• 제목/요약/키워드: medical exchange

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Regulation of Magnesium Release by cAMP during Chemical Hypoxia in the Rat Heart and Isolated Ventricular Myocytes

  • Kim, Jin-Shang;Scarpa, Antonio
    • The Korean Journal of Physiology and Pharmacology
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    • 제3권1호
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    • pp.59-68
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    • 1999
  • Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free $Mg^{2+}\;([Mg^{2+}]_i)$ appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in $[Mg^{2+}]_i$ would result in $Mg^{2+}$ extrusion following hormonal stimulation. To determine the relation between $Mg^{2+}$ efflux and cellular energy state in a hypoxic rat heart and isolated myocytes, $[Mg^{2+}]_i,$ ATP and $Mg^{2+}$ content were measured by using mag-fura-2, luciferin-luciferase and atomic absorbance spectrophotometry. $Mg^{2+}$ effluxes were stimulated by norepinephrine (NE) or cAMP analogues, respectively. $Mg^{2+}$ effluxes induced by NE or cAMP were more stimulated in the presence of metabolic inhibitors (MI). Chemical hypoxia with NaCN (2 mM) caused a rapid decrease of cellular ATP within 1 min. Measurement of $[Mg^{2+}]_i$ confirmed that ATP depletion was accompanied by an increase in $[Mg^{2+}]_i.$ No change in $Mg^{2+}$ efflux was observed when cells were incubated with MI. In the presence of MI, the cAMP-induced $Mg^{2+}$ effluxes were inhibited by quinidine, imipramine, and removal of extracellular $Na^+.$ In addition, after several min of perfusion with $Na^+-free$ buffer, a large increase in $Mg^{2+}$ efflux occurred when $Na^+-free$ buffer was switched to 120 mM $Na^+$ containing buffer. A similar $Mg^{2+}$ efflux was observed in myocytes. These effluxes were inhibited by quinidine and imipramine. These results indicate that the activation of $Mg^{2+}$ effluxes by hormonal stimulation is directly dependent on intracellular $Mg^{2+}$ contents and that these $Mg^{2+}$ effluxes appear to occur through the $Na^+-dependent\;Na^+/Mg^{2+}$ exchange system during chemical hypoxia.

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한국과 베트남의 전통의학 현황 비교를 통한 발전 방향 모색 (Groping for the Direction of Development from the Comparison of Traditional Medicine between Korea and Vietnam)

  • 권지혜;이시우;유종향
    • 한국콘텐츠학회논문지
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    • 제15권2호
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    • pp.370-376
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    • 2015
  • 본 연구는 베트남 전통의학병원 임상의들을 대상으로 베트남 전통의학 인식도 및 활용현황에 대해 조사하고 이를 한국의 전통의학 현황과 비교하여 각국의 전통의학 발전 방향을 모색해 보고자 하였다. 2012년 9월부터 2012년 11월까지 약 3개월에 걸쳐 350명의 베트남 임상의를 대상으로 1:1 인터뷰식 설문조사를 실시하였고, 그 중 설문 누락 항목이 없는 337건의 설문자료를 분석에 사용하였다. 베트남 임상의들은 전통의학 중 침구학과 약초학에 대한 인식도가 가장 높았으며, 응답자의 90% 이상이 실제 임상에서 침구학을 사용해 본적이 있다고 응답하였고, 마사지와 지압, 약초학 순으로 임상 활용도가 높았다. 이는 한국의 한의사를 대상으로 한 조사에서 98.6%가 침 치료 경험이 있고, 90.7%가 한약 복용 경험이 있다고 응답한 결과와 유사하였다. 또한 베트남 전통의학 임상의들이 진료하는 주요 질환으로는 신경정신성 질환이 가장 많았고, 주로 사용하고 있는 진단 방법으로는 설진과 맥진이라고 응답하였다. 본 연구를 통해 베트남의 전통의학의 현황을 파악함으로써 향후 한국과의 전통의학에 대한 국제적 교류를 위한 기초자료로 사용되기를 기대한다.

간호진단과 중재분류에 관한 조사연구 -가정 간호 대상자를 중심으로- (A Study on Nursing Diagnoses and Nursing Intervention Classification -focused on Home Health Care Clients-)

  • 김조자;최애규;김기란;송희영
    • 대한간호학회지
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    • 제29권1호
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    • pp.72-83
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    • 1999
  • The purpose of this study was to classify, from collected home health care records data, nursing diagnoses according to the NANDA system and nursing interventions according to the NIC system, and to link nursing interventions to nursing diagnoses. For this study, 101 home health care records of clients seen between September, 1994 and November, 1996 at Yonsei Medical Center, Seoul, were analyzed. The results of this study are summarized as follows : 1. The most frequent nursing diagnoses were ‘Risk for infection’ and ‘Altered nutrition : Less than body requirements’, then ‘Impaired skin intergrity’ and ‘Ineffective airway clearance’ in the Exchange pattern of NANDA nine human response patterns. 2. The most frequent nursing interventions were the interventions in the Physiological : Complex domain, there were 690(50.7%) interventions among a total 1347 interventions. This results corresponds to Yom, Young Hee(1995)’s research, both Korean and U.S. nurses used the interventions in the Physiological : Complex do main most often on a daily basis. And respiratory nursing interventions were most frequent because 32.7% of the subjects were respiratory patients. 3. The next step was to link the nursing interventions to nursing diagnoses. The most frequent nursing diagnosis was ‘Risk for infection’ and 19 interventions for ‘Risk for infection’ were used 267 times. Then 14 interventions for ‘Impaired skin integrity’ were used 258 times, 12 interventions for ‘Ineffrective airway clearance’ were used 193 times, 12 interventions for ‘Altered nutrition : Less than body requirements’ were used 122 times, 10 interventions for ‘Activity intolerance’ were used 75 times, and 11 interventions for ‘Knowledge deficit’ were used 52 times. 4. The use of standardized classification in the areas of nursing diagnoses and nursing interventions facilitates clinical decision making and prompt nursing activity, and so enhances the effectiveness of nursing care.

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트래픽 스케줄링 기반 데이터 중복 회피 알고리즘 (Data Overlap Avoidance Algorithm Based on Traffic Scheduling)

  • 최명수;김범무;이성로
    • 한국통신학회논문지
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    • 제39C권9호
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    • pp.841-851
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    • 2014
  • 동일한 주파수 대역을 공유하는 무선기술들은 상호 간섭에 의해 가끔 심각한 성능저하를 일으킨다. 본 논문에서는 근거리 4S (Ship to Ship, Ship to Shore) 해상채널 환경에서 상호 간섭에 의한 성능저하를 개선하기 위해 2.4GHz의 ISM 대역에서 동작하는 서로 다른 통신방식에서 트래픽 스케줄링을 기반의 중복회피 알고리즘을 제안하였다. 특히 IEEE 802.11의 WLAN과 블루투스의 데이터 전송을 고려하여 두 시스템들이 서로 독립적으로 동작할 때 제안된 알고리즘이 동작하는 것을 보인다. 모의실험 결과에 따르면, 제안된 알고리즘은 데이터 전송시 추가적인 작은 지연으로 WLAN과 블루투스 사이에서 간섭을 완화시킴을 확인할 수 있었다.

학교 보건 실습 경험에 관한 현상학적 연구 (The Phenomenological Study of School health practice experience of Nursing Students)

  • 우선혜;박영숙
    • 지역사회간호학회지
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    • 제6권2호
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    • pp.161-172
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    • 1995
  • This study was conducted to have better understanding of the students' experience in field practice by school health practice experience. The study subjects were 40 nursing students working in department of nursing K Univ. in C city. This study was approached by phenomenological method. Collected data were analyzed by Colaizzi's method. The results were from the protocol 980 significant statements and organized into 240 formulated meanings. From formulated meaning 89 themes were identified, organized into 18 them clusters, and then into 16 categories. The nursing students took part in the practice with (expectation and readiness) different from those of the clinical practice, expressed wonder at the school which had progressed much more than their primary schools used to be. They said that they began to feel (Fatigue and stress), and that experienced tension for the lack of nursing knowledge and skill during the health education and clinical treatment activity. In addition, they experienced 'ambivalence of satisfaction and something wanted', that is to say, they could have done better by means of video education and health education. The 10-day-school health practice brought about the change in( the image of teacher) and (cognition about the nursing teacher's role), made the students have(love to the client) and (desire to be nursing teacher), and then turned out experience benefical enough to be expressed 'satisfaction' However, they pointed out many problems in (School Eniviroment), (Clinic), (Physical assessment), (Recording and reporting), so they had a chance to apply the school nursing process to the school. The professor should play the role of promoting the learning through the field practice and providing the stimulant of learning to help the learner get as much from the field situation as they could. Therefore, I suggest that the students always have a chance to exchange actual affairs and educational study, and that the concrete discussion and continuous cooperation be done. The professors should keep doing their best to find the way to professors should keep doing their best to find the way to promote the ability of thinking through the process the learners experienced themselves.

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고령사회 주민공유공간의 발전방향에 관한 연구 (A Study on the Improvement of Shared Space for Aging society)

  • 김혜진;이연숙;윤혜경
    • 한국실내디자인학회:학술대회논문집
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    • 한국실내디자인학회 2008년도 춘계학술발표대회 논문집
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    • pp.214-219
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    • 2008
  • The aging of the population has been in process all over the world including most of advanced countries. With the improvement of living standards and medical technology due to the growth and development of the modern industrial society, the continuous Increase of the average lifespan has led to an abrupt growth in the population ratio of the aged. The senescence is the period where both physical and mental functions get dwindled, and due to a loss of roles in a society and a weakened social bond, the elderly people feel often neglected and isolated. Consequently, the elderly people spend a lot of time in their houses. As this means that the elderly gets higher possibility to stay within housing units and housing complex environment, residents' public space needs to be developed within the housing complex for them. Therefore, constructive programs and plans are required for the elderly who experience distance constraint because of corporal aging, for them to sustain community activities within their housing environment. Contrary to them in the 20th century, the elderly living in the nowadays informational society tend to enjoy their leisure times with arts and cultures and underscore the significance of social exchange under diverse possibility and sustainableness. Thus, it is important to preserve those circumstances to provide continuously them. Thus, the purpose of this paper is to grope a growth direction of residents' public space for the elderly to include them to their community through a socially integrated way by grasping present condition of apartment residents' public space's facilities and to be used practically as a basic housing environment data to raise quality of community life.

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목이버섯 추출물로부터 항혈전물질의 정제와 항혈전효과 (Purification of Antithrombotic Material from Auricularia auricular-judae Extracts and Its Antithrombotic Activity)

  • 박영서;최혁준;최태현
    • 산업식품공학
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    • 제13권4호
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    • pp.326-334
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    • 2009
  • 목이버섯으로부터 항혈전활성과 항혈소판응집활성을 지니는 물질을 추출하여 추출물의 혈행개선활성을 조사하였다. 건조 목이버섯을 0.1 N NaOH, methanol, ethanol 등의 용매를 사용하여 추출하여 각 추출물의 항혈전활성을 activated partial thromboplastin time, thrombin time과 prothrombin time 값으로 측정한 결과 methanol 용해성 분획이 각각 100, 124, 54 s로 조사한 분획 중에서 가장 높은 활성을 나타내었다. 활성 분획을 DEAE-Sepharose CL6B ion exchange column chromatography와 Sephacryl 400-HR gel permeation column chromatography로 정제하였으며 활성물질은 분자량이 150 kDa 이상인 다당류이며 mannose가 주요 구성당으로 되어 있는 xyloglucomannan의 복합다당체인 것으로 확인되었다. 정제된 다당류의 항혈전활성은 thrombin 활성을 저해하기 때문인 것으로 해석되었다.

Mendeley co-readership 정보를 활용한 한국 관련 논문의 글로벌 독자 국가 네트워크 분석 (Network Analysis of Readers' Countries of Korean Studies using Mendeley Co-readership Data)

  • 조재인;박종도
    • 정보관리학회지
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    • 제35권4호
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    • pp.107-124
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    • 2018
  • Mendeley의 독자 정보는 학계 밖에서 학문의 결과물이 어떻게 소비되고 있는지 다각도로 파악하여 피인용도로는 해석할 수 없었던 미지의 세계를 예측하는데 활용될 수 있다. 본 연구는 Mendeley의 co-readership 데이터를 활용해 한국 관련 논문의 독자 국가 네트워크 분석을 수행하여 공통의 학문적 관심사를 공유하는 국가 군집을 이해하고 이들 국가가 네트워크 상에서 어떠한 영향력을 가지는지 확인하였다. 그 결과 전 분야에서 미국을 비롯한 선진국은 대체로 높은 전역중심성을 보여 한국 관련 연구에 대한 전반적인 협력과 잠재적 교류 가능성을 가지는 것으로 나타났으며, 일부 개발도상국은 높은 지역중심성을 보여 상호간 공통의 학문적 관심사로 연계되어 있는 것으로 확인되었다. 한편 의학과 사회과학 분야는 OECD 국가와 개발도상국이 분리된 독자층을 이루었으며, 공학 분야는 신흥경제개발국이 대규모 독자 군집으로 형성되는 특징을 보였다. 또한 공학은 네트워크 밀도가 상대적으로 높게 나타나 국가간 학문적 교류와 지식의 확산, 협력의 가능성이 높은 것으로 분석되었다.

급성심근경색 환자에게 적용된 정맥-정맥 체외막산화기의 임상 효과 (Clinical effects of veno-venous extra-corporeal membrane oxygenation for acute myocardial infarction)

  • 김수완;성길명;이재근
    • Journal of Medicine and Life Science
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    • 제15권2호
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    • pp.108-111
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    • 2018
  • Extra-corporeal membrane oxygenation (ECMO) has the potential to rescue patients in cardiac arrest or respiratory failure. ECMO has two systems such as veno-arterial and veno-venous circulation. In cardiac arrest resulting from acute myocardial infarction, veno-arterial ECMO is mandatory for systemic circulation and oxygenation. A 75-year old female patient underwent primary coronary intervention for acute myocardial infarction. Despite successful revascularization, recurrent ventricular tachycardia and heart failure were progressing. We performed a veno-arterial ECMO through the femoral artery and vein, then the patient seemed to be stable clinically. However, laboratory studies, echocardiography, and vital signs indicated multi-organ failure and decreasing cardiac function. We found out an error that we performed veno-venous ECMO instead of veno-arterial ECMO. We added a femoral artery cannula and exchange the circuit system to veno-arterial ECMO. While the systemic circulation seemed to be recovered, the left ventricular function was decreased persistently. A hypovolemia resulting from pulmonary hemorrhage was occurred, which lead to ECMO failure. The patient died of cardiac arrest and multi-organ failure 23 hours after ECMO. Because the color of arterial and venous circuits represent the position and efficacy of ECMO, if unexpected or abnormal circuit colors are detected, prompt and aggressive evaluation for ECMO function is mandatory.

간호관리자의 감성리더십 관련 변인: 체계적 문헌 고찰 및 메타분석 (Factors Related to Emotional Leadership in Nurses Manager: Systematic Review and Meta-Analysis)

  • 장세영;박찬미;양은희
    • 대한간호학회지
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    • 제54권2호
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    • pp.119-138
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    • 2024
  • Purpose: This study aimed to identify research trends related to emotional leadership among nurse managers by conducting a systematic literature review and meta-analysis. This study sought to derive insights that could contribute to improving emotional leadership in nursing practice. Methods: A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. Databases including PubMed, Cumulative Index to Nursing and Allied Health Literature, Scopus, Web of Science, Research Information Sharing Service, Koreanstudies Information Service System, Korean Medical Database, KoreaMed, ScienceON, and DBpia were searched to obtain papers published in English and Korean. Literature searches and screenings were conducted for the period December 1, 2023 to December 17, 2023. The effect size correlation (ESr) was calculated for each variable and the meta-analysis was performed using the statistical software SPSS 29.0, R 4.3.1. Results: Twenty-five (four personal, six job, and fifteen organizational) relevant variables were identified through the systematic review. The results of the meta-analysis showed that the total overall effect size was ESr = .33. Job satisfaction (ESr = .40) and leader-member exchange (ESr = .75) had the largest effect size among the job and organizational-related factors. Conclusion: Emotional leadership helps promote positive changes within organizations, improves organizational effectiveness, and increases member engagement and satisfaction. Therefore, it is considered an important strategic factor in improving organizational performance.