• YAKHAK HOEJI
• /
• v.32 no.1
• /
• pp.20-25
• /
• 1988

New prednisolone derivatives including methyl $20{\xi}-acetoxy-prednisolonate$ have been synthesized and evaluated for local anti-inflammatory agents with reduced systemic side effect. Methyl $20{\beta}-dihydroprednisolonate$ and methyl $20{\xi}-acetoxyprednisolonate$ showed comparable anti-inflammtory activity in vivo with significantly reduced systemic side effects.

• Journal of Dental Anesthesia and Pain Medicine
• /
• v.21 no.6
• /
• pp.583-587
• /
• 2021

Lidocaine is the most commonly used local anesthetic (LA) agent in various dental as well as oral and maxillofacial procedures. Although rare, adverse effects and allergic reactions to lidocaine have been reported. In patients with suspected allergy to LA or a history of such reaction, careful history-taking and allergy testing should be performed to choose an alternative LA agent to avoid any adverse effects. Here, we present two cases of delayed hypersensitivity reaction to lidocaine, wherein the patients presented with erythema, edema, and itching. Intradermal testing confirmed allergic reaction to lidocaine, and the patients underwent successful dental treatment using an alternative LA agent. This report highlights the importance of allergy testing prior to LA use considering the serious consequences of allergy to these agents and describes the management of such patients using an alternative LA agent.

• ETRI Journal
• /
• v.44 no.2
• /
• pp.313-326
• /
• 2022

This study presents a noble scheme for distributed and parallel simulations with optimized agent placement for simulation instances. The traditional parallel simulation has some limitations in that it does not provide sufficient performance even though using multiple resources. The main reason for this discrepancy is that supporting parallelism inevitably requires additional costs in addition to the base simulation cost. We present a comprehensive study of parallel simulation architectures, execution flows, and characteristics. Then, we identify critical challenges for optimizing large simulations for parallel instances. Based on our cost-benefit analysis, we propose a novel approach to overcome the performance constraints of agent-based parallel simulations. We also propose a solution for eliminating the synchronizing cost among local instances. Our method ensures balanced performance through optimal deployment of agents to local instances and an adaptive agent placement scheme according to the simulation load. Additionally, our empirical evaluation reveals that the proposed model achieves better performance than conventional methods under several conditions.

• Journal of the Economic Geographical Society of Korea
• /
• v.12 no.1
• /
• pp.38-55
• /
• 2009

Recently, attention has been drawn to the issue of local community revitalization. In the U.S., CDC(Community Development Corporation) has become a main vehicle for revitalizing dilapidated inner-city communities. Using the case of Philadelphia in the U.S., this paper investigates the way in which local community revitalization or downtown revitalization can be successfully achieved through the formation of social capital and public-private partnership. Futhermore, exploring the cases of West Philadelphia CDC and University City, this paper seeks to provide insight into the dynamics of successful community development. In order to examine the dynamics, this paper focuses on local governance in terms of both the reciprocal partnerships and the close networking among participating agents. The implications of the case studies of this research for the Korean context would be that the bottom-up approach starting from the local-scale community revitalization and local governance is very crucial and indispensable for the sustainable regional or national development.

• Asia Marketing Journal
• /
• v.17 no.1
• /
• pp.69-95
• /
• 2015

This paper examines a highly used social networking site (SNS) by studying the behavior of more than 11 million members over a 20 month period. The importance of the most highly active members to the overall network is demonstrated by the significant fraction of total visits by extremely active members in a given period but such members have surprisingly short lifespans (an average of only 2.5 months) as social hubs. We form and test a number of hypotheses concerning these social hubs and the determinants of their lifespan. We find that the speed of achieving social hub status increases the lifespan of a social hub. The norm of reciprocity is strongly confirmed to be present in the social hub population as visits are reciprocated. We also find that increasing local dominance in terms of activities over neighboring agents leads to a longer lifespan of a social hub. Contrary to expectations, local clustering in the vicinity of social hubs is smaller (rather than larger) than overall clustering. We discuss managerial implications in the paper.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.32 no.3
• /
• pp.267-271
• /
• 2006

Lymphangiomas are benign tumors of the lymphatic system characterized by congenital lymphatic malformation such as anastomosis or obstruction of the lymphatic channels. They are most frequently diagnosed in children younger than 2 years, and the lymphangiomas in head and neck represent about 50-75% of all lymphangiomas. Spontaneous regression is rare, and rapid enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequence such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosing agents. Problems associated with surgical excision include the risk of scarring, damage to surrounding vital structure and the high risk of incomplete excision. The sclerosing agents previously used have numerous local and systemic side effects as their problems. We present a case of lymphangioma occured in tongue that was treated by surgical excision and sclerotherapy with OK-432.

• CELLMED
• /
• v.4 no.2
• /
• pp.8.1-8.6
• /
• 2014

Despite the remarkable advancements of the modern medicine, the traditional system of medicine (TSM) still serves as a potential primary health care modality in the in low- and middle-income countries. The recent reports suggest that there is a renewed interest has been observed towards TSM in the developed countries too, because of the adverse side-effect of modern medicines. Medicinal plants have been widely serving as a rich source of therapeutic agent. Ethiopia is one of the most reserves rich countries in the world. It is renowned for well-diversified and natural resources in terms of its unique flora and fauna. Ethiopian deep-rooted tradition and culture largely depends on the usage of plants for their religious ceremonies, impressive festivals, traditional medicinal uses and other basic necessities. The present scrutiny is an attempt to understand the omnipotent nature of an Ethiopian Ethnomedicinal plant called Tinjute [vernacular name (local native language, Amharic); Otostegia integrifolia]. There are several studies suggest that Tinjute can be used as a natural medicine or health-promoting agents for various disorders and ailments. Nevertheless, in Ethiopia, it is renowned as an insect repellent to drive-away insect vector of diseases, particularly mosquitoes in the early evening. However, there are many more issues and challenges which must be urgently addressed to scientifically formulate various potent, efficacious, safe and highly selective phytotherapeutic agents and insects' repellent from the Tinjute plant in the near future.

• KSBB Journal
• /
• v.26 no.6
• /
• pp.491-504
• /
• 2011

This review article provides an overview of the evolution of diphtheria vaccine, its value and its future. Diphtheria is an infectious illness caused by diphtheria toxin produced by pathogenic strains of Corynebacterium diphtheriae. It is characterized by a sore throat with membrane formation due to local tissue necrosis, which can lead to fatal airway obstruction; neural and cardiac damage are other common complications. Diphtheria vaccine was first brought to market in the 1920s, following the discovery that diphtheria toxin can be detoxified using formalin. However, conventional formalin-inactivated toxoid vaccines have some fundamental limitations. Innovative technologies and approaches with the potential to overcome these limitations are discussed in this paper. These include genetic inactivation of diphtheria toxoid, innovative vaccine delivery systems, new adjuvants (both TLR-independent and TLR-dependent adjuvants), and heat- and freeze-stable agents, as well as novel platforms for producing improved conventional vaccine, DNA vaccine, transcutaneous (microneedle-mediated) vaccine, oral vaccine and edible vaccine expressed in transgenic plants. These innovations target improvements in vaccine quality (efficacy, safety, stability and consistency), ease of use and/or thermal stability. Their successful development and use should help to increase global diphtheria vaccine coverage.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.20 no.1
• /
• pp.11-16
• /
• 2009

OPD based laryngeal procedures offers a new avenue to the modern laryngologist, incorporating new technology in the office setting. With the development of flexible fiberoptic endoscopes, compact video system, and short acting anesthetics and sedatives allow these procedures. The success or failure of procedures are depend on excellent topical anesthesia. An inadequately anesthetized patient is apt to be uncomfortable, anxious and hyperresponsive and therefore unlikely to tolerate the procedure. On the other hand, a patient who is well informed, reassured, and thoroughly anesthetized can complete procedures. Therefore, optimal anesthesia is obligatory for excellent surgical results. The phonosurgeon should choose the anesthetic and sedative agents based on duration of action, time of onset of action, and any medical contraindications that the patient may have. And should be familiar with the properties and interaction of the agents used, as well as the signs of toxicity.

• KIEE International Transactions on Power Engineering
• /
• v.2A no.3
• /
• pp.89-94
• /
• 2002

In this paper, a protection system using a Multi-Agent concept for power distribution networks is proposed. Every digital over current relay(OCR) is developed as an agent by adding its own intelligence, self-tuning and communication ability. The main advantage of the Multi-Agent concept is that a group of agents work together to achieve a global goal which is beyond the ability of each individual agent. In order to cope with frequent changes in the network operation condition and faults, an OCR agent, suggested in this paper, is able to detect a fault or a change in the network and find its optimal parameters for protection in an autonomous manner considering information of the whole network obtained by communication between other agents. Through this kind of coordination and information exchanges, not only a local but also a global protective scheme is completed. Simulations in a simple distribution network show the effectiveness of the suggested protection system.