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http://dx.doi.org/10.5352/JLS.2007.17.11.1511

Inhibitory Effects of Acanthopanax chiisanensis Ethanolic Extracts on FcεRI α Chain Expression  

Shim, Sun-Yup (Oriental Medicine Research and Development Institute, Pukyong National University)
Sung, Chan-Ki (Department of Food Science, Jinju National University)
Lee, Sang-Won (Department of Microbiological Engineering, Jinju National University)
Choi, Young-Ju (Department of Food and Nutrition, Silla University)
Kim, Hyeung-Rak (Major of Nutrition, Pukyong National University)
Byun, Dae-Seok (major of Nutrition, Pukyong National University)
Publication Information
Journal of Life Science / v.17, no.11, 2007 , pp. 1511-1516 More about this Journal
Abstract
Basophils and mast cells play an important role in $Fc{\varepsilon}RI-mediated$ allergic reaction as effector cells. We studied the effects of Acanthopanax chiisanensis on $Fc{\varepsilon}RI\;{\alpha}$ chain expression in human basophilic KU812F cells. Ethanol extracts from root and stem of A. chiisanensis were tested for inhibitory effects of $Fc{\varepsilon}RI\;{\alpha}$ chain expression. The cell surface $Fc{\varepsilon}RI\;{\alpha}$ chain expression was examined by flow cytometric analysis. All of the extracts of A. chiisanensis reduced the cell surface $Fc{\varepsilon}RI\;{\alpha}$ chain expression. Furthermore, A. chiisanensis extracts caused a decrease in the level of $Fc{\varepsilon}RI\;{\alpha}$ chain mRNA level and $Fc{\varepsilon}RI-mediated$ histamine release. These results suggest that root and stem extracts of A. chiisanensis play an important role in anti-allergic activity via down-regulation of $Fc{\varepsilon}RI\;{\alpha}$ chain expression and decrease in release of inflammatory mediator such as histamine.
Keywords
Acanthopanax chiisanensis; $Fc{\varepsilon}RI$; histamine; KU812F;
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