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http://dx.doi.org/10.3795/KSME-A.2016.40.10.851

Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle  

Kim, Jonghun (Dept. of Mechanical Engineering, Inha Univ.)
Park, Sungmin (Dept. of Mechanical Engineering, Inha Univ.)
Nam, Gyungmok (Dept. of Mechanical Engineering, Inha Univ.)
Yoon, Sang-Hee (Dept. of Mechanical Engineering, Inha Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers A / v.40, no.10, 2016 , pp. 851-856 More about this Journal
Abstract
Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.
Keywords
Skin Tissue; Microneedle; Insertion; Prestrain; Puncture Force;
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