• 공업화학
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• 제24권2호
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• pp.132-137
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• 2013

포스파티딜콜린이 다량 함유된 수첨레시틴을 이용한 실험에서 액정구조가 잘 형성됨을 알 수 있었다. 액정구조를 형성하는 물질로는 포스포리피드, 에탄올, 물로 이루어짐을 알 수 있었고 로즈마린산을 지표물질로 캡슐화하였다. 액정의 평균입자크기는 480 nm ~ $3{\mu}m$로 이는 액의 구성물질과 물리적인 힘에 따라 다양한 크기의 형태로 존재하였다. 리포좀과 비교했을 때 액정구조는 매우 높은 캡슐화 효율을 보였다. 수첨레시틴의 함량이 증가하면 많은 액정을 형성하였고, 수첨레시틴의 함량이 적으면 액정의 양도 적게 나타났다. 로즈마린산을 함유한 액정구조의 방출실험결과 리포좀으로 형성된 베지클보다 훨씬 적은 양이 방출됨을 알 수 있었다.

• 한국응용과학기술학회지
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• 제25권2호
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• pp.205-210
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• 2008

The transformation of the liquid crystal complex made by binding of anionic surfactant, sodium dodecyl sulfate (SDS), into high charge density cationic polymer, the homopolymer of diallyldimethylammonium chloride (PDADMAC) was induced by adding of nonionic surfactants and investigated by means of microscopy and FE.SEM. Among nonionic surfactants in this experiments polyethylene glycol (3 mol) ether of lauryl alcohol (laureth-3) made variation in the complex. The laureth-3 transformed the complex into spherulite vesicle with the size of ca.$100{\mu}m$. This change increased the viscosity and the turbidity of the solution phase separated originally. Microscope showed that they are spherulite particles and polarized microscope suggested they are multi.lamellar liquid crystals. FE-SEM also proved that explicitly.

• 대한화장품학회지
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• 제24권3호
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• pp.116-122
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• 1998

It is well known that all-trans-retinol is not only very unstable in heat, light, air, and water, but also skin-irritant despite a good anti-wrinkle effect. Therefore, it is very difficult to stabilize retinol and make the safe retinol containing cosmetics by using a certain concentration of retinol with real effect. In order to dissolve these problems and apply retinol for skin care cream, firstly retinol is to be encapsulated in the vesicle called Liposphere (pseudo-liposome) which is made by homogenizing under high pressure the mixtures of lecithin, retinol, caprylic/capric triglyceride, and hydroalcoholic solution ; and then this retinol containing Liposphere is to be intercalated in lamellar liquid crystal layer which is prepared by emulsifying in an optimal ratio the mixtures composed of non-ionic emulsifier (cetearyl glucoside, sorbitan stearate & sucrose cocoate etc), cetearyl alcohol, stearic acid, cholesterol, and ceramide. In addition, the stability of the retinol containing oil in water cream by adding the polymeric emulsifier such as acrylate /C10-30 alkyl alkylate crosspolymer is to be ensured even at 55 C. Retinol containing oil in water cream prepared through above procedure could be very stable at 45 C for at least 50 days. The structure identification of lamellar liquid crystal was determined using polarized light microscope and electron microscope Conclusively, we could make the very stable retinol containing oil in water cream by triple procedure, that is, encapsulation of retinol in Liposphere, intercalation of retinol in lamellar liquid crystal layer, and assurance of the high temperature stability of cream even at 55 C.

• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.279-285
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• 1999

Retinoids in anti-wrinkle cosmetics are widely used for the treatment of the photoaging skin these days, but very unstable in the presence of water. Multilamellar liquid crystal vesicles consisted of $poly(oxyethylene)_{15}oleyl$ ether $(POE_{15}OE)$ or $poly(oxyethylene)_{15}stearyl$ ether $(POE_{15}SE)$, cetostearyl alcohol (CSA) and cholesterol or oils were prepared to increase the stability of retinyl acetate or retinyl palmitate. $POE_{15}SE-CSA-Water$ systems were more unstable than $POE_{15}SE-CSA-Water$ systems due to the bended structure of oleyl groups. For the modification of vesicles, cholesterol was added. The enthalpy values were decreased reaching to zero and the water permeability of systems was decreased, but the stabilizaton of retinyl acetate was not greatly improved. The stability of retinyl acetate may depend on its location in the structure. Various oils were added for further stabilization and isopropyl myristate was most effective. In practice, retinyl palmitate showed better stability in the same vesicle than retinyl acetate, and the improved vesicles could be used for the anti-wrinkle cosmetics

• 한국응용과학기술학회지
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• 제30권2호
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• pp.280-289
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• 2013

피부 노화를 방지하고 지속적으로 보습을 유지하기 위해 다양한 베시클들이 연구되고 있다. 최근에 활성물질의 흡수, 투과 및 보습의 유지와 관련하여 리포좀, 액정 및 다중층 라멜라 에멀젼 같은 많은 제조 방법들이 소개되고 있다. 본 연구에서는 인지질과 유사한 cetearyl alcohol/ceteth-20 phosphate/dicetyl phosphate 계면활성제를 이용하여 전단세기 및 pH 변화에 따른 다중층 라멜라 베시클을 개발하였으며 편광현미경을 통해 확인하였다. 결과로서 낮은 전단세기 및 pH에서는 라멜라 베시클 입자의 형태가 불균일하게 형성됨을 확인하였다. $42^{\circ}C$에서 2개월 간의 라멜라 베시클 내의 레티놀 함량의 변화를 측정한 결과 낮은 pH에서 레티놀의 함량이 감소하였다. 또한, 이 라멜라 베시클은 일반 O/W 에멀젼에 비해 피부 수분손실량이 14% 감소됨을 확인하였으며, O/W 썬 크림과 내수성 in vitro SPF를 측정하여 비교한 결과 UVB와 UVA 영역 모두에서 자외선을 잘 차단하여 유사한 내수성을 보이고 있음을 확인하였다.

• 한국응용과학기술학회지
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• 제19권1호
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• pp.10-18
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• 2002

In this study, it should be mentioned that Lipid-LCG can be prepared with the main compound of hydrogenated lecithin in oil-in water emulsion. The results of its physical property and stability are as follows. First, the best suitable compositions of Lipid-LCG are made from 4.0wt% of the hydrogenated lecithin, 4.0wt% of cetostearyl alcohol as emulsifier and gelling agent, 3.0wt% of butylene glycol and 2.0wt% glycerin as moisturizers, 3.0wt% of cyclomethicone, 3.0wt% of isononyl-isononanoate, 3.0wt% of capric/caprylic triglycerides, 3.0wt% of macadamia oil as emollients. Second, As the optimum conditions to form Lipid-LCG, which figured out 6.0 ${\pm}$ 1.0 for pH level, 32kg/mm, min for hardness to make a .essence to be formed the ternary phase of liquid crystal(multi-lamellar type). Third, as the analytical result of this system, it obtained that particle size is $1{\sim}8{\mu}m$ level, and is certified with it at 400 and 1,000 magnifications by microscope. The stability of Lipid-LCG is very stable on condition of a low temperature ($4^{\circ}C$), a room temperature ($25^{\circ}C$) and a high temperature ($40^{\circ}C$), which is not to be split in for a long time(for 3-month). We produced our own moisturizing essence, which has a good affinity to skin by means of this system.