• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.34 no.2
• /
• pp.101-107
• /
• 2008

In order to investigate the potential of a Angelica keiskei Koidzumi extract and its fractions as an active ingredient for whitening cosmetics, we prepared Angelica keiskei Koidzumi extract(70% ethanol), and the aqueous suspension was successively extracted with hexane, ethyl acetate(EA), and n-butanol fraction. We measured their inhibitory effects on mushroom tyrosinase and melanin synthesis in B16 melanoma cells and normal human kerationocytes in vitro. They did not show inhibitory activity against mushroom tyrosinase and the melanin synthesis except hexane and EA fractions. Hexane and EA fractions markedly inhibited cellular tyrosinase activity at a lower concentration(25 and 5 ${\mu}g/mL$, respectively) than arbutin(250 ${\mu}g/mL$). We also quantified the released amount of endothelin-1(ET-1), a mitogen of melanocyte, and interleukin-$1{\alpha}$(IL-$1{\alpha})$, a mediator of UVB-induced inflammation. Hexane and EA fractions did not affect IL-$1{\alpha}$ production, but they decreased UVB-induced ET-1 production in normal human keratinocytes in a dose dependant manner. As a result, hexane and EA fractions could inhibit the melanogenesis through the inhibition of UVB-induced ET-1 production in normal human keratinocytes. This result suggests that hexane and EA fractions of Angelica keiskei Koidzumi extract could be used as an active ingredient for cosmetics.

• The Korean Journal of Zoology
• /
• v.39 no.4
• /
• pp.337-351
• /
• 1996

Melatonin Is a multifunctional hormone secreted from the pineal gland in the middle of cerebrum and cerebellum. Its synthesis and release reflect photopedod;Photopedod is a yearly predictable ambient factor that most animals utilize as an environmental cue for maximum survival. Hamsters maintaln reproductive activity in summer during which day length exceeds night time. Upon the advent of autumnal equinox they undergo gonadal regression. The photoperiodic effects are prevented by removal of the pineal gland and restored by the timed repiacument of melatonin. The results suggest that melatonin constitutes part of control mechanism whereby environmental information is transduced to neuroendocrine signal responsIble for the functional integrity of the reproductive system. From the studies for the action site of melatonin following the treatment of photopedod or melatonin in the lesion of a spedflc portion of hypothalamus, suprachiasmatic nuclei and pars tuberalis are shown to be a consensus site for melatonIn. The action of melatonin. In the regulation of reproduction is largely unknown. It is mainly due to the lack of acute effect of melatonin on gonadotropin secretion. However, reduction of the gonadotropln release and augmentation of the hypothalamic gonadotropin-releasing hormone (GnRH) content by long-term treatment of melatonln Indicate that constant presence of melatonln may partidpate in the regulation of sexual activity via the GnRH neuronal system. The action mechanism by which melatonin exerts Its effect on GnRH neuron needs to be eluddated. The inability of opiold analogues to affect the reproductive hormones in sexually regressed animals by inhibftory photopedod and melatonin suggests that the opioldergic neuron may be a prime intervening mediator. Recent cloning of melatonin receptor will contribute to investigate its anatomical Identification and the action mechanism of melatonin on target tissues at the molecular level.

• The Korea Journal of Herbology
• /
• v.35 no.4
• /
• pp.51-60
• /
• 2020

Objective : The objective of this study was to demonstrate the effect of Persicae Semen (PS) in DNCB-induced atopic dermatitis mouse and HaCaT cell. Methods : The BALB/c mice were divided into four groups. To develop atopic dermatitis, 200 ㎕ of 1 and 0.5% DNCB solution was put on the back of mice in the Control group, the PS-Low group and the PS-High group once a day. After application of DNCB, 200 ㎕ of the PS extract was also treated. The Normal group was given PBS. The mice dorsal skin was stained with Masson's trichrome, H&E, and toluidine blue to evaluate the thickness of the epidermis and dermis, infiltration of eosinophils and mast cells respectively. ELISA was applied to measure the serum level of IgE and IL-6. Toxicity of PS was measured by MTS assay in HaCaT cell. To investigate the effects of PS on HaCaT cells, cells were pre-treated with PS for 1h, and then stimulated with TNF-α and IFN-γ. After 24 hours, the expression of TARC was analyzed using RT-PCR. Results : PS not only significantly diminished the thickness of the epidermis and dermis, but also reduced the infiltration of eosinophil and mast cell in skin lesion. PS also reduced the serum IgE and IL-6 level which plated important roles in the atopic dermatitis. The expression of TARC was decreased significantly in TNF-α/IFN-γ stimulated HaCaT cell. Conclusion : These results suggest that PS may be effective in alleviating the atopic dermatitis induced by DNCB and inflammation by TNF-α/IFN-γ.

• Korean Journal of Social Welfare
• /
• v.61 no.1
• /
• pp.5-32
• /
• 2009

The purpose of this study is to examine the effects of organizational culture types (rational culture, developmental culture, group culture, and hierarchical culture) on Community-Centered Social Inclusion Orientation(COSI) among social service organizations for people with disabilities. More specifically, this study developed and empirically tested two theoretical models where each of organizational culture types were hypothesized to affect COSI either directly or indirectly through market orientation. For data collection, self-administered type questionnaires were mailed to 416 social service organizations for people with disabilities across the nation and 293 responded (response rate: 70.4%) from June 1 to September 22, 2006. For analysis, however, only 263 respondents were used, excluding Independent living centers due to their small size and short history. Structural Equation Modeling was employed for analysis and Full Information Maximum Likelihood was used for estimation. Findings indicated that market orientation had a significant effect on COSI. In addition, developmental culture and hierarchical culture were found to affect COSI directly while rational culture and group culture were found to affect COSI indirectly through market orientation. These findings imply that market orientation needs to be emphasized as a strategy in order to enhance social inclusion orientation for those organizations. Given that all the four types of organizational culture have direct or indirect impacts on COSI, those organizations are also advised to develop the four types of organizational culture harmoniously rather than one single type of organizational culture.

• Journal of Gifted/Talented Education
• /
• v.25 no.6
• /
• pp.951-970
• /
• 2015

The purpose of this study is to explore related variables to influence gifted college students' career conviction and to propose a structural model. For the study, 292 college students who have experienced university affiliated gifted education program during their school days. Rational decision making test, intrinsic motivation test, career decision efficacy test, and major conviction test were utilized. SPSS program and AMOS were used for statistical analyses. The results are summarized as follows. The fit of measurement model was found to be TLI=.923, CFI=.951, RMSEA=.077, indicating most of the fit indexes were acceptable. The path to career conviction from rational decision making and intrinsic motivation was found to be insignificant, suggesting a revised model. The fit of final revised measurement model was found to be TLI =.926, CFI=.951, RMSEA=.075, indicating the model was acceptable. Interestingly, the career decision efficacy was found to be the complete mediator among the rational decision making, intrinsic motivation, and career conviction. The results of the study showed that career decision efficacy has a very important role in gifted college students'career choice and decision. Implication of the study related to the career education and counseling has been discussed in depth.

• Journal of Life Science
• /
• v.17 no.11
• /
• pp.1511-1516
• /
• 2007

Basophils and mast cells play an important role in $Fc{\varepsilon}RI-mediated$ allergic reaction as effector cells. We studied the effects of Acanthopanax chiisanensis on $Fc{\varepsilon}RI\;{\alpha}$ chain expression in human basophilic KU812F cells. Ethanol extracts from root and stem of A. chiisanensis were tested for inhibitory effects of $Fc{\varepsilon}RI\;{\alpha}$ chain expression. The cell surface $Fc{\varepsilon}RI\;{\alpha}$ chain expression was examined by flow cytometric analysis. All of the extracts of A. chiisanensis reduced the cell surface $Fc{\varepsilon}RI\;{\alpha}$ chain expression. Furthermore, A. chiisanensis extracts caused a decrease in the level of $Fc{\varepsilon}RI\;{\alpha}$ chain mRNA level and $Fc{\varepsilon}RI-mediated$ histamine release. These results suggest that root and stem extracts of A. chiisanensis play an important role in anti-allergic activity via down-regulation of $Fc{\varepsilon}RI\;{\alpha}$ chain expression and decrease in release of inflammatory mediator such as histamine.

• Journal of the Korean Electrochemical Society
• /
• v.2 no.4
• /
• pp.183-189
• /
• 1999

A study on the destruction of organic cation and anion exchange resins by electro-generated Ag(II) as a mediator was carried out to develop the ambient-temperature aqueous process, known as Ag(II)-mediated electro-chemical oxidation (MEO) process, for the treatment of a large quantity of spent organic ion exchange resins as the low and Intermediated-level radioactive wastes arising from the operation, maintenance and repairs of nuclear facilities. The effects of controllable process parameters such as applied current density, temperature, and nitric acid concentration on the MEO of organic ion exchange resins were investigated. The cation exchange resin was completely decomposed to $CO_2$. The current efficiency increased with a decrease in applied current density while nitric acid concentration and temperature on the MEO of cation exchange resin did not affect the MEO. On the other hand, anion exchange resins were decomposed to CO and $CO_2$. The ultimate conversion to CO was about $10\%$ regardless of temperature. The destruction efficiencies to $CO_2$ were dependent upon temperature and the effective destruction of anion exchange resin could be obtained above $60^{\circ}C$.

• Journal of Environmental Policy
• /
• v.10 no.2
• /
• pp.3-19
• /
• 2011

Nagoya Protocol designed to establish criteria about material trade of biological genetic resources(ABS) was adopted in the 10th conference of the Parties to the Convention on Biological Diversity. In the course of the negotiation for adoption of the protocol, there was conflict between developed and developing countries, resource-rich and poor countries, and multinational corporations and environmentalists. This study investigates conflict process, subjects, issues and major factors in the negotiation case, and analyzes the negotiation by using the Conflict Management Process. To develope conflict management strategies for various conflict cases, we examine previous studies and analyze the intersectional conflict factors of this case and general cases, such as Fundamental side, Resource-allocation side, and Communication/Information-sharing side. These analyses of conflict prevention/resolution of the ABS negotiation show the importance of building mutual trust among stakeholders, enhancing mediator training, and constructing appropriate legislative/policy systems for successful conflict management.

• Journal of KIISE:Software and Applications
• /
• v.31 no.4
• /
• pp.447-456
• /
• 2004

Information extraction is a process of recognizing and fetching particular information fragments from a document. In order to extract information uniformly from many heterogeneous information sources, it is necessary to produce information extraction rules called a wrapper for each source. Previous methods of information extraction can be categorized into manual wrapper generation and automatic wrapper generation. In the manual method, since the wrapper is manually generated by a human expert who analyzes documents and writes rules, the precision of the wrapper is very high whereas it reveals problems in scalability and efficiency In the automatic method, the agent program analyzes a set of example documents and produces a wrapper through learning. Although it is very scalable, this method has difficulty in generating correct rules per se, and also the generated rules are sometimes unreliable. This paper tries to combine both manual and automatic methods by proposing a new method of learning information extraction rules. We adopt the scheme of supervised learning in which a user-interface agent is designed to get information from the user regarding what to extract from a document, and eventually XML-based information extraction rules are generated through learning according to these inputs. The interface agent is used not only to generate new extraction rules but also to modify and extend existing ones to enhance the precision and the recall measures of the extraction system. We have done a series of experiments to test the system, and the results are very promising. We hope that our system can be applied to practical systems such as information-mediator agents.

• The Journal of the Korea Contents Association
• /
• v.17 no.9
• /
• pp.563-574
• /
• 2017

The predominant concerns of the study consist of: (1) the direct effects of social work students' evaluation toward connivers of exam-cheating on their evaluation toward connivers of corruptio ns in social welfare organizations; (2) the dual mediation effects of their concerning dysfunction of whistle-blowing and needing of protection arrangement for whistle-blowers. The notable findi ngs are as follows: First, the evaluation toward a person conniving at exam-cheating significantl y has an effect on the evaluation toward connivers committing corruptions in social welfare orga nizations($.211^{***}$). Second, the more positive evaluation for connivers of exam-cheating, the more concerning dysfunction of whistle-blowing, the less needing protection arrangement for whistle-blowers($-.191^{^{\prime}***}$). The students, concerning dysfunction of whistle-blowing more, show less neg ative evaluation toward a person, conniving at corruption in social welfare organizations($.245^{***}$). The more needing protection arrangement for whistle-blowers, the less positive evaluation regar ding whistle-blowers in the organizations($-.122^{***}$). Lastly, both mediating effects of the needing protection arrangement for whistle-blowers and concerning about dysfunction of whistle-blowing are significant so dual mediator are proved. Some practical implications are discussed based on the study's findings.