• Korean Journal of Child Studies
• /
• v.30 no.3
• /
• pp.85-98
• /
• 2009

The purpose of this study was to examine the path model of child's sex, temperament, maternal parenting behavior, and child's emotion regulation on child social behaviors. The subjects were 286 elementary school children. Data were gathered through questionnaires reported by mothers and teachers. Path analysis revealed that (1) mother's overprotective or coercive parenting behaviors effected neither child's emotion regulation nor social behaviors (2) child's sex and activity level effected child's aggression both directly and indirectly through child's emotion regulation (3) child's 'activity level' and 'avoidance' temperament effected child's social withdrawal both directly and indirectly through child' emotion regulation. Findings underscore the role of emotion regulation as a mediator in predicting child aggression and social withdrawal.

• Korean Journal of Child Studies
• /
• v.35 no.2
• /
• pp.43-61
• /
• 2014

The main purpose of this study was to investigate the paths from the cumulative risk factors to infant's development at 24 months of age via the mediation of maternal parenting behaviors. The data consisted of 3 year's worth of data harvested from 1802 families participating in the Panel Study on Korean Children (PSKC). The results revealed that cumulative family risk factors tended to stay in the family in relatively stable ways. Early risk factors significantly predicted later risk factors. Cumulative risk factors were negatively associated with the parenting styles of mothers, which in turn, significantly predicted the development of the infants concerned. Statistical tests supported the notion that mothers' parenting behavior is the mediator of the relation between family risk factors and infant's developmental outcomes.

• Journal of the Korea Safety Management & Science
• /
• v.16 no.2
• /
• pp.175-184
• /
• 2014

This paper examines how learning orientation and self-efficacy contributed to explaining innovation behaviors. In order to verify the relationships and mediating effect, data were collected from 368 individuals in employees working in small and medium-sized firms at Gyeongnam region to test theoretical model and its hypotheses. All data collected from the survey were analyzed using with SPSS 18.0. This study reports findings as follows: first, the relationship between the learning orientation and the employee's self-efficacy is positively related. Second, there was also a positive correlation between the employee's self-efficacy and the innovation behaviors. Third, the relationship between the learning orientation and the innovation behaviors is positively related. Finally, the employee's self-efficacy played as a partial mediator on the relationship between learning orientation and innovation behaviors. Based on these findings, the implications and the limitations of the study were presented including some directions for future studies.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.12 no.2
• /
• pp.280-286
• /
• 2006

Purpose: To test whether a hope carries the influence of pain to health related quality of life in patients with cancer. Method: 114 cancer patients recruited with. Data were collected through the Visual analog Scale, the Herth Hope Index, and the SF-36 Standard Korean Version. Results: The results showed that the measurement variables (pain, hope and health-related quality of life) were all significantly interrelated. The results of MedGraph revealed that the full mediation effect of hope in the relation between pain and mental component summary of quality of life was significant. Conclusion: These results imply that hope need to be considered in planning intervention programs for the enhancement of quality of life in patients with cancer.

• Natural Product Sciences
• /
• v.16 no.2
• /
• pp.111-115
• /
• 2010

Anti-inflammatory and anti-oxidant effect of Spirodela polyrrhiza (Lemnaceae), a widely used traditional medicinal plant were investigated. In macrophages nitric oxide (NO) is released as an inflammatory mediator and has been proposed to be an important modulator of many pathophysiological conditions including inflammation. 85% MeOH extracts of S. polyrrhiza (0.01, 0.1, 1 mg/mL) suppressed nitric oxide production in interferone-$\gamma$ (IFN-$\gamma$) and lipopoloysaccharide(LPS)-stimulated macrophages. It also attenuated the expression of inflammatory enzymes like inducible NOS (iNOS) and cyclooxygenase-2(COX-2) as assessed by immunoblotting with specific antibodies. Moreover, the values obtained with DPPH radical, superoxide anion and NO radical scavenging assay showed that S. polyrrhiza has potent antioxidant properties as a natural ROS scavenger. The results of the present study suggest the potential use of S. polyrrhiza in the treatment of ROS-mediated chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis.

• Biomolecules & Therapeutics
• /
• v.19 no.4
• /
• pp.390-397
• /
• 2011

G protein-coupled receptor kinases (GRKs) and ${\beta}$-arrestins have been known as regulators of G protein-coupled receptors. However, it has been recently reported that GRKs and ${\beta}$-arrestins mediate receptor-mediated cellular responses in a G proteinin-dependent manner. In this scheme, GRKs work as a mediator or a scaffold protein. Among 7 members of the GRK family (GRK1-GRK7), GRK2 is the most extensively studied in vitro and in vivo. GRK2 is involved in cellular migration, insulin signaling, and cardiovascular disease. GRK6 in concert with ${\beta}$-arrestin 2 mediates chemoattractant-stimulated chemotaxis of T and B lymphocytes. GRK5 shuttles between the cytosol and nucleus, and regulates the activities of transcription factors. GRK3 and GRK4 do not seem to have striking effects on cellular responses other than receptor regulation. GRK1 and GRK7 play specific roles in regulation of rhodopsin function. In this review, these newly discovered functions of GRKs are briefly described.

• Journal of the Korea Safety Management & Science
• /
• v.19 no.4
• /
• pp.261-271
• /
• 2017

The paper examines how empowering leadership and intrinsic motivation contributed to explaining in-role behavior. In order to verify the relationships and mediating effect, data were collected from 414 individuals in employees working in small and medium-sized firms at Jinju, Changwon, Gimhae, Busan City to test theoretical model and its hypotheses. All data collected from the survey were analyzed using with SPSS 18.0. This study reports findings as follows: first, the relationship between the empowering leadership and the intrinsic motivation is positively related. Second, there was also a positive correlation between the intrinsic motivation and the in-role behavior. Third, the relationship between the empowering leadership and the in-role behavior is positively related. Finally, the intrinsic motivation played as a partial mediator on the relationship between empowering leadership and in-role behavior. Based on these findings, the implications and the limitations of the study were presented including some directions for future studies.

• Biomedical Science Letters
• /
• v.24 no.4
• /
• pp.305-310
• /
• 2018

Microglia are emerging as critical regulators of innate immune responses in AD and other neurodegenerative disorders, highlighting the importance of understanding their molecular and cellular mechanisms. We attempted to determine the role of crosstalk signaling between $IFN-{\gamma}$ and $TGF-{\beta}$ in $A{\beta}$ clearance by microglia cells. We used in vitro and in vivo mouse models that recapitulated acute and chronic aspects of microglial responses to $A{\beta}$ peptides. We showed that crosstalk signaling between $TGF-{\beta}$ and Smad2 was an important mediator of neuro-inflammation. These findings suggest that microglial $TGF-{\beta}$ activity enhances the pathological progression to AD. As $TGF-{\beta}$ displays broad regulatory effects on beneficial microglial functions, the activation of inflammatory crosstalk signaling between $TGF-{\beta}$ and Smad2 may be a promising strategy to restore microglial functions, halt the progression of $A{\beta}$-driven pathology, and prevent AD development.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2019.10a
• /
• pp.70-70
• /
• 2019

Hepatic fibrosis is a common chronic liver diseases, characterized by the excessive deposition of extracellular matrix (ECM). Activation of hepatic stellate cells (HSC) is proliferative and fibrogenic and accumulating ECM. Transforming growth factor $(TGF)-{\beta}1$ is a critical mediator of HSC activation and ECM accumulation leading to fibrosis. Tenebrio molitor (TM), known as yellow mealworms, is reported in many countries as the nutritional value of foods. Our study has aims of finding liver function improvement effect of S. cerevisiae fermented Tenebrio molitor (SCTM) in vitro model. SCTM regulates $TGF-{\beta}1$ induced hepatic fibrosis via regulation of the $TGF-{\beta}1/Smad$ signaling. Also, we compared the components increased by yeast fermentation. It is possible to make a useful insect-derived alternative food in the improvement of hepatic liver disease.

• Journal of the Korea Safety Management & Science
• /
• v.22 no.4
• /
• pp.27-34
• /
• 2020

This investigation was carried out in Liaoning, Shandong, and Shaanxi where classified most of their geological organizations into profit organizations, which means they must implement enterprise-oriented reform immediately. The valid 311 questionnaires were collected and used to verify the serial mediating model by AMOS 23.0. Results verified the crucial mediating effects of structural and psychological empowerment between external-focused organizational culture and openness for change. Adhocracy culture positively affects employees' openness for change through three indirect paths, including one mediator and two mediators. Market culture impacts individuals' openness for change through two indirect paths, one is through structural empowerment and another one is through two mediators. The findings provide managers in geological organizations with an empowering management practice model which could promote geological industry reform effectively.