• 제목/요약/키워드: mechanical stress response

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The effect of UNCL inactivation on the expression of mechanical stress related genes in cultured human PDL fibroblasts

  • Choi, Yong-Seok;Jang, Hyun-Sun;Lee, Dong-Seol;Kim, Heung-Joong;Park, Jong-Tae;Bae, Hyun-Sook;Park, Joo-Cheol
    • International Journal of Oral Biology
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    • v.33 no.2
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    • pp.51-58
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    • 2008
  • A mutation of UNCL, an inner nuclear membrane RNAbinding protein, has been found to eliminate mechanotransduction in Drosophila. UNCL is expressed in human periodontal tissue including in periodontal ligament (PDL) fibroblasts. However, it is unclear how a mechanical stimulus is translated into cellular responses in PDL fibroblasts. The aim of this study was to evaluate the effect of UNCl on mechanical stress related genes in PDL fibroblasts in response to mechanical stress. The mRNA of TGF-$\beta$, COX-2, and MMP-2 was up-regulated after UNCL inactivation in PDL fibroblasts under the compression force. Under the tensile force, inactivation of UNCL decreased the expression of Biglycan, RANKL, MMP-2, and TIMP-2 mRNAs while it increased the expression of TIMP-1. p38-MAPK was expressed in PDL fibroblasts under compression forces whereas phospho-ERK1/2, p65-NFkB, and c-fos were expressed under tension forces. The expression and phosphorylation of the mechanical stress related genes, kinases, and transcription factors were changed according to the types of stress. Furthermore, most of them were regulated by the inactivation of UNCL. This suggests that UNCL is involved in the regulation of mechanical stress related genes through the signaling pathway in PDL fibroblasts.

Structural Strength Analysis due to Rib Thickness of Lower Arm (로워암 리브 두께에 따른 구조 강도 해석)

  • Cho, Jaeung;Han, Moonsik
    • Transactions of the Korean Society of Automotive Engineers
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    • v.22 no.1
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    • pp.126-134
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    • 2014
  • This study investigates the structural strength analysis due to rib thickness of lower arm. At structural analysis, model 1 has the most deformation by comparing three models. As most equivalent stress is shown at the part connected with wheel knuckle, the strength becomes weaker in cases of three models. At fatigue analysis, model 1 becomes most unstabilized among three models. Model 3 has most fatigue life and the next model is model 2. The range of maximum harmonic response frequencies becomes 140 to 175Hz in cases of three models. Because the critical frequency at model 3 becomes highest among three models but the stress exceeds yield stress, model 3 becomes most unstabilized at vibration durability. As models 1 and 2 has less than yield stress, these models become stabilized. Model 2 becomes most favorable by comparing three models at structural, fatigue and vibration analyses. This study result can be effectively utilized with the design of lower arm by investigating prevention against damage and its strength durability.

Transient Response of an Electrorheological Fluid in Shear Flow (전단 유동 하에서 전기유변유체의 과도응답 특성)

  • Choi, Byung-Ha;Nam, Yun-Joo;Park, Myeong-Kwan
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.33 no.6
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    • pp.411-417
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    • 2009
  • The transient shear stress response of an electrorheological fluid is investigated experimentally. The characteristic time constants of an electrorheological fluid sheared between two concentric cylinders were obtained under various electric field strengths and shear rates. Also, two experimental modes are adopted to investigate the effect of the shear flow on the dynamic behavior of the fluid; one is that the electric field is induced before shearing, and the other is the electric field is induced after shearing. From the difference in the response time between two modes, the cluster formation time were obtained. The response times were decreased with the increase of the shear rate, irrelatively of the electric field strength. The cluster formation time were monotonically increased with increase of shear rate, and thereafter, were converged with a certain value.

Approximate Optimization Design Considering Automotive Wheel Stress (자동차용 휠의 응력을 고려한 근사 최적 설계)

  • Lee, Hyunseok;Lee, Jongsoo
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.24 no.3
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    • pp.302-307
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    • 2015
  • The automobile is an important means of transportation. For this reason, the automotive wheel is also an important component in the automotive industry because it acts as a load support and is closely related to safety. Thus, the wheel design is a very important safety aspect. In this paper, an optimal design for minimizing automotive wheel stress and increasing wheel safety is described. To study the optimal design, a central composite design (CCD) and D-optimal design theory are applied, and the approximate function using the response surface method (RSM) is generated. The optimal solutions using the non-dominant sorting genetic algorithm (NSGA-II) are then derived. Comparing CCD and D-optimal solution accuracy and verified the CCD can deduce more accuracy optimal solutions.

Topology Optimization of a Structure under Harmonic Excitation caused by Magnetic Fields (자기장에 의한 조화가진을 받는 구조물의 위상 최적화)

  • Yu, Jeong-Hun
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.25 no.10
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    • pp.1613-1620
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    • 2001
  • This study is focused on the application of the homogenization design method (HDM) to reduce the vibration level of a structure excited by magnetic harmonic farces. This is accomplished by obtaining the optimal material distribution in a design domain to minimize the frequency response caused by the magnetic harmonic excitation. The Maxwell stress method is used to compute the magnetic force and the HDM is applied leer the optimization. The developed method is applied to a simple pole model that is excited by the harmonic bending farce caused by the current around an adjacent stator. Results shows that the HDM is valid to minimize the frequency response.

Inverse Analysis Approach to Flow Stress Evaluation by Small Punch Test (소형펀치 시험과 역해석에 의한 재료의 유동응력 결정)

  • Cheon, Jin-Sik
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.24 no.7 s.178
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    • pp.1753-1762
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    • 2000
  • An inverse method is presented to obtain material's flow properties by using small punch test. This procedure employs, as the objective function of inverse analysis, the balance of measured load-di splacement response and calculated one during deformation. In order to guarantee convergence to global minimum, simulated annealing method was adopted to optimize the current objective function. In addition, artificial neural network was used to predict the load-displacement response under given material parameters which is the most time consuming and limits applications of global optimization methods to these kinds of problems. By implementing the simulated annealing for optimization along with calculating load-displacement curve by neural network, material parameters were identified irrespective of initial values within very short time for simulated test data. We also tested the present method for error-containing experimental data and showed that the flow properties of material were well predicted.

Optimization of the Television Packing System Using Equivalent Static Loads (등가정하중법을 이용한 텔레비전 포장재의 구조최적설계)

  • Lee, Youngmyung;Jung, Ui-Jin;Park, Gyung-Jin;Han, In-Sik;Kim, Tai-Kyung
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.39 no.3
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    • pp.311-318
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    • 2015
  • A nonlinear dynamic response structural optimization process is proposed for the television (TV) packing system that protects the damage from a drop situation using the equivalent static loads (ESLs). Topology optimization using ESLs is carried out for conceptual design, and shape optimization using stress ESLs for a virtual model is performed for detailed design. Stress ESLs are static loads that generate the same displacement as well as the stress fields of linear static analysis as those of nonlinear dynamic analysis. Thus, the response of nonlinear dynamic analysis can be utilized as a constraint in the linear static structural optimization. An actual example is solved to validate the process. The drop test of a television packaging system is analyzed by LS-DYNA, and NASTRAN is used for optimization.

Hygrothermal effects on the vibration and stability of an initially stressed laminated plate

  • Wang, Hai;Chen, Chun-Sheng;Fung, Chin-Ping
    • Structural Engineering and Mechanics
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    • v.56 no.6
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    • pp.1041-1061
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    • 2015
  • The influence of hygrothermal effects on the vibration frequency and buckling load of a shear deformable composite plate with arbitrary initial stresses was investigated. The governing equations of the effects of humid, thermal and initial stresses are established using the variational method. The material properties of the composite plate are affected by both temperature and moisture. The initial stress is taken to be a combination of uniaxial load and pure bending in a hygrothermal environment. The influence of various parameters, such as the fiber volume fraction, temperature, moisture concentration, length/thickness ratios, initial stresses and bending stress ratio on the vibration and stability of the response of a laminated plate are studied in detail. The behavior of vibration and stability are sensitive to temperature, moisture concentration, fiber volume fraction and initial stresses.

Studying the influences of mono-vacancy defect and strain rate on the unusual tensile behavior of phosphorene NTs

  • Hooman Esfandyari;AliReza Setoodeh;Hamed Farahmand;Hamed Badjian;Greg Wheatley
    • Advances in nano research
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    • v.15 no.1
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    • pp.59-65
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    • 2023
  • In this present article, the mechanical behavior of single-walled black phosphorene nanotubes (SW-αPNTs) is simulated using molecular dynamics (MD). The proposed model is subjected to the axial loading and the effects of morphological parameters, such as the mono-vacancy defect and strain rate on the tensile behavior of the zigzag and armchair SW-αPNTs are studied as a pioneering work. In order to assess the accuracy of the MD simulations, the stress-strain response of the current MD model is successfully verified with the efficient quantum mechanical approach of the density functional theory (DFT). Along with reproducing the DFT results, the accurate MD simulations successfully anticipate a significant variation in the stress-strain curve of the zigzag SW-αPNTs, namely the knick point. Predicting such mechanical behavior of SW-αPNTs may be an important design factor for lithium-ion batteries, supercapacitors, and energy storage devices. The simulations show that the ultimate stress is increased by increasing the diameter of the pristine SW-αPNTs. The trend is identical for the ultimate strain and stress-strain slope as the diameter of the pristine zigzag SW-αPNTs enlarges. The obtained results denote that by increasing the strain rate, the ultimate stress/ultimate strain are respectively increased/declined. The stress-strain slope keeps increasing as the strain rate grows. It is worth noting that the existence of mono-atomic vacancy defects in the (12,0) zigzag and (0,10) armchair SW-αPNT structures leads to a drop in the tensile strength by amounts of 11.1% and 12.5%, respectively. Also, the ultimate strain is considerably altered by mono-atomic vacancy defects.

Forced Vibration Modeling of Rail Considering Shear Deformation and Moving Magnetic Load (전단변형과 시간변화 이동자기력을 고려한 레일의 강제진동모델링)

  • Kim, Jun Soo;Kim, Seong Jong;Lee, Hyuk;Ha, Sung Kyu;Lee, Young-Hyun
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.12
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    • pp.1547-1557
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    • 2013
  • A forced vibration model of a rail system was established using the Timoshenko beam theory to determine the dynamic response of a rail under time-varying load considering the damping effect and stiffness of the elastic foundation. By using a Fourier series and a numerical method, the critical velocity and dynamic response of the rail were obtained. The forced vibration model was verified by using FEM and Euler beam theory. The permanent deformation of the rail was predicted based on the forced vibration model. The permanent deformation and wear were observed through the experiment. Parametric studies were then conducted to investigate the effect of five design factors, i.e., rail cross-section shape, rail material density, rail material stiffness, containment stiffness, and damping coefficient between rail and containment, on four performance indices of the rail, i.e., critical velocity, maximum deflection, maximum longitudinal stress, and maximum shear stress.