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http://dx.doi.org/10.14348/molcells.2016.0072

Impaired Memory in OT-II Transgenic Mice Is Associated with Decreased Adult Hippocampal Neurogenesis Possibly Induced by Alteration in Th2 Cytokine Levels  

Jeon, Seong Gak (Department of Biochemistry, College of Medicine, Konyang University)
Kim, Kyoung Ah (Department of Biochemistry, College of Medicine, Konyang University)
Chung, Hyunju (Department of Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong)
Choi, Junghyun (Department of Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong)
Song, Eun Ji (Department of Biochemistry, College of Medicine, Konyang University)
Han, Seung-Yun (Department of Anatomy, College of Medicine, Konyang University)
Oh, Myung Sook (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University)
Park, Jong Hwan (Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University)
Kim, Jin-il (Department of Nursing, College of Nursing, Jeju National University)
Moon, Minho (Department of Biochemistry, College of Medicine, Konyang University)
Publication Information
Molecules and Cells / v.39, no.8, 2016 , pp. 603-610 More about this Journal
Abstract
Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.
Keywords
adult neurogenesis; CD4 T cells; cognition; OT-II transgenic mice; Th2 cytokines;
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