• Title/Summary/Keyword: medical fibers

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Manufacturing and Material Analysis of Collagen/Chitosan Conjugated Fibers for Medical Application (의료용 소재 활용을 위한 콜라겐/키토산 복합섬유의 제조 및 특성 분석)

  • Gwak, Hyeon Jung;Ahn, Hyunchul;Lee, Won Jun;Yeo, Sang Young
    • Textile Coloration and Finishing
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    • v.33 no.3
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    • pp.131-140
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    • 2021
  • Collagen and chitosan are used in medical and cosmetic materials as natural polymers. In order to utilize the advantages of the materials, collagen/chitosan conjugated wet-spun fibers were prepared. The analysis of surface, optical, thermal and mechanical properties was carried out on the various composition of collagen and chitosan. As a result of images analysis, it was verified that the collagen/chitosan conjugated fibers were stably spun. In addition, the optical and thermal properties of fibers were observed to be changed by hydrogen bond. As a result, an optimized composition could be found at an appropriate content. Moreover, the optimized fibers have mechanical properties similar to chitosan fibers, while improving the structural and thermal stability by its hydrogen bond. In addition, the wet-spun collagen/chitosan conjugated fibers can be applied to medical and various fields through mechanical properties according to content control.

Synergistic bond properties of new steel fibers with rounded-end from carbon nanotubes reinforced ultra-high performance concrete matrix

  • Nguyen Dinh Trung;Dinh Tran Ngoc Huy;Dmitry Olegovich Bokov;Maria Jade Catalan Opulencia;Fahad Alsaikhan;Irfan Ahmad;Guljakhan Karlibaeva
    • Advances in nano research
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    • v.14 no.4
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    • pp.363-373
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    • 2023
  • A novel type of steel fiber with a rounded-end shape is presented to improve the bonding behavior of fibers with Carbon Nanotubes (CNT)-reinforced Ultra-High Performance Concrete (UHPC) matrix. For this purpose, by performing a parametric study and using the nonlinear finite element method, the impact of geometric characteristics of the fiber end on its bonding behavior with UHPC has been studied. The cohesive zone model investigates the interface between the fibers and the cement matrix. The mechanical properties of the cohesive zone model are determined by calibrating the finite element results and the experimental fiber pull-out test. Also, the results are evaluated with the straight steel fibers outcomes. Using the novel presented fibers, the bond strength has significantly improved compared to the straight steel fibers. The new proposed fibers increase bond strength by 1.1 times for the same diameter of fibers. By creating fillet at the contact area between the rounded end and the fiber, bond strength is significantly improved, the maximum fiber capacity is reachable, and the pull-out occurs in the form of fracture and tearing of the fibers, which is the most desirable bonding mode for fibers. This also improves the energy absorbed by the fibers and is 4.4 times more than the corresponding straight fibers.

Evolutionary Patterns with Age of Acetylcholinesterase Activity of Rect al Suction Biopsies in Hirschsprung's Disease (Hirschsprung씨 질환에서 직장 흡인 생검의 Acetylcholinesterase 활성도의 연령에 따른 변화)

  • Park, Woo-Hyun;Choi, Soon-Ok;Kim, Sang-Pyo;Chang, Eun-Soak;Paik, Tae-Won
    • Advances in pediatric surgery
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    • v.1 no.1
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    • pp.1-7
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    • 1995
  • The acetylcholinesterase(ACHE) activity in 37 biopsies from the patients with Hirschsprung's disease was analyzed for histochemical patterns according to age, and its evolutional behavior was also assessed. The histochemical criterion used for the diagnosis of Hirschsprung's disease was that of Chow, i.e., "the presence of many coarse discrete cholinergic fibers in the muscularis mucosae and in the immediately subjacent submucosa regard less of an infiltration of cholinergic fibers in the lamina propria." The acetylcholinesterase activity in Hirschsprung's disease was further classified into 3 patterns, advocated by de Brito and Maksoud : Pattern I-many thick fibers exclusively in the muscularis mucosae and submucosa(newborn pattern). Pattern II-many thin fibers in the muscularis mucosae and submucosa with a clear infiltration of cholinergic fibers in the lamina propria(classical pattern). Pattern III-an intermediate pattern showing morphological characteristics of the two patterns with predominance of one or the other. Of 37 biopsies, Pattern 1 was seen exclusively in 16 biopsies taken from the neonates. Pattern III was 11 of 37 biopsies and it was mainly seen in children between 2 to 12 months of age. Pattern II was seen in all 3 biopsies of older than 1 year of age and in 6 ones of 3 to 12 months of age. In summary, this study reinforces the impression that there is an evolutional character of the distribution and morphology of the cholinergic ACHE positive fiber with age. In other words, ACHE activity in Hirschsprung's disease appears to evolve with age from the newborn pattern to the intermediate pattern finally to the classical pattern.

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Protective System from Medical Needle-sticks. Part II: Evaluation of Woven Structures and Bifid Needles

  • Seyam, Abdelfattah M.;Turner, LaDawnya C.;Banks-Lee, Pamela
    • Fibers and Polymers
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    • v.4 no.3
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    • pp.129-134
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    • 2003
  • We have shown in Part I [1] of this study that medical needle-stick injuries are causing serious health problems to healthcare personnel and other professionals that require the attention of healthcare and textile researchers to develop new protective systems. Responding to such need, a needle force measurement device that is capable of measuring dynamic forces experienced by medical needles during needle penetration through protective articles was developed and described in part I. This paper reports the results of evaluation of protective woven fabrics from high performance fibers and standard and bifid medical needles using the force measurement system. The woven fabrics varied in cover factor, number of layers, and orientation angle. Standard and bifid needles with different gap widths were used to evaluate the resistance of the fabric to needle penetration.

Cell-laden Gelatin Fiber Contained Calcium Phosphate Biomaterials as a Stem Cell Delivery Vehicle for Bone Repair (세포 함유 젤라틴 파이버 응용을 통한 골 재생 유도용 인산칼슘 생체재료 세포 탑재 연구)

  • Kim, Seon-Hwa;Hwang, Changmo;Park, Sang-Hyug
    • Journal of Biomedical Engineering Research
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    • v.43 no.1
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    • pp.61-70
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    • 2022
  • Natural and synthetic forms of calcium phosphate cement (CPC) have been widely used in bone repair and augmentation. The major challenge of injectable CPC is to deliver the cells without cell death in order to regenerate new bone. The study objective was to investigate for the potential of stem cell-laden gelatin fibers containing injectable, nanocrystalline CPC to function as a delivery system. Gelatin noddle fiber method was developed to delivered cells into nCPC. Experimental groups were prepared by mixing cells with nCPC, mixing cell-laden gelatin fibers with nCPC and mixing cell-laden gelatin fibers containing BMP-2 with nCPC. Media diffusion test was conducted after dissolving the gelatin fibers. SEM examined the generated channels and delivered cell morphology. Fibers mixed with nCPC showed physical setting and hardening within 20 min after injection and showed good shape maintenances. The gelatin fibers mixed nCPC group had several vacant channels generated from the dissolved gelatin. Particularly, proliferation and attachment of the cells were observed inside of the channels. While live cells were not observed in the cell mixed nCPC group, cells delivered with the gelatin fibers into the nCPC showed good viability and increased DNA content with culture. Cell-laden gelatin fiber was a novel method for cell delivery into nCPC without cell damages. Results also indicated the osteogenic differentiation of gelatin fiber delivered cells. We suggest that the cell-laden gelatin fibers mixed with nCPC can be used as an injectable cell delivery vehicle and the addition of BMP-2 to enhances osteogenesis.

Histology and immunohistochemistry of the human carotid sinus nerve

  • Davin Bryant;Erin McCormack;Juan J. Cardona;Arada Chaiyamoon;Devendra Shekhawat;Francisco Reina;Ana Carrera;Joe Iwanaga;Aaron S. Dumont;R. Shane Tubbs
    • Anatomy and Cell Biology
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    • v.56 no.4
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    • pp.463-468
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    • 2023
  • The carotid sinus nerve (CSN) is well known as mediating baroreflexes. However, studies of its detailed histological analysis are scant in the literature. Therefore, the current anatomical study sought to better elucidate the microanatomy of the CSN. Ten fresh frozen adult cadavers underwent dissection of the CSN. Then, it was harvested and submitted for histological and immunohistochemical staining. Specimens were all shown to be nerve fibers on histology and immunohistochemistry. We identified tyrosine hydroxylase positive fibers in all CSN specimens. These fibers were always found to be within the CSN and not on its surface i.e., epineurium. Based on our findings, the majority of fibers contained in the CSN are tyrosine positive in nature. Further studies are necessary to understand the true function of this autonomic nerve fibers.

Application of Carbon Materials for the Development of Medical Devices (의료기기의 발전을 위한 탄소소재의 활용)

  • Yeong-Gon Kwak
    • The Korean Journal of Nuclear Medicine Technology
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    • v.27 no.1
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    • pp.23-28
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    • 2023
  • Carbon materials are widely used in many areas of our lives. A fiber having a carbon content of 90% or more obtained by heating an organic fiber precursor is referred to as a "carbon fiber". Carbon fibers are currently used in the medical market to manufacture radiation transmission device parts, artificial joints, and medical aids, as many developments have been made to utilize carbon fibers' characteristics such as light weight, radiation permeability, biocompatibility, high strength, high heat resistance, thermal conductivity, and electrical conductivity. In order to maintain body temperature and increase immunity in long-lasting nuclear medical examination and treatment through the idea of convergence of carbon materials and radiation technology, the quality of medical services can be improved by utilizing carbon materials. We should be aware of the domestic carbon-based medical device industry and make efforts to contribute to the development of medical devices. As a radiation expert, we should try to use our skills and experience to find items that can be fused with medical devices to develop various nuclear medical examination fields and radiographic examination fields that can be widely applied. We should actively engage in future technology development and carbon material research to strengthen the global competitiveness of the domestic medical device industry and improve the quality of medical services.

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Preparation of Coil-Embolic Material Using Syndiotactic Poly(vinyl alcohol) Gel Spun Fibers (교대배열 PVA 젤 섬유를 이용한 고분자 색전 코일 제조)

  • Seo, Young Ho;Oh, Tae Hwan;Han, Sung Soo;Joo, Sang Woo;Khil, Myeong Seob
    • Polymer(Korea)
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    • v.37 no.4
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    • pp.486-493
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    • 2013
  • The structure, morphology, and physical properties of syndiotatic poly(vinyl alcohol) (s-PVA) gel spun fibers were investigated to prepare polymeric embolization coils. S-PVA was prepared by saponification of the poly(vinyl acetate)/poly(vinyl pivalate)(PVAc/PVPi) copolymer. The viscosity of s-PVA solutions showed shear thinning behavior and the solution formed a homogeneous phase. Based on shear viscosity change with concentration, the optimum dope concentration was selected as 13 wt%, after which s-PVA fibers were spun and the solvent was removed. The fibers were then drawn with a maximum draw ratio of 15. A polymeric embolization coil was made of the s-PVA gel-spun fibers. The fibers were wound densely onto rigid rod and then annealed at different annealing temperatures. The polymeric embolization coil annealed at $200^{\circ}C$ was similar to metallic coils and its shape was maintained well after extension. Overall, gel-spun PVA fibers performed well for the preparation of primary and secondary coils to replace metallic coils.

Mechanical properties related to the microstructure of seven different fiber reinforced composite posts

  • de la Pena, V?ctor Alonso;Darriba, Iria L;Valea, Martin Caserio;Rivera, Francisco Guitian
    • The Journal of Advanced Prosthodontics
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    • v.8 no.6
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    • pp.433-438
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    • 2016
  • PURPOSE. The aim of this in vitro study was to evaluate the mechanical properties (bending strength and hardness) of seven different fiber reinforced composite posts, in relation to their microstructural characteristics. MATERIALS AND METHODS. Two hundred eighty posts were divided into seven groups of 40, one group for each type of post analyzed. Within each group, 15 posts were subjected to three-point bending strength test, 15 to a microhardess meter for the Knoop hardness, and 10 to Scanning Electron Microscope in order to determine the diameter of the fibers and the percentage of fibers embedded in the matrix. To compare the flexural strength in relation to the type of fiber, matrix, and the hardness of the posts, a Kruskal-Wallis H test was used. The Jonckheere-Terpstra test was used to determine if the volume percent of fibers in the post influenced the bending strength. RESULTS. The flexural strength and the hardness depended on the type of fibers that formed the post. The lower flexural strength of a post could be due to deficient bonding between the fiber and the resin matrix. CONCLUSION. According to the results, other factors, besides the microstructural characteristics, may also influence the mechanical properties of the post. The feature that has more influence on the mechanical properties of the posts is the type of fiber.