• 대한통합의학회지
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• 제9권4호
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• pp.91-103
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• 2021

Purpose : This study aimed to evaluate the effects of a cognitive enhancement brain yoga program on short-term memory and serum brain-derived neurotrophic factor (BDNF) levels according to the cognitive state in men aged 20-29 years. Methods : Thirty healthy volunteers aged 20-29 years were divided into four groups: brain yoga group, yoga group, combined exercise group, and control group. Seven people were assigned randomly per group. A single-session intervention was conducted over 50 min and consisted of three parts: warm-up, main exercise (brain yoga, yoga, combined exercise, or non-exercise), and cool-down. Serum BDNF levels were measured using enzyme-linked immunosorbent assay, and short-term memory was evaluated using the forward number span test before and after the intervention. Results : BDNF levels significantly increased within the brain yoga group after the intervention (from 28874.37±5185.57 to 34074.80±7321.12, p=.003), whereas there were no significant differences pre-and post-intervention in the other groups. The inter-group comparison showed a significant interaction between the brain yoga group and the combined exercise group (p=.036) but no significant interaction between any of the other groups. Forward number span scores were significantly increased in the brain yoga group (from 9.43±9.83 to 23±7.92, p=.012) and theyoga group after the intervention (from 13.43±9.41 to 24.14±8.45, p=.011), whereas there were no significant changes after the intervention in any other groups. Conclusion : Our findings showed that a single-session, 50-minute brain yoga exercise improved short-term memory and increased serum BDNF levels in healthy men aged 20-29 years and that yoga improved only short-term memory in healthy men of this age group.

• 구강회복응용과학지
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• 제23권2호
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• pp.179-186
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• 2007

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

• Annals of Clinical Neurophysiology
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• 제19권2호
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• pp.101-112
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• 2017

Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

• 감성과학
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• 제21권3호
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• pp.151-164
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• 2018

기존의 사회인지와 정서 연구들은 주로 얼굴자극을 이용하여 초기지각단계 및 후기인지과정에의 정서 효과를 조사해 왔다. 그러나, 정서의 효과가 정보처리과정의 각 단계에서 어떤 양상으로 나타나는지와, 정서유형에 따른 효과 양상의 변화 여부는 불확실하다. 본 연구에서는 얼굴 대신 생물형운동자극을 이용해 자극에 내포된 행복, 분노, 중립정서가 지각과제와 작업기억과제 수행에 미치는 영향을 조사하였다. 참가자는 연달아(지각과제) 또는 시간차를 두고(작업기억과제) 제시되는 두 생물형운동의 동일 여부를 판단하였다. 지각과제에서는 정서가를 가진 자극 시행의 정확도가 중립정서자극에 비해 낮아 정서정보가 초기지각처리에는 부정적 영향을 미치는 것으로 보였으나, 작업기억과제에서의 기억정보유지에는 도움이 되는 것으로 나타났다. 또한, 각 과제에서 정서유형에 따라 다른 수행 양상이 관찰되었다. 분노정서는 지각단계에서 더 많은 정신적 자원을 요구하여 부하가 증가할 경우 정확도가 낮아지지만 기억유지에는 긍정적으로 작용하는 것으로 보이며. 행복정서의 경우 중립정서가 이어서 제시될 때 이를 행복정서와 유사하게 처리하려는 편향을 유도하는 것으로 보인다. 본 연구는 생물형운동자극을 이용하여 정보처리과정에서의 정서 영향을 재확인하였고, 처리단계별 및 정서 종류별로 다른 양상의 영향이 나타난다는 점을 추가로 밝혀, 정서정보의 정교한 조작 및 통제를 위한 유용한 단서를 제공한다.

• 한국약용작물학회지
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• 제28권2호
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• pp.85-94
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• 2020

Background: Alzheimer's disease (AD) is caused by various factors, such as cholinergic dysfunction, regulation of neurotrophic factor expression, and accumulation of amyloid-beta. We investigated whether or not a combination of Carthamus tinctorius L. seed and Taraxacum coreanum (CT) has a protective effect on scopolamine-induced memory impairment in a mouse model. Methods and Results: Mice were orally pretreated with CT (50, 100 and 200 mg/kg/day) for 14 days, and scopolamine (1 mg/kg/day) was injected intraperitoneally before subjecting them to behavior tests. CT-administered mice showed better novel object recognition and working memory ability than scopolamine-treated control mice. In T-maze and Morris water maze tests, CT (100 and 200 mg/kg/day) significantly increased space perceptive ability and occupancy to the target quadrant, respectively. In addition, 100 and 200 mg/kg/day of CT attenuated cholinergic dysfunction through inhibition of butyryl cholinesterase in brain tissue. Furthermore, CT-administered mice showed higher cyclic adenosine monophosphate-response element-binding protein (CREB) levels and lower amyloid precursor protein (APP) levels compared to scopolamine-treated control mice. Conclusions: CT improved scopolamine-induced memory impairment through inhibition of cholinergic dysfunction, up-regulation of CREB, and down-regulation of APP. Therefore, CT could be a useful therapeutic agent for AD with protective effects on cognitive impairment.

• The Korean Journal of Physiology and Pharmacology
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• 제8권4호
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• pp.173-179
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• 2004

Amyloid ${\beta}-peptide\;(A{\beta})$ contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against $A{\beta}-induced$ toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated $A{\beta}-induced$ apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

• Biomolecules & Therapeutics
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• 제21권6호
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• pp.462-469
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• 2013

Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the effects of EUE aqueous extract in graded doses to protect and enhance cognition in scopolamine-induced learning and memory impairments in mice. EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. One day after the last trial session of the Morris water maze test (probe trial session), EUE dramatically increased the latency time in the target quadrant in a dose-dependent manner. Furthermore, EUE significantly inhibited acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner. EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice. Based on these findings, we suggest that EUE may be useful for the treatment of cognitive deficits, and that the beneficial effects of EUE are mediated, in part, by cholinergic signaling enhancement and/or protection.

• Molecules and Cells
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• 제39권8호
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• pp.603-610
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• 2016

Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.

• 한국콘텐츠학회논문지
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• 제19권9호
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• pp.101-111
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• 2019

이 연구는 작업기억과 사회인지능력 사이의 관계 및 이야기의 이용이 사회인지 능력에 미치는 영향을 탐구하고자 했다. 이를 위해 연구참여자 82명에 대해 작업기업(n-back)을 측정한 다음, 사회인지 부하로서의 지향성 수준(5차 지향성 대 3차 지향성)을 달리한 이야기 및 설명문 등 3개 집단에 무작위로 배치해 사회인지능력으로서 관점채택과 감정추론 정확성을 비교분석했다. 분석결과 관점채택은 작업기억과 유의한 정비례의 관계가 나타났다. 반면 감정추론은 작업기억과 유의한 관계가 나타나지 않았다. 실험집단별 차이는 연구가설과는 반대로 인지부하가 가장 높은 5차지향성 이야기집단의 관점채택이 인지부하가 낮은 3차지향성 이야기집단의 관점채택보다 유의하게 낮았다. 설명문 집단과는 2종의 이야기 집단 모두 유의한 차이가 없었다. 감정추론은 3개 집단 사이에 모두 유의한 차이가 없었다. 전체적으로 이 연구는 일관되지 않은 결과가 나타났는데, 이에 대한 이론 및 방법론적 의의에 대한 논의를 제시했다.

• 한국융합학회논문지
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• 제6권2호
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• pp.13-18
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• 2015

본 연구의 목적은 소방공무원의 외상후 스트레스 장애의 원인을 파악하고 스트레스를 진단하기 위한 척도와 도구에 대한 고찰을 통해 위기상황 스트레스 관리 교육프로그램과 대책을 제안하고자 하는데 그 목적이 있다. 외상후 스트레스 장애는 침습 증상, 회피 증상, 인지와 기분의 부정적 변화, 과각성 증상을 특징을 포함한다. 트라우마의 기억은 외현 기억(explicit memory)과 암묵 기억(implicit memory)이 있다. 외현 기억은 의식적, 인지적, 서술적이며, 변연계 구조물 중 해마가 관여한다. 사건 당시 정보 처리는 억제적이며, 내러티브 언어구성을 갖는다. 암묵 기억은 무의식적, 정서적, 절차적이며, 몸이 기억을 한다. 관련된 변연계 구조물은 편도체이고 사건 당시 정보처리는 활성화되어 있고, 말로 표현할 수 없는 언어구성을 갖는다. 암묵 기억의 소거가 트라우마 치료에서 가장 중요하다. 위기상황 스트레스 관리(critical incident stress management, CISM)는 위기 상황으로 인해 발생되는 스트레스의 유해성을 감소시키고, 조절하기 위한 포괄적이고 체계적인 접근 방법이다. 결론적으로 CISM의 핵심적 목표는 외상후 스트레스 장애에 의한 심리적 상태의 종결이라고 할 수 있다. 본 연구는 외상후 스트레스 장애의 원인과 대처방법에 대한 문헌 고찰을 통해 소방공무원의 외상후 스트레스 장애 해소를 위한 교육프로그램 개발을 제안하고자 하였다.