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http://dx.doi.org/10.5667/tang.2013.0033

Tinjute [Labiatae; (Otostegia integrifolia)]: A versatile Ethiopian ethnomedicinal plant - a systematic review of the scientific evidences  

Karunamoorthi, Kaliyaperumal (Unit of Medical Entomology and Vector Control, Department of Environmental Health Science& Technology, College of Public Health and Medical Sciences, Jimma University)
Publication Information
CELLMED / v.4, no.2, 2014 , pp. 8.1-8.6 More about this Journal
Abstract
Despite the remarkable advancements of the modern medicine, the traditional system of medicine (TSM) still serves as a potential primary health care modality in the in low- and middle-income countries. The recent reports suggest that there is a renewed interest has been observed towards TSM in the developed countries too, because of the adverse side-effect of modern medicines. Medicinal plants have been widely serving as a rich source of therapeutic agent. Ethiopia is one of the most reserves rich countries in the world. It is renowned for well-diversified and natural resources in terms of its unique flora and fauna. Ethiopian deep-rooted tradition and culture largely depends on the usage of plants for their religious ceremonies, impressive festivals, traditional medicinal uses and other basic necessities. The present scrutiny is an attempt to understand the omnipotent nature of an Ethiopian Ethnomedicinal plant called Tinjute [vernacular name (local native language, Amharic); Otostegia integrifolia]. There are several studies suggest that Tinjute can be used as a natural medicine or health-promoting agents for various disorders and ailments. Nevertheless, in Ethiopia, it is renowned as an insect repellent to drive-away insect vector of diseases, particularly mosquitoes in the early evening. However, there are many more issues and challenges which must be urgently addressed to scientifically formulate various potent, efficacious, safe and highly selective phytotherapeutic agents and insects' repellent from the Tinjute plant in the near future.
Keywords
traditional system of medicine; Otostegia integrifolia; Tinjute; insect repellent; Ethiopia;
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1 Andemariam SW. Legislative regulation of traditional medicinal knowledge in Eritrea vis-a-vis Eritrea's commitments under the convention on biological diversity: Issues and alternatives. Law Environ Dev J. 2010;6:130-162.
2 Bekele E. Study on actual situation of medicinal plants in Ethiopia. Japan Association for International Collaboration of Agriculture and Forestry. 2007. Available at: http://www.endashaw.com (accessed on 29th January 2011).
3 Bhumiratana A, Intarapuk A, Sorosjinda-Nunthawarasilp P, Maneekan P, Koyadun S. Border malaria associated with multidrug resistance on Thailand-Myanmar and Thailand-Cambodia borders: transmission dynamic, vulnerability, and surveillance. Biomed Res Int. 2013;2013:ID363417.
4 Cunningham AB. African Medicinal Plants: Setting Priorities at the Interface between Conservation and Primary Health Care. UNESCO. 1993.
5 WHO. Pesticides and their application. (Geneva, Switzerland: World Health Organization), 2006.
6 Tesso H, Konig WA. Terpenes from Otostegia integrifolia. Phytochem. 2004;65:2057-2062.   DOI   ScienceOn
7 Vural K, Ezer N, Erol K, Sahin FP. Anxiolytic and antidepressant activity of some Ballota species. J Fac Pharm Gazi. 1996;13:29-32.
8 Waka M, Hopkins RJ, Curtis C. Ethnobotanical survey and testing of plants traditionally used against hematophagous insects in Eritrea. J Ethnopharmacol. 2004;95:95-101.   DOI   ScienceOn
9 WHO. WHO Traditional Medicine Strategy 2002-2005. (Geneva, Switzerland: World Health Organization), 2002.
10 WHO. Traditional Medicine: Fact Sheet No 134. 2003. Available at: http://www.who.int/mediacentre/factsheets/2003/fs134/en/ (accessed on 01th November 2014).
11 Wilson RT, Mariam WG. Medicine and Magic in Central Tigre: A Contribution to the Ethnobotany of the Ethiopian Plateau. Econ Botany. 1979;33:29-34.   DOI
12 Martin GJ. Ethnobotany: A method Manual. (London, UK: Chapman and Hall), 1995.
13 Mekonnen A and Hailemariam K. Baseline and Climate Change Scenarios for Ethiopia. (Addis Ababa, Ethiopia: National Meteorological Services Agency), 2000.
14 Khan F, Syed F. Bioactive Constituents from Genus Otostegia. SARJ of Physical Sci. 2013;1:15-25.
15 Kidane D, Tomass Z, Dejene T. Community knowledge of traditional mosquito repellent plants in Kolla Temben District, Tigray, Northern Ethiopia. Sci Res Essays. 2013;8:1139-1144.
16 Muthaura CN, Rukunga GM, Chhabra SC, Omar SA, Guantai AN, Gathirwa JW, Tolo FM, et al. Antimalarial Activity of Some Plants Traditionally used in Meru district of Kenya. Phytother Res. 2007;21:860-867.   DOI   ScienceOn
17 Panda S, Jafri M, Kar A, Meheta BK. Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma. Fitoterapia. 2009;80:123-126.   DOI   ScienceOn
18 Roberson E. Medicinal Plants at Risk. Nature's Pharmacy, Our Treasure Chest: Why We Must Conserve Our Natural Heritage. (Tucson ,USA: Center for Biological Diversity), 2008.
19 Ros MM, Sterk SS, Verhagen H, Stalenhoef AF, de Jong N. Phytosterol consumption and the anabolic steroid boldenone in humans: a hypothesis piloted. Food Addit Contam. 2007;24:679-684.   DOI   ScienceOn
20 Sneader W. Drug Discovery: a History. (Chichester, UK: Wiley), 2005.
21 Sofowora A. Medicinal plants and Traditional medicine in Africa. (New York, USA: Wiley), pp 255-256, 1982.
22 Karunamoorthi K, Sabesan S. Laboratory evaluation of Dimethyl phthalate treated wristbands against three predominant mosquito (Diptera: Culicidae) vectors of disease. Eur Rev Med Pharmacol Sci. 2010;14:443-448.
23 Teklay A, Abera B, Giday M. An ethnobotanical study of medicinal plants used in Kilte Awulaelo District, Tigray Region of Ethiopia. J Ethnobiol Ethnomed. 2013;9:65.   DOI   ScienceOn
24 Teklehaymanot T, Giday M, Medhin G, Mekonnen Y. Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia. J Ethnopharmacol. 2007;111:271-283.   DOI   ScienceOn
25 Karunamoorthi K. Plant-Based Insect Repellents: Is That a Sustainable Option to Curb the Malaria Burden in Africa? J Med Aromat Plants. 2012b;1:e106
26 Karunamoorthi K, Tsehaye E. Ethnomedicinal Knowledge, Belief and Self-reported Practice of local inhabitants on Traditional Antimalarial Plants and Phytotherapy. J Ethnopharmacol. 2012;141:143-150.   DOI   ScienceOn
27 Karunamoorthi K. Global Malaria Burden: Socialomics Implications. J Socialomics. 2012;1:e108.
28 Karunamoorthi K. Yellow Fever Encephalitis: An Emerging and Resurging Global Public Health Threat in a Changing Environment. In Encephalitis, Sergey Tkachev ed. (Croatia: licensee InTech), pp. 207-230, 2013.
29 Karunamoorthi K.Vector Control: A Cornerstone in the Malaria Elimination Campaign. Clin Microbiol Infect. 2011;17:1608-1616.   DOI   ScienceOn
30 Karunamoorthi K, Mulelam A, Wassie F. Assessment of knowledge and usage custom of traditional insect/mosquito repellent plants in Addis Zemen Town, South Gonder, North Western Ethiopia. J Ethnopharmacol. 2009;121:49-53.   DOI   ScienceOn
31 Karunamoorthi K, Ramanujam S, Rathinasamy R. Evaluation of leaf extracts of Vitex negundo L. (Family: Verbenaceae) against larvae of Culex tritaeniorhynchus (Insecta; Diptera; Culicidae) and repellent activity on adult vector mosquitoes. Parasitol Res. 2008;103:545-550.   DOI
32 Karunamoorthi K, Ilango K, Murugan K. Laboratory evaluation of traditionally used plant-based insect repellent against the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae). Parasitol Res. 2010;106:1217-1223.   DOI
33 Karunamoorthi K, Jegajeevanram K, Jerome X, Vijayalakshmi J, Melita L. Tamil Traditional Medicinal System - Siddha: An Indigenous Health Practice in the International Perspectives. TANG. 2012;2:e12.
34 Karunamoorthi K, Jegajeevanram K, Vijayalakshmi J, Embialle M. Traditional Medicinal Plants: A Source of Phytotherapeutic Modality in the Resource-Constrained Health Care Settings. J Evidence-Based Complemen Altern Med. 2013;18:67-74.   DOI
35 Karunamoorthi K, Sabesan S, Jegajeevanram K, Vijayalakshmi J. The Role of Traditional Anti-malarial Plants in the Battle against Global Malaria Burden. Vector Borne Zoonotic Dis. 2013;13:521-544.   DOI   ScienceOn
36 Karunamoorthi K, Sabesan S. Field trials on the efficacy of DEET impregnated anklets, wristbands, shoulder, and pocket strips against mosquito vectors of disease. Parasitol Res. 2009;105:641-645.   DOI
37 Getahun A. Some common medicinal and poisonous plants used in Ethiopian folk medicine. (Addis Ababa, Ethiopia: Addis Ababa University), 1976.
38 Endale A, Bisrat D, Animut A, Bucar F, Asres K. In vivo Antimalarial Activity of a Labdane Diterpenoid from the Leaves of Otostegia integrifolia Benth. Phytother Res. 2013;27:1805-1809.   DOI   ScienceOn
39 Giday M, Teklehaymanot T, Animut A, Mekonnen Y. Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in North West Ethiopia. J Ethnopharmacol. 2007;110:516-525.   DOI
40 Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, et al. Stigmasterol: a phytosterol with potential antiosteoarthritic properties. Am J Clin Nutr. 2010;18:106-116.
41 Gurib-Fakim A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006;27:1-93.   DOI   ScienceOn
42 Karunamoorthi K, Deboch B, Tafere Y. Knowledge and practice concerning malaria, insecticide-treated net (ITN) utilization and antimalarial treatment among pregnant women attending specialist antenatal clinics. J Pub Health. 2010;18:559-566.   DOI
43 Karunamoorthi K, Girmay A, Fekadu S. Mosquito Repellent Activity of Essential oil of Ethiopian Ethnomedicinal Plant against Afro-tropical Malaria Vector Anopheles arabiensis. J King Saud University - Sci. 2014. [Article In Press]
44 Karunamoorthi K, Husen E. Knowledge and Self-reported Practice of the Local Inhabitants on Traditional Insect Repellent Plants in Western Hararghe Zone, Ethiopia. J Ethnopharmacol. 2012;141:212-219.   DOI   ScienceOn
45 Karunamoorthi K, Ilango K, Endale A. Ethnobotanical survey of knowledge and usage custom of traditional insect/mosquito repellent plants among the Ethiopian Oromo ethnic group. J Ethnopharmacol. 2009;125:224-229.   DOI   ScienceOn
46 Abulafatih HA. Medicinal Plants in Southwestern Saudi Arabia. Econ Botany. 1987;41:354-360.   DOI
47 Alemayehu YA, Wurzinger M, Tegegne A, Zollitsch W. Handling, processing and marketing of milk in the north western Ethiopian highlands. Livestock Research for Rural Dev. 2009;21:97.
48 Draisci R, Merlanti R, Ferretti G, Fantozzi L, Ferranti C, Capolongo F, et al. Excretion profile of boldenone in urine of veal calves fed two different milk replacers. Analytica Chimica Acta. 2007;586:171-176.   DOI   ScienceOn
49 Karunamoorthi K, Mulelam A, Wassie F. Laboratory evaluation of traditional insect/mosquito repellent plants against Anopheles arabiensis, the predominant malaria vector in Ethiopia. Parasitol Res. 2008;103:529-534.   DOI
50 Gallina G, Ferretti g, Merlanti R, Civitareale C, Capolongo F, Draisci R, Montesissa C, Boldenone, Boldione, and Milk Replacers in the Diet of Veal Calves: The Effects of Phytosterol Content on the Urinary Excretion of Boldenone Metabolites. J Agric Food Chem. 2007;55:8275-8283.   DOI   ScienceOn