• Communications for Statistical Applications and Methods
• /
• v.30 no.1
• /
• pp.65-73
• /
• 2023

Contemporary biomedical data often involve an ill-posed problem owing to small sample size and large number of multi-collinear variables. Partial least squares (PLS) method could be a plausible alternative to an ill-conditioned ordinary least squares. However, in the case of a PLS model that includes a random-effect, how to deal with a random-effect or mixed effects remains a widely open question worth further investigation. In the present study, we propose a modified multivariate PLS method implementing mixed-effect model (PLSM). The advantage of PLSM is its versatility in handling serial longitudinal data or its ability for taking a randomeffect into account. We conduct simulations to investigate statistical properties of PLSM, and showcase its real clinical application to predict treatment outcome of esthetic surgical procedures of human faces. The proposed PLSM seemed to be particularly beneficial 1) when random-effect is conspicuous; 2) the number of predictors is relatively large compared to the sample size; 3) the multicollinearity is weak or moderate; and/or 4) the random error is considerable.

• Environmental and Resource Economics Review
• /
• v.16 no.4
• /
• pp.803-832
• /
• 2007

Electricity and heat load profiles by use types on an hourly basis at the least are essential for assessing economic viability of new cogeneration and CES projects and for optimally operating existing cogeneration and CES facilities. We adopt a multilevel model to specify heat load profiles so as to utilize in a flexible manner the panel nature of our data on weather and heating/cooling use. Converting the multilevel model to the linear mixed-effects model, we estimate the model by panel FGLS. The estimated load profile model for each distinct use type accounts for the effects of temperature, humidity, each hour over the year, each day of the week, each type of legal holidays, and heating/cooling area on energy use. To save space, we feature in detail the heating profile of the household.

• The Korean Journal of Applied Statistics
• /
• v.27 no.6
• /
• pp.923-932
• /
• 2014

The Hurdle model can to analyze zero-inflated count data. This model is a mixed model of the logit model for a binary component and a truncated Poisson model of a truncated count component. We propose a new hurdle model with a general heterogeneous random effects covariance matrix to analyze longitudinal zero-inflated count data using modified Cholesky decomposition. This decomposition factors the random effects covariance matrix into generalized autoregressive parameters and innovation variance. The parameters are modeled using (generalized) linear models and estimated with a Bayesian method. We use these methods to carefully analyze a real dataset.

• Journal of Applied Reliability
• /
• v.18 no.1
• /
• pp.33-39
• /
• 2018

Purpose: Accelerated degradation tests can be effective in assessing product reliability when degradation leading to failure can be observed. This article proposes an accelerated degradation test model for highly reliable solid state drives (SSDs). Methods: We suggest a nonlinear mixed-effects (NLME) model to degradation data for SSDs. A Monte Carlo simulation is used to estimate lifetime distribution in accelerated degradation testing data. This simulation is performed by generating random samples from the assumed NLME model. Conclusion: We apply the proposed method to degradation data collected from SSDs. The derived power model is shown to be much better at fitting the degradation data than other existing models. Finally, the Monte Carlo simulation based on the NLME model provides reasonable results in lifetime estimation.

• Asian-Australasian Journal of Animal Sciences
• /
• v.13 no.12
• /
• pp.1691-1698
• /
• 2000

An in situ digestion trial (Experiment 1) and a lactation trial (Experiment 2) were conducted to determine the effects of replacing corn and wheat bran with soyhulls (SH) in lactating dairy cow diets on the extent and kinetics of digestion of DM and NDF, and lactation performance. In experiment 1, five mixed feeds consisting of mixed concentrate and roughages (50:50 on a DM basis) were formulated on isonitrogenous and isoenergetic bases to produce five levels (0, 25, 50, 75 and 100%) of SH replacement for corn and wheat bran. SH had high in situ digestion (92 and 89% for potentially digestible DM and NDF) and fairly fast digestion rate (7.2 and 6.3 %/h for DM and NDF). Increasing level of SH replacement resulted in increased NDF digestibility (linear, p=0.001-0.04) and similar DM digestibility (beyond 12 h incubation, p=0.10-0.41). As level of SH replacement increased, percentage of slowly digestible fraction (b) of DM increased (linear, p=0.03), percentage of rapidly digestible fraction (a) of DM tended to decrease (linear, p=0.14), and DM digestion lag time tended to be longer (linear, p=0.13). Percentage of potentially digestible fraction (a+b) and digestion rate (c) of slowly digestible fraction of dietary DM remained unaltered (p=0.36-0.90) with increasing SH in the diet. Increasing level of SH for replacing corn and wheat bran in the diet resulted in increases in percentages of b (quadratic, p<0.001), a (linear, p=0.08), a+b (quadratic, p=0.001) and a tendency to increase in c for NDF (linear, p<0.19). It was also observed that there was a satisfactory fit of a non-linear regression model to NDF digestion data ($R^2=0.986-0.998$), but a relatively poor fit of the model to DM digestion data ($R^2=0.915-0.968$). In experiment 2, 42 lactating Holstein cows were used in a randomized complete block design. SH replaced corn and wheat bran in mixed concentrates at 0, 25, and 50%, respectively. These mixed concentrates were mixed with roughages and fed ad libitum as complete diets. Replacing corn and wheat bran with SH at 0, 25 and 50% levels did not influence (p=0.56-0.95) DM intakes (18.4, 18.6, and 18.5 kg/d), milk yields (27.7, 28.4 and 27.6 kg/d), 4% fat-corrected-milk (FCM) yields (26.2, 27.6, and 27.3 kg/d) and percentages of milk protein (3.12, 3.17 and 3.18%), milk lactose (4.69, 4.76 and 4.68%) and SNF (8.50, 8.64, and 8.54%). On the other hand, milk fat percentges linearly increased (3.63, 3.85 and 3.90% for SH replacement rates of 0, 25 and 50% in the diet, p=0.08), while feed costs per kg FCM production were reduced.

• Journal of the Korean Data and Information Science Society
• /
• v.28 no.1
• /
• pp.1-10
• /
• 2017

Longitudinal data of Korean child academic achievement have been used to find the significant exploratory variables under the assumption of independent repeated measured data. Using the exploratory variables in previous research works, we analyze the linear mixed model incorporating the fixed and random effects for child academic achievement to detect the significant exploratory variables. Korea welfare panel study data observed three times between 2006 and 2012 by additional survey for children. The child academic achievement is evaluated by the sum of academic achievements of Korean, English and Mathematics. We also investigate the multicollinearity and the missing mechanism and select some popular correlation matrices to analyze the linear mixed model.

• Asian-Australasian Journal of Animal Sciences
• /
• v.13 no.3
• /
• pp.413-422
• /
• 2000

In the class of models which include random effects, the variance component estimates are important to obtain accurate predictors and estimators. Variance component estimation is straightforward for balanced data but not for unbalanced data. Since orthogonality among factors is absent in unbalanced data, various methods for variance component estimation are available. REML estimation is the most widely used method in animal breeding because of its attractive statistical properties. Recently, Bayesian approach became feasible through Markov Chain Monte Carlo methods with increasingly powerful computers. Furthermore, advances in variance component estimation with complicated models such as generalized linear mixed models enabled animal breeders to analyze non-normal data.

• Journal of the Korean Data and Information Science Society
• /
• v.25 no.4
• /
• pp.941-949
• /
• 2014

Unit level logistic regression model with mixed effects has been used for estimating small area proportions, which treats the spatial effects as random effects and assumes linearity between the logistic link and the covariates. However, when the functional form of the relationship between the logistic link and the covariates is not linear, it may lead to biased estimators of the small area proportions. In this paper, we relax the linearity assumption and propose two types of kernel-based logistic regression models for estimating small area proportions. We also demonstrate the efficiency of our propose models using simulated data and real data.

• Communications for Statistical Applications and Methods
• /
• v.12 no.3
• /
• pp.759-771
• /
• 2005

Twin studies are one of the most widely used methods for quantifying the influence of genetic and environmental factors on some traits such as a life span or a disease. In this paper we propose a genetic mixed linear model for twin survival time data, which allows us to separate the genetic component from the environmental component. Inferences are based upon the hierarchical likelihood (h-likelihood), which provides a statistically efficient and simple unified framework for various random-effect models. We also propose a simple and fast computation method for analyzing a large data set on twin survival study. The new method is illustrated to the survival data in Swedish Twin Registry. A simulation study is carried out to evaluate the performance.

• The Korean Journal of Applied Statistics
• /
• v.28 no.2
• /
• pp.201-210
• /
• 2015

Repeated measurements on each variables of interest often arise in bioscience or medical research. We need to account for correlations among repeated measurements to assess the correlation between two variables in the presence of replication. This paper reviews methods to estimate a correlation coefficient between two variables in repeated measurements using the variance-covariance matrix of linear mixed effect models. We analyze acoustic radiation force impulse imaging (ARFI) data to assess correlation between three shear wave velocity (SWV) measurements in liver or spleen and spleen length by ultrasonography. We present how to obtain parameter estimates for the variance-covariance matrix and correlations in mixed effects models using PROC MIXED in SAS.