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Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle (초기변형률에 의한 미소바늘의 피부조직 관통력 감소)

  • Kim, Jonghun;Park, Sungmin;Nam, Gyungmok;Yoon, Sang-Hee
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.10
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    • pp.851-856
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    • 2016
  • Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.

The Effects of the Microstructures on the Fatigue Crack Propagation Behaviors of Cast Irons (주철의 피로전파거동에 미치는 미세조직의 영향)

  • Kim, Sug-Won;Park, Jin-Sung;Lee, Hyung-Chul;Kim, Dong-Keun;Woo, Kee-Do
    • Journal of Korea Foundry Society
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    • v.25 no.1
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    • pp.16-22
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    • 2005
  • This study aims to investigate the effects of the microstructures and nodule type on the fatigue characteristics of cast iron. Fatigue tests were carried out in tension-tension mode using a servo-hydraulic testing machine with load control mode operating at a frequency of 15 Hz. The tests were conducted at stress ratio R=Kmin/Kmax, of 0.1. Initial crack ${\Dalta}K$ values were highly performed with increase in tensile strength of DCI fatigue specimens. ${\Dalta}K_{th}$ region, fatigue crack propagation was primarily advanced through cell boundary and in periphery of near nodule. Fatigue crack propagation rate of D2 consisted with 2Phase(Ferrite+Pearlite) was slow due to crack closure enhanced by crack deflection and occurred crack branching. The generation of crack branch was occurred due to interaction of crack-nodule. At Threshold and Paris zone, the fractographs of the fatigue fracture surface for DCI show typical striations of a ductile fracture and isolated cleavage planes near graphite. The effect of microstructure on fatigue crack propagation of GC strongly depends on the type of flake. The generation of crack branch occurred due to interaction of crack-nodule. The fractographs of the fatigue fracture surface for GC show cleavage plane along the flake graphite.

THE INFLUENCE OF CATCH VOLUME ON TRAWLER WARP TENSION (어류가 대량으로 입강했을 때의 선미 trawl의 warp 장력)

  • Kim Cha Dol
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.2 no.2
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    • pp.173-178
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    • 1969
  • Few reports have been written regarding the measurement of stern trawler warp tension under conditions of a full catch. This report compares the tension imposed on the warps at the time the boat begins to tow the net and the tension at the time the cod end is filled with a large quantity of fish. The structure of the otter boards and trawl net used for the experiment was the same types as used by Koyama, Sakurai, and Sumikawa (1968). The warp tension was measured with a load cell tension meter. 3) This meter continuously records the tension on a pen oscillograph. The net towing speed was measured with the CM-lA type current meter, Toho Dentan Co. Ltd., Japan. The data collected in the experiment are shown in Table 1. This table indicates that shooting No. 2 and No. 11 show a large catch volume, and the types of fish caught are shown in Table 2. The tension meter recordings when the boat began to tow the net and when the cod end was filled with a large quantity are shown in Fig. 1 and Fig. 2. It is indicated that the barracouta Thyrsites atun (EUPHRASEN) causes little tension difference between the time before they enter the net and the time after they enter the net before hauling. Other types of fish influence tension similarly. According to these results, the warp tension measurements as recorded on a big stern trawler are more influenced by rough sea wave action than by the volume of fish caught.

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The Effect of Aspect Ratio on the Aerodynamic Characteristics of an Insect-based Flapping Wing (곤충 모방형 플래핑 날개의 공력특성에 관한 가로세로비 효과)

  • Han, Jong-Seob;Chang, Jo-Won;Jeon, Chang-Soo
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.40 no.8
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    • pp.662-669
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    • 2012
  • The effect of aspect ratio (AR) on the aerodynamic characteristics of a flapping wing was examined to analyze the design parameters of an insect-based MAV. The experimental model constructed with 4-bar linkages was operated in a water tank with the condition of a low Reynolds number. A water-proof micro-force load cell was fabricated and installed at the root of the wing which is made of a plexiglas. The wing shapes were based on the planform of a fruit fly wing. The ARs selected were 1.87, 3.74 and 7.48 and the Reynolds number was fixed at $10^4$. For AR=1.87 and 3.74, distinct lift peaks which indicate unsteady effects such as 'wake-capture' were observed at the moment of the start of the wing-stroke. However, for AR=7.48, no unsteady effects were observed. These phenomena were also observed in the delayed rotation case. The results indicate that a larger AR provides better aerodynamic performance for the insect-based flapping wing which can be applied in MAV designs.

Application of tubular membrane to thickening process as a pre-treatment of anaerobic digester (관형막을 이용한 혐기소화조의 전처리 농축공정으로써 적용가능성 연구)

  • Kang, Hee-Seok;Park, Ki-Tae;Park, Jung-Woo;Kim, Hyung Soo
    • Journal of Korean Society of Water and Wastewater
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    • v.29 no.2
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    • pp.203-209
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    • 2015
  • The purpose of this study is to estimate the applicability of a stable anaerobic digester using a separator membrane to the preprocessing thickening process. The results of the experiments showed about a 47.16% weight loss rate for the sludge under anaerobic condition, and about 41.17% under intermittent aeration condition. The concentrations of rejection water were $SCOD_{Cr}$ 25 mg/L, T-N 16.6 mg/L, and T-P 1.4 mg/L on the average under the intermittent aeration condition, which were lower than the concentrations of rejection water under an anaerobic condition. As for the factors affecting the reduction of the flux, correlation analyses of TTF, MLSS, $SCOD_{Cr}$, and $EPS_{Protein}$, $EPS_{Polysacchride}$ resulted in -0.97, -0.95, -0.84 and -0.86, -0.95, respectively, which showed that TTF had the highest correlation to the reduction of the flux. In addition, it was concluded that MLSS, $SCOD_{Cr}$ and $EPS_{Protein}$, $EPS_{Polysacchride}$ also have close correlations. The results are considered to show that, in the case of the process using a tubular membrane in the preprocessing process of an anaerobic digester, an intermittent aeration condition of the thickener considering the contamination of the membrane and load of rejection water is appropriate for the stable preprocessing process.

Microcomputer-based Data Acquisition System for the Measurements of Temperature and Weight in Food Processing (마이크로 컴퓨터를 이용한 식품가공(食品加工) 공정중(工程中)의 온도및 무게 측정용(測定用) Analog-digital 변환(變換)및 접속(接續) 시스템의 제작(製作))

  • Choi, Boo-Dol;Chun, Jae-Kun
    • Korean Journal of Food Science and Technology
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    • v.19 no.2
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    • pp.129-133
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    • 1987
  • To develop a microcomputer-based data acquisition system for measurement of variables such as temperature and weight in food process, a low-cost data acquisition system was developed using an Apple II microcomputer. The system consisted of a microcomputer, a temperature sensor made of pt-100, a strain gauge load cell for weighing, a preamplifier for signal conditionings and an interface device. Interface device was built with programmable interface chip MC 6821, tristate buffer 74244 and analog-to-digital converter ADC 0809. The analog signals of temperature and weight were serially acquisited upon the program. The BASIC language was used for operating the data acquisition and data handling programs. The system successfully measured the variables such as temperature and weight with various sampling intervals in food dehydration process.

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Development of a Real-Time Measurement System for Horizontal Soil Strength

  • Cho, Yongjin;Lee, Dong Hoon;Park, Wonyeop;Lee, Kyou Seung
    • Journal of Biosystems Engineering
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    • v.40 no.3
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    • pp.165-177
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    • 2015
  • Purpose: Accurate monitoring of soil strength is a key technology applicable to various precision agricultural practices. Soil strength has been traditionally measured using a cone penetrometer, which is time-consuming and expensive, making it difficult to obtain the spatial data required for precision agriculture. To improve the current, inefficient method of measuring soil strength, our objective was to develop and evaluate an in-situ system that could measure horizontal soil strength in real-time, while moving across a soil bin. Methods: Multiple cone-shape penetrometers were horizontally assembled at the front of a vertical plow blade at intervals of 5 cm. Each penetrometer was directly connected to a load cell, which measured loads of 0-2.54 kN. In order to process the digital signals from every individual transducer concurrently, a microcontroller was embedded into the measurement system. Wireless data communication was used between a data storage device and this real-time horizontal soil strength (RHSS) measurement system travelling at 0.5 m/s through an indoor experimental soil bin. The horizontal soil strength index (HSSI) measured by the developed system was compared with the cone index (CI) measured by a traditional cone penetrometer. Results: The coefficient of determination between the CI and the HSSI at depths of 5 cm and 10 cm ($r^2=0.67$ and 0.88, respectively) were relatively less than those measured below 20 cm ($r^2{\geq}0.93$). Additionally, the measured HSSIs were typically greater than the CIs for a given numbers of compactor operations. For an all-depth regression, the coefficient of determination was 0.94, with a RMSE of 0.23. Conclusions: A HSSI measurement system was evaluated in comparison with the conventional soil strength measurement system, CI. Further study is needed, in the form of field tests, on this real-time measurement and control system, which would be applied to precision agriculture.

Measurements of Separation Properties of AM, ARM Oxidesin Molten LiC1 (AM, AEM 산화물들의 용융 LiC1에서의 분리 물성 측정)

  • 오승철;박병흥;강대승;서중석;박성원
    • Proceedings of the Korean Radioactive Waste Society Conference
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    • 2003.11a
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    • pp.363-367
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    • 2003
  • Much attention has been given to an electrochemical reduction process for converting uranium oxide to uranium metal in molten salt. The process has the versatility of being adopted for reducing other actinide and rare-earth metals from their oxides. Using the metal oxide to be reduced as a integrated cathode designed originally and inert conductors as anodes, oxygen anions are removed from the cathode and oxidized at the surface of the anodes in a molten salt cell. However, the electrochemical properties of alkali and alkali-earth metal oxides in molten salt have not been investigated thoroughly, which made the process incomplete when it is considered as a unit process in a back-end fuel cycle. It is well known that cesium and strontium Isotopes in spent fuel are main contributors for head load. The properties of cesium, strontium, and barium oxides such as the dissolution rates and reduction potentials in molten LiC1 dissolving $Li_2O$ are examined.

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Whole Mount Preparation of Primary Cultured Neuron for HVEM Observation (배양된 시경세포 관찰을 위한 초고압전자현미경 홀마운트 시료제작기법)

  • Kim, Hyun-Wook;Hong, Soon-Taek;Oh, Seung-Hak;Park, Chang-Hyun;Kim, Hyun;Rhyu, Im-Joo
    • Applied Microscopy
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    • v.41 no.1
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    • pp.69-73
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    • 2011
  • High-voltage electron microscope (HVEM) has higher resolution and penetration power than conventional transmission electron microscope that could be load thick specimen. Some researchers have taken this advantage of HVEM to explore 3-dimensional configuration of the biological structures including tissue and cells. Whole mount preparations has been employed to study some cell lines and primary culture cells. In this study, we would like to introduce useful whole mount preparation method for neuronal studies. The plastic coverslips were punched, covered by formvar membrane and coated with carbon. The neurons obtained embryonic 18 rat hippocampus were seeded on the prepared cover slip. The coverslips were fixed, dried in freeze drier and kept in a descicator until HVEM observation. We could observe detailed neuronal structures such as soma, dendrite and spine under HVEM without conventional thin section and heavy metal stain. The anaglyphic image based on stereo paired image ($-8^{\circ},+8^{\circ}$) provides three dimensional perception of the neuronal dendrites and their spines. This method could be applied to sophisticated analysis of dendritic spine under the various experimental conditions.

A study on correlation between frictional coefficients and subjective evaluation while rubbing cosmetic product on skin (화장품을 바를 때 피부 마찰계수의 변화와 주관적인 평가와의 상관관계 연구)

  • Kwon Young-Ha;Kwon Hyun-Joon;Rang Moon-Jeong;Lee Su-Min
    • Science of Emotion and Sensibility
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    • v.8 no.4
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    • pp.385-391
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    • 2005
  • A frictional coefficients of in-vivo skin characteristic is the most important factor of the cutaneous mechanical properties ant the method of evaluating skin care in the fields of cosmetics products. In-vivo skin characteristic varies in many different ways depends on what is applied to the skin, loading condition, shape, surface roughness, and material of the probe. In this research, we designed a system which can be measured frictional coefficients of a human skin on real time. It consists of multi-components load-cell, actuator, linear motor and arm fixator. This measurement system was automatically controlled by computer. We measured frictional coefficients between probe an4 skin using this system ant inquired adjectives for subjective evaluation while rubbing cosmetic product on skin. Lastly, we analyzed correlation between two factors by calculating Pearson Correlation Coefficient. As a result, we could know that frictional coefficients varied from 0.17-1.2 according to cosmetic products, normal forte, materials and surface conditions of probe. We also confirmed sensual feelings of cosmetic products have close correlation with frictional coefficients.

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