• Investigative Magnetic Resonance Imaging
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• v.7 no.1
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• pp.39-46
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• 2003

Purpose : To develop a theoretical model for magnetic relaxation behavior of the superparamagnetic nano-particle agent, which demonstrates multi-functionality such as liver- and lymp node-specificity. Based on the developed model, the computer simulation was performed to clarify the relationship between relaxation time and the applied magnetic field strength. Materials and Methods : The ultrasmall superparamagnetic iron oxide (USPIO) was encapsulated with biocompatiable polymer, to develop a relaxation model based on outsphere mechanism, which was resulting from diffusion and/or electron spin fluctuation. In addition, Brillouin function was introduced to describe the full magnetization by considering the fact that the low-field approximation, which was adapted in paramagnetic case, is no longer valid. The developed model describes therefore the T1 and T2 relaxation behavior of superparamagnetic iron oxide both in low-field and in high-field. Based on our model, the computer simulation was performed to test the relaxation behavior of superparamagnetic contrast agent over various magnetic fields using MathCad (MathCad, U.S.A.), a symbolic computation software. Results : For T1 and T2 magnetic relaxation characteristics of ultrasmall superparamagnetic iron oxide, the theoretical model showed that at low field (<1.0 Mhz), $\tau_{S1}(\tau_{S2}$, in case of T2), which is a correlation time in spectral density function, plays a major role. This suggests that realignment of nano-magnetic particles is most important at low magnetic field. On the other hand, at high field, $\tau$, which is another correlation time in spectral density function, plays a major role. Since $\tau$ is closely related to particle size, this suggests that the difference in R1 and R2 over particle sizes, at high field, is resulting not from the realignment of particles but from the particle size itself. Within normal body temperature region, the temperature dependence of T1 and T2 relaxation time showed that there is no change in T1 and T2 relaxation times at high field. Especially, T1 showed less temperature dependence compared to T2. Conclusion : We developed a theoretical model of r magnetic relaxation behavior of ultrasmall superparamagnetic iron oxide (USPIO), which was reported to show clinical multi-functionality by utilizing physical properties of nano-magnetic particle. In addition, based on the developed model, the computer simulation was performed to investigate the relationship between relaxation time of USPIO and the applied magnetic field strength.

• Journal of Powder Materials
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• v.11 no.1
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• pp.50-54
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• 2004

Nanoparticles of iron oxides have been prepared by the levitational gas condensation (LGC) method, and their structural and magnetic properties were studied by XRD, TEM and Mossbauer spectroscopy. Fe clusters were evaporated from a surface of the levitated liquid Fe droplet and then condensed into nanoparticles of iron oxide with particle size of 14 to 30 nm in a chamber filled with mixtures of Ar and $O_2$ gases. It was found that the phase transition from both $\gamma$-$Fe_2O_3$ and $\alpha$-Fe to $Fe_3O_4$, which was evaluated from the results of Mossbauer spectra, strongly depended on the $O_2$ flow rate. As a result, $\gamma$-$Fe_2O_3$ was synthesized under the $O_2$ flow rate of 0.1$\leq$$Vo_2$(Vmin)$\leq$0.15, whereas $Fe_3O_4$ was synthesized under the $O_2$, flow rate of 0.15$\leq$$Vo_2$(Vmin)$\leq$0.2.

• Journal of Magnetics
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• v.20 no.3
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• pp.221-228
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• 2015

Colloidal particles consisted of individual nanosized magnetite grains on the surface of the silica cores were obtained by two-stage sol-gel technique. Size distribution and microstructure of the particles were analyzed using atomic force microscopy, X-ray diffraction and Nitrogen thermal desorption. Magnetic properties of the particles were studied by the method of the longitudinal nonlinear response. It has been shown that nanoparticles of magnetite have a size corresponding to a superparamagnetic state but exhibit hysteresis properties. The phenomenon was explained using the magnetostatic interaction model based on the hypothesis of iron oxide particles cluster aggregation on the silica surface.

• Journal of Powder Materials
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• v.26 no.6
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• pp.481-486
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• 2019

Iron oxides currently attract considerable attention due to their potential applications in the fields of lithiumion batteries, bio-medical sensors, and hyperthermia therapy materials. Magnetite (Fe₃O₄) is a particularly interesting research target due to its low cost, good biocompatibility, outstanding stability in physiological conditions. Hydrothermal synthesis is one of several liquid-phase synthesis methods with water or an aqueous solution under high pressure and high temperature. This paper reports the growth of magnetic Fe₃O₄ particles from iron powder (spherical, <10 ㎛) through an alkaline hydrothermal process under the following conditions: (1) Different KOH molar concentrations and (2) different synthesis time for each KOH molar concentrations. The optimal condition for the synthesis of Fe₃O₄ using Fe powders is hydrothermal oxidation with 6.25 M KOH for 48 h, resulting in 89.2 emu/g of saturation magnetization at room temperature. The structure and morphologies of the synthesized particles are characterized by X-ray diffraction (XRD, 2θ = 20°-80°) with Cu-kα radiation and field emission scanning electron microscopy (FE-SEM), respectively. The magnetic properties of magnetite samples are investigated using a vibrating sample magnetometer (VSM). The role of KOH in the formation of magnetite octahedron is observed.

• Journal of the Korean Ceramic Society
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• v.55 no.3
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• pp.230-238
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• 2018

Superparamagnetic iron oxide nanoparticles (SPIONs) have been prepared without using surfactants to assess their stability at different time intervals. The synthesized particles were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, ultraviolet-visible-near infrared spectroscopy, and energy dispersive spectroscopy. Field emission scanning electron microscopy and high-resolution transmission electron microscopy images of the samples were also investigated. The average particle size was measured to be 12.7 nm even in the polydispersed form. The magnetic and dielectric characteristics of the $Fe_3O_4$ nanoparticles have also been studied and discussed in detail.

• Journal of Magnetics
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• v.1 no.1
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• pp.51-54
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• 1996

The effects of additional P-doping on the magnetic properties, thermal stability and cation distribution of Co-doped ${\gamma}-{Fe_2} {O_3}$have been investigated by means of magnetic annealing and measurements with vibration sample magnetometer and torque magnetometer. It is found that the P-doping promotes the coercivity and its magnetic-thermal stability, which may be attributed to increase of the cubic magneto-crystalline anisotropy constant, $K_1$ and the activation energy, E, for cation rearrangement, respectively. The cation distribution of P and Co-substituted iron oxide was calculated from the variation of the saturation magnetization with P-doping on the basis of the Neel model. It was found that the most of P ions in the iron oxides occupied the B-site of spinel lattice.

• Journal of Magnetics
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• v.21 no.3
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• pp.460-467
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• 2016

Magnetic hyperthermia mediated by superparamagnetic particles is mainly based in sinusoidal waveforms as excitation signals. Temperature changes are conventionally explained by rotation of the particles in the surrounding medium. This is a hypothesis quite questionable since habitual experimental setups only produce changes in the magnetic module, not in the field lines trajectories. Theoretical results were tested by changing the waveform of the exciting signal in order to compare non-sinusoidal signals against sinusoidal signals. Experiments were done at different frequencies: 200 KHz, 400 KHz, 600 KHz, 800 KHz and 1 MHz. Superparamagnetic Iron Oxide samples (SPION), made of magnetite ($Fe_3O_4$) and suspended in water (100 mg/ml), were used. Magnetic field strength varies from $0.1{\pm}0.015KA/m$ to $0.6{\pm}0.015KA/m$. In this study was observed that the power loss depends on the applied frequency: for 1 to 2.5 RMS current the responses for each signal are part of the higher section of the exponential function, and for 3.5 to 8 RMS current the response is clearly the decrement exponential function's tale (under $1{\times}10^3LER/gr$).

• Journal of Magnetics
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• v.14 no.2
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• pp.75-79
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• 2009

Nickel (Ni) and ferrite ($Fe_3O_4$, $NiFe_2O_4$) nanoparticles were synthesized by LGC using both wire feeding (WF) and micron powder feeding (MPF) systems. Phase evolution and magnetic properties were then investigated. The Ni nanopowder included magnetic-ordered phases. The LGC synthesis yielded spherical particles with large coercivity while the abnormal initial magnetization curve for Ni indicated a non-collinear magnetic structure between the core and surface layer of the particles. Since the XRD pattern cannot actually distinguish between magnetite ($Fe_3O_4$) and maghemite (${\gamma}-Fe_2O_3$) as they have a spinel type structure, the phase of the iron oxide in the samples was unveiled by $M{\ddot{o}}ssbauer$ spectroscopy. The synthesized Ni-ferrite consisted of single domain particles, including an unusual ionic state. The synthesized nanopowder bore an active surface due to the defects that affected abnormal magnetic properties.

• Journal of the Korean institute of surface engineering
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• v.50 no.3
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• pp.212-218
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• 2017

$Mg_xNi_yZn_{1-x-y}Fe_2O_4$ ferrite powders were prepared by self-propagating high temperature synthesis followed by classifying with an ultrasonic wet-magnetic separation unit to get high pure nano-sized particles. The $Mg_xNi_yZn_{1-x-y}Fe_2O_4$ ferrites were well formed by using several powders like iron, nickel oxide, zinc oxide and magnesium oxide at 0.1 MPa of oxygen pressure. The ultrasonic wet-magnetic separation of pre-mechanical milled ferrite powders resulted in producing the powders with average size of 800 nm. The addition of a surfactant during the wet-magnetic separation process improved productivity more than twice. The coercive force, maximum magnetization and residual magnetization of the $Mg_xNi_yZn_{1-x-y}Fe_2O_4$ nano-powders with 800 nm size were 3651 A/m, $53.92Am^2/kg$ and $4.0Am^2/kg$, respectively.

• Journal of the Korean Magnetics Society
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• v.2 no.1
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• pp.8-14
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• 1992

To improve the coercivity of ${\gamma}-Fe_{2}O_{3}$ particles. We have made cobalt ferrite epitaxial ${\gamma}-Fe_{2}O_{3}$ particles by crystallizing cobalt ferrite on the surface of ${\gamma}-Fe_{2}O_{3}$ particles. The coercivity of $Co_{x}Fe_{3-x}O_{4}$ which is conform to coating layer showed the most superior characteristic when the value of x was 1. On the formation of cobalt epitaxial ${\gamma}-Fe_{2}O_{3}$ particles, controlling reaction atmosphere as oxidation at. mosphere after non-oxidation atmosphere was the optimum condition to prepare cobalt epitaxial ${\gamma}-Fe_{2}O_{3}$ particles with superior magnetic properties. Epitaxial growth of cobalt ferrite on the surface of ${\gamma}-Fe_{2}O_{3}$ particles was accomplished at $90^{\circ}C$ for 30 minutes.