• Title/Summary/Keyword: low-temperature induction

Search Result 176, Processing Time 0.024 seconds

Induction of antiviral mechanisms by interferon-related genes in rock bream (Oplegnathus fasciatus) infected with rock bream iridovirus (RBIV)

  • Myung-Hwa Jung
    • Journal of fish pathology
    • /
    • v.36 no.2
    • /
    • pp.213-228
    • /
    • 2023
  • We evaluated the transcriptional response of interferon (IFN)-related genes in rock bream iridovirus (RBIV)-infected rock bream under high-, low-, or no-mortality conditions induced by different stocking water temperatures. Under the high susceptibility condition (group A, water temperature 26℃, 100% mortality), only the Mx gene was expressed early, with prolonged expression, and with heavy viral loads of approximately 106~107 major capsid protein gene copies/μL from 4 to 10 days post infection (dpi). However, IRF1, IRF3, IRF8, STAT1, ISG15, PKR, Viperin, GVIN1, IFI44, and ISG56 were activated at later time points (8 dpi) and then quickly decreased (10 dpi). For the low susceptibility condition, the water temperature was set at 23℃ for 7 days (group B) and then reduced to 17℃. Group B exhibited a 28% mortality rate, in which persistent and effective antiviral responses were observed for long periods of time. In particular, at 20 and 22 dpi, when virus replication was peaked at approximately 107/μL, the expressions of most of the IFN-related genes (IRF1, IRF3, IRF8, Mx, STAT1, ISG15, PKR, Viperin, GVIN1, IFI44, and ISG56) were significantly higher in group B than in the control group. Moreover, prolonged and higher levels of IRF3 (at least 30 dpi), IRF8 (at least 30 dpi), ISG15 (at least 30 dpi), PKR (at least 28 dpi), Viperin (at least 30 dpi), and IFI44 (at least 30 dpi) were also observed in the recovery stage of infection. Under the no-susceptibility condition at 17℃ (0% mortality), significantly elevated levels of IRF3, Mx, ISG15, and PKR were observed mostly until 20 dpi. The findings indicate that RBIV infection can induce an efficient IFN-mediated antiviral immune response in low- and no-susceptibility conditions. The findings could be valuable for effective control of viral pathogens in fish.

Simultaneous Synthesis and Consolidation of Nanostructured MoSi2-NbSi2 Composite by High-Frequency Induction Heated Sintering and Its Mechanical Properties

  • Kang, Hyun-Su;Shon, In-Jin
    • Korean Journal of Materials Research
    • /
    • v.24 no.4
    • /
    • pp.180-185
    • /
    • 2014
  • The current concern about these materials ($MoSi_2$ and $NbSi_2$) focuses on their low fracture toughness below the ductile-brittle transition temperature. To improve the mechanical properties of these materials, the fabrication of nanostructured and composite materials has been found to be effective. Nanomaterials frequently possess high strength, high hardness, excellent ductility and toughness, and more attention is being paid to their potential application. In this study, nanopowders of Mo, Nb, and Si were fabricated by high-energy ball milling. A dense nanostructured $MoSi_2-NbSi_2$ composite was simultaneously synthesized and sintered within two minutes by high-frequency induction heating method using mechanically activated powders of Mo, Nb, and Si. The high-density $MoSi_2-NbSi_2$ composite was produced under simultaneous application of 80MPa pressure and an induced current. The sintering behavior, mechanical properties, and microstructure of the composite were investigated. The average hardness and fracture toughness values obtained were $1180kg/mm^2$ and $3MPa{\cdot}m^{1/2}$, respectively. These fracture toughness and hardness values of the nanostructured $MoSi_2-NbSi_2$ composite are higher than those of monolithic $MoSi_2$ or $NbSi_2$.

A Study on the Thermal Deformation Simulation of Spur Gear According to the Heat Zones in Heat Treatment Process (열처리 공정에서 가열 영역에 따른 평기어의 열변형 해석에 관한 연구)

  • Kim, Jin-Rok;Yoon, Sung-Ho;Jung, Yun-Chul;Suh, Chang-Hee;Kwon, Tae-Ha
    • Journal of the Korean Society of Manufacturing Process Engineers
    • /
    • v.19 no.7
    • /
    • pp.60-66
    • /
    • 2020
  • In order to improve fatigue life of transmission gear carburizing is normally used. Carburizing is a very good process to achieve low cost and high performance. The machined gears are heated up to carburizing temperature and then cooled rapidly in an oil bath to produce high surface hardness. The gears may undergo excessive thermal distortion during heating and rapid cooling. In order to predict the distortion during heating and rapid cooling, a coupled thermo-mechanical simulation is needed. In the current research, the simulation of heating and cooling was performed. The results show that the thermal distortion and the residual stresses are well predicted by the coupled simulation. In addition, induction heating and rapid cooling simulation is carried out to predict the thermal distortion. The amount of distortion is compared. It is shown that induction heating is very effective to reduce thermal distortion.

Effects of Sulfur Segregation on Tertiary Recrystallization Kinetics in Thin-gauged 3% Si-Fe Electrical Strip

  • Chai, K.H.;Na, J.G.;Heo, N.H.;Kim, J.C.;Lee, S.R.;Woo, J.S.
    • Journal of Magnetics
    • /
    • v.4 no.1
    • /
    • pp.5-9
    • /
    • 1999
  • Effect of sulfur segregation on tertiary recrystallization and magnetic induction during final annealing was investigated in a 3% Si-Fe electrical strip containing 6 ppm(LS) and 15 ppm(HS) sulfur. During final annealing, Auger peak height of segregated sulfur on the surface of the strips reached a maximum, and then decreased to low level with increasing annealing time, which is attributed to sulfur segregation and evaporation. The magnetic induction of the thin-gauged 3% Si strip was inversely proportional to the Auger peak height of segregated sulfur on the surface. The overall profile for surface segregation of sulfur and B10 was observed, irrespective of sulfur content in Si-Fe strips, but the peaks of LS strips appeared earlier than those of HS strips. The grain growth rate of the LS strips during final annealing was faster than that of the HS strips, which may be attributed to the pinning effects of segregated sulfur. With increasing final annealing temperature, B10 value increased rapidly and the saturation level in B10 increased.

  • PDF

Design of High-Frequency Induction Heating Welder for Synthetic Resin Sheet (합성수지 소재 접착을 위한 고주파 유도가열 접착기 설계)

  • 추연규;김현덕;장우환
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.7 no.7
    • /
    • pp.1533-1538
    • /
    • 2003
  • The present technology of dielectric heating welding for synthetic resin sheet has a switching frequency over 10MHz by using vacuum tube elements, and has restrictively been applied to PVC whose dielectric loss is comparably high. The technology, however, has a difficulty in applying to materials which are made for environment and have low dielectric lose compared with other synthetic resin materials. Recently, the application of materials made for environment is increased so that the technology is faced with the limit. In this paper, a high frequency induction heating welder for synthetic resin sheet is designed applying temperature control by indirect heating to solve the problems about direct heating synthetic resin made for environment.

Effects of Rearing Condition during the Winter Period on Artificial Maturation and Reproduction of Cultured Female Eel, Anguilla japonica (겨울철 사육조건이 양식산 뱀장어 Anguilla japonica의 인위적인 성성숙 유도 및 번식에 미치는 영향)

  • Kim, Dae-Jung;Kim, Yi-Cheong;Choi, Yong-Ki;Son, Maeng-Hyun;Lee, Jung-Uie;Park, Mi-Seon;Heo, Youn-Seong
    • Development and Reproduction
    • /
    • v.13 no.1
    • /
    • pp.35-41
    • /
    • 2009
  • In the present study, we investigated the effects of rearing condition during the winter period on artificial maturation and reproduction of cultured female eel, Anguilla japonica. The female eel was adapted by combination of environmental conditions (seawater/low temperature, $10^{\circ}C$; seawater/high temperature, $20^{\circ}C$; freshwater/low temperature, $10^{\circ}C$; freshwater/high temperature, $20^{\circ}C$) during 8 weeks of the winter period. Then, the female eel cultivated by different conditions during the winter were transferred to seawater at $20^{\circ}C$ for induction of artificial maturation by salmon pituitary extraction (SPE) injection. The results shown that gonadosomatic index (GSI) and plasma levels of estradiol-$17{\beta}$ (E2) were significantly higher in female eel were reared in seawater than in freshwater, and were the highest at eel adapted by seawater/low temperature. Also, reproduction coefficient were higher in seawater/low temperature than in the other groups. These results will provide valuable information for elevation of the artificial maturation and reproduction coefficient in the cultured female eel.

  • PDF

Adhesion Performance of Electromagnetic Induction Heating Pixture for the Integration with a Waterproof & Root Barrier Sheet and a Roof Green Unit System (방수·방근시트와 옥상녹화 박스유닛 시스템의 일체화를 위한 전자기 유도가열 융착 고정구의 부착성능)

  • Oh, Chang-Won
    • Journal of the Korea Institute of Building Construction
    • /
    • v.18 no.5
    • /
    • pp.463-469
    • /
    • 2018
  • A currently used roof green system with multi layers has a low constructability. Therefore a new integrated waterproof & root barrier sheet and roof green box unit system was developed using steel plate fixture and cone type fixture by electromagnetic induction heating method. This study was proceeded to evaluate adhesion performance of two types of fixtures on Engineering PE, TPO, PVC sheet in a normal condition, repeated heating and cooling condition. As a result, adhesion load on Engineering PE sheet showed the highest value. The adhesion loads of steel plate fixture showed higher value as heating temperature was getting higher. However adhesion loads of cone type fixture showed opposite tendency. Regarding to the test conditions, test results of normal condition, repeated heating and cooling condition showed same value. The cone type fixture using butyl tape showed 7 times lower adhesion load than that of cone type fixture using electromagnetic heating and 28% lower adhesion load in a repeated heating and cooling condition than a usual condition.

Comparative Anesthetic Effect as Propofol Infusion Rate During Maintenance of Anesthesia in Dog (개에서 Propofol 점적투여율 변화에 따른 마취효과)

  • 장광호;임재현;장인호
    • Journal of Veterinary Clinics
    • /
    • v.17 no.1
    • /
    • pp.109-120
    • /
    • 2000
  • To evaluate anesthetic effecto of propofol infusion after premedication with xylazine, 20 days were randomly assigned 4 groups. Propofol was infused (group 1: 0.2 mg/kg/min, group 2 : 0.4 mg/kg/min, group 3 : 0.6 mg/kg/min, group 4 : 0.8 mg/kg/min) for a period of 90 minute immediately after premedication with xylazine(1 mg/kg) and atropine(0.05mg/kg) under oxygen supplementation. Induction of anesthesia was rapid and smooth providing satisfactory conditions for intubation in all the dogs. No vomiting and cyanosis were observed after induction and during propofol infustion. There was pain reflex in group 1 but not in group 3 and 4. Mean arousal times (mins) were $6.18{\pm}3.65(group 1), 13.07{\pm}5.05(group 2), 22.06{\pm}6.48(group 3) and 23.33{\pm}9.28 (group 4) and Mean walking times were 16.20{\pm}6.15(group 1), 15.80{\pm}4.73(group 2), 28.27{\pm}7.55 (group 3), 39.10{\pm}13.75$ (group 4) respectively. In group 4, body temperature during total infusion period in group 3, 4. Hematologic values (WBC, RBC, PCV) and serum chemistry values(ALT, AST, BUN, creatinite) were monitored before anesthesia, 1 hour and 1 day after termination of infusion postanestesia. No significant changes were monitored in all experimental group. Although propofol infusions of 0.2 mg/kg/min and 0.4mg/kg/min were considered too low to maintain a suitable depth of anesthesia, but that of 0.6mg/kg/min were considered too low to maintain a suitable depth of anesthesia, but that of 0.6mg/kg/min proper to provide a light planes for minor surgical procedure during 90 minutes with xylazine premedication.

  • PDF

Synthesis and Rapid Consolidation of W-1.5 ZrO2 Composite (W-1.5 ZrO2 복합재료 합성과 급속소결)

  • Kim, Seong-Eun;Shon, In-Jin
    • Korean Journal of Materials Research
    • /
    • v.28 no.11
    • /
    • pp.653-658
    • /
    • 2018
  • $ZrO_2$ is a candidate material for hip and knee joint replacements because of its excellent combination of biocompatibility, corrosion resistance and low density. However, the drawback of pure $ZrO_2$ is a low fracture toughness at room temperature. One of the most obvious tactics to cope with this problem is to fabricate a nanostructured composite material. Nanomaterials can be produced with improved mechanical properties(hardness and fracture toughness). The high-frequency induction heated sintering method takes advantage of simultaneously applying induced current and mechanical pressure during sintering. As a result, nanostructured materials can be achieved within very short time. In this study, W and $ZrO_2$ nanopowders are mechanochemically synthesized from $WO_3$ and Zr powders according to the reaction($WO_3+3/2Zr{\rightarrow}W+3/2ZrO_2$). The milled powders are then sintered using high-frequency induction heating within two minutes under the uniaxial pressure of 80MPa. The average fracture toughness and hardness of the nanostructured W-3/2 $ZrO_2$ composite sintered at $1300^{\circ}C$ are $540kg/mm^2$ and $5MPa{\cdot}m^{1/2}$, respectively. The fracture toughness of the composite is higher than that of monolithic $ZrO_2$. The phase and microstructure of the composite is also investigated by XRD and FE-SEM.

A Study on Synthesis and Magnetic Properties of Soft Magnetic Materials Sintered at Low Temperature (저온 소결용 연자성 물질의 합성 및 자기적 특성 연구)

  • Koh Jae Gu
    • Resources Recycling
    • /
    • v.12 no.6
    • /
    • pp.13-18
    • /
    • 2003
  • The initial NiCuZn synthetic ferrite were acquired from thermally decomposing the metal nitrates Fe($NO_3$)$_3$$9H_2$O, Zn($NO_3$)$_2$$6H_2$O, Ni($NO_3$3)$_2$$6H_2$O and Cu(NO$_3$)$_2$$3H_2$O at 1$50^{\circ}C$ for 24 hours and was calcined at $500^{\circ}C$. Each of those was pulverized for 3 and 9 hours in a steel ball mill and was sintered between $700^{\circ}C$ and $1,000^{\circ}C$ for 1 hour, and then their microstructures and magnetic properties were examined. We could make the initial specimens chemically bonded in liquid at the temperature as low as $150 ^{\circ}C$, by using the melting points less than $ 200^{\circ}C$ of the metal nitrates instead of the mechanical ball milling, then narrowed a distance between the particles into a molecular level, and thus lowed sintering temperature by at least $200 ^{\circ}C$ to $300^{\circ}C$ Their initial permeability was 50 to 490 and their saturation magnetic induction density and coercive force 2,400G and 0.3 Oe to 1.2 Oe each, which were similar to those of NiCuZn ferrite synthesized in the conventional process.