• 한국재난정보학회 논문집
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• 제15권1호
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• pp.121-132
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• 2019

연구목적:알바알토의 건축적 사고에서 가장 우선시되는 사람과 자연에 대한 해석 및 지역의 전통적 측면을 고려하여 근대의 사회적 특성과 시대변화가 빛, 형태, 재료 측면에서 건축공간에 어떻게 반영되는지 분석하고자 한다. 연구방법: 근대의 북구건축 및 핀란드건축의 특성을 파악하고 모더니즘의 관점에서 알바알토의 건축 어휘를 종합하여 빛, 형태, 재료를 삼각 구도로 잡고 이들의 상호관계를 문헌자료 및 도면을 통해 분석한다. 연구결과:알바알토의 건축작품은 빛, 형태, 재료, 공간의 다양함을 조합한 것이 중심을 이룬다. 사회적인 지각이 강조되고 휴먼스케일과 건물 환경이 연결된다. 건축의 기능에 따라 새로운 적용방식으로 이들 요소는 재창조된다. 결론: 알바알토의 건축은 전통과 모더니즘 사이에서 자연과 문화, 사회와 개인, 표준화와 다양성, 보편성과 지역성, 지적인 것과 감성적인 것, 과학기술과 인간심리적인 것, 합리성과 직관적인 것 등 서로 이질적이면서 상반된 요소들을 건축공간에 종합적으로 적용시키고 사회적 변화를 수용하여 건축적 언어의 네트워크를 통해 재통합하는 특성을 갖는다.

• 한국임상수의학회지
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• 제22권3호
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• pp.175-180
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• 2005

본 연구는 개에서 키토산 비드를 이용한 cefadroxil 방출에 영향을 주는 인자, 약물을 함유한 최적의 키토산 비드의 제조, 그리고 키토산 비드로부터 약물의 방출을 평가하는 것이다. 키토산 비드는 tripolyphosphate (TPP)와 이온결합으로 생성되며 비드의 크기는 1 mm 미만이었다. 비드로부터 cefadroxil 방출은 여러 인자에 영항을 받는다. TPP의 pH가 감소할수록 cefadroxil의 비드내 함유량은 증가하지만, 비드로부터 방출량은 감소한다. Cefadroxil의 방출속도은 TPP 농도가 증가할수록 감소한다. 결합시간이 길어지면, 방출량이 감소한다. Cefadroxil을 함유한 키토산 비드를 50 mg/kg 용량으로 건강한 개 4두의 피하에 이식한 결과, cefadroxil의 혈청내 농도는 1 ${\mu}g/ml$ 이상으로 7일간 유지되었다. 따라서 cefadroxil을 함유한 키토산 비드는 개의 농피증 치료에 유용한 것으로 사료되며 약물방출을 통제할 수 있는 약물수송체가 이용될 수 있다고 사료된다.

• Macromolecular Research
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• 제8권1호
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• pp.12-18
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• 2000

Six aromatic polyesters with ether-linkages were prepared from 4,4'-oxybis(benzoic acid) and naphthalenediol (ND) isomers which were 1,4-, 1,5-, 1,6-, 2,3-, 2,6- and 2,7-derivatives. The solution viscosity numbers ranged from 0.23 to 0.65 dL/g. The glass transition temperatures ranged from 142 to 179$\^{C}$. The initial decomposition temperatures were all above 400$\^{C}$, and the residue weights at 600$\^{C}$ were in the range of 50-64%. Only the polyesters derived from 1,5- and 2,6-NDs, which have a linear linking mode, were found to be semicrystalline and could form thermotropically nematic phase. Multiple melting phenomena and annealing of the polyester derived from 1,5-ND and related polymers are described. The experimental results show that the polyester derived from 1,4-ND of linear shape was amorphous and non-liquid crystalline. Particularly, the polyester derived from 2,3-ND could form a smectic mesophase as banana-shaped molecules, and this is ascribed to the C/sub_2v/ symmetry where highly kinked molecules are packed in the same direction.

• 한국실내디자인학회논문집
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• 제21호
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• pp.3-9
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• 1999

Contemporary society that is apt to be homogeneity because of the development of computer communication and mass-media desires to seek its own identity in native realm. Contemporary Korean architecture has endeavored continuous discussion and practice to keep its identity within the current tendency. The purpose of this study is to grope the alternative for genuine 'Koreaness' to analyse the variant trend of its characteristics 1990's. The variation of Korean society in 1990's that emphasize self-regulation and individual value has influence on the realm of architecture so much. The cognition of 'Koreaness' has changed with center in the individual and small -size design group, not present accommodation of past, but continuous research to find archetype of tradition which can play a decisive role of linking present and future on the foundation of past. Many attempts and practical works that express 'Koreaness' in 1990's are performed in the area of residence works that reflect Korean emotion and life-style directly. This change can be an answer to solve the problem of peculiarity and universality in 'Koreaness'. After 1960's the main theme of 'Koreaness' was traditional architecture form, but because of the induction of Postmodernism and at once its reflection and critical attitude with limit of formal duplication, which lost its meaning. In 1990's, research for spatial form as korean emotion and image has carried out and played an important part of original expression for 'Koreaness'

• 한국실내디자인학회논문집
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• 제18권2호
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• pp.61-70
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• 2009

Architectural color would be understood as a essential tool to be reflected the architect's value criteria, thinking process and the specific methodology. This study was established the characteristics of color use correlated with Eisenman's architectural features based on his point of view. At first, it could be organized with data and use the color in view points with the becomming process. Especially it would be expressed the color as a trace of unsynchronized formation. Second, it was introduced the color by graphics engaged with form, to be expressed the dividing, folding, reiteration for deliver of escape from graphic thinking process. Third, it was analyzed to be imported the color to have a multi-lateral space experience in center of user's space recognition and behavior by introduction of color. Finally, it could be inducted the consistent color by viewpoint of interfacial between interior and exterior environment, communicated with strong meaning by conversion from interior elements to color from these processes. A characteristics of Eisenman's architecture color is reflected his thinking process in architecture color as it is and can be understand of 'becomming process use of color' as a tool that is corresponded in form creation. Specially, it would be kept continuous viewpoint of interior and exterior space, giving user color as a viewpoint of linking space, enable many-sidedness experiences through space.

• The Korean Journal of Physiology and Pharmacology
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• 제18권1호
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• pp.1-14
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• 2014

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with their normal functions by disrupting molecular conformation, altering enzymatic activity, and interfering with receptor functioning. AGEs form intra- and extracellular cross linking not only with proteins, but with some other endogenous key molecules including lipids and nucleic acids to contribute in the development of diabetic complications. Recent studies suggest that AGEs interact with plasma membrane localized receptors for AGEs (RAGE) to alter intracellular signaling, gene expression, release of pro-inflammatory molecules and free radicals. The present review discusses the glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs. Furthermore, the role of AGEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is also discussed.

• BMB Reports
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• 제43권3호
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• pp.182-187
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• 2010

family (CMTM) is a novel family of proteins linking classical chemokines and the transmembrane 4 superfamily (TM4SF). Our earlier studies indicated several CMTM members (such as CKLF1 and CMTM2) have a secreted form. This is the first report of the secreted form of CMTM5-v1, the major RNA splicing form of CMTM5, which is produced as small vesicles (<100 nm diameter) and floats at a peak density of 1.19 g/ml on continuous sucrose gradients. CMTM5-v1 has no obvious co-localization with CD63 or Golgi complex. In addition, brefeldin A but not wortmannin can inhibit the secretion of CMTM5-v1. Our results suggest that CMTM5-v1 might be secreted via a different vesicle-mediated secretory pathway, which will be helpful for the studies of vesicle-mediated secretion and MARVEL domain-containing proteins.

• Korea-Australia Rheology Journal
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• 제15권4호
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• pp.179-185
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• 2003

Associating polymers act as flocculants in colloidal suspensions, because the hydrophobic groups (hydrophobes) can adsorb onto particle surfaces and create intermolecular cross-linking. The steady-shear viscosity and dynamic viscoelasticity were measured for suspensions flocculated by multichain bridging of associating polymers. The effects of surfactant on the suspension rheology are studied in relation to the bridging conformation. The surfactant molecule behaves as a displacer and the polymer chains are forced to desorb from the particle surfaces. The overall effect of surfactant is the reduction of suspension viscosity. However, the additions of a small amount of surfactant to suspensions, in which the degree of bridging is low, cause a viscosity increase, although the number of chains forming one bridge is decreased by the forced desorption of associating polymer. Since the polymer chains desorbed from one bridge can form another bridge between bare particles, the bridging density over the system is increased. Therefore, the surfactant adsorption leads to a viscosity increase. The surfactant influences the viscosity in two opposing ways depending on the degree of bridging.

• 한국해안해양공학회지
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• 제5권4호
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• pp.369-383
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• 1993

잉여응력의 수정된 형태가 현 모델에서 제시되며 자유수면 이류항의 존재가 파랑에너지식과의 비교를 통해서 입증되었다. 수식모델은 편평한 해빈경사에서의 3차원적인 흐름의 순환패턴을 산출하며 그 결과는 실험치와 비교하여 좋은 일치를 보였다. 마지막으로 수심적분된 특성과 그 수직분포를 연계하여 전 연안역에 적용가능한 준3차원적 모델이 개발되었다.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.296-296
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• 2006

Highly temperature stable mesoporous materials have excellent properties and potential applications. Here we show a novel poly(vinyl)silazane-block-polystyrene diblock copolymer, which was synthesized by controlled/living free radical polymerization with reversible addition fragmentation chain transfer (RAFT) route. The obtained diblock copolymer occurs the phaseseparation on the nanoscale to form ordered nanostructure, which is converted to mesoprorous ceramic after heating at 800oC. This route demonstrates the preparation of highly temperature stable mesoporous silicon carbon nitrides (SiCN) ceramic film directed from highly cross-linking poly(vinyl)silazane blocks with high ceramic yield, which is different from previous pathway.