• 한국전자파학회논문지
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• 제18권2호
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• pp.136-142
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• 2007

휴대폰 몸체 전류 변화를 이용하여 PIFA의 방사 패턴을 변화시키고, 휴대폰용 모노폴 안테나의 대역폭을 증가시키는 방법을 소개한다. 방사 패턴 변화를 위하여 후엽을 억제하는 변형된 접지면 구조를 제안하였으며, 그 결과 변형하기 전보다 0.5 dB의 이득 향상을 가져왔다. 대역폭 증가를 위하여 모노폴 안테나에 두 개의 공진 주파수를 형성시키도록 평행한 두 개의 기생 도체선을 추가하는 방법을 제안하였다. 대역폭은 341 MHz로 기존의 모노폴 안테나 구조보다 2배 이상 향상되었다.

• Biomolecules & Therapeutics
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• 제23권4호
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• pp.320-326
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• 2015

The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK pathway, Spry2, in acquired resistance using BRAF inhibitor-resistant derivatives of the BRAF-V600E melanoma (A375P/Mdr). Real-time RT-PCR analysis indicated that the expression of Spry2 was higher in A375P cells harboring the BRAF V600E mutation compared with wild-type BRAF-bearing cells (SK-MEL-2) that are resistant to BRAF inhibitors. This result suggests the ability of BRAF V600E to evade feedback suppression in cell lines with BRAF V600E mutations despite high Spry2 expression. Most interestingly, Spry2 exhibited strongly reduced expression in A375P/Mdr cells with acquired resistance to BRAF inhibitors. Furthermore, the overexpression of Spry2 partially restored sensitivity to the BRAF inhibitor PLX4720 in two BRAF inhibitor-resistant cells, indicating a positive role for Spry2 in the growth inhibition induced by BRAF inhibitors. On the other hand, long-term treatment with PLX4720 induced pERK reactivation following BRAF inhibition in A375P cells, indicating that negative feedback including Spry2 may be bypassed in BRAF mutant melanoma cells. In addition, the siRNA-mediated knockdown of Raf-1 attenuated the rebound activation of ERK stimulated by PLX4720 in A375P cells, strongly suggesting the positive role of Raf-1 kinase in ERK activation in response to BRAF inhibition. Taken together, these data suggest that RAF signaling may be released from negative feedback inhibition through interacting with Spry2, leading to ERK rebound and, consequently, the induction of acquired resistance to BRAF inhibitors.

• 한국실내디자인학회논문집
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• 제14권5호
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• pp.98-105
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• 2005

Through advanced computer technology, our physical environment became a flexible and liquid space that is a multi-functional space structure, hetero-alliance, formless, interactivity. We attempt to interpretate Deleuze's Other geometry as a space designer. Hence first, the aim of this study is to define the meaning of the Other and Other geometry. Second, to extract keywords out of the Other geometry to analyze the work. Third, to analyze the work using the space formative languages(blob, blurring, distortion, folding, layering, lightness, nesting, repetition, shear, transparency, twisting, unfolding, warping, waving, and weaving). The 13 works were selected which have been issued after year 2000 with the focus on liquid space studies. The methods of this study are literature research and contents analysis. The results of the analysis were as follows. First, the source is the Other who is a hidden potentials in the surrounding environment, and this source has the capability of making it part of reality anytime. Other geometry means it is a theory that is comprised of various lines that with the kind of experiences that one has in life. Second, the key words that were extracted from the theory of Deleuze's Other geometry were of (1)hetero-alliance(reflected in a sculptured shape or a fluid abstract form), (2)dis-form(by speculating the user's movements, and combining space elements with external forces), (3)interactivity (information was exchanged real time between the user and his environment where the space took on a sensory institution). Finally, after studying the works using the space formative languages, we found that blob, warping, waving were used externally, and repetition, warping and waving for mostly used internally.

• 한국전산구조공학회논문집
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• 제30권2호
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• pp.153-158
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• 2017

본 논문에서는 재료 탄성계수의 공간적 불확실성을 고려한 위상최적화 문제를 다루었다. 88줄로 작성된 MATLAB Code를 사용하여 MBB(messerschmidt-$b{\ddot{o}}lkow$-blohm) model에 대해 5,000개의 추계장 표본을 작성하여 해석에 사용하였다. 재료탄성계수의 추계장 표본은 스펙트럼 모사법을 적용하여 작성하였고, 구조계영역 내에서 정규분포하는 것으로 가정하였다. 해석결과에 대한 통계처리를 통하여 형상최적화의 결과를 나타내는 체적률의 변화도를 추계장의 상관거리에 대하여 나타내었다. 최적형상의 변화도는 상관거리가 작을 경우 크게 산정되었고, 상관거리가 큰 경우에는 적은 값을 나타내었다. 큰 상관거리에서 변화도가 적은 것은 위상최적화가 선형해석에 따르기 때문이다. 따라서 위상최적화 시 구조재료 불확실성의 특성에 따른 고려가 필요한 것으로 사료된다.

• 한국엔터테인먼트산업학회논문지
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• 제14권1호
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• pp.107-116
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• 2020

홍콩영화<무쌍>은 위조지폐 제작과정, 스릴있는 총격전, 폭파장면을 기반으로 한 복잡한 스토리 전개와 예상 밖의 반전 결말, 그리고 월드스타 주윤발의 개성 등 다양한 요소로 영화 흥행에 성공시켰다. 영화의 전개과정에서, 감독은 사건의 전개자인 이문을 이용해 시각을 한정시켜 경찰과 관중을 속임수에 빠지도록 이끌었고, 배우 주윤발의 상징성을 통해 관객들에게 "화가"로서의 이미지를 부각시켰으며, 각기 다른 인물과 장소의 복합적인 서술과 플래시백을 도입함으로써 복선층의 전개구조로 진상을 층층이 밝혀내었다. 영화에서 3번의 대반전이 나타나는데, 반전 때마다 영화의 전개가 완전히 뒤집혔고, 또 뒤집힌 전개가 앞 스토리와 어떠한 관련이 있는지 관객이 알아채지 못하도록 하였다. 이 때문에 충만한 긴장감을 불러일으켜 관객들로 하여금 공감대를 형성하였고, 진실을 가려내는 심리게임 과정을 통해 완벽한 해방감과 해탈감을 느끼도록 하였다.

• 한국자기학회지
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• 제4권4호
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• pp.335-339
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• 1994

$Eu(Fe_{1-x}In_{x})O_{3}$ (x=0, 0.03과 0.05)의 결정구조와 자기적 성질을 상온에서의 X선 회절, $M\"{o}ssbauer$ 분광학 및 자기이력곡선 측정 방법에 의해서 연구하였다. X선 회절 분석 결과는 모든 시료가 orthorhombic 결정구조를 가지며, 단위포의 체적은 x=0을 제외하면 In 농도의 증가에 따라 증가함을 보인다. $M\"{o}ssbauer$ 스펙트럼은 두셋트 여섯 lines을 갖는다는 가정하에 분석하였다. 분석 결과는 각 셋트에서의 초미세 자기장은 x의 증가에 따라 감소하였다. 본 연구의 시료에서 공명 흡수선의 반폭이 x의 증 가에 따라 증가함은, 측정 data가 $Fe^{3+}$ 이온 주위 z개의 $In^{3+}$ 이온이 존재할 확률 분포, $_{n}P_{z}(x)$에 비례하는 초미세 구조에 의한 흡수선의 합으로 이루어졌음을 의미한다. 자기이력 곡선에서 $M_{s}$와 $H_{c}$는 각각 X의 증가에 따라 감소와 증가를 보인다.

• 가정과삶의질연구
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• 제29권5호
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• pp.1-17
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• 2011

This study aimed to analyze health promotion villages from the perspective of therapeutic architecture, and to provide basic information for planning relevant health facilities. On the basis of a review of previous literature, the characteristics of therapeutic architecture were classified into eight categories: safety, comfort, sociality, autonomy, openness, diversity, privacy, and natural environment. Field study and observation were performed in four health promotion villages that conduct programs for lifestyle improvement, physical fitness, and treatment; these villages were also considered to have a healthy residential environment. The researcher and three assistants visited the facilities and checked utilization of space through interviews with the staff and guided tours. Basic information about the subject facilities, such as the purpose of establishment, was gathered from websites before visits. Two of the villages examined in this study had a traditional Korean wooden structure, while the other two were reinforced concrete and masonry block structures. All the facilities emphasized the use of environmentally friendly material and harmony with nature. Each site was divided into the following areas: office, residence, health/treatment, public/rest, and outdoor. The safety standards of the healing architecture were not completely satisfactory at all facilities. In particular, it was found that they lacked adequate universal design equipment. However, the healing characteristics of autonomy and diversity were strong. With regard to autonomy, the facilities allowed visitors to select indoor-outdoor moving lines and the use of front- and backyards constructed on slopes. In addition, they were equipped with many entries, staircases, void, terraces, and crossroads. The architecture was aesthetically designed using feng shui symbolism, and visitors found the scenes depicted in various spaces in the villages to be stimulating. Besides, the facilities were constructed using natural materials, had a natural indoor environment, and provided a sense of spaciousness and flexibility.

• Journal of Microbiology and Biotechnology
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• 제26권3호
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• pp.452-460
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• 2016

Acid stress can affect the viability of probiotics, especially Bifidobacterium. This study aimed to improve the acid tolerance of Bifidobacterium longum BBMN68 using adaptive evolution. The stress response, and genomic differences of the parental strain and the variant strain were compared by acid stress. The highest acid-resistant mutant strain (BBMN68m) was isolated from more than 100 asexual lines, which were adaptive to the acid stress for 10^th, 20^th, 30^th, 40^th, and 50^th repeats, respectively. The variant strain showed a significant increase in acid tolerance under conditions of pH 2.5 for 2 h (from 7.92 to 4.44 log CFU/ml) compared with the wild-type strain (WT, from 7.87 to 0 log CFU/ml). The surface of the variant strain was also smoother. Comparative whole-genome analysis showed that the galactosyl transferase D gene (cpsD, bbmn68_1012), a key gene involved in exopolysaccharide (EPS) synthesis, was altered by two nucleotides in the mutant, causing alteration in amino acids, pI (from 8.94 to 9.19), and predicted protein structure. Meanwhile, cpsD expression and EPS production were also reduced in the variant strain (p < 0.05) compared with WT, and the exogenous WT-EPS in the variant strain reduced its acid-resistant ability. These results suggested EPS was related to acid responses of BBMN68.

• The Korean Journal of Physiology and Pharmacology
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• 제16권2호
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• pp.145-151
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• 2012

In the present work, we studied the structure-activity relationship (SAR) of tautomycetin (TMC) and its derivatives. Further, we demonstrated the correlation between the immunosuppressive fuction, anticancer activity and protein phosphatase type 1 (PP1) inhibition of TMC and its derivatives. We have prepared some TMC derivatives via combinatorial biosynthesis, isolation from fermentation broth or chemical degradation of TMC. We found that the immunosuppressive activity was correlated with anticancer activity for TMC and its analog compounds, indicating that TMC may home at the same targets for its immunosuppressive and anticancer activities. Interestingly, TMC-F1, TMC-D1 and TMC-D2 all retained significant, albeit reduced PP1 inhibitory activity compared to TMC. However, only TMC-D2 showed immunosuppressive and anticancer activities in studies carried out in cell lines. Moreover, TMC-Chain did not show any significant inhibitory activity towards PP1 but showed strong growth inhibitory effect. This observation implicates that the maleic anhydride moiety of TMC is critical for its phosphatase inhibitory activity whereas the C1-C18 moiety of TMC is essential for the inhibition of tumor cell proliferation. Furthermore, we measured $in$ $vivo$ phosphatase activities of PP1 in MCF-7 cell extracts treated with TMC and its related compounds, and the results indicate that the cytotoxicity of TMC doesn't correlate with its $in$ $vivo$ PP1 inhibition activity. Taken together, our study suggests that the immunosuppressive and anticancer activities of TMC are not due to the inhibition of PP1. Our results provide a novel insight for the elucidation of the underlying molecular mechanisms of TMC's important biological functions.

• 한국구조물진단유지관리공학회 논문집
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• 제21권2호
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• pp.60-68
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• 2017

본 연구에서는 지내력이 기초판에 미치는 영향을 충분히 고려할 수 있도록 현장여건과 동일한 옥외의 지반에서 실험할 수 있는 시스템을 구축하였으며, 대상 실험체는 경제성 및 시공성 향상을 위하여 강판을 "ㄷ"자형으로 절곡하여 단면 2차모멘트를 극대화 하고 현장조립이 가능하도록 제안 하였다. 대상 실험체는 무보강 실험체 1개, 강판 두께를 동일하게 하여 보강 길이를 달리한 실험체 3개, 강판 두께를 달리하고 위험단면 부근에 스티프너 보강한 실험체 2개 총 6개의 실험체를 대상으로 비교 검토 한다. 실험 결과 스티프너 보강에 의한 효과는 없는 것으로 나타났으며, 전단보강재의 보강길이는 확장된 위험단면에서 전단력을 지내력으로 나타낸 값과 위험단면에서 보강재가 받을 수 있는 전단내력을 지내력으로 환산여하여 두 선의 교차점을 유효보강 길이로 산정하는 강판두께별 유효보강길이 산정방법을 제안하였다.