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Controlled Release of Cefadroxil from Chitosan Beads in Dogs  

Kim Dae-Keun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Park Seung-Chun (Department of Veterinary Pharmacology, College of Veterinary Medicine, Kyungpook National University)
Kim Tae-Wan (Department of Veterinary Physiology, College of Veterinary Medicine, Kyungpook National University)
Lee Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Oh Tae-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.3, 2005 , pp. 175-180 More about this Journal
Abstract
The purpose of this study is to investigate the effects of formulation variables on the release of cefadroxil form chitosan beads, to optimize the preparation of chitosan beads loaded with the drug for controlled release, and to evaluate the drug release form chitosan beads in dogs. Chitosan beads were prepared with tripolyphosphate (TPP) by ionic cross-linking and those sizes were less than 1 mm in diameter. The release behaviour of cefadroxil was affected various factors. As pH of TPP solutions decreased, the entrapment efficiency of cefadroxil increased, whereas the release of cefadroxil decreased. The release rate of cefadroxil form chitosan beads decreaed with the increased TPP solution concentration. When cross-linking time increased, the release of the drug from chitosan beads decreased. The cefadroxil loaded beads were implanted to 4 mixed breed dogs. The concentration of cefadroxil in sera due to chitosan beads implanted with 50 mg/kg body weight of beads was sustained more than 1 ug/ml for the whole 7 days period. Therefore, the cefadroxil loaded beads can be used successfully in pyoderma of dogs. These results indicate that chitosan beads may become a potential delivery system to control the release of drug.
Keywords
chitosan; cefadroxil; dog;
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