• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.3
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• pp.105-121
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• 2022

Objectives: It is a statistical analysis study to examine the results of CaPSPI (Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification), developed for objective defecation of climacteric and postmenopausal syndrome. Methods: Total 341 people's questionnaire responses were statistically analyzed. 275 people involved in developing CaPSPI 2018 (E) and 146 people involved in 2019-2020 study of research1,3). Results: The frequency of diagnosis for examination was the highest at liver depression, 93.8% for 320 times, the lowest at heartheat, 62.8% for 214 times. The frequency of treatment for examination was the highest at liver depression, 54.3% for 185 times, and the lowest at dual deficiency of heart-spleen, 16.7% for 57 times. The diagnosis ratio was the lowest at dual deficiency of heart-spleen, 19.72%, and the highest at liver depression, 57.81%. As a result of comparing these diagnoses with the Kupperman's index, all showed significant differences. As a result of comparing these disease elements, all showed significant differences. The correlation between diagnosis and dialectic elements was found to have similar results with the korean medical pathology, and in 7 dialectics except for heartheat, the treatment version was more severe or progressing to perjury than for examination. Conclusions: The CaPSPI shows the characteristics of korean medicine well, and it is needed to utilize the high correlative disease elements to upgrade the system.

• Journal of Korean Medicine Rehabilitation
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• v.32 no.2
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• pp.65-81
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• 2022

Objectives This study aimed to assess the effects of oral administration of deer antler extracts on an osteoporosis-induced animal model. We analyzed the results of using deer antler single extracts on animal models with osteoporosis through a systematic review and meta-analysis. Methods We included osteoporosis studies in animal experiments that administrated deer antler extracts orally. We searched the following 13 databases without a language restriction: PubMed, EMBASE, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure (CNKI), Wanfang, Korean Medical Database (KMbase), National Digital Science Library (NDSL), Korean Traditional Knowledge (Koreantk), Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Sharing Service (RISS), Korea Institute of Science and Technology Information (KISTI), and Koreanstudies Information Service System (KISS). We used Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool for assessing the methodological quality of the included studies. Results A total of 299 potentially relevant studies were searched and 11 were included for a systematic review. Nine studies used a single deer antler extract. A study compared the effects of single extracts of deer antler and antler glue, while another study compared the effects of three single extracts of deer antler, old antler, and antler glue. For evaluating the intervention effect, bone mineral density (BMD) was measured as the primary outcome, while the histomorphometric indicators of the bone and serum alkaline phosphatase and osteocalcin levels were used as the secondary outcome variables. On conducting a meta-analysis of studies on single deer antler extract, BMD was observed to be significantly increased compared to that in control group (standardized mean difference [SMD]=2.11; 95% confidence interval [CI]=1.58~2.65; Z=7.75; p<0.00001; I²=56%). As a result of meta-analysis, according to the concentration of deer antler, the group with high concentration showed statistically significantly higher BMD than the group with low concentration (SMD=1.28; 95% CI=0.74~1.82; Z=4.63; p<0.00001; I²=9%). Conclusions The research shows that the deer antler extracts have significant anti-osteoporotic effects on the osteoporosis-induced animal model. However the studies included in this research had a high methodological risk of bias. This indicates the requirement of considerable attention in the interpretation of the study results.

• Journal of Korea Entertainment Industry Association
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• v.14 no.6
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• pp.221-230
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• 2020

The purpose of this study was to investigate the effect of resistance exercise with vibration stimulation methods on static balance and gait parameters in experienced back pain adults. This study was Three group pretest-posttest design. A total of 30 experienced back pain adults voluntarily participated in the study. Subjects were randomly assigned to the resistance exercise with 8 Hz vibration stimulation(n=10), resistance exercise with 30 Hz vibration stimulation(n=10), and lumbar stabilization exercise groups(n=10). The static balance and the gait parameters, as such stance phase, swing phase, stride length and cadence, were measured using balance measuring equipment and gait analysis treadmill at before and after 6 week. Intervention of each group were performed, three times a week for 6 weeks, and 30 minutes a day. The effect of intervention on static balance, stance phase, swing phase, stride length and cadence were significantly differences after 6 weeks in each group(p<.05). In the comparison of the effects between the groups, static balance and stance phase were significantly difference after 6 weeks(p<.05), but in the swing phase, stride length and cadence, there were no significant differences. As a result, it is considered that resistance exercise with vibration stimulation improved leg muscle strength by a mechanism causing muscle contraction, and the strengthened leg muscle enhanced had a positive effect on balance ability. And improved balance ability was considered a more positive effect on walking ability by allowing the body to stably control posture while moving.

• Journal of the Korean Society of Radiology
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• v.16 no.6
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• pp.751-759
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• 2022

Currently, ultrasound examination for diagnostic ultrasound and health examination purposes is widely used, and it is showing an increasing trend due to the application of health insurance. However, the risk of ultrasound has not been clearly identified so far, and in this study, surface and deep temperature changes according to frequency and mode were measured by using a tissue mimicking phantom and TI and MI values were compared. A simulated phantom was manufactured by adding a small amount of kappa-caraginan powder with acoustic characteristics similar to that of the human body and potassium chloride for solidification, and the change of surface and depth temperature was measured using a surface thermometer and a probe thermometer. As a result, the convex probe using low frequency showed a higher temperature increase than the linear probe using high frequency, so there was a significant difference, and the temperature increase was the highest on the surface, and the depth of 1cm showed a temporary temperature increase, but there was no significant temperature change. There was no change in the deep temperature of 5 cm to 15 cm, and the TI and MI values did not change during the test time. Since only the surface temperature rose during the 15-minute test and there was no temperature change in the core, so it is not expected to show a temperature change that is harmful to the human body. However, it is thought that prolonged examination of one area may cause temperature rise, so it should be avoided.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.975-984
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• 2022

Since a linear transducer has an area of interest equal to the length of the transducer, the area of interest can be expanded using the virtual convex function installed in the device.However, it was thought that the change in the direction of the ultrasonic sound velocity according to the change in the visual area of interest would affect the image quality, so this was objectively confirmed. For this study, image evaluation and SNR·CNR of the phantom for ultrasound quality control were measured. As a result, in the phantom image evaluation, both images were able to identify structures in functional resolution, grayscale, and dynamic range. However, it was confirmed that the standard image was excellent in the reproducibility of the size and shape of the structure. As a result of SNR·CNR evaluation, SNR·CNR of most trapezoidal images was low, except for structures at specific locations. In addition, through the statistical analysis graph, it was further confirmed that the SNR and CNR for each depth decreased as the size of the cystic structure decreased. Through this study, it was confirmed that the use of the function has the advantage of providing a wide visual area of interest, but it has an effect on the image quality. Therefore, when using the virtual convex function, it is judged that the examiner should use it in an appropriate situation and conduct various studies to acquire high-quality images and to improve the understanding and proficiency of the equipment.

• The Korea Journal of Herbology
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• v.29 no.4
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• pp.83-89
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• 2014

Objectives : The purpose of this study was to investigate effects of Houttuyniae Herba water extract (HC) on calcium release and production of various inflammatory mediators such as nitric oxide (NO), interferon-inducible protein (IP)-10, platelet derived growth factor (PDGF)-BB, keratinocyte-derived chemokine (KC), vascular endothelial growth factor (VEGF), interleukin (IL)-4, and IL-5 in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages. Methods : NO production was measured by Griess reagent assay. Intracellular calcium level was measured with Fluo-4 assay. Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results : HC significantly decreased NO production for 24 hrs incubation at the concentrations of 10, 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC significantly decreased production of IP-10, KC, VEGF, and PDGF-BB for 24 hrs incubation at the concentrations of 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC also significantly decreased intracellular calcium release for 24 hrs incubation at the concentrations of 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). But HC did not show any significant effect on production of IL-4 and IL-5 in LPS-induced RAW 264.7. Conclusions : The results suggested that HC has anti-inflammatory property related with its inhibition on the production of NO, IP-10, KC, VEGF, and PDGF-BB in LPS-induced macrophages via calcium pathway.

• Therapeutic Science for Rehabilitation
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• v.11 no.3
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• pp.37-50
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• 2022

Objective : This study aimed to investigate the use of electromyography (EMG) to evaluate upper limb movement or function in stroke patients. Methods : We reviewed papers published in journals between January 2018 and December 2021 using PubMed, EMBASE, Scopus, RISS, and KISS. The main keywords of databases were ('stroke' OR 'hemiplegia') AND ('EMG' OR 'electromyography' OR 'electromyogram' OR 'muscle activity') AND ('Upper limb' OR 'Hand'). Results : Fifteen studies were selected, most of which evaluated muscle activity. Interventions performing tasks related to activities of daily living (ADLs), using assistive technology, and interventions that provide repetitive training were most frequently applied. Conclusions : When evaluating upper limb functions using electromyography, it is meaningful to present an evaluation that can be used according to the purpose of the study and to provide a basis for setting up interventions that can utilize electromyography during evaluation.

• Investigative Magnetic Resonance Imaging
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• v.26 no.2
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• pp.104-116
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• 2022

The purpose of this study is to systematically determine an optimal percentile cut-off in histogram analysis for calculating the mean parameters obtained from a non-Gaussian continuous-time random-walk (CTRW) diffusion model for differentiating individual glioma grades. This retrospective study included 90 patients with histopathologically proven gliomas (42 grade II, 19 grade III, and 29 grade IV). We performed diffusion-weighted imaging using 17 b-values (0-4000 s/mm²) at 3T, and analyzed the images with the CTRW model to produce an anomalous diffusion coefficient (D_m) along with temporal (𝛼) and spatial (𝛽) diffusion heterogeneity parameters. Given the tumor ROIs, we created a histogram of each parameter; computed the P-values (using a Student's t-test) for the statistical differences in the mean D_m, 𝛼, or 𝛽 for differentiating grade II vs. grade III gliomas and grade III vs. grade IV gliomas at different percentiles (1% to 100%); and selected the highest percentile with P < 0.05 as the optimal percentile. We used the mean parameter values calculated from the optimal percentile cut-offs to do a receiver operating characteristic (ROC) analysis based on individual parameters or their combinations. We compared the results with those obtained by averaging data over the entire region of interest (i.e., 100th percentile). We found the optimal percentiles for D_m, 𝛼, and 𝛽 to be 68%, 75%, and 100% for differentiating grade II vs. III and 58%, 19%, and 100% for differentiating grade III vs. IV gliomas, respectively. The optimal percentile cut-offs outperformed the entire-ROI-based analysis in sensitivity (0.761 vs. 0.690), specificity (0.578 vs. 0.526), accuracy (0.704 vs. 0.639), and AUC (0.671 vs. 0.599) for grade II vs. III differentiations and in sensitivity (0.789 vs. 0.578) and AUC (0.637 vs. 0.620) for grade III vs. IV differentiations, respectively. Percentile-based histogram analysis, coupled with the multi-parametric approach enabled by the CTRW diffusion model using high b-values, can improve glioma grading.

• Quality Improvement in Health Care
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• v.28 no.1
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• pp.45-54
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• 2022

Purpose: The study aims to identify the theme list and priority criteria of patient safety theme reports in South Korea. Methods: The survey was conducted twice, and the importance of each criterion and theme was measured on a nine-point scale using the Delphi technique by a panel of 19 patient safety experts. The criteria included severity, universality, preventability, and organizational-social impact. Descriptive statistics such as frequency, percentage, mean, standard deviation, median, and interval quartile range were used to analyze the data. Results: The parameters were assigned a weighted average of 35% for severity, 20% for universality, 30% for preventability, and 15% for organizational-social impact, respectively. The final top three rankings were surgery safety, blood transfusion safety, and medication safety. In addition to expert opinion, for the theme that is selected based on the priority ranking, one to five sub-topics can be derived from the theme based on the priority ranking, societal demands, or the yearly priority list of patient safety incidents. Conclusion: It is recommended that the official patient safety center distribute the report in the form of a summary that can be utilized nationwide at medical institutions, government institutions, and other places. Updates, as well as accumulated theme reports, will serve as the baseline data for the proposal of the system and for the policy designed to implement and improve institutions' safety practices as a standard of domestic patient safety practice guidelines.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.81-90
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• 2021

There are various optimization problems in real world and research continues to solve them. An optimization problem is the problem of finding a combination of parameters that maximizes or minimizes the objective function. Harmony search is a population-based metaheuristic algorithm for solving optimization problems and it is designed to mimic the improvisation of jazz music. Harmony search has been actively applied to optimization problems in various fields such as civil engineering, computer science, energy, medical science, and water quality engineering. Harmony search has a simple working principle and it has the advantage of finding good solutions quickly in constrained optimization problems. Especially there are various application cases showing high accuracy with a low number of iterations by improving the solution through the empirical derivative. In this paper, we explain working principle of Harmony search and classify the leading research in recent 3 years, review them according to category, and suggest future research directions. The research is divided into review by field, algorithmic analysis and theory, and application to real world problems. Application to real world problems is classified according to the purpose of optimization and whether or not they are hybridized with other metaheuristic algorithms.