The reliability of 3D NAND flash memory cell is affected by the charge migration which can be divided into the vertical migration and the lateral migration. To clarify the difference of two migrations, the activation energy of the charge loss is extracted and compared in a conventional square device pattern and a new test pattern where the perimeter of the gate is exaggerated but the area is same. The charge loss is larger in the suggested test pattern and the activation energy is extracted to be 0.058 eV while the activation energy is 0.28 eV in the square pattern.

• Proceedings of the Korean Society Of Semiconductor Equipment Technology
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• 2006.05a
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• pp.21-40
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• 2006

[ ${\Box}$ ] Opportunities for PRAM Nearly ideal memory characteristics Potential for high density & low cost memory ${\Box}$ Technical Challenges Writing current reduction is the most urgent issue. ${\to}$ chalcogenide, programming volume, current density, heat loss control Improvement of writing speed, reliability ${\Box}$ Prospects (PRAM as a Mainstream Memory) Evenn, We have demonstrated 256Mb PRAM Realization of high density and low cost PRAM with good reliability will be key succss factor. We need to develop PRAM specific applications.

• Journal of Information Technology Services
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• v.7 no.2
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• pp.181-195
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• 2008

The rapid growth of mobile communication technology has provided the expansion of mobile internet services, particularly mobile realtime transaction takes much weight among mobile fields. There is an increasing demand for various mobile applications to process transactions in a mobile computing fields. Thus, During transmission in wireless networks a base station failure inevitably causes data loss of the base station buffer. It is required to compensate the loss for communication. The existing methods for a base station failure are not adequate because they all suffer from too much overhead and resolve only the link failure. In this paper, we study an efficient recovry systems for a mobile DBMS. We propose SLL (Segment Log List) that enables the mobile host to compensate data loss efficiently in the case of base station failure. In SLL, a base station deliveries an output information of data cells to a mobile host. when a base station fails, the mobile host can retransmit just next data cells. We also prove the efficiency of new method.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.11
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• pp.2850-2861
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• 1996

This paper describes the design of AATM switch LIS of shared buffer type with linked-list architecture to control memory access. The proposed switch LSI consists of the buffer memory, controller and FIFO memory blocks and two special circuits to avoid the cell blocking. One of the special circuit is a new address control scheme with linked-list architecture which maintains the address of buffer memory serially ordered from write address to read address. All of the address is linked as chain is operated like a FIFO. The other is slip-flag register it will be hold the address chain when readaddress missed the reading of data. The circuits control the buffer memory efficiently and reduce the cell loss rate. As a result the designed chip operates at 33ns and occupied on 2.7*2.8mm$^{2}$ using 0.8.mu.m CMOS technology.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.5
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• pp.842-849
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• 2011

The transponder simulator designed to simulate the transponder of military satellite communication systems in the geostationary orbit is required to have time delay function, because of 250 ms delay time, when a radio wave transmits the distance of 36,000 km in free space. But, it is very difficult to develop 250 ms time delay device in the transponder simulator of 100 MHz bandwidth, due to unstable operation of FPGA, loss of memory data for the high speed rate signal processing. Up to date, bandwidth of the time delay device is limited to 45 MHz bandwidth. To solve this problem, we propose the new time delay techniques up to 100 MHz bandwidth without data loss. Proposed techniques are the low speed down scaling and high speed up scaling methods to read and write the external memory, and the matrix structure design of FPGA memory to treat data as high speed rate. We developed the satellite link simulator in 100 MHz bandwidth using the proposed new time delay techniques, implemented to the transponder simulator and verified the function of 265 ms time delay device in 100 MHz bandwidth.

• Journal of Communications and Networks
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• v.17 no.3
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• pp.286-295
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• 2015

Avionic databuses fulfill a critical function in the connection and communication of aircraft components and functions such as flight-control, navigation, and monitoring. Ethernet-based avionic databuses have become the mainstream for large aircraft owning to their advantages of full-duplex communication with high bandwidth, low latency, low packet-loss, and low cost. As a new generation aviation network communication standard, avionics full-duplex switched ethernet (AFDX) adopted concepts from the telecom standard, asynchronous transfer mode (ATM). In this technology, the switches are the key devices influencing the overall performance. This paper reviews the avionic databus with emphasis on the switch architecture classifications. Based on a comparison, analysis, and discussion of the different switch architectures, we propose a new avionic switch design based on a time-division switch fabric for high flexibility and scalability. This also merges the design concept of space-partition switch fabric to achieve reliability and predictability. The new switch architecture, called space partitioned shared memory switch (SPSMS), isolates the memory space for each output port. This can reduce the competition for resources and avoid conflicts, decrease the packet forwarding latency through the switch, and reduce the packet loss rate. A simulation of the architecture with optimized network engineering tools (OPNET) confirms the efficiency and significant performance improvement over a classic shared memory switch, in terms of overall packet latency, queuing delay, and queue size.

• Dementia and Neurocognitive Disorders
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• v.17 no.3
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• pp.120-129
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• 2018

Background and Purpose: Prospective memory (PM) has a known relationship with frontal function, and PM decline has been observed in amnestic mild cognitive impairment (aMCI). Cerebral small vessel disease, as evidenced by white matter hyperintensities (WMHs), is linked to frontal dysfunction. This study was undertaken to evaluate the relationship between PM decline and WMHs in patients with aMCI. Methods: Of 74 enrollees with aMCI, 69 completed this prospective study. We compared total scores and sub-scores of the Prospective and Retrospective Memory Questionnaire (PRMQ) administered at baseline and 3 months later, stratifying patients by degree of WMHs. Results: A significant decline was seen in PRMQ total scores and PM scores at the 3-month mark in patients with moderate (vs. mild) degrees of WMHs ($-2.8{\pm}7.2$ vs. $0.2{\pm}7.1$; p=0.032). In addition, patients with moderate (vs. mild) degrees of deep WMHs (DWMHs) showed greater PM decline, whereas PM loss in patients with mild, moderate, or severe degrees of periventricular WMHs (PVWMHs) did not differ significantly. Conclusions: Findings of this study indicate that the burden of WMHs is consistently implicated in PM deterioration experienced by patients with aMCI, and signifies greater PM decline, especially in instances of extensive DWMHs. Greater attention to the change of PM is therefore needed in aMCI patients with WMHs.

• Journal of English Language & Literature
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• v.59 no.4
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• pp.545-567
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• 2013

Keeping in mind the hybridity and plurality of Southern Literature, this paper discusses the traits of Southern literature in Jayne Ann Phillips's first novel, Machine Dream. The novel's frequent use of memory and oral reconstruction of a family history accompanied by the feeling of loss in the process of depicting the South's past typically signifies "The Southern" which reminds us of the works of William Faulkner, Katherine Ann Porter, and Eudora Welty. Nevertheless, Phillips's South is more fragmented and her narrative is more evasive and varied than any of her Southern predecessors. The South of the twentieth century from the period of Depression until 1972 is reconstructed differently depending on memories and desires of the four members of Hampson family in this novel, either as a place of nostalgia or as the place of trauma or as the place to survive only in memory. The oxymoronic title of the novel, "machine dreams" signifies that dream and memory of the South cannot remain independent in its epistemological entity but exist as a mixture of materiality of every day life in the modern South. The hybridity of this dream and of the South is what defines itself as Southern. Yet Phillips retains feeling of loss and lament enough to create a modern Southern novel rooted in Southern Literature. Thus, the title itself works an antinomic signifier of both the presence and absence of the dream of the South and of Southern Literature.

• The Journal of Korean Medicine
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• v.38 no.2
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• pp.31-40
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• 2017

Objectives: We investigated the effect of acupuncture on memory function in relation with neurogenesis in old rats. Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU) were performed. Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint. Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions.