1 |
Penela, P., Murga, C., Ribas, C., Lafarga, V. and Federico Mayor, F., Jr. (2010a) The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br. J. Pharmacol. 160, 821-832.
DOI
ScienceOn
|
2 |
Penela, P., Rivas, V., Salcedo, A. and Mayor, F., Jr. (2010b) G proteincoupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc. Natl. Acad. Sci. USA. 107, 1118-1123.
DOI
|
3 |
Penela, P., Ribas, C., Aymerich, I., Eijkelkamp, N., Barreiro, O., Heijnen, C. J., Kavelaars, A., Sánchez-Madrid, F. and Mayor. F., Jr. (2008) G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 27, 1206-1218.
DOI
|
4 |
Penela, P., Ribas, C. and Mayor, F., Jr. (2003) Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 15, 973-981.
DOI
|
5 |
Premont, R. T. and Gainetdinov, R. R. (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 69, 511-534.
DOI
|
6 |
Premont, R. T., Perry, S. J., Schmalzigaug, R., Roseman, J. T., Xing, Y. and Claing, A. (2004) The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cell Signal. 16, 1001-1011.
DOI
|
7 |
Premont, R. T., Claing, A., Vitale, N., Freeman, J. L., Pitcher, J. A., Patton, W. A., Moss, J., Vaughan, M. and Lefkowitz, R. J. (1998) 2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc. Natl. Acad. Sci. USA. 95, 14082-14087.
DOI
|
8 |
Pronin, A. N., Morris, A. J., Surguchov, A. and Benovic, J. L. (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275, 26515-26522.
DOI
|
9 |
Martini, J. S., Raake, P., Vinge, L. E., DeGeorge, B. R. Jr., Chuprun J. K., Harris, D. M., Gao, E., Eckhart, A. D., Pitcher, J. A. and Koch, W. J. (2008) Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc. Natl. Acad. Sci. U S A. 105, 12457-12462.
DOI
|
10 |
Mayor, F., Jr., Lucas, E., Jurado-Pueyo, M., Garcia-Guerra, L., Nieto- Vazquez, I., Vila-Bedmar, R., Fernández-Veledo, S. and Murga, C. (2011) G Protein-coupled receptor kinase 2 (GRK2): a novel modulator of insulin resistance. Arch. Physiol. Biochem. 117, 125-130.
DOI
|
11 |
Meloni, A. R., Fralish, G. B., Kelly, P., Salahpour, A., Chen, J. K., Wechsler-Reya, R. J., Lefkowitz, R. J. and Caron, M. G. (2006) Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol. Cell Biol. 26, 7550-7560.
DOI
|
12 |
Molnar, C., Holguin, H., Mayor, F., Jr., Ruiz-Gomez, A. and de Celis, J. F. (2007) The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci. USA. 104, 7963-7968.
DOI
|
13 |
Noma, T., Lemaire, A., Naga Prasad, S. V., Barki-Harrington, L., Tilley, D. G., Chen, J., Le Corvoisier, P., Violin, J. D., Wei, H., Lefkowitz, R. J. and Rockman, H. A. (2007) -Arrestin-mediated 1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 117, 2445-2458.
DOI
|
14 |
Pao, C. S., Barker, B. L. and Benovic, J. L. (2009) Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry 48, 7325-7333.
DOI
|
15 |
Parameswaran, N., Pao, C. S., Leonhard, K. S., Kang, D. S., Kratz, M., Ley, S. C. and Benovic, J. L. (2006) Arrestin-2 and G proteincoupled receptor kinase 5 interact with NF p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J. Biol. Chem. 281, 34159-34170.
DOI
|
16 |
Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R. A., Bond, R. A., Milano, C. A., Lefkowitz, R. J. (1999) Cardiac function in mice overexpressing the -adrenergic receptor kinase or a ARK inhibitor. Science 268, 1350-1353.
|
17 |
Jimenez-Sainz, M. C., Murga, C., Kavelaars, A., Jurado-Pueyo, M., Krakstad, B. F., Heijnen, C. J., Mayor, F. Jr. and Aragay, A. M. (2006) G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol. Biol. Cell 17, 25-31.
|
18 |
Kahsai, A. W., Zhu, S. and Fenteany, G. (2010) G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochim. Biophys. Acta. 1803, 300-310.
DOI
|
19 |
Kawashima, S. and Yokoyama, M. (2004) Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24, 998-1005.
DOI
|
20 |
Kurnik, D., Cunningham, A. J., Sofowora, G. G., Kohli, U., Li, C., Friedman, E. A., Muszkat, M., Menon, U. B., Wood, A. J. J. and Stein, M. (2009) GRK5 Gln41Leu polymorphism is not associated with sensitivity to 1-adrenergic blockade in humans. Pharmacogenomics 10, 1581-1587.
DOI
|
21 |
Liggett, S. B., Cresci, S., Kelly, R. J., Syed, F. M., Matkovich, S. J., Hahn, H. S., Diwan, A., Martini, J. S., Sparks, L., Parekh, R. R., Spertus, J. A., Koch, W. J., Kardia, S. L. R. and Dorn, II, G. W. (2008) A GRK5 polymorphism that inhibits -adrenergic receptor signaling is protective in heart failure. Nature Med. 14, 510-517.
DOI
|
22 |
Liu, J., Rasul, I., Sun, Y., Wu, G., Li, L., Premont, R. T. and Suo, W. Z. (2009) GRK5 defi ciency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. J. Biol. Chem. 284, 19564-19571.
DOI
|
23 |
Fong, A. M., Premont, R. T., Richardson, R. M., Yu, Y. R. A., Lefkowitz, R. J. and Patel, D. D. (2002) Defective lymphocyte chemotaxis in -arrestin2- and GRK6-defi cient mice. Proc. Natl. Acd. Sci. USA. 99, 7478-7483.
DOI
|
24 |
Liu, S., Premont, R. T., Kontos, C. D., Zhu, S. and Rockey, D. C. (2005) A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat. Med. 11, 952-958.
DOI
|
25 |
Eichmann, T., Lorenz, K., Hoffmann, M., Brockmann, J., Krasel, C., Lohse, M. J. and Quitterer, U. (2003) The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory G binding site. J. Biol. Chem. 278, 8052-8057.
DOI
|
26 |
Fernandez, N., Gottardo, F. L., Alonso, M. N., Monczor, F., Shayo, C. and Davio, C. (2011) Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2. J. Biol. Chem. 286, 28697-28706.
DOI
|
27 |
Frank, S. R. and Hansen, S. H. (2008) The PIX-GIT complex: a G protein signaling cassette in control of cell shape. Semin. Cell Dev. Biol. 19, 234-244.
DOI
|
28 |
Gainetdinov, R. R., Bohn, L. M., Walker, J. K., Laporte, S. A., Macrae, A. D., Caron, M. G., Lefkowitz, R. J. and Premont, R. T. (1999) Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-defi cient mice. Neuron 24, 1029-1036.
DOI
|
29 |
Gordon, J. W., Shaw, J. A. and Kirshenbaum, L. A. (2011) Multiple facets of NF- in the heart: to be or not to NF- . Circ. Res. 108, 1122-1132.
DOI
|
30 |
Hoefen, R. J. and Berk, B. C. (2006) The multifunctional GIT family of proteins. J. Cell Sci. 119, 1469-1475.
DOI
|
31 |
Ciaccarelli, M., Chuprun, J. K., Rengo, G., Gao, E., Wei, Z., Peroutka, R. J., Gold, J. I., Gumpert, A., Chen, M., Otis, N. J., Dorn II, G. W., Trimarco, B., Iaccarino, G. and Koch, W. J. (2011) G proteincoupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation 123, 1953-1962.
DOI
|
32 |
Hughes, S. C. and Fehon, R. G. (2007) Understanding ERM proteins - the awesome power of genetics fi nally brought to bear. Curr. Opin. Cell Biol. 19, 51-56.
DOI
|
33 |
Iino, M., Furugori, T., Mori, T., Moriyama, S., Fukuzawa, A. and Shibano, T. (2002) Rational design and evaluation of new lead compound structures for selective ARK1 inhibitors. J. Med. Chem. 45, 2150-2159.
DOI
|
34 |
Cheng, S., Li, L., He, S., Liu, J., Sun, Y., He, M., Grasing, K., Premont, R. T. and Suo, W. Z. (2010) GRK5 defi ciency accelerates -amyloid accumulation in Tg2576 mice via impaired cholinergic activity. J. Biol. Chem. 285, 41541-41548.
DOI
|
35 |
Cipolletta, E., Campanile, A., Santulli, G., Sanzari, E., Leosco, D., Campiglia, P., Trimarco, B. and Guido Iaccarino, G. (2009) The G protein coupled receptor kinase 2 plays an essential role in betaadrenergic receptor-induced insulin resistance. Cardiovasc. Res. 84, 407-415.
DOI
|
36 |
Claing, A., Perry, S. J., Achiriloaie, M., Walker, J. K., Albanesi, J. P., Lefkowitz, R. J. and Premont, R. T. (2000) Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proc. Natl. Acad. Sci. USA. 97, 1119-1124.
DOI
|
37 |
Craig, L. A., Hong, N. S. and McDonald, R. J. (2011) Revisiting the cholinergic hypothesis in the development of Alzheimer's disease. Neurosci. Biobehav. Rev. 35, 1397-1409.
DOI
|
38 |
Dawson, T. M. and Dawson, V. L. (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302, 819-822.
DOI
ScienceOn
|
39 |
Hoefen, R. J. and Berk, B. C. (2006) The multifunctional GIT family of proteins. J. Cell Science 119, 1469-1475.
DOI
|
40 |
Dorn, G. W., II. (2010) Adrenergic signaling polymorphisms and their impact on cardiovascular disease. Physiol. Rev. 90, 1013-1062.
DOI
|
41 |
Eckhart, A. D., Duncan, S. J., Penn, R. B., Benovic, J. L., Lefkowitz, R. J. and Koch, W. J. (2000) Hybrid transgenic mice reveal in vivo specifi city of G protein-coupled receptor kinases in the heart. Circ. Res. 86: 43-50.
DOI
ScienceOn
|
42 |
Brinks, H., Boucher, M., Gao, E., Chuprun, J. K., Pesant, S., Raake, P. W., Huang, Z. M., Wang, X., Qiu, G., Gumpert, A., Harris, D. M., Eckhart, A. D., Most, P. and Koch, W. J. (2010) Level of G proteincoupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ. Res. 107,1140-1149.
DOI
|
43 |
Cadigan, K. M. and Liu, Y. I. (2006) Wnt signaling: complexity at the surface. J. Cell Sci. 119, 395-402.
DOI
|
44 |
Cant, S. H. and Pitcher, J. A. (2005) G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol. Biol. Cell 16, 3088-3099.
DOI
|
45 |
Carman, C. V., Parent, J. L., Day, P. W., Pronin, A. N., Sternweis, P. M., Wedegaertner, P. B., Gilman, A. G., Benovic, J. L. and Tohru Kozasa, T. (1999) Selective regulation of Gαq/11 by an RGS domain in the G Protein-coupled receptor kinase, GRK2. J. Biol. Chem. 274, 34483-34492.
DOI
|
46 |
Chen, L. and Feany, M. B. (2005) -Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8, 657-663.
DOI
|
47 |
Aiyar, N., Disa, J., Dang, K., Pronin, A. N., Benovic, J. L. and Nambi, P. (2000) Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors. Eur. J. Pharmacol. 403, 1-7.
DOI
|
48 |
Chen, M., Philipp, M., Wang, J., Premont, R. T., Garrison, T. R., Caron, M. G., Lefkowitz, R. J. and Chen, W. (2009) G protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J. Biol. Chem. 284, 35040-35048.
DOI
ScienceOn
|
49 |
Chen, W., Ren, X. R., Nelson, C. D., Barak, L. S., Chen, J. K., Beachy, P. A., de Sauvage, F. and Lefkowitz, R. J. (2004) Activity-dependent internalization of smoothened mediated by -arrestin 2 and GRK2. Science 306, 2257-2260.
DOI
|
50 |
Chen, X., Zhu, H., Yuan, M., Fu, J., Zhou, Y. and Ma, L. (2010) Gprotein- coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis. J. Biol. Chem. 285, 12823-12830.
DOI
|
51 |
Anis, Y., Leshem, O., Reuveni, H., Wexler, I., Ben Sasson, R., Yahalom, B., Laster, M., Raz, I., Ben Sasson, S., Shafrir, E. and Ziv, E. (2004) Antidiabetic effect of novel modulating peptides of G-protein- coupled kinase in experimental models of diabetes. Diabetologia 47, 1232-1244.
|
52 |
Benovic, J. L., Onorato, J., Lohse, M. J., Dohlman, H. G., Staniszewski, C., Caron, M. G. and Lefkowitz, R. J. (1990) Synthetic peptides of the hamster β2-adrenoceptor as substrates and inhibitors of the β-adrenoceptor kinase. Br. J. Clin. Pharmacol. 30, 3S-12S.
DOI
|
53 |
Arawaka, S., Wada, M., Goto, S., Karube, H., Sakamoto, M., Ren, C. H., Koyama, S., Nagasawa, H., Kimura, H., Kawanami, T., Kurita, K., Tajima, K., Daimon, M., Baba, M., Kido, T., Saino, S., Goto, K., Asao, H., Kitanaka, C., Takashita, E., Hongo, S., Nakamura, T., Kayama, T., Suzuki, Y., Kobayashi, K., Katagiri, T., Kurokawa, K., Kurimura, M., Toyoshima, I., Niizato, K., Tsuchiya, K., Iwatsubo, T., Muramatsu, M., Matsumine, H. and Kato, T. (2006) The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. J. Neurosci. 26, 9227-9238.
DOI
|
54 |
Barthet, G., Carrat, G., Cassier, E., Barker, B., Gaven, F., Pillot, M., Framery, B., Pellissier, L. P., Augier, J., Kang, D. S., Claeysen, S., Reiter, E., Banères, J. L., Benovic, J. L., Marin, P., Bockaert, J. and Dumuis, A. (2009) -arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J. 28, 2706-2718.
DOI
|
55 |
Belmonte, S. L. and Blaxall, B. C. (2011) G protein coupled receptor kinases as therapeutic targets in cardiovascular disease. Circ. Res. 109, 309-319.
DOI
|
56 |
Whalen, E. J., Rajagopal, S. and Lefkowitz, R. J. (2011) Therapeutic potential of -arrestin- and G protein-biased agonists. Tends. Mol. Med. 17, 126-139.
DOI
|
57 |
Tesmer, J. J., Tesmer, V. M., Lodowski, D. T., Steinhagen, H. and Huber, J. (2010) Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J. Med. Chem. 53, 1867-1870.
DOI
|
58 |
Thal, D. M., Yeow, R. Y., Schoenau, C., Huber, J. and Tesmer, J. J. (2011) Molecular, mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol. Pharmacol. 80, 294-303.
DOI
|
59 |
Vazquez, A., Bond, E. E., Levine, A. J. and Bond, G. L. (2008) The genetics of the p53 pathway, apoptosis and cancer therapy. Nature Rev. Drug Discov. 7, 979-987.
DOI
|
60 |
Walker, J. K., Gainetdinov, R. R., Feldman, D. S., McFawn, P. K., Caron, M. G., Lefkowitz, R. J., Premont, R. T. and Fisher, J. T. (2004) G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. Am. J. Physiol. Lung Cell Mol. Physiol. 286, L312-319.
DOI
|
61 |
Wilke, R. A., Reif, D. M. and Moore, J. H. (2005) Combinatorial pharmacogenetics. Nat. Rev. Drug Discov. 4, 911-918.
DOI
|
62 |
Willets, J. M., Challiss, R. A. J. and Nahorski, S. R. (2003) Non-visual GRKs: are we seeing the whole picture? Trends Pharmacol. Sci. 24, 626-633.
DOI
|
63 |
Winstel, R., Ihlenfeldt, H. G., Jung, G., Krasel, C. and Lohse, M. J. (2005) Peptide inhibitors of G protein-coupled receptor kinases. Biochem. Pharmacol. 70, 1001-1008.
DOI
|
64 |
Zhang, P. and Mende, U. (2011) Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ. Res. 109, 320-333.
DOI
|
65 |
Puca, R., Nardinocchi, L., Givol, D. and D'Orazi, G. (2010) Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 29, 4378-4387.
DOI
|
66 |
Setyawan, J., Koide, K., Diller, T. C., Bunnage, M. E., Taylor, S. S., Nicolaou, K. C. and Brunton, L. L. (1999) Inhibition of protein kinases by balanol: specifi city within the serine/threonine protein kinase subfamily. Mol. Pharmacol. 56, 370-376.
|
67 |
Rockman, H. A., Koch, W. J. and Lefkowitz, R. J. (2002) Seven-transmembrane- spanning receptors and heart function. Nature 415, 206-212.
DOI
|
68 |
Rockman, H. A., Choi, D. J., Rahman, N. U., Akhter, S. A., Lefkowitz, R. J. and Koch, W. J. (1996) Receptor-specifi c in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc. Natl. Acad. Sci. USA. 93, 9954-9959.
DOI
|
69 |
Scott, J. D. and Pawson, T. (2009) Cell signaling in space and time: where proteins come together and when they're apart. Science 326, 1220-1224.
DOI
|
70 |
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G. G., Cimini, V., Galasso, G., Astone, D., Piscione, F., Pastore, L., Trimarco, B. and Iaccarino, G. (2008) The G-protein-coupled receptor kinase 5 inhibits NF transcriptional activity by inducing nuclear accumulation of . Proc. Natl. Acad. Sci. USA. 105, 17818-17823.
DOI
|
71 |
Tarantino, P., De Marco, E. V., Annesi, G., Rocca, F. E., Annesi, F., Civitelli, D., Provenzano, G., Scornaienchi, V., Greco, V., Colica, C., Nicoletti, G. and Quattrone, A. (2011) Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 156B, 104-107.
|
72 |
Terry, A. V. Jr. and Buccafusco, J. J. (2003) The cholinergic hypothesis of age and Alzheimer's disease-related cognitive defi cits: recent challenges and their implications for novel drug development. J. Pharmacol. Exp. Ther. 306, 821-827.
DOI
|