• Nuclear Medicine and Molecular Imaging
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• 제40권3호
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• pp.188-189
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• 2006

A 53-year -old man underwent $^{18}F$-FDG whole body PET/CT because of the detected liver mass on abdominal CT. The PET/CT showed a huge liver mass ($9{\times}9cm$, SUV: 12.12 ) in the right lobe and a focally hypermetabolic lesion in the right lower quadrant of abdomen (SUV: 9.12). At first, we suspected that the focal hypermetabolic lesion in RLQ was the physiologic uptake of ureter or a metastatic lesion of small bowel. We repeated the abdominal PET/CT next day. The focally hypermetabolic lesion was identified as the appendiceal mass. He underwent right hemicolectomy and right lobectomy of the liver. It was confirmed that the lesion was appendiceal adenocarcinoma with liver metastasis. Cancer of the appendix is an uncommon disease that is rarely suspected before surgery. But, we suggest that PET/CT is useful to identify the small lesion like appendiceal malignant mass.

• 대한수의학회지
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• 제16권1호
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• pp.35-44
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• 1976

The livers of 300 cases of Korean native cattle which were collected at slaughted house in Pusan were examined by gross and histopathological means to study patterns of pathological changes of the organ. 1. The most dominated lesion of the liver was those of fascioliasis showing incidence rate as 907 per cent of inspected cattle. 2. On age distribution of the fascioliasis lesion in the liver, higher incidence was seen in animals that were from 6 to 9 years of age. 3. Significant changes of the hepaticparenchyma caused by immature flukes included thrombosis, migrational tracks such as hemorrhagic foci with massive eosinophilia and hepatic necrosis. The changes of chronically infected livers of cattle were recognized as proliferation of periductal eosinophilic granuloma of various degrees in each portal triad. And this easential cholangiohepatitis might develop into multiple focal cirrhosis or diffuse perilobular cirrhosis. 4. Most cases with gross lesion of swelled bile ducts on visceral surface of the liver showed histological evidences of fascioliasis lesion throughout hepatic lobes.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2022년도 제66차 하계학술대회논문집 30권2호
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• pp.343-344
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• 2022

간암에는 크게 두 종류가 있는데 하나는 간에서 생긴 종양이 악성종양으로 진행된 것이고 다른 하나는 다른 장기에서 생긴 암이 간으로 전이되는 것이다. 본 논문에서는 간에서 생긴 종양이 악성종양으로 진행되는 것을 조기 발견하고 막고자 Object Detect 모델인 YOLO v5의 다섯 가지 모델을 비교하여 악성 종양으로의 발전 가능성이 있는 간의 lesion을 찾아보았다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.271-272
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• 1998

Contrast-enhanced CT has an important role in the assessment of liver lesions. However, the optimal protocol to get most effective result is not clear. The main principle for deciding injection protocol is to optimize lesion detectability by rapid scanning when lesion-to-liver contrast is maximum. For this purpose, we developed a physiological model of contrast medium enhancement based on the compartment modeling and pharmacokinetics. Blood supply to liver was modeled in two paths. This dual supply character distinguishes the CT enhancement of liver from that of the other organs. The first path is by hepatic artery and the second is by portal vein. It is assumed that only hepatic artery can supply blood to hepatocellular carcinoma (HCC) compartment. It is known that this causes the difference of contrast enhancement between normal liver tissue and hepatic tumor. By solving differential equations for each compartment simultaneously using computer program Matlab, CT contrast-enhancement curves were simulated. Simulated enhancement curves for aortic, hepatic, portal vein, and HCC compartments were compared with mean enhancement curves from 24 patients exposed to the same protocols as simulation. These enhancement curves were in a good agreement. Furthermore, we simulated lesion-to-liver curves for various injection protocols, and analyzed the effects. These may help to optimize the scanning protocols for good diagnosis.

• Korean Journal of Radiology
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• 제22권6호
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• pp.912-921
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• 2021

Objective: To compare the performance of the deep learning-based lesion detection algorithm (DLLD) in detecting liver metastasis with that of radiologists. Materials and Methods: This clinical retrospective study used 4386-slice computed tomography (CT) images and labels from a training cohort (502 patients with colorectal cancer [CRC] from November 2005 to December 2010) to train the DLLD for detecting liver metastasis, and used CT images of a validation cohort (40 patients with 99 liver metastatic lesions and 45 patients without liver metastasis from January 2011 to December 2011) for comparing the performance of the DLLD with that of readers (three abdominal radiologists and three radiology residents). For per-lesion binary classification, the sensitivity and false positives per patient were measured. Results: A total of 85 patients with CRC were included in the validation cohort. In the comparison based on per-lesion binary classification, the sensitivity of DLLD (81.82%, [81/99]) was comparable to that of abdominal radiologists (80.81%, p = 0.80) and radiology residents (79.46%, p = 0.57). However, the false positives per patient with DLLD (1.330) was higher than that of abdominal radiologists (0.357, p < 0.001) and radiology residents (0.667, p < 0.001). Conclusion: DLLD showed a sensitivity comparable to that of radiologists when detecting liver metastasis in patients initially diagnosed with CRC. However, the false positives of DLLD were higher than those of radiologists. Therefore, DLLD could serve as an assistant tool for detecting liver metastasis instead of a standalone diagnostic tool.

• Journal of the Korean Physical Society
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• 제73권9호
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• pp.1289-1294
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• 2018

The present study aims to investigate experimentally and theoretically thermal ablation in soft tissues by using high intensity focused ultrasound (HIFU) to assess tissue damage during HIFU thermotherapy. The HIFU field was calculated by solving the axisymmetric Khokhlov-Zabolotskaya-Kuznetsov equation from the frequency-domain perspective. The temperature field was calculated by solving Pennes' bioheat transfer equation, and the thermal dose required to create a thermal lesion was calculated by using the thermal dose formula based on the thermal dose of a 240-min exposure at $43^{\circ}C$. In order to validate the simulation results, we performed thermal ablation experiments in a tissue-mimicking phantom and ex-vivo porcine liver for two different HIFU source conditions by using a 1.1-MHz, single-element, spherically focused HIFU transducer. The small difference between the measured and the predicted lesion sizes suggests that the implementation of the numerical model used here should be modified to iteratively allow for temperature-dependent changes in the physical properties of tissues.

• 한국임상수의학회지
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• 제16권2호
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• pp.321-327
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• 1999

This study was performed to examine the clinical, serological, ultrasonographic and pathological findings in dogs with acute liver disease induced by tetrachlorethylene at 4 times of anthelminthic oral dose. The results obtained through this experiment could be summarized as follows: 1. The dogs administered with tetrachlorethylene, revealed decreased body weight, and showed lethargy and depression. 2. In serological findings, bilirubin values slightly increased, AST and ALT was decreased at 1∼3 days, and after that time increased according to the lapse of days, and revealed the highest at 5 days, and decreased to normal values at 6 days. 3. In ultrasonographic findings, branches of the portal vein were increased, the echodensity of the liver parenchyma was decreased at early stage, and increased at mid stage, and decreased at last stage. 4. In histopathological findings, necrosis of parenchymal cell, and perivascular hemorrhage were observed more severely at 6 days, as compared with 3 days. There results suggest that ultrasonographic examination is considered to be a more simple, rapid, non-invasive and useful diagnostic method for acute liver parenchymal lesion.

• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.173-182
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• 1999

조영 증강제를 이용한 나선식 CT는 간 질환을 진단하는데 있어 중요한 역할을 하고있음에도 불구하고 진단의 효율을 최적화하는 프로토콜은 명확하게 알려져 있지 않다. 따라서 나선식 CT에서의 간암-간 대조 곡선을 모의 실험(simulation) 하여 다양한 요소들이 시간-조영 곡선에 어떻게 영향을 미치는지 파악하고, 또한 CT 검사 전에 모의 실험을 하여 이론적으로 최적의 스캔을 할 수 있도록 하기 위하여 약동학(pharmacokinetics)에 기초한 compartment model을 구성하였다. 간암, 간, 대동맥 및 간문맥 등을 각 구획(compartment)으로 설정하여 각 구획에서의 미분방정식을 얻은 후 적분하여 Hounsfield unfit 값을 조영제 주입 후 시간의 함수로 얻었으며 각 구획의 시간-조영 곡선을 출력하였다. 구현한 프로그램에서는 간암의 크기 및 종양 혈관의 분포 등과 같은 간암의 성질, 간경화의 정도에 따른 간 혈관 공급의 양상 및 조영제의 부피, 농도, 주입 속도 등의 조영제 주입 방법, 환자의 몸무게, 키 등의 환자의 신체 계수, 그리고 심박출량 등의 환자의 혈역학적 계수 등을 입력 받아 간암을 비롯한 각 구획의 시간-조영 곡선 및 간-간암 대조 곡선을 출력할 수 있도록 하였다. 모델링을 통해 얻은 조영 증강 곡선은 같은 환경하에서 얻은 24명의 환자 데이터와 비교하여 유사한 결과를 얻을 수 있었으며, 조영 증강제 주입 방법의 변화가 간암-간 대조 곡선에 미치는 영향을 비교할 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제16권2호
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• pp.173-176
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• 2012

본 저자들은 우측 부신에서 발생한 갈색세포종과 인접한 간에서 보이는 국소적인 조영 증강의 영상의학적 소견을 보고하고자 한다. 전산화단층촬영과 자기공명영상의 동맥기 영상에서 인접한 간조직에 국소적인 강한 조영증강이 보였다. 그러나 지연기 영상에서 병변은 정상 간조직과 동일한 감쇄를 보여 잘 구분되지 않았다. 또한 병변은 자기공명 T1, T2 강조 영상에서도 비정상적인 신호강도를 보이지 않았으며 정상 조직과 구분되어 보이지 않았다. 이 조영증강되는 간의 병소는 부신절제술을 시행한지 수개월 후 다시 시행한 수술 후 전산화 단층촬영에서는 저절로 소실되어 보이지 않았다.

• Korean Journal of Radiology
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• 제1권4호
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• pp.185-190
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• 2000

Objective: To document the imaging findings of hepatic cavernous hemangioma detected in cirrhotic liver. Materials and Methods: The imaging findings of 14 hepatic cavernous hemangiomas in ten patients with liver cirrhosis were retrospectively analyzed. A diagnosis of hepatic cavernous hemangioma was based on the findings of two or more of the following imaging studies: MR, including contrast-enhanced dynamic imaging (n = 10), dynamic CT (n = 4), hepatic arteriography (n = 9), and US (n = 10). Results: The mean size of the 14 hepatic hemangiomas was 0.9 (range, 0.5-1.5) cm in the longest dimension. In 11 of these (79%), contrast-enhanced dynamic CT and MR imaging showed rapid contrast enhancement of the entire lesion during the early phase, and hepatic arteriography revealed globular enhancement and rapid filling-in. On contrast-enhanced MR images, three lesions (21%) showed partial enhancement until the 5-min delayed phases. US indicated that while three slowly enhancing lesions were homogeneously hyperechoic, 9 (82%) of 11 showing rapid enhancement were not delineated. Conclusion: The majority of hepatic cavernous hemangiomas detected in cirrhotic liver are small in size, and in many, hepatic arteriography and/or contrast-enhanced dynamic CT and MR imaging demonstrates rapid enhancement. US, however, fails to distinguish a lesion of this kind from its cirrhotic background.