Browse > Article
http://dx.doi.org/10.3344/kjp.2010.23.3.172

Antiallodynic Effect of Thalidomide and Morphine on Rat Spinal Nerve Ligation-induced Neuropathic Pain  

Choi, Jeong-Il (Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School)
Kim, Woong-Mo (Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School)
Yoon, Myung-Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School)
Lee, Hyung-Gon (Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School)
Publication Information
The Korean Journal of Pain / v.23, no.3, 2010 , pp. 172-178 More about this Journal
Abstract
Background: Tumor necrosis factor-alpha and other proinflammatory cytokines are becoming well recognized as key mediators in the pathogenesis of many types of neuropathic pain. Thalidomide has profound immunomodulatory actions in addition to their originally intended pharmacological actions. There has been debate on the analgesic efficacy of opioids in neuropathic pain. The aim of this study was to investigate the effect of thalidomide and morphine on a spinal nerve ligation model in rats. Methods: Male Sprague-Dawley rats weighing 100-120 g were used. Lumbar (L) 5 and 6 spinal nerve ligations were performed to induce neuropathic pain. For assessment of mechanical allodynia, mechanical stimulus using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of intraperitoneal thalidomide (6.25, 12.5, 25 and 50 mg/kg, respectively) and morphine (3 and 10 mg/kg, respectively) were examined on a withdrawal threshold evoked by spinal nerve ligation. Results: After L5 and 6 spinal nerve ligation, paw withdrawal thresholds on the ipsilateral side were significantly decreased compared with pre-operative baseline and with those in the sham-operated group. Intraperitoneal thalidomide and morphine significantly increased the paw withdrawal threshold compared to controls and produced dose-responsiveness. Conclusions: Systemic thalidomide and morphine have antiallodynic effect on neuropathic pain induced by spinal nerve ligation in rat. These results suggest that morphine and thalidomide may be alternative therapeutic approaches for neuropathic pain.
Keywords
antinociceptive; cytokine; morphine; neuropathy; thalidomide;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bian D, Nichols ML, Ossipov MH, Lai J, Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport 1995; 6: 1981-4.   DOI   ScienceOn
2 Zhao C, Tall JM, Meyer RA, Raja SN. Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats. Anesthesiology 2004; 100: 905-11.   DOI   ScienceOn
3 George A, Marziniak M, Schä8fers M, Toyka KV, Sommer C. Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain 2000; 88: 267-75.   DOI   ScienceOn
4 Rajkumar SV, Fonseca R, Witzig TE. Complete resolution of reflex sympathetic dystrophy with thalidomide treatment. Arch Intern Med 2001; 161: 2502-3.   DOI   ScienceOn
5 Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50: 355-63.   DOI   ScienceOn
6 Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 1991; 173: 699-703.   DOI   ScienceOn
7 Vale ML, Cunha FQ, Brito GA, Benevides VM, Ferreira SH, Poole S, et al. Anti-nociceptive effect of thalidomide on zymosan-induced experimental articular incapacitation. Eur J Pharmacol 2006; 536: 309-17.   DOI   ScienceOn
8 White FA, Jung H, Miller RJ. Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci USA 2007; 104: 20151-8.   DOI   ScienceOn
9 Rocha AC, Fernandes ES, Quintão NL, Campos MM, Calixto JB. Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br J Pharmacol 2006; 148: 688-95.   DOI   ScienceOn
10 Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci 2001; 24: 450-5.   DOI   ScienceOn
11 Bennett GJ. A neuroimmune interaction in painful peripheral neuropathy. Clin J Pain 2000; 16(3 Suppl): S139-43.   DOI
12 Laffitte E, Revuz J. Thalidomide: an old drug with new clinical applications. Expert Opin Drug Saf 2004; 3: 47-56.   DOI   ScienceOn
13 Wallace JM. Update on pharmacotherapy guidelines for treatment of neuropathic pain. Curr Pain Headache Rep 2007; 11: 208-14.   DOI   ScienceOn
14 Teo SK, Stirling DI, Zeldis JB. Thalidomide as a novel therapeutic agent: new uses for an old product. Drug Discov Today 2005; 10: 107-14.   DOI   ScienceOn
15 Backonja MM. Defining neuropathic pain. Anesth Analg 2003; 97: 785-90.
16 Barkin RL, Barkin SJ, Barkin DS. Perception, assessment, treatment, and management of pain in the elderly. Clin Geriatr Med 2005; 21: 465-90.   DOI   ScienceOn
17 Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med 1993; 177: 1675-80.   DOI   ScienceOn
18 Lee YW, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett 1995; 199: 111-4.   DOI   ScienceOn
19 Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury. Neurosci Lett 1995; 199: 83-6.   DOI   ScienceOn
20 Yu W, Hao JX, Xu XJ, Wiesenfeld-Hallin Z. Comparison of the anti-allodynic and antinociceptive effects of systemic; intrathecal and intracerebroventricular morphine in a rat model of central neuropathic pain. Eur J Pain 1997; 1: 17-29.   DOI   ScienceOn
21 Turk BE, Jiang H, Liu JO. Binding of thalidomide to alpha1- acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci USA 1996; 93: 7552-6.   DOI   ScienceOn
22 Zimmermann M. Ethical guidelines for investigations on experimental pain in conscious animals. Pain 1983; 16: 109-10.   DOI   ScienceOn
23 Gimbel JS, Richards P, Portenoy RK. Controlled-release oxycodone for pain in diabetic neuropathy: a randomized controlled trial. Neurology 2003; 60: 927-34.   DOI   ScienceOn
24 Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.   DOI   ScienceOn
25 DeLeo JA, Yezierski RP. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 2001; 90: 1-6.   DOI   ScienceOn
26 Myers RR, Campana WM, Shubayev VI. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today 2006; 11: 8-20.   DOI   ScienceOn
27 Arné.r S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988; 33: 11-23.   DOI   ScienceOn
28 Dellemijn P. Are opioids effective in relieving neuropathic pain? Pain 1999; 80: 453-62.   DOI   ScienceOn
29 Raja SN, Haythornthwaite JA, Pappagallo M, Clark MR, Travison TG, Sabeen S, et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 2002; 59: 1015-21.   DOI   ScienceOn
30 Xu JT, Xin WJ, Zang Y, Wu CY, Liu XG. The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat. Pain 2006; 123: 306-21.   DOI   ScienceOn
31 Ching DW, McClintock A, Beswick F. Successful treatment with low-dose thalidomide in a patient with both Behcet's disease and complex regional pain syndrome type I: case report. J Clin Rheumatol 2003; 9: 96-8.   DOI   ScienceOn
32 Laffitte E. The revival of thalidomide: an old drug with new indications. Rev Prat 2006; 56: 1977-83.
33 Ribeiro RA, Vale ML, Ferreira SH, Cunha FQ. Analgesic effect of thalidomide on inflammatory pain. Eur J Pharmacol 2000; 391: 97-103.   DOI   ScienceOn