• 정보보호학회논문지
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• 제15권6호
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• pp.105-110
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• 2005

유한체에서 정의된 선형 다항식의 역원은 함수 거 일반화로 볼 수 있으므로, 암호학적 응용에서 유용한 부울 하수를 설계하는 데 좋은 후보가 될 수 있다 특히, Crypto 2001에서는 선형 다항식 및 선형 부호를 이용하여 큰 대수적 차수를 가지는 resilient 함수를 설계하는 방법이 제안되었다. 그러나 Crypto 2001에서 대수적 차수를 분석한 결과에 오류가 있었으며, 본 논문에서 정확한 대수적 차수를 제시한다.

• Journal of Photoscience
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• 제9권2호
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• pp.225-228
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• 2002

Bcl-2 is a member of large bcl-2 family and protects cells from apoptosis. Using bcl-2-expressing adenovirus vector (Ad-bc1-2), we investigated the effect of bc1-2 on UVB-induced apoptosis. Adenovirus vector efficiently introduced bc1-2 gene in cultured normal mouse keratinocytes (NMK cells); almost all NMK cells (lx10$^{6}$ ) were transfected at Ixl0$^{8}$ PFU/ml. Bcl-2-transfected NMK cells were significantly resistant to UVB-induced apoptosis with the suppressive effect dependent on bcl-2-expression level. Following UVB irradiation caspase 8, 3, 9 activities were stimulated in NMK cells, while in bc1-2-transfected cells, only caspase 8, but not caspase 3 or 9 activities were stimulated. In order to investigate the effect of bc1-2 in vivo, topical application of Ad-bc1-2 on tape-stripped mouse skin was performed. Following the application, Bc1-2 was efficiently overexpressed in almost all viable keratinocytes. The expression was transient with the maximal expression of Bc1-2 at 1st day following the application of lxl0$^{9}$ PFU in 200ml. The introduced Bc1-2 remained at least for 6 days. UVB irradiation (1250 J/m$^2$) induced apoptosis within 12 h and the maximal effect was observed at 24 h in control mouse skin. Bc1-2-transfected mice skin were resistant to UVB-induced apoptosis. Topical application of empty adenovirus vector alone had no effect on Bc1-2 expression or UVB-induced apoptosis. These results indicate that adenovirus vector is an efficient gene delivery system into keratinocytes and that Bcl-2 is a potent inhibitor of UVB-induced apoptosis both in vitro and in vivo.

• 대한수학회보
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• 제52권1호
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• pp.149-157
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• 2015

We show that $C^1$-generically, the shadowable chain component of a $C^1$-vector field containing a hyperbolic periodic orbit is hyperbolic if it is locally maximal.

• 대한의생명과학회지
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• 제25권4호
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• pp.398-406
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• 2019

Cancer immunotherapy using gene-modified tumor cells is safe and customized cancer treatment method. In this study, we made gene-modified tumor cells by transferring costimulatory molecules, 4-1BBL and OX40L, into tumor cells using lentivirus vector, and identified anti-cancer effect of gene-modified tumor cells in CT26 mouse colorectal tumor model. We construct pLVX-puro-4-1BBL, -OX40L vector for lentivirus production and optimized the transfection efficiency and transduction efficiency. The transfection efficiency is maximal at DNA:cationic polymer = 1:0.5 and DNA 2 ㎍ for lentivirus production. Then, the lentiviral including 4-1BBL and OX40L was used to deliver CT26 mouse tumor cells to establish optimal delivery conditions according to the amount of virus. The transduction efficiency is maximal at 500 μL volume of lentiviral stock without change in cell shape or growth rate. CT26-4-1BBL, CT26-OX40L significantly inhibited the tumor growth compare with CT26-WT or CT26-β-gal cell line. These data showed the possibility the use of genetically modified tumor cells with costimulatory molecule as cancer immunotherapy agent.

• IMMUNE NETWORK
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• 제3권2호
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• pp.110-117
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• 2003

Background: The usefulness of DNA vaccine at priming step of heterologous prime-boost vaccination led to DNA vaccine closer to practical reality. DNA vaccine priming followed by recombinant viral vector boosting via systemic route induces optimal systemic immunity but no mucosal immunity. Mucosal vaccination of the reversed protocol (recombinant viral vector priming-DNA vaccine boosting), however, can induce both maximal mucosal and systemic immunity. Here, we tried to address the reason why the mucosal protocol of prime-boost vaccination differs from that of systemic vaccination. Methods: To address the importance of primary immunity induced at priming step, mice were primed with different doses of DNA vaccine or coadministration of DNA vaccine plus mucosal adjuvant, and immunity including serum IgG and mucosal IgA was then determined following boosting with recombinant viral vector. Next, to assess influence of humoral pre-existing immunity on boosting $CD8^+$ T cell-mediated immunity, $CD8^+$ T cell-mediated immunity in B cell-deficient (${\mu}K/O$) mice immunized with prime-boost regimens was evaluated by CTL assay and $IFN-{\gamma}$-producing cells. Results: Immunity primed with recombinant viral vector was effectively boosted with DNA vaccine even 60 days later. In particular, animals primed by increasing doses of DNA vaccine or incorporating an adjuvant at priming step and boosted by recombinant viral vector elicited comparable responses to recombinant viral vector primed-DNA vaccine boosted group. Humoral pre-existing immunity was also unlikely to interfere the boosting effect of $CD8^+$ T cell-mediated immunity by recombinant viral vector. Conclusion: This report provides the important point that optimally primed responses should be considered in mucosal immunization of heterologous prime-boost regimens for inducing the effective boosting at both mucosal and systemic sites.

• 한국멀티미디어학회논문지
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• 제11권7호
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• pp.1035-1042
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• 2008

이진 분류기로서 지지벡터기계는 다양한 응용을 통해 이진 분류 문제에서 기존의 패턴 분류기들보다 우수한 성능을 보였다. 지지벡터기계의 바탕이 되는 최대 마진 분류 이론을 다중 분류 문제에 확장은 어려움이 있다. 이 논문에서는 다중 분류 문제를 위한 지지벡터기계의 학습 전략을 논의하였으며 성능 비교를 수행하였다. 학습 데이터의 분배 전략에 따라 지지벡터기계는 고유의 이진 분류 특징을 수정하지 않고 다중분류 문제에 쉴게 적용될 수 있다. 다양한 벤치마킹 데이터에 대해 선택된 학습 전략, 커널함수, 학습 소요시간 등에 따라 성능비교가 수행되었고 오류역전파 학습의 신경망의 테스트 결과와 비교되었다. 신경망 모델과 비교 실험에서 지지벡터기계는 일반적인 다중 분류 문제에 응용성과 효과가 있음을 보였다.

• 대한수학회보
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• 제36권4호
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• pp.737-746
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• 1999

For a locally compact Abelian group G, and a commutative Banach algebra B, let $L^1$(G, B) be the Banach algebra of all Bochner integrable functions. We show that if G is noncompact and B is a semiprime Banach algebras in which every minimal prime ideal is cnotained in a regular maximal ideal, then $L^1$(G, B) contains no nontrivial separating idal. As a consequence we deduce some automatic continuity results for $L^1$(G, B).

• 충청수학회지
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• 제7권1호
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• pp.33-39
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• 1994

The purpose of this paper prove the following property; Suppose A has many units (local global ring) and |A/m| > 5 for every maximal ideal $m{\subseteq}A$. Let(E, q) ${\in}$ Q(A) and $E=E_1{\bot}{\cdots}{\bot}E_t$ be an orthogonl decomposition of E with $t{\geq}2$ and $rk(E_i){\geq}1$, for $i=1,{\cdots},t$. Let $x{\in}E$ be a primitive vector. Then there exists ${\sigma}{\in}O(q)$ such that ${\sigma}(x)$ is transversal to this decomposition.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (2)
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• pp.703-705
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• 2004

Conventional support vector machines (SVMs) find optimal hyperplanes that have maximal margins by treating all data equivalently. In the real world, however, the data within a data set may differ in degree of uncertainty or importance due to noise, inaccuracies or missing values in the data. Hence, if all data are treated as equivalent, without considering such differences, the optimal hyperplanes identified are likely to be less optimal. In this paper, to more accurately identify the optimal hyperplane in a given uncertain data set, we propose a membership-induced distance from a hyperplane using membership values, and formulate three kinds of membership-induced SVMs.

• 한국통신학회논문지
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• 제34권7C호
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• pp.635-639
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• 2009

본 논문에서는 행벡터의 집합이 이진 벡터합 연산에 관해 닫혀있는 모든 하다마드 (Hadmard) 행렬들은 서로 동치(equivalent) 임융 증명한다. 이를 이용하면, 최대길이 수열로부터 생성된 순회 (cyclic) 하다마드 행렬과 크로네커 (Kronecker) 곱에 의해 생성된 월쉬-하다마드 (Walsh-Hadamard) 행렬이 동치임을 간단히 보일 수 있다.