• Clinical and Experimental Pediatrics
• /
• 제62권3호
• /
• pp.108-112
• /
• 2019

Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal central nervous system disorder resulting from persistent measles virus infection. Long-term data are scarce, with a maximum follow-up period of 10 years. Interferon-alpha ($IFN-{\alpha}$) is a protein that exerts its antiviral activity via enhancement of cellular immune response and is reported to be an effective drug for the treatment of SSPE. However, there is currently no consensus regarding the optimal duration of $IFN-{\alpha}$ therapy. Here, we present a case report of a patient with SSPE treated with long-term intraventricular $IFN-{\alpha}$ therapy, which facilitated clinical improvement and neurological stabilization without causing serious adverse effects. To the best of our knowledge, this is one of the longest follow-up studies investigating a patient with SSPE receiving intraventricular $IFN-{\alpha}$ treatment. Further studies are necessary to validate the benefits and safety of long-term intraventricular $IFN-{\alpha}$ treatment in patients with SSPE.

• Translational and Clinical Pharmacology
• /
• 제26권3호
• /
• pp.118-127
• /
• 2018

The safety and efficacy of fimasartan have been evaluated through post-marketing surveillance in real world clinical practice. The multi-center, prospective, open-label and non-interventional study. A total of 3,945 patients (3,729 patients for safety assessment and 3,473 patients for efficacy assessment) were screened in patients with essential hypertension in 89 study centers from 9 September 2010 through 8 September 2016. Among the total patients, 2,893 patients (77.6%) were administered fimasartan for 24 weeks or longer and were classified as 'patients with long-term follow-up', and the additional safety and efficacy analysis were performed. The improvement was defined as systolic blood pressure (SBP) controlled to ${\leq}140mmHg$ or decreased SBP differences ${\geq}20mmHg$ after treatment or diastolic blood pressure (DBP) controlled to ${\leq}90mmHg$ or decreased DBP differences ${\geq}10mmHg$ after treatment. Adverse drug reactions (ADRs) were reported in 3.8% patients; dizziness, and hypotension were the most frequently reported ADRs in total patients. The results of patients with long-term follow-up were comparable with total patients. The overall improvement rate in all efficacy assessment at the last visit was 87.1% (3,025/3,473 patients). The overall improvement rate of the patients with long-term follow-up was 88.9%. Fimasartan was well tolerated, with no new safety concerns identified and an effective treatment in the real world clinical practice for Korean patients with hypertension.

• Nuclear Engineering and Technology
• /
• 제47권6호
• /
• pp.719-728
• /
• 2015

Following the Fukushima accident, a special safety inspection was conducted in Korea. The inspection results show that Korean nuclear power plants have no imminent risk for expected maximum potential earthquake or coastal flooding. However long- and short-term safety improvements do need to be implemented. One of the measures to increase the mitigation capability during a prolonged station blackout (SBO) accident is installing injection flow paths to provide emergency cooling water of external sources using fire engines to the steam generators or reactor cooling systems. This paper illustrates an evaluation of the effectiveness of external cooling water injection strategies using fire trucks during a potential extended SBO accident in a 1,000 MWe pressurized water reactor. With regard to the effectiveness of external cooling water injection strategies using fire engines, the strategies are judged to be very feasible for a long-term SBO, but are not likely to be effective for a short-term SBO.

• International Journal of Concrete Structures and Materials
• /
• 제11권2호
• /
• pp.199-213
• /
• 2017

Chloride penetration is among the main causes of corrosion initiation in reinforced concrete (RC) structures producing premature degradations. Weather and exposure conditions directly affect chloride ingress mechanisms and therefore the operational service life and safety of RC structures. Consequently, comprehensive chloride ingress models are useful tools to estimate corrosion initiation risks and minimize maintenance costs for RC structures placed under chloride-contaminated environments. This paper first presents a coupled thermo-hydro-chemical model for predicting chloride penetration into concrete that accounts for realistic weather conditions. This complete numerical model takes into account multiple factors affecting chloride ingress such as diffusion, convection, chloride binding, ionic interaction, and concrete aging. Since the complete model could be computationally expensive for long-term assessment, this study also proposes model simplifications in order to reduce the computational cost. Long-term chloride assessments of complete and reduced models are compared for three locations in France (Brest, Strasbourg and Nice) characterized by different weather and exposure conditions (tidal zone, de-icing salts and salt spray). The comparative study indicates that the reduced model is computationally efficient and accurate for long-term chloride ingress modeling in comparison to the complete one. Given that long-term assessment requires larger climate databases, this research also studies how climate models may affect chloride ingress assessment. The results indicate that the selection of climate models as well as the considered training periods introduce significant errors for mid- and long- term chloride ingress assessment.

• 한국건축시공학회:학술대회논문집
• /
• 한국건축시공학회 2023년도 봄 학술논문 발표대회
• /
• pp.153-154
• /
• 2023

Neglected buildings for long period can seriously reduce the durability of the building due to rust in rebars and deterioration in concrete quality due to exposure to outside air, and the seriousness of suspended buildings such as safety accidents and social crimes is emerging due to poor management. In this study, various problems such as the occurrence of safety accidents were analyzed through a fact-finding survey of buildings that have not been maintained due to long-term neglect in all areas of Jeju. In order to reuse a building that has been discontinued, the safety of the building structure itself must be checked. After securing safety through durability investigation, construction should be resumed or converted into a normal building through re-purposing, dismantling, remodeling, etc.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2005년도 추계학술발표회
• /
• pp.640-641
• /
• 2005

• 한국직업건강간호학회지
• /
• 제25권2호
• /
• pp.118-129
• /
• 2016

Purpose: This study aims to examine the levels of the perception and work performance of patient safety based on the healthcare accreditation criteria among long-term care hospital nurses. Methods: A cross-sectional study was performed using questionnaires. Out of 205 criteria, 39 items relevant to patient safety were selectively adapted for this study. Data were analyzed with descriptive statistics, t-test, ANOVA, and Pearson correlation coefficient. Results: The mean scores of perception and work performance were 4.36 and 4.24 out of 5, respectively, and the difference between them was significantly different (t=5.78, p<.001). The two variables were both significantly higher among those nurses who were older, married, head nurses, had many nursing experiences, and aware of Healthcare Accreditation than the other nurses. Positive correlations were observed between perception and work performance in all three sub-systems. The relations between these two in the patient care system was the most highly correlated (r=.894, p<.001). The lowest scores of perception and work performances were fire-related criteria (i.e., reporting). Conclusion: Overall, subject's perception proves to be higher than their work performance. It is necessary to develop some viable environment and training programs to enhance their work performance up to the level of their perception of patient safety.

• 한국방사성폐기물학회:학술대회논문집
• /
• 한국방사성폐기물학회 2009년도 학술논문요약집
• /
• pp.497-497
• /
• 2009

• 한국지진공학회논문집
• /
• 제17권3호
• /
• pp.117-125
• /
• 2013

Seismic isolation has been considered and utilized in various industries as a way to prevent huge damage on to structures by large earthquakes in various industries. The laminated Laminated rubber bearings is are most frequently used in seismic isolation systems. The structural Structural safety could not be assured unless the performance of the rubber bearing is not guaranteed for the life time of the structure under the consideration that the bearing is a critical structural member to sustain vertical loads in the seismically isolated structure. However, there are few studies on the deterioration problems of rubber bearings during their service life. The long term performance of the rubber bearings was not considered in past designs of seismically isolated structures. This study evaluates the long term performance and creep characteristics of laminated natural rubber bearings that are used in seismically isolated buildings. For the this study, a set of accelerated thermal aging tests and creep tests are were performed on real specimens. The experimental results show that the natural rubber bearings would have a stable change rate of change for durability under severe environmental conditions for a long time.

• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 1999년도 봄 학술발표회 논문집
• /
• pp.105-112
• /
• 1999

In recent the superior economic benefits and the convenience of installation increased the use of geosynthetics, especially geogrids with the effects of high tensile strength. In this study, various tests were conducted to determine the physical and chemical properties of geogrids which contains durability under various critical conditions, creep behavior and the stability for installation damage in fields. With analysis of test results, the partial and total safety factors were determined and presented the long term design strength of flexible geogrids.