• Reproductive and Developmental Biology
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• v.38 no.3
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• pp.99-105
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• 2014

In this study, to further understand the mechanism of animal growth and to develop a miniature transgenic animal model, we constructed and tested tetracycline-inducible RNAi system using shRNA targeting the mRNA of mouse insulin-like growth factor (mIGF-1) or mouse growth hormone receptor (mGHR) gene. Quantitative real-time PCR analysis of mouse liver cell (Hepa1c1c7) cells transfected with these vectors showed 85% or 90% of expression inhibition effect of IGF-1 or GHR, respectively. In ELISA analysis, the protein level of IGF-1 in the cells expressing the shRNA targeting IGF-1 mRNA was reduced to 26% of non-transformed control cells. Unexpectedly, in case of using shRNA targeting GHR, the IGF-1 protein level was decreased to 75% of control cells. Further experiments are needed to explain the lower interference effect of GHR shRNA in IGF-1 protein. Accumulated knowledge of this approach could be applicable to a variety of related biological area including gene function study, gene therapy, development of miniature animals, etc.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.45-50
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• 2011

Purpose: It appears the different value when the injection dose is calculating for patients on each PET/CT systems. It directly affects the technologists' radiation exposed dose. We studied the effect of the variable injection doses from several PET/CT systems to exposure dose for technologists. Materials and Methods: Six technologists have worked for 5 months through unit rotations with 3 PET/CT systems {Scanner 1 (S1): 0.15 mCi/kg, Scanner 2 (S2): 0.17 mCi/kg, Scanner 3 (S3): 0.12 mCi/kg}. Eighteen to 19 patients have had examinations per a day on each PET/CT systems. Examination parameters were adjusted to the same. TLDs were used for checking the exposure dose of technologists. Results: Each technologists' the monthly average exposure dose was as follows; S1: 0.76 mSv, S2: 0.93 mSv, S3: 0.47 mSv. The maximum exposure dose was 1.12 mSv, and minimum was 0.42 mSv. The results showed significance in the correlation between the PET/CT system and the exposure dose (p<0.005). Conclusion: When the amount of injection dose was small, the exposure dose was decreased not only the patients but also the technologists. The exposure dose was decreased by the individual proficiency of technologists. However, the low injection dose can highly reduce the exposure dose for technologist so that there will be needed to following studies.

• Journal of Astronomy and Space Sciences
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• v.26 no.1
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• pp.127-140
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• 2009

COMS DATS C&M software is an integrated management system providing control and monitoring functionalities for COMS IDACS (Image Data Acquisition and Control System). DATS C&M S/W consists of a system management module, a control and monitoring module, a data management module, and a trend analysis module. COMS SOC is supposed to operate IDACS as a backup of MSC. Especially, for the backup operation, the control and monitoring module of DATS C&M S/W is designed to support the synchronization of the two IDACS systems. This paper describes design, implementation, and result of development of DATS C&M S/W.

• Communications of the Korean Mathematical Society
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• v.25 no.4
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• pp.647-653
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• 2010

We consider an M/M/1 retrial queue with collision and impatience. It is shown that the generating functions of the joint distributions of the server state and the number of customers in the orbit at steady state can be expressed in terms of the confluent hypergeometric functions. We find the performance characteristics of the system such as the blocking probability and the mean number of customers in the orbit.

• Korean Journal of Food Science and Technology
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• v.24 no.5
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• pp.414-422
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• 1992

To keep up with urgent need of continuous, effective and rapid drying unit, a fluidized bed drying system with computer controlling air temperature, velocity and relative humidity was designed. This study was attempted to determine physical properties and some basic experiments of fluidized bed d교ing of barley. Also experimental data of the designed fluidized bed drying system using the barely were compared with those of published equations to confirm the reliability of the system and the following results were obtained. The physical dimension husked barley were shown larger than that of naked barley from the experiment. When air temperature. relative humidity and charged amount were $35^{\circ}C$, 30% and 300g respectively, the minimum fluidization velocity of naked and husked barley were found 1.5 m/s and 1.7 m/s. And the optimum fluidization velocity was shown as 3.0 m/s from the experiment. The empirical equation of $U_{mf}$ in this fluidized system was obtained as follow; $U_{mf}^2= \frac{{\phi_s}\;d_p}{Hk}\;{\cdot}\;\frac{(\rho_s-\rho_g)g\;{{\varepsilon}_{mf}^3}} {\rho_g}(Re_p>1,000)$ Where HK=0.4881 for naked barley, 0.6649 for husked barley.

• Journal of Astronomy and Space Sciences
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• v.30 no.1
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• pp.49-58
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• 2013

ARGO-M is a satellite laser ranging (SLR) system developed by the Korea Astronomy and Space Science Institute with the consideration of mobility and daytime and nighttime satellite observation. The ARGO-M optical system consists of 40 cm receiving telescope, 10 cm transmitting telescope, and detecting optics. For the development of ARGO-M optical system, the structural analysis was performed with regard to the optics and optomechanics design and the optical components. To ensure the optical performance, the quality was tested at the level of parts using the laser interferometer and ultra-high-precision measuring instruments. The assembly and alignment of ARGO-M optical system were conducted at an auto-collimation facility. As the transmission and reception are separated in the ARGO-M optical system, the pointing alignment between the transmitting telescope and receiving telescope is critical for precise target pointing. Thus, the alignment using the ground target and the radiant point observation of transmitting laser beam was carried out, and the lines of sight for the two telescopes were aligned within the required pointing precision. This paper describes the design, structural analysis, manufacture and assembly of parts, and entire process related with the alignment for the ARGO-M optical system.

• 전기의세계
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• v.15 no.2
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• pp.1-7
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• 1966

It is well known that the speed of induction motor can be controlled in wide range by changing the second exciting e.m.f. of rotor circuit, but that is well not practised because of its complicated system. In order to simplify such a system, the Kramer system of which silicon rectifier substitutes for synchronous converter has analyzed in this paper. The result of this investigation show that in this system, only the equivlent synchronous speed it changed by second exciting e.m.f., but the mechanical output power, torque and power factor is not changed, and that this system is able to compensate the regulated speed on account of the load changed.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.2
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• pp.63-70
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• 2002

Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the conventional whole-cell patch recording configuration. Muscarine $(10{\mu}M)$ reversibly and concentration-dependently decreased mIPSC frequency without affecting the current amplitude distribution. Muscarine action on GABAergic mIPSCs was completely blocked by $1{\mu}M$ methoctramine, a selective $M_2$ receptor antagonist, but not by $1{\mu}M$ pirenzepine, a selective $M_1$ receptor antagonist. NEM $(10{\mu}M),$ a G-protein uncoupler, attenuated the inhibitory action of muscarine on GABAergic mIPSC frequency. Muscarine still could decrease GABAergic mIPSC frequency even in the $Ca^{2+}-free$ external solution. However, the inhibitory action of muscarine on GABAergic mIPSCs was completely occluded in the presence of forskolin. The results suggest that muscarine acts presynaptically and reduces the probability of spontaneous GABA release, and that such muscarine-induced inhibitory action seems to be mediated by G-protein-coupled $M_2$ receptors, via the reduction of cAMP production. Accordingly, $M_2$ receptor-mediated disinhibition of nBM neurons might play one of important roles in the regulation of cholinergic outputs from nBM neurons as well as the excitability of nBM neurons themselves.

• Bulletin of the Korean Mathematical Society
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• v.51 no.2
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• pp.519-530
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• 2014

Let (R,m) be a Noetherian local ring and M a finitely generated R-module. For an integer s > -1, we say that M is Cohen-Macaulay in dimension > s if every system of parameters of M is an M-sequence in dimension > s introduced by Brodmann-Nhan [1]. In this paper, we give some characterizations for Cohen-Macaulay modules in dimension > s in terms of the Noetherian dimension of the local cohomology modules $H^i_m(M)$, the polynomial type of M introduced by Cuong [5] and the multiplicity e($\underline{x}$;M) of M with respect to a system of parameters $\underline{x}$.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.726-733
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• 2016

In this study, a computer simulation of the three types of air distribution systems, open type system, aisle partition system and aisle containment system, to evaluate the applicability of the aisle partition system on a data center server room. The variables of the simulation were the height and location of the partition fixed on the top server rack. The energy efficiency of the air distribution systems were confirmed to be excellent in the order of the aisle containment system, aisle partition system, and open type system. In the cold aisle partition system, the height of the partition that can be effective in saving cooling energy by obstructing sufficient air recirculation was found to be more than 0.9m. In the hot aisle partition system, the height of the partition was found to be more than 0.8m.