• Journal of Pharmaceutical Investigation
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• 제28권3호
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• pp.171-175
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• 1998

KHPC-002 $[(trans-l-diaminocyclohexane-bis-l,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ and $KHPC-006[(cis-diaminocyclohexane-bis-1,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ were synthesized as candidates for third platinum antitumor agent. Before their pharmacokinetic study, we optimized the analytical condition with HPLC and identified the major metabolites in the rat plasma. HPLC analysis by $C_{18}$ reverse-phase column showed that standard peak of both compounds appeared rapidly at around 1 minutes, whereas metabolites of KHPC-002 and KHPC-006 which were extracted from plasma after single I.V. administration in rats or incubation for 24 hr at $37^{\circ}C$ showed retention time of $10{\sim}11$ minutes. These metabolites were identified as the major compound by Matrix Associated Laser Deposition/Ionization (MALDI), which only lose the 2 molecules of $NO_3$. Based on these results, we suggest that the major metabolites of KHPC-002 and KHPC-006 were [trans-l-diamino-cyclohexane-bis-l,2(diphenylphosphinoethane)platinum] and [cis-diaminocyclohexane-bis-l.2(diphenylphosphinoethane)platinum], respectively.

• 경영과정보연구
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• 제1권
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• pp.75-112
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• 1997

This Report aims at Development of field approached MIS curriculumn appropriate to specialty of junior college, based on the thoughts that it is necessary to set the skill and the conception rightly through the knowledge and the theory about the whole field of management, to provide a continous and consistant education, to produce MIS graduates required at enterprises. For that, considering function and roll of the junior college, curriculumns which have been opened and managed as a major study, the level of knowledge which is required to the men who is in charge of practical information business at demand site, subjects which is desirable to be a major study, the knowledge which is required to the MIS graduates in present and future, a condition of deucation investment.

• 한국임상약학회지
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• 제33권1호
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• pp.62-69
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• 2023

Objective: Adherence is an important component in the treatment of various diseases, and poor adherence to antidepressants in patients with major depressive disorder is common. Non-adherence can be more prevalent in elderly patients with multiple morbidity and polypharmacy, resulting in negative treatment outcomes. The purpose of this study was to analyze adherence to antidepressants in Korean elderly patients with major depressive disorder. Method: A retrospective study was conducted using the Korean National Health Insurance claims database, and the subjects of this study were patients aged 65 or older who received at least one prescription of antidepressant monotherapy for the treatment of major depressive disorder between January 1, 2020 and June 30, 2020. Adherence was measured using the proportion of days covered at 6 months after the initial antidepressant prescription date. Logistic regression analysis was used to identify factors associated with adherence. Results: A total of 416,766 patients were finally included in the study. Over half of patients were non-adherent (52.67%) to antidepressants. According to the multivariate logistic regression analysis, national health insurance or medical aid, taking selective serotonin reuptake inhibitors or selective norepinephrine reuptake inhibitors, and having comorbidities were significantly associated with greater rates of adherence in the study subjects. The highest adherence rate was observed in patients taking vortioxetine. Conclusion: There was a considerable rate of non-adherence in Korean elderly patients with major depressive disorder. Health care professionals should try to improve adherence in elderly patients with major depressive disorder.

• 한국학교수학회논문집
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• 제20권4호
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• pp.423-443
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• 2017

본 연구는 고등학교 인문계 수학과 대학 경상계열 전공학문 내용과의 연계성을 알아보기 위하여 M대학교 경영대학 경제학과, 경영학과와 금융보험학과에 재학 중인 대학생과 교수들을 대상으로 고등학교 인문계 수학 학습 내용과 대학 경상계열 전공학문과의 연계성에 대한 인식을 분석하였다. 그 결과 다음과 같은 결론을 얻었다. 첫째, 고등학교 인문계 수학과 대학 경상계열 전공학문의 연계성을 강화하기 위하여 고등학교 학생들이 수학적 개념과 원리에 대해 충분히 이해할 수 있는 수학교육이 이루어져야 한다. 둘째, 경상계열로 진학하고자 하는 인문계 고등학생들에게 수학이 전공학문을 공부하는데 필요한 교과목이라는 인식을 심어줄 필요가 있다.

• International Journal of Advanced Culture Technology
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• 제7권2호
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• pp.67-76
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• 2019

As the attracting foreign student has become a very important strategy, detailed researches on their college selection and their satisfaction with college life are needed. Especially it is necessary to distinguish ordinary international students and those who take classes in Local Education Centers (LEC) before coming to Korea. The central purpose of this study is to identify how the two types of students differ in their perception of college selection factors and what factors affect their satisfaction with college life. A total of 186 international students participated in the study. It was found that the most important college selection factor of the pre-educated LEC students was 'obtaining academic ability through online classes and transfer of credit hours'. Second, these students reported that the two influential factors for their satisfaction with college life were 'quality of education' and 'cultural experience program'. Third, it was found that the major college selection factors influencing ordinary international students' college life satisfaction were 'expertise of faculty', 'transfer of credit through curriculum links', and 'recommendation from teachers at home country'. Fourth, the major factors affecting the pre-educated LEC students' satisfaction with college life were 'KSL classes at LE's', 'expertise of faculty', and 'financial aid system'.

• 한국보육지원학회지
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• 제18권1호
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• pp.71-90
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• 2022

Objective: This study examined the experiences of pre-service Early Childhood teachers who participated in major-associated autonomous club activities. Methods: Participants were 31 students of the Department of Child Care at A University located in Gyeonggi-do, who participated in a major-associated autonomous music club activity. A content analysis was conducted to examine the meaning of the participation experience of pre-service Early Childhood teachers. Qualitative content analysis was the best method to analyze the meaning of their experience while participating in the activities. Results: The meaning of the experience of music club activities was organized into three categories: "enjoying abundant college life," "growing as a competent childcare teacher," and "being a responsible member of a community." Conclusion/Implications: The results show that pre-service Early Childhood teacher's participation in the activities of major-associated autonomous clubs has a positive impact on desirable changes in college life and adaptation to the department and on the growth of future professional Early Childhood teachers.

• 한국지역사회생활과학회지
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• 제12권1호
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• pp.51-62
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• 2001

The purpose of the study were to investigate the differences of Image on male and female\\` The purpose of the study were to investigate the differences of Image on male and female´ Contemporary folk costume of Female College Students according to their life styles and their major. The data were collected from 300 female college students in Cheongju city through self-administerd questionnaires, and were analyzed by frequencies, Cronbach´s $\alpha$, F-test, Factor Analysis, Cluster Analysis, one way ANOVA and Duncan Test. The results of the study were as follows: The image on male and female´ Contemporary folk costume were found to include four different dimensions- fashion, activity, gracefulness, ability. There were not significant differences between dimensions of image on male and female´ contemporary folk costume according to student´s major. Life styles were classified five types. There were significantly different at dimensions of fashion and gracefulness, ability between life style dimensions and image on males´ contemporary folk costume. There was significantly different at dimension of gracefulness between life style dimensions and image on females´ contemporary folk costume.

• 대한치위생과학회지
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• 제1권2호
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• pp.21-39
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• 2018

The purpose of this study was to examine the learning competencies of students at a college from September 1 to November 30, 2017, in an effort to provide some information on how to foster learning competencies in college years, which lay the foundation for work and social lives. 1. The learning competencies of the subjects consisted of academic vision, student identity, cognitive regulation, emotional regulation, learning management and creating learning environments. Out of five points, they scored the highest in academic vision and student identity with 3.34, followed by learning management with 3.20, creating learning environments with 3.18, emotional regulation with 3.16 and cognitive regulation with 3.14. 2. There were statistically significant differences in academic vision according to age, the area of major, the academic credential of their fathers, commuting time, military service experience and career plans. 3. There were statistically significant differences in student identity and cognitive regulation according to gender, age, the area of major, the academic credential of their fathers, commuting time, military service experience and career plans. 4. There were statistically significant differences in emotional regulation according to age, the area of major, the academic credential of their fathers, commuting time, career plans and daily mean study hours. 5. There were statistically significant differences in learning management according to gender, age, the area of major, grade point average, the academic credential of their fathers, career plans and daily mean study hours. 6. There were statistically significant differences in creating learning environments according to gender, age, the area of major, the academic credential of fathers, commuting time, career plans and daily mean study hours. As they were poorest at the cognitive regulation area among the areas of learning competencies, self-directed learning programs that deal with how to study, learning process, how to take notes and arrange them, how to link different pieces of acquired knowledge and how to map out study plans should be developed to give support to students.

• 한국대기환경학회지
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• 제24권3호
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• pp.367-375
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• 2008

To characterize atmospheric particles in Cheonan area, 5 monitoring sites representing highway area, commercial area, residential area, and industrial areas were selected, and the mass concentrations of PM10 and PM2.5 were monitored for 14 days at each site during 2007. The daily average PM10 and PM2.5 concentrations were in the range from 18.5 to $140.9{\mu}g/m^3$ and 8.2 to $116.6{\mu}g/m^3$, respectively, showing the highest mean concentrations at the commercial area site and the lowest concentration at the residential area site. The daily average PM 10 concentrations at Shinan (Commercial area) and Bakseok (Industrial area) sites were exceeded the current National Standard for 1 and 2 days during the monitoring periods. The fractions of PM2.5 in PM10 were above 70% for all sites, indicating fine particles are the major constituent of atmospheric particles in Cheonan. The results indicate that PM10 concentrations in Cheonan are at the concerning level, and the control strategy for fine particles is necessary to address this issue.

• 대한임상독성학회지
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• 제7권2호
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• pp.164-171
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• 2009

Purpose: The number of patients who take warfarin is growing and so is the number of complications. Hemorrhage is the major complication, but the clinical characteristics and outcomes have not been determined for Korean patients. Therefore, we tried to evaluate the characteristics of the patients with hemorrhagic complications after taking warfarin as anticoagulation therapy. Methods: We retrospectively reviewed the medical records of the patients who visited the emergency room with bleeding complications after taking warfarin anticoagulation at the out-patient clinic for 1 year from 1 st January 2008. We compared between two groups (the major hemorrhage group vs. the minor hemorrhage group) according to the clinical criteria, the unstable vital signs that required blood transfusion, transfusion more than 2 units of blood, the need for further laboratory follow-up, the need for interventional treatment and the development of critical complications or death due to bleeding. Results: There were 150 patients who met the criteria and had acute hemorrhagic complications (the major group: 90 patients and the minor group: 60 patients). In the major hemorrhage group, the frequent sites of bleeding were the gastro-intestinal system (40 patients), lung (14 patients) and intracranium (7 patients). At the emergency room, the major group showed a higher initial INR of the activated prothrombin time than did the minor group (p=0.02). The bleeding sites of the fatal cases were the gastro-intestinal system (3 patients), lung (3 patients) and intracranium (3 patients), but the percentage of fatality was the highest for intracranium bleeding. Conclusion: In the major hemorrhage group, gastrointestinal bleeding was the most frequent complication and fatality was the highest for intracranium bleeding. An initially higher INR showed a greater risk of major bleeding, but not more fatalities.