• 디지털콘텐츠학회 논문지
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• 제19권4호
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• pp.615-620
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• 2018

당뇨병성 다발성 신경병증 환자들을 진단하는 전류지각 역치 시험과 진동 감각 지각 역치의 임상학적 유용성에 대한 평가는 당뇨병성 다발성 신경병증에 대한 진단방법 중의 하나이다. 현재까지 당뇨병성 다발성 신경병증 환자들에 대해 몇 가지 방법들이 사용되어 왔는데, 예를 들면, 하지 신경병증 장애 시험, 신경전도 시험, 냉각감지 역치 시험, 열-고통 역치 시험 등을 들 수 있다. 그러나, 이들 대부분의 시험은 고가이거나 시험하는데 많은 시간을 필요로 한다. 본 논문에서는 진동 감지 능력을 평가하는 새로운 기구가 소개되고, 이를 위해 환자의 말초 신경을 자극하는 보이스 코일 모터(voice coil motor)와 전류 증폭기를 제작하였다. 또한, 당뇨병성 다발성 신경병증 환자들의 정량적 진동 감지 수준을 측정하기 위하여 진동 감지 역치 시험을 센싱하고 구동하는 소프트웨어가 개발되었다.

• The Korean Journal of Pain
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• 제23권3호
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• pp.172-178
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• 2010

Background: Tumor necrosis factor-alpha and other proinflammatory cytokines are becoming well recognized as key mediators in the pathogenesis of many types of neuropathic pain. Thalidomide has profound immunomodulatory actions in addition to their originally intended pharmacological actions. There has been debate on the analgesic efficacy of opioids in neuropathic pain. The aim of this study was to investigate the effect of thalidomide and morphine on a spinal nerve ligation model in rats. Methods: Male Sprague-Dawley rats weighing 100-120 g were used. Lumbar (L) 5 and 6 spinal nerve ligations were performed to induce neuropathic pain. For assessment of mechanical allodynia, mechanical stimulus using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of intraperitoneal thalidomide (6.25, 12.5, 25 and 50 mg/kg, respectively) and morphine (3 and 10 mg/kg, respectively) were examined on a withdrawal threshold evoked by spinal nerve ligation. Results: After L5 and 6 spinal nerve ligation, paw withdrawal thresholds on the ipsilateral side were significantly decreased compared with pre-operative baseline and with those in the sham-operated group. Intraperitoneal thalidomide and morphine significantly increased the paw withdrawal threshold compared to controls and produced dose-responsiveness. Conclusions: Systemic thalidomide and morphine have antiallodynic effect on neuropathic pain induced by spinal nerve ligation in rat. These results suggest that morphine and thalidomide may be alternative therapeutic approaches for neuropathic pain.

• The Korean Journal of Pain
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• 제21권1호
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• pp.18-26
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• 2008

Background: Because genetic manipulation is commonly accomplished in mice, mouse models for pain have advanced our understanding of the mechanisms of persistent pain. The purpose of this experimental study is to develop a mouse model for understanding incision induced postoperative pain. Methods: A longitudinal incision was made at the hindpaw of male DBA/2 mice. The withdrawal frequency(WF) from applications of von Frey filaments and the response frequency (RF) to blunt mechanical stimulation were examined in an incision group and a control grouP. The withdrawal latency (WL) to radiant heat and a pain score based on weight bearing were also measured. Tests were performed 1 day before incision, and 2 hours, 1-3 days, 5 days and 7 days after incision. Results: The WF for the strongest filament was $35.0{\pm}9.1%$ before incision and this increased to $100.0{\pm}0%$ at 2 hours and to $65.0{\pm}9.1%$ at 7 days after incision. The RF to the blunt stimulus was $4.1{\pm}4.1%$ before incision and $100.0{\pm}0.0%$ at 2 hours and $42.8{\pm}10.8%$ at 7 days after incision. The WL was $6.6{\pm}0.5sec$ before incision and $2.4{\pm}0.3sec$ at 2 hours and $5.9{\pm}0.6sec$ at 7 days after incision. The pain score increased from $1.1{\pm}0.8$ to $7.4{\pm}1.5$ at 2 days after incision. Conclusions: A mouse model of acute postoperative pain was developing by making a surgical incision in the mouse hindpaw. Mechanical hyperalgesia and allodynia lasting for several days demonstrate that this model has similarities to the human post-operative pain state. Future studies will allow us to further investigate the genetic and molecular mechanisms of incisional pain.

• The Korean Journal of Physiology and Pharmacology
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• 제12권5호
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• pp.253-258
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• 2008

Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fact, earlier pharmacological studies have provided results that support either a facilitatory or inhibitory role for SOM in nociception. In the current study, the effects of SOM were investigated using anesthetized cats. Specifically, the responses of rostrally projecting spinal dorsal horn neurons (RPSDH neurons) to different kinds of noxious stimuli (i.e., heat, mechanical and cold stimuli) and to the $A{\delta}$ -and C-fiber activation of the sciatic nerve were studied. Iontophoretically applied SOM suppressed the responses of RPSDH neurons to noxious heat and mechanical stimuli as well as to C-fiber activation. Conversely, it enhanced these responses to noxious cold stimulus and $A{\delta}$-fiber activation. In addition, SOM suppressed glutamate-evoked activities of RPSDH neurons. The effects of SOM were blocked by the SOM receptor antagonist cyclo-SOM. These findings suggest that SOM has a dual effect on the activities of RPSDH neurons; that is, facilitation and inhibition, depending on the modality of pain signaled through them and its action site.

• Journal of Acupuncture Research
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• 제19권3호
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• pp.64-76
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• 2002

Objective : The purpose of this study is to investigate the mechanism and effect of moxibustion objectively and to be used as the quantitative data for developing the new thermal stimulating treatment by observing the combustion characteristics of commercial moxaes. Methods : We have selected two types(large-size moxa A(LMA), large-size moxa B(LMB)) among large moxaes used widely in the clinic. We examined combustion times, temperatures, temperature gradients in each period during a combustion of moxa. Results : 1. The ascending temperature gradient measured in the central point of non-contacted surface was fastest, the average ascending temperature gradient of both moxaes was $0.0384^{\circ}C/sec$, $0.0123^{\circ}C/sec$ respectively, 3.1 times faster in LMA. The maximum ascending temperature gradient was also about 2.9 times faster in LMA. The time required for the maximum ascending temperature gradient from ignition was 254sec, 411sec respectively. 2. The minimum descending temperature gradient in the retaining period was $-0.0250^{\circ}C/sec$, $-0.0090^{\circ}C/sec$ respectively and the average descending temperature gradient was $-0.0160^{\circ}C/sec$, $-0.0037^{\circ}C/sec$ respectively on the non-contact surface. 3. On the basis of the non-contact surface($A_I$), the time at which the effective stimulus period began to occur was about 264sec, 796sec respectively after an ignition, the time at which the maximum temperature began to occur was about 373sec, 1323sec respectively after an ignition, and the maximum temperature was $0.9^{\circ}C$ higher in LMA. The maximum ascending temperature gradient was also about 4.2 times faster in LMA. Conclusion : It was thought that not only the figure of moxicombustion device, but also the form and size of moxa had influence on the combustion characteristics deciding the performance of stimulus seriously.

• Journal of Oral Medicine and Pain
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• 제30권4호
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• pp.465-473
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• 2005

냉온자극 또는 잇솔질에 불편감을 호소하는 치과 외래 환자를 72명을 대상으로 레이저 조사를 시행한 실험군(45명)과 모의 레이저 조사를 시행한 대조군(27명)으로 나누어 지각 과민 치아의 치경부에 냉자극 및 기계적 자극을 가하여 대상자가 느끼는 불편감을 NPS로 평가하였다. 치아의 통증역치 평가를 위하여 전기치수검사기(EPT)를 사용하였다. 각 치아에 대한 레이저 조사에는 pulsed Nd:YAG 레이저를 사용하였고 조사조건은 1.5W, 20Hz, 75mJ/pulse으로 4분간 비접촉식으로 시행하였다. 대상자의 반응을 레이저 조사 전과 직후, 1주 이내, 2주 이내 각각 평가하여 다음과 같은 결과를 얻었다. 1. 지각 과민 치아에 대한 Nd:YAG 레이저 조사는 지각 과민을 완화시켜 주었으며 대조군에 비해 그 효과가 현저하였다. 2. 심한 지각 과민을 호소하는 치아에 대한 위약 효과는 존재하였으나 중등도의 지각 과민을 호소하는 치아에 대한 위약효과는 배제할 수 있었다. 3. 지각 과민 치아에 대한 Nd:YAG 레이저 조사는 전기치수검사에 의한 통증역치에 영향을 주지 않았다. 4. 지각 과민 치아에 대한 Nd:YAG 레이저 조사의 효과는 최소 2주는 지속되었다. 따라서 지각 과민 치아에 대한 치료법의 하나로 Nd:YAG 레이저 조사가 임상적으로 유용할 것으로 사료된다.

• 한국콘텐츠학회논문지
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• 제19권10호
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• pp.198-205
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• 2019

본 연구의 목적은 목 디스크 환자에게 기계적 자극을 적용하여 피부 감각의 변화를 유도하고 동일한 척수분절의 통증 역치와 근 긴장도 전-후 변화를 확인하고자 하였다. 이에 목 디스크 질환을 가지고 있는 남성 10명, 여성 20명으로 구성된 대상자를 총 30명 선정하고 실험을 진행하였다. 기계적 자극 그룹은 Graston 장비를 이용하여 5분간 피부 감각 변화를 유도하였고, 대조군은 아무런 조치를 받지 않았다. 피부 감각 변화는 Von Frey filament를 통해 검사를 진행하였고, 압통 역치의 변화는 압통 역치 측정기를 통해 측정하였고, 근 긴장도의 변화는 Myotone pro를 사용하여 측정하였다. 기계적 자극 적용 시 피부 감각의 역치는 통계적으로 유의하게 증가하였다(p<0.05). 동일한 척수 분절의 신경 지배를 받는 오른쪽 가시아래근의 압통 역치와 근 긴장도는 통계적으로 유의하게 증가하였고(p<0.05), 오른쪽 등세모근의 압통 역치는 통계적으로 유의하게 감소하였다(p<0.05). 하지만 다른 근육들의 압통 역치와 근 긴장도는 통계적으로 유의한 변화가 나타나지 않았다. 또한, 대조군에서는 피부 감각, 압통 역치, 근 긴장도의 변화가 통계적으로 유의하게 나타나지 않았다. 결과적으로 기계적 자극에 의해 유도된 피부 감각 변화는 동일 척수 분절의 압통 역치와 근 긴장도의 변화시켰다. 따라서 동일 척수 분절에 대한 기계적 자극의 적용을 통해 목 디스크 환자의 압통 역치, 근 긴장도의 증가와 통증 조절을 위한 새로운 재활 방법으로 임상적 의의가 있다고 판단된다.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.171-187
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• 2001

Objective : Moxibustion has been proved efficacious for many diseases, but isn't widespread in the clinics due to a danger of skin burning, the smoke produced while burning a moxa combustion and so on. Therefore, another type of moxa that can be resolved these troubles is required. To improve the effect of moxibustion and develop the new thermal stimulating treatment, the performance of commercial moxibustion widely used are studied systematically and found out quantitatively. Methods : We have selected two types (small-size moxa A(sMA), small-size moxa B (sMB)) among small-size moxaes used widely in the clinic. We examined combustion time, various temperatures, temperature gradient in each period during a combustion of moxa. Results : 1. The combustion time in the preheating period appeared somewhat longer in sMA than in sMB. 2, The combustion time in the heating period appeared longer in sMA by 26% than in sMB. 3. The average temperature in the heating period was $37.6{\sim}37.8^{\circ}C\;in\;sMA\;and\;36.2{\sim}36.8^{\circ}C$ in sMB and the maximum temperature measured at a center of contact surface in sMA was $48.6^{\circ}C$, higher by over $2.8^{\circ}C$ than that of sMB moxibustion. 4. The average ascending temperature gradient in the heating period was $0.08{\sim}0.1^{\circ}C/sec$ in both moxaes, and the average ascending temperature gradient of heating period in sMB appeared larger. The maximum ascending temperature gradient appeared higher in sMB, and the time reaching maximum ascending temperature gradient appeared much earlier in sMA than in sMB. 5. The combustion time in the retaining period was around 100 sec in sMA and around 275 sec in sMB. 6. The average temperature in the retaining period was $42.2{\sim}46.0^{\circ}C\;in\;sMA\;and\;39.3{\sim}41.4^{\circ}C/sec$ in sMB. The minimum temperature in the retaining period was over $38.80^{\circ}C$ in sMA but just $34.7^{\circ}C$ in sMB. 7. The average descending temperature gradient in sMA was $-0.050{\sim}0.067^{\circ}C/sec$ and in sMB was $-0.030{\sim}0.037^{\circ}C/sec$ 8. The combustion time in the cooling period appeared longer over two times in sMA than in sMB, and the time which the cooling period (minimum temperature) finished at appeared later in sMB by 55 sec. 9. We classified the combustion process that the measured temperature rose over body heat($37^{\circ}C$) into the effective combustion period. The effective combustion time was 233.3 sec in sMA and 300.4 sec in sMB respectively, and was longer by about 29% in sMB. The average temperature and maximum temperature in the effective combustion time appeared higher in sMA. The time taken until the maximum temperature was reached was 225.1 sec in sMA and 244.5 sec in sMB, faster by about 20 sec in sMA. The maximum ascending temperature gradient during the effective combustion period appeared larger about 1.4 times in sMB, but the time when the maximum ascending temperature gradient happened was faster in sMA. Conclusion : It appears that sMB, compared with sMA, is proper if necessary to apply the long time and weak stimulus, because of the gentle stimulus during the relatively longer time. In contrast, sMA that the symmetrical combustion happened is proper if necessary to apply the short time and strong stimulus.

• 사물인터넷융복합논문지
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• 제7권2호
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• pp.13-19
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• 2021

에너지 패턴은 국가 경제 침체에 따라 에너지 소비가 감소한 질병 트렌드의 사회 문제에 영향을 받는 것으로 분석됩니다. 사람들을 위한 사회적 거리 캠페인은 2019 년 코로나 바이러스 질병 (COVID-19)의 전염병으로 인해 자발적으로 또는 법적으로 수행되었습니다. 미국, 한국 등 일부 국가에서 일부 경제 부양 정책이 시행되었습니다. S, I, R로 논리적 모델링이 구성되는 시스템 역학 (SD)에 의해 적용된 SIR (Sceptible, Infectious, Recovery) 모델링을 보여줍니다. 특히 I 는 인구, 인종, 성숙도를 포함한 사회와 연결되어 있습니다. 또한 경제 및 정치는 소득, GDP, 자원, 대통령, 인기, 통치 정부 및 리더십과 관련이 있습니다. 그래프는 S 값 곱셈이 시작되는 2020년 4월의 큰 도약을 보여줍니다. 이것은 COVID-19의 영향과 관련 유행병 이후 추세를 보여줍니다. OECD와 비 OECD의 경향은 매우 유사하며 바이러스 위험의 영향은 경제 침체를 크게 유발합니다.

• The Korean Journal of Pain
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• 제34권3호
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• pp.250-261
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• 2021

Background: Complex regional pain syndrome type I (CRPS-I) consists of disorders caused by spontaneous pain or induced by some stimulus. The objective was to verify the effects of photobiomodulation (PBM) using 830 nm wavelength light at the affected paw and involved spinal cord segments during the warm or acute phase. Methods: Fifty-six mice were randomized into seven groups. Group (G) 1 was the placebo group; G2 and G3 were treated with PBM on the paw in the warm and acute phase, respectively; G4 and G5 treated with PBM on involved spinal cord segments in the warm and acute phase, respectively; G6 and G7 treated with PBM on paw and involved spinal cord segments in the warm and acute phase, respectively. Edema degree, thermal and mechanical hyperalgesia, skin temperature, and functional quality of gait (Sciatic Static Index [SSI] and Sciatic Functional Index [SFI]) were evaluated. Results: Edema was lower in G3 and G7, and these were the only groups to return to baseline values at the end of treatment. For thermal hyperalgesia only G3 and G5 returned to baseline values. Regarding mechanical hyperalgesia, the groups did not show significant differences. Thermography showed increased temperature in all groups on the seventh day. In SSI and SFI assessment, G3 and G7 showed lower values when compared to G1, respectively. Conclusions: PBM irradiation in the acute phase and in the affected paw showed better results in reducing edema, thermal and mechanical hyperalgesia, and in improving gait quality, demonstrating efficacy in treatment of CRPS-I symptoms.