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Hepatic microRNAome reveals potential microRNA-mRNA pairs association with lipid metabolism in pigs

  • Liu, Jingge;Ning, Caibo;Li, Bojiang;Li, Rongyang;Wu, Wangjun;Liu, Honglin
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.9
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    • pp.1458-1468
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    • 2019
  • Objective: As one of the most important metabolic organs, the liver plays vital roles in modulating the lipid metabolism. This study was to compare miRNA expression profiles of the Large White liver between two different developmental periods and to identify candidate miRNAs for lipid metabolism. Methods: Eight liver samples were collected from White Large of 70-day fetus (P70) and of 70-day piglets (D70) (with 4 biological repeats at each development period) to construct sRNA libraries. Then the eight prepared sRNA libraries were sequenced using Illumina next-generation sequencing technology on HiSeq 2500 platform. Results: As a result, we obtained 346 known and 187 novel miRNAs. Compared with the D70, 55 down- and 61 up-regulated miRNAs were shown to be significantly differentially expressed (DE). Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis indicated that these DE miRNAs were mainly involved in growth, development and diverse metabolic processes. They were predicted to regulate lipid metabolism through adipocytokine signaling pathway, mitogen-activated protein kinase, AMP-activated protein kinase, cyclic adenosine monophosphate, phosphatidylinositol 3 kinase/protein kinase B, and Notch signaling pathway. The four most abundantly expressed miRNAs were miR-122, miR-26a and miR-30a-5p (miR-122 only in P70), which play important roles in lipid metabolism. Integration analysis (details of mRNAs sequencing data were shown in another unpublished paper) revealed that many target genes of the DE miRNAs (miR-181b, miR-145-5p, miR-199a-5p, and miR-98) might be critical regulators in lipid metabolic process, including acyl-CoA synthetase long chain family member 4, ATP-binding casette A4, and stearyl-CoA desaturase. Thus, these miRNAs were the promising candidates for lipid metabolism. Conclusion: Our study provides the main differences in the Large White at miRNA level between two different developmental stages. It supplies a valuable database for the further function and mechanism elucidation of miRNAs in porcine liver development and lipid metabolism.

The Characteristic and Stigma of Children and Adolescents in NPO's Fundraising Advertisement Videos in Korea (국내 비영리단체 후원모금 광고영상에 나타난 아동·청소년의 특징과 낙인)

  • Kim, Jua;Hyun, Eunja
    • The Journal of the Korea Contents Association
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    • v.19 no.2
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    • pp.424-437
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    • 2019
  • The purpose of this study is to analyze the characteristics and stigma of children and adolescents, and the message types for them in NPO's fundraising advertisement videos in Korea. The subjects are 152 children and adolescents in 147 videos from seven major non-profit organizations. The analysis tools were constructed based on prior studies, and it was carried out after preliminary study. The results are as follows. First, the characteristics of children and adolescents indicated that the ratio of children and infants, main-role, poverty situation, one-parent family, and ward-role appeared the most. Second, 'general' was the highest in the stigma format, and 'hazard' and 'mark' was high in the challenge format. Third, the stigma message was the highest in message type. Finally, as of 2014, the ratio of stigma message and value-exclusion message increased, and the ratio of challenge message and mixed message decreased. The research suggests that a paradigm shift in the format of NPO's typical fundraising advertisement videos is necessary, as the videos may not protect the human rights of children and adolescents and may have negative effects such as stigma.

An Exploratory Study on the "Trust" Operational Scheme for Income Security and Asset Management for People with Developmental Disabilities in Adulthood (성인기 발달장애인의 소득보장과 재산관리를 위한 「신탁」 운영방안에 대한 탐색적 연구)

  • Kim, Seong-Cheon;Kang, Ji-Hyun
    • 재활복지
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    • v.21 no.2
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    • pp.29-62
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    • 2017
  • The purpose of this study is to find out the main operational scheme of the "financial planning" and "the trust" for people with developmental disabilities as a means of property protecting and managing for them. The results are as follows; Regarding to "Financial planning", it is necessary to establish a measure to meet the financial needs for people with developmental disabilities in future plan; Issues to be taken care of in the point of financial planning include plan for the maintenance and use of property for their independent life; and public and private resources and support for the disabled. Obstacles are lack of national awareness of the financial planning for the disabled. In relation to the contents of the "trust" of people with developmental disabilities, the principles of operation are assuring universality, publicness, stability, self-decision making, and individuality; operating system is a mixture of public and private; subjects of target are people with developmental disabilities with no parents or caring family as well as income. The required support is a supervisory system for the secure management of asset to entrusted institutions; the decision support system for people with developmental disabilities; maintaining the qualification of government receipt of public assistance for those who do not redeem up to a certain amount of personal property utilizing the trust system.

A Systematic Review on Non-Medication Intervention for Self- Injurious Behavior of Individuals With Autism Spectrum Disorders (자폐스펙트럼장애의 자해행동 중재에 관한 체계적 고찰 : 비약물치료 중심으로)

  • Kim, Seul-kee;Choi, Jeong-sil
    • The Journal of Korean Academy of Sensory Integration
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    • v.17 no.1
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    • pp.30-42
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    • 2019
  • Objective : The purpose of this study is to analyze non-medication interventions for self-injurious behavior of individuals with autism spectrum disorders, using a systematic review, and to provide evidence of appropriate services for individuals with autism spectrum disorders with self-injury behaviors in the clinical practice of occupational therapy. Methods : Using the electronic databases PubMed, Medline (ProQuest), DBpia, RISS, KISS, and NDSL, we searched for articles published in Korean and international journals from December 2004 to November 2018. The main search term were "Autism OR Autism Spectrum Disorder AND Therapy OR Treatment Or Intervention AND Self Injurious Behavior." Qualitative analysis was performed, and the results are presented in the PICO format. Results : A total of 12 articles were selected. The quality of the evidence was highest in level IV and level V. Single studies with an experimental design were the most common. Behavior therapy was the most common type of intervention. The next most common interventions were behavioral therapy, brain stimulation and control, and sensory integration therapy with behavioral therapy. The self-injury behaviors of individuals autism spectrum disorders were decreased, and was statistically significant. Conclusion : This study investigated the use of non-medication interventions for children with autism spectrum disorders who showed self-injury behavior. Future research should use higher-level designs, and investigate differences between various non-medication interventions.

A Decision Tree Analysis-based Exploratory Study on the Effects of Using Smart Devices on the Expansion of Social Relationship (의사결정나무 분석을 활용한 스마트 기기의 사용이 사회관계 확대에 미치는 영향에 관한 탐색적 연구)

  • Son, Woong-Bee;Jang, Jae-Min
    • Informatization Policy
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    • v.26 no.1
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    • pp.62-82
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    • 2019
  • This study attempts to make an empirical analysis on how mobile devices affect users in building their social relationship and if their influences are negative or positive. The purpose of this research is to explain the results by considering all the possibilities and exploring everyday lives of using mobile devices. We used the survey data from the "Research on Mobile Environment Awareness" conducted by Gyeonggi Research Institute(GRI). The main question was about the use of mobile devices and social network services (SNS) and users' opinions on using the devices. All of the 31 municipalities in Gyeonggi Province were included as a spatial range, and the final validity sample was 1,004 residents. The extent of the relationship with people is selected as a dependent variable through the multinomial logistic model and the decision tree model. As a result of the multinomial logistic analysis on the questionnaire, the characteristics of the respondents with some changes in the scope of the human relationship were found to have a significant (+) effect on conversation with family, SNS usage, residence in the rural area but not urban area, and device usage for obtaining news. The largest variable affecting the extent of relationship was the SNS usage. As the amount of SNS usage increases, the extent of the relationship also changes a lot.

Material Analysis of Bosu of the Royal Seals of the Joseon Dynasty and the Korean Empire (조선 왕실과 대한제국 황실 어보 보수(寶綬)의 재료학적 분석)

  • Lee, Hyeyoun;Kim, Jooyoung;Cho, Mungyeong;Kim, Minji;Park, Daewoo;Lee, Jungmin
    • Journal of Conservation Science
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    • v.37 no.2
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    • pp.154-166
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    • 2021
  • The royal seal, in either gold or jade, is used to symbolize Joseon's royal family, and it is made up of a Bonu (a handle), Bosin (a body), Bomun (a letter inscribed on the seal), and Bosu (a string attached to the seal). The Bosu was designed to enhance the seal's dignity and facilitate convenient handling. Bosu consists of Kkeun-mog and Bangwool-sul (decorated with gilt paper), which are made of Bangwool, Bangwool-mog, and Sul. In this study, the form survey, color, material, and composition of 318 Bosu pieces from the Joseon Dynasty and Korean Empire produced from 1441 to 1928 were analyzed. As time passed, the strings on the seals became longer and thinner. Bangwool-mog disappeared from the mid-1800s, and a ring appeared at the end of the Sul. Most of the colors used were scarlet, but orange and purple were also identified. Although most of the Bosu are silk, five Bosu from the 1900s and one Bosu from the 1740s (likely replaced in the 1900s) are estimated to be rayon. The gilt paper's main chemical components used to decorate the Bangwool-sul vary according to age. Until the mid-1800s, gold (Au) was used for the Sul and Bangwool, but since the mid-1800s, gold (Au) and brass (Cu-Zn) were used for Sul and Bangwool, respectively, and then brass (Cu-Zn) was used for Sul and Bangwool. While the Bosu was a seal accessory, it can be used to identify changes in the manufacturing techniques and materials of the period.

The Influence of Soldier's Self-esteem on Adaptation to Military Life: Focused on the Mediating Effect of Depression (병사의 자아존중감이 군 생활 적응에 미치는 영향: 우울의 매개효과를 중심으로)

  • Kim, Jung-Hee
    • The Journal of the Korea Contents Association
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    • v.21 no.10
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    • pp.564-575
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    • 2021
  • This study explored the relationship between self-esteem of soldiers and adaptation to military life and verified the mediating effect of depression in such relationships. The subjects of this study were 230 Army soldiers based in Gangwon-do. The collected data were analyzed through descriptive statistics, difference verification, hierarchical regression analysis, and the mediating effect method. First, according to the difference verification, the level of adaptation to military life was higher when the health status was good, among the general characteristics, when the family health was good, when the soldiers had friends, when they were sergeants rather than privates or corporals, and when they had someone to discuss their concerns. Second, the hierarchical regression analysis showed that the soldiers adapted to the military life better with better health status, when they served as combat soldiers, and when they had someone to consult. In addition, the higher the self-esteem, the main variable, and the lower the depression level, the higher the level of adaption to military life. Third, as a result of the mediating effect analysis, depression was found to have a partial mediating effect in the relationship between self-esteem and military adaptation. Therefore, this study presented practical alternatives to increase self-esteem and reduce depression as a factor to cope with soldiers' adaptation to military life.

Study on Environmental Project Factors in Peripheral Spaces around Children's Parks within Low-rise Housing Areas by Using IPA Analysis - Focusing on user consciousness survey - (IPA분석을 이용한 저층주거지 내 어린이공원 주변공간의 환경계획요인에 관한 연구 - 이용자 의식조사를 중심으로 -)

  • Bae, Yeonhee;Byun, Gidong;Ha, Mikyoung
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.35 no.1
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    • pp.73-81
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    • 2019
  • The purpose of this study is to draw safe environmental project factors for enhancing the safety of children in peripheral space around children's park and suggest environmental project measures for peripheral spaces around children's parks, based on the survey of children's park users' consciousness on peripheral spaces. Physical space range for this study was limited to low-rise housing area wihtin the radius of 250m, as peripheral spaces around children's parks in which children's playgrounds were built. In addition, the target areas for examining users' consciousness on peripheral spaces around children's parks were selected according to following criteria. 1)areas with highter portion of children; 2) those with higher portion of single-family houses/multi-housing/tenement houses, which constitute low-rise housing areas; and 3) those with higher safety accident rate of children, which was measured based on criminal and traffic accidents. The finding are as follows: first, users' consciousness on safety accidents that are likely to occur in peripheral spaces around children's parks was examined to show that there is most prominent difference between satisfaction and necessity. This result suggests that users are clearly conscious of the necessity of environmental improvement rather than the satisfaction with the current peripheral environment around children's park.; second, for the difference between satisfaction with and necessity of environmental project factors for access/boundary spaces around children's pakrs, there is most significant difference between the satisfaction with and the necessity of establishment of facilities against illegal parking for clear visibility of community roads, for access spaces, and the separate establishment of bicycle racks around main entry into parks, for boundary spaces. Users' necessity of the establishment of them is judged to be derived from the fact that the safety of children and even adults is threatened, because bicycles invaded into the deep inside of children parks. This study analyzed a correlation between satisfaction and necessity through factor and IPA analysis, and should be initially considenred if the future environmental improvement project would be conducted to promote safe environment in peripheral spaces around children's parks in the future. It will be necessary to provide practical environmental project factors through a field investigation.

An IoT based Green Home Architecture for Green Score Calculation towards Smart Sustainable Cities

  • Kumaran, K. Manikanda;Chinnadurai, M.;Manikandan, S.;Murugan, S. Palani;Elakiya, E.
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.15 no.7
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    • pp.2377-2398
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    • 2021
  • In the recent modernized world, utilization of natural resources (renewable & non-renewable) is increasing drastically due to the sophisticated life style of the people. The over-consumption of non-renewable resources causes pollution which leads to global warming. Consequently, government agencies have been taking several initiatives to control the over-consumption of non-renewable natural resources and encourage the production of renewable energy resources. In this regard, we introduce an IoT powered integrated framework called as green home architecture (GHA) for green score calculation based on the usage of natural resources for household purpose. Green score is a credit point (i.e.,10 pts) of a family which can be calculated once in a month based on the utilization of energy, production of renewable energy and pollution caused. The green score can be improved by reducing the consumption of energy, generation of renewable energy and preventing the pollution. The main objective of GHA is to monitor the day-to-day usage of resources and calculate the green score using the proposed green score algorithm. This algorithm gives positive credits for economic consumption of resources and production of renewable energy and also it gives negative credits for pollution caused. Here, we recommend a green score based tax calculation system which gives tax exemption based on the green score value. This direct beneficiary model will appreciate and encourage the citizens to consume fewer natural resources and prevent pollution. Rather than simply giving subsidy, this proposed system allows monitoring the subsidy scheme periodically and encourages the proper working system with tax exemption rewards. Also, our GHA will be used to monitor all the household appliances, vehicles, wind mills, electricity meter, water re-treatment plant, pollution level to read the consumption/production in appropriate units by using the suitable sensors. These values will be stored in mass storage platform like cloud for the calculation of green score and also employed for billing purpose by the government agencies. This integrated platform can replace the manual billing and directly benefits the government.

Planting Patterns and Landscape Redevelopement of Pilam Seowon in Jangseong-Gun (장성 필암서원(筆巖書院)의 식재현황과 정비방안)

  • Lee, Won-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.29 no.1
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    • pp.131-141
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    • 2011
  • This study, as a purpose of base study for landscape redevelopement of Seowon, pointed out problems of planting patterns in each sector and suggested an alternative through analyzing old literature, complete enumeration survey in each sector and taking aerial images. the conclusions drawn from this study are as follows. A Pilam Seowon(historic site no 242) is located in a Pyungya-Sanrok(plain and mountain) district in Jangsung-gun and has Junhak-Humyo(Study room in the front and Shirne in the back) type. 23 taxonomic group of arbor, 6 taxonomic group of shrub and 5 taxonomic group of flowers are planted high-densitily in limited flat surface. It can be classified into being planted by family and being planted through landscape redevelopement in 1980s. Korean traditional trees are planted in this area like Pinus densiflora, Juniperus chinensis L., Thuja orientalis L., Zelkova serrato Makino, Sophora japonica L., Lagerstroemia indica, Prunus mume include Ginkgo biloba which is old big tree and is registered in Jangsung-gun as protected trees. The tea tree in this area was introduced from wild tea plantation in Yonhwa moutain and was planted. From now on, we have to pay consideration a form management of planted trees in the historical area, rearrangement of plant density due to over planting, removal of alien trees like Pinus bungeana and Canna generalisa, prevention a dwarfishness of main area due to over planting in outside facilities, recovery a alienation among each planting area, and planting concept from plants drawings on wall of buildings can be suggested. The implications of this case study is that introduction of over planting can make more problems like losing sense of place. Therefore, we must do a actual state survey on traditional landscape area like Seowon from preservation point of view.