Browse > Article

TREATMENT OF LYMPHANGIOMA BY SURGICAL EXCISION AND SCLEROTHERAPY WITH OK-432 : A CASE REPORT  

Cho, Ju-Yeon (Department of Dentistry, Daegu Fatima Hospital)
Cha, Du-Won (Department of Dentistry, Daegu Fatima Hospital)
Baek, Sang-Heum (Department of Dentistry, Daegu Fatima Hospital)
Lee, Ju-Duck (Department of Dentistry, Daegu Fatima Hospital)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.32, no.3, 2006 , pp. 267-271 More about this Journal
Abstract
Lymphangiomas are benign tumors of the lymphatic system characterized by congenital lymphatic malformation such as anastomosis or obstruction of the lymphatic channels. They are most frequently diagnosed in children younger than 2 years, and the lymphangiomas in head and neck represent about 50-75% of all lymphangiomas. Spontaneous regression is rare, and rapid enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequence such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosing agents. Problems associated with surgical excision include the risk of scarring, damage to surrounding vital structure and the high risk of incomplete excision. The sclerosing agents previously used have numerous local and systemic side effects as their problems. We present a case of lymphangioma occured in tongue that was treated by surgical excision and sclerotherapy with OK-432.
Keywords
Lymphangioma; Surgical excision; OK-432; Sclerotherapy; Intralesional injection;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kaban LB, Mulliken JB: Vascular anomalies of the maxillofacial region. J Oral Maxillofac Surg 1986;44(3):203-13   DOI   ScienceOn
2 Ogita S, Tsuto T, Nakamura K, Deguchi E, Iwai N: OK-432 therapy in 64 patients with lymphangioma. J Pediatr Surg 1994;29(6):784-5   DOI   ScienceOn
3 Giguere CM, Bauman NM, Sato Y, Burke DK, Greinwald JH, Pransky S, et al: Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg 2002;128(10):1137-44   DOI
4 Ogita S, Tsuto T, Nakamura K, Deguchi E, Tokiwa K, Iwai N: OK- 432 therapy for lymphangioma in children: why and how does it work? J Pediatr Surg 1996;31(4):477-80   DOI   ScienceOn
5 Laranne J, Keski-Nisula L, Raurio R, Rautiainen M, Airaksinen M: OK-432($Picibanil^{\circledR}$) therapy for lymphangiomas in children. Eur Arch Otolaryngol 2002;259(5):274-278   DOI   ScienceOn
6 Jackson IT, Carreno R, Potparic Z, Hussain K: Hemangiomas, vascular malformations, and lymphovenous malformations: classification and methods of treatment. Plast Reconstr Surg 1993;91(7):1216-30   DOI   ScienceOn
7 Zhong PQ, Zhi FX, Li R, Xue JL, Shu GY: Long-term results of intratumorous bleomycin-A5 injection for head and neck lymphangioma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86(2):139-44   DOI   ScienceOn
8 Sato M, Tanaka N, Sato T, Amagasa T: Oral and maxillofacial tumours in children: a review. Br J Oral Maxillofac Surg 1997; 35(2):92-5   DOI   ScienceOn
9 Schloss MD, Sweet RC, Blais C, Tewfik TL: Lymphangioma in children. J Otolaryngol 1984;13(2):95-8
10 Fonkalsrud EW: Surgical management of congenital malformations of the lymphatic system. Am J Surg 1974;128(2):152-9   DOI   ScienceOn
11 박영욱, 심광섭: OK-432를 이용한 두경부 다발성 임파관종의 치 료. 대한구강악안면외과학회지 1996;22(4):728-735
12 Balakrishnan A, Bailey CM: Lymphangioma of the tongue. A review of pathogenesis, treatment and the use of surface laser photocoagulation. J Laryngol Otol 1991;105(11):924-9   DOI   ScienceOn
13 Hancock BJ, St-Vil D, Luks FI, Di Lorenzo M, Blanchard H: Complications of lymphangiomas in children. J Pediatr Surg 1992;27(2):220-4; discussion 224-6   DOI   ScienceOn
14 Alqahtani A, Nguyen LT, Flageole H, Shaw K, Laberge JM:. 25 years'experience with lymphangiomas in children. J Pediatr Surg 1999;34(7):1164-8   DOI   ScienceOn
15 Ogita S, Tsuto T, Tokiwa K, Takahashi T: Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 1987;74(8):690-1   DOI   ScienceOn
16 Brennan T D, Miller A S, Chen S Y: Lymphangiomas of the oral cavity. J Oral Maxillofac Surg 1997;55:932-935   DOI   ScienceOn
17 Ogita S, Tsuto T, Deguchi E, Tokiwa K, Nagashima M, Iwai N: OK- 432 therapy for unresectable lymphangiomas in children. J Pediatr Surg 1991;26(3):263-8; discussion 268-70   DOI   ScienceOn
18 Orford J, Barker A, Thonell S, King P, Murphy J: Bleomycin therapy for cystic hygroma. J Pediatr Surg 1995;30(9):1282-7   DOI   ScienceOn
19 Mulliken JB, Glowacki J: Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982;69(3):412-22   DOI   ScienceOn
20 Tanaka N, Murata A, Yamaguchi A, Kohama G: Clinical features and management of oral and maxillofacial tumors in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88(1):11-5   DOI   ScienceOn
21 김일규, 이성호, 오성섭, 최진호, 오남식, 김왕식 외: OK- 432($Picibanil^{\circledR}$)와 외과적 절제술을 이용한 선천성 임파관종의 치험례. 대악성외지 2001;23(3):281-288
22 Grabb WC, Dingman RO, Oneal RM, Dempsey PD: Facial hamartomas in children: neurofibroma, lymphangioma, and hemangioma. Plast Reconstr Surg 1980;66(4):509-27   DOI   ScienceOn