• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1541-1542
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• 2013

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.104-107
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• 1998

The studies for antithrombotic substances from medicinal plants in my laboratory were started from the studies on PAF-antagonistic substances from Korean medicinal plants. The screening studies of PAF-receptor binding antagonistic activity were conducted on the extracts of 300 Korean medicinal plants, 37 tropical medicinal plants, 20 mushrooms, and 30 vegetables. From the results of screening studies, it was possible to select two Korean medicinal plants, i.e. 1) the leaf of Biota orientalis and 2) the seed of Arctium lappa, and two tropical medicinal plants, i.e. 3) the rhizome of Alpinia officinarum and 4) the leaf of Ardisia crispa as the candidates for the activity guided isolation of PAF-antagonistic substances.

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.61-110
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• 1998

1. Purpose : This study is a try for making a historical examinatiom of the symptom, principal medicinal substances and prescription of Soyangin Bisoohan-Pyohan disease. 2. Methods : I have examined the changes of the recognition of symptom and the history of the development of prescription by comparing the exterior syndrome of Soyangin, related prescription and principal medicinal substances quoted in "DongYi-Soose-Bowon" with past original texts and "DongYi Bogam". 3. Results and Conclusion : Lee Je-Ma adopted most of the exterior syndrome of Soyangin from Zhang Zhong-jung's "Shanghanlun". But he adopted only a few medicinal substances for prescription and most of prescriptions written after the Song period. The prescriptions for Soyangin Bisoohan-Pyohan disease are fundamentally composed of medicinal substances to lower yinqi and to eliminate the heat of thoracic part caused acording to the degree of symptom and medicinal substances to strengthen damaged yinqi are added to the prescriptions.

• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.67-94
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• 1997

The main purpose of this study is to arrange the diseases, principal medicinal substances and the prescriptions for the Soumin's Sinsooyul-Pyoyul-Byung(少陽人 腎受熱表熱病) by historical examination in the viewpoint of the Constitutional Medicine(四象醫學). In this study, first I collected the original texts of the diseases and priscriptions in Dongyi-Soose-Bowon(東醫壽世保元), and described the development process of the Soumin(少陽人)'s diseases and priscriptions by comparing with the contents in Dongyi-Soose-Bowon(東醫壽世保元). Next, I collected the efficacy of the medicinal substances and priscriptions by the examination of successive literatures referred it, and tried to explain the efficacy of each medicinal substances in the viewpoint of the Constitutional Medicine(四象醫學) by the analysis of successive literatures. As a result, the conclusions could be summarized as follows. 1. The Differentiation of Syndromes(辦證) in the Existing Medicine(旣存醫學) was formed according to the Eight Principal Syndromes(八綱), the Five Elements(五行), the Merdian system(經絡), therefore there were many confusions with the changes of the times. The differentiation of Syndromes(辦證) in the Constitutional Medicine(四象醫學) was formed according to the pathological change of Ascending and Descending Yin Yang(陰陽升降) in the Four Internal Organs(四臟), therefore, there was the consistency in the recognition of diseases. 2. The classification of the Soumin's Pyoyul-Byung(少陽人 表熱病) was divided into Yukuang Disease(鬱狂證) and Mangyang Disease(亡陽證) according to sweating or not. The conception of these diseases was mostly achived in Shanhanlun(優寒論). The treatment of Shanhanlun(優寒論) was alike to that of Dongyi-Soose-Bowon(東醫壽世保元) in a part. 3. Je ma, Lee thinked that the cause of the Soumin's Pyoyul-Byung(少陽人 表熱病) is the breakdown of the balanced equilibrium in ascending and descending Yin Yang(陰陽升降) for a Large Sin and a Small Bi(腎大脾小), and it is treated by warming and ascending Yang(溫補升陽). 4. The medicinal substances composing prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is characterized with the efficacy of Ascending Yang and supplying Qi(升陽益氣) and regulating the digestive organs with the efficacy of warming it. 5. The medicinal substances composing the precriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is divided into four parts with the state of Yang Qi(陽氣) in the disease it used. 6. The purpose of prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is to strengthen the Soumin(少陰人)'s Yangnan Qi(陽暖之氣). Je ma, Lee kept the principle not to mix with another constitution's medicinal substances in the creation of the priscription.

• The Korea Journal of Herbology
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• v.37 no.5
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• pp.37-51
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• 2022

Objectives : The purpose of this study was to apply informations related to herbal medicines to IDMP (Identification of Medicinal Products), an ISO standards related to medicinal products substances, for systematic collection of data through the integration of informations on distribution, manufacturing, and management of herbal medicines. Methods : By analyzing ISO 11238 and ISO/TS 19844, elements that can be used in the information model of herbal medicine were derived from the identification of medicinal products information model on substances. The labeling specified in the safety and quality control regulations for herbal medicines was mapped to the IDMP information model, and ginseng was applied as an example. Results : Herbal medicine corresponded to substance in IDMP. Among the five types of substances specified by IDMP, herbal medicines were expressed as structurally diverse. Scientific name was used as an invariant property of herbal medicine, and the substance level included information about source material and modification, and specifically included information about the scientific name, medicinal part, fraction, and processing. In addition, the specified substance level had information on the constituents, characteristic attributes, manufacturing, and grade of the herbal medicine. Conclusions : It is necessary to establish a code system for identifying herbal medicines. In order to apply the IDMP standards, research on the development of standard terms is required to express the characteristics of herbal medicines. In addition, information for identification of herbal medicines is also required, and information from production to consumption should be systematically accumulated and managed for actual application.

• Korean Journal of Medicinal Crop Science
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• v.1 no.1
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• pp.49-57
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• 1993

Seedling of Aralia continentalis is more effective method rather than use of vegetative organ for mass propagation. However, lower germination rate is the main problem for seeding. In this study, we analyzed substances in aim to relate to germination process. The results indicated that longer period of stratification brought lower amount of phenolic compounds in the seeds and both promoting and inhibiting substances were at very low level or gradually disappeared.

• Korean Journal of Pharmacognosy
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• v.22 no.1
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• pp.1-12
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• 1991

Nearly 50 highly sweet substances have been isolated and structurally characterized from green plants, and such compounds comprise mainly various types of terpenoids, flavonoids, and proteins. Among the sweet substances that have been studied as constituents of North and South American medicinal plants are the sesquiterpene, hernandulcin, the triterpene glycosides, abrusosides A-D, the steroidal saponins, polypodosides A and B, and the dihydroflavonol, dihydroquercetin-3-acetate. In addition, safety studies have been performed on the potently sweet substance, stevioside, from the 'sweet herb of Paraguay' (Stevia rebaudiana), a compound now produced on a commercial scale.

• International Journal of Contents
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• v.7 no.4
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• pp.108-115
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• 2011

The current study aims to analyze the acceptance of International Standard Terminology (IST) related to herbs and formulas used in Korea. It also intends to examine limitations of each term source by linking texts for herbal medicine research and formula research used in schools of oriental medicine with medicinal substance-formula classification names within the IST framework. This study examined 64 medicinal classification names of IST, including synonyms, 41 formula classification names, 65 classification names of "Herbal Medicine Study," 89 medicinal classification names of "Shin's Clinical Herbal Medicine Study," and lastly 83 formula classification names of "Formula Study." Data on their chief virtue, efficacy and characteristics as medicinal substances were extracted from their definitions, and such data were used to perform Chinese character-English mapping using the IST. The outcomes of the mapping were then analyzed in terms of both lexical matching and semantic matching. In terms of classification names for medicinal substances, "Herbal Medicine Study" had 60.0% lexical matching, whereas "Shin's Clinical Herbal Medicine Study" had 48.3% lexical matching. When semantic matching was also applied, "Herbal Medicine Study" showed a value of 87.7% and "Shin's Clinical Herbal Medicine Study" 74.2%. In terms of formula classification names, lexical matching was 28.9% of 83 subjects, and when semantic matching was also considered, the value was 30.1%. When the conceptual elements of this study were applied, some IST terms that are classified with other codes were found to be conceptually consistent, and some terms were not accepted due to different depths in the classification systems of each source.

• Korean Journal of Medicinal Crop Science
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• v.21 no.4
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• pp.282-288
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• 2013

Gastrodia elata Blume is a achlorophyllous orchid plant that has been used in traditional medicine to treat many human illnesses, such as vertigo, hemiplegia, and epilepsy. It contains three major pharmacological substances; gastrodin, ergothioneine, and vanillyl alcohol. Here we investigated the quantitative changes in those functional components by cultivation conditions and harvest times. The content of ergothioneine was different with cultivation areas, while gastrodin accumulated the higher levels than vanillyl alcohol regardless of cultivation areas. The smaller tubers contained the higher concentrations of gastrodin and the lower concentrations of ergothioneine than did the larger tubers. The cultivation under sun shade screen increased the concentrations of both gastrodin and vanillyl alcohol but decreased the levels of ergothioneine. We also determined the contents of functional substances depending on the harvest times. The concentration of gastrodin was higher in October than in April, while the level of ergothioneine was higher in April than in October. Interestingly, the use of sexually propagated seed tubers produced 1.9 times higher levels of gastrodin compared to vegetatively propagated seed tubers. In this study, we found that three major functional substances in G. elata tubers altered depending on various cultivation practices, which might be important to increase the economic values of G. elata tubers.

• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.347-362
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• 2016

Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge's derived compounds to examine its pharmacological properties. Such compounds proved to have antibacterial, antiviral, antifungal, antimalarial, antitumor, immunosuppressive, and cardiovascular activity. Although, the mode of action of many compounds by which they interfere with human pathogenesis have not been clear till now, in this review not only the capability of the medicinal substances have been examined in vitro and in vivo against serious pathogenic microbes but, the mode of actions of medicinal compounds were explained with diagrammatic illustrations. This knowledge is one of the basic components to be known especially for transforming medicinal molecules to medicines. Sponges produce a different kind of chemical substances with numerous carbon skeletons, which have been found to be the main component interfering with human pathogenesis at different sites. The fact that different diseases have the capability to fight at different sites inside the body can increase the chances to produce targeted medicines.