• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.89.1-89.8
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• 2018

Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy. Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission. Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%-30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.

• 한국전기전자재료학회논문지
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• 제23권4호
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• pp.298-302
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• 2010

We investigated the resistance change behavior of SABiT (Samsung Advanced Bump interconnection Technology) technology-applied PCB (Printed Circuit Board) with the various bump sizes and fabrication conditions. Many testing samples with different bump size, prepreg thickness, number of print on the formation of Ag paste bump, were made. The resistance of Ag paste bump itself was calculated from the Ag paste resistivity and bump size, measured by using 4-point probe method and FE-SEM (Field Emission Scanning Electron Microscope), respectively. The contact resistance between Ag paste bump and conducting Cu line were obtained by subtracting the Cu line and bump resistances from the measured total resistance. It was found that the contact resistance drastically changed with the variation of Ag paste bump size and the contact resistance had the largest influence on total resistance. We found that the bump size and contact resistance obeyed the power law relationship. The resistance of a circuit in PCB can be estimated from this kind of relationship as the bump size and fabrication technique vary.

• Journal of Power Electronics
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• 제9권3호
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• pp.354-364
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• 2009

Rotor resistance variation due to changing rotor temperature is a significant issue in the design of induction motor controls. In this work, a new on-line rotor resistance estimator is proposed based on an alternate qd induction machine model which provides better mathematical representation of an induction machine than the classical qd model (which uses constant parameters). This is because the former simultaneously includes leakage saturation, magnetizing path saturation, and distributed circuit effects in the rotor conductors. The comparisons via computer simulation studies show the ability of the proposed estimator to accurately track rotor resistance variation. For the experimental studies, due to the difficulty in measuring the actual rotor resistance, comparison of the controller performance using the proposed estimator, the classical qd model based estimator, and no estimator is made.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1990년도 추계학술대회 논문집 학회본부
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• pp.184-187
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• 1990

This paper presents the self-matched line pulse generator and the concerned principles on its operation and characteristics are mentioned. The circuit consists of a charged transmission line and a high speed switch, and it generates a square wave pulse with the very fast rise time. The generated waveform depends on the load resistance. As the load resistance is infinite, a single rectangular wave pulse is generated and its efficiency is nearly unity.

• 한국잡초학회지
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• 제30권3호
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• pp.225-232
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• 2010

과산화계 제초제 oxyfluorfen이 처리된 비형질전환 벼와 형질전환 벼에서 Protox 발현 위치가 제초제 저항성에 미치는 영향을 비교하였다. Arabidopsis protoporphyrinogen oxidase(Protox; AP 계통)를 색소체에만 발현하는 형질전환 벼와 Myxococcus xanthus Protox 유전자를 색소체와 미토콘드리아에 모두 발현하는 형질전환 벼(TTS 계통)가 형질전환 시스템으로 사용되었다. Oxyfluorfen이 처리된 TTS4 계통은 AP 계통이나 비형질전환 벼에 비해 낮은 수준의 세포질 누출 및 malonyldialdehyde를 보여주었고, 높은 5-aminolevulinic acid 합성 능력을 유지하였다. Oxyfluorfen 작용 동안, TTS4 계통은 AP1 계통보다 높은 제초제 저항성을 보여주었는데, 이는 색소체만에서의 Arabidopsis Protox의 발현에 비해 색소체와 미토콘드리아에서의 M. xanthus Protox의 쌍발현이 광역학적인 protoporphyrin IX의 축적을 더 효율적으로 억제하였기 때문일 것이다. 이 결과들은 미토콘드리아 내 Protox의 발현이 Protox 저해형 제초제에 대한 식물의 저항성에 크게 기여함을 의미한다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 하계종합학술대회 논문집(2)
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• pp.266-269
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• 2000

As the device geometry continuously shrink down less than sub-quarter micrometer, DRAM makers are going to replace conventional tungsten-polycide with tungsten bit-line structure in order to reduce the chip size and use it as a local interconnection. In this paper we showed low resistance and leakage tungsten bit-line process with various RTP(Rapid Thermal Process) temperature. As a result we obtained that major parameters impact on tungsten bit-line process are RTP Anneal temperature and BF2 ion implantation dopant. These tungsten bit-line process are promising to fabricate high density chip technology.

• Journal of Information Processing Systems
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• 제16권2호
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• pp.394-405
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• 2020

The parameters of transmission lines have an influence on the electromagnetic environment surrounding the line. This paper proposes a method based on phasor measurement unit (PMU) and supervisory control and data acquisition (SCADA) to achieve online estimation of transmission line full parameters, such as resistance, reactance and susceptance. The proposed full parameter estimation method is compared with the traditional method of estimating resistance independently based on SCADA system. Then, the electromagnetic environment is analyzed based on the different parameter estimation methods. The example results illustrate that online estimation of transmission line full parameters is more accurate in the analysis of electromagnetic environment, which further confirms its necessity and significance in engineering application.

• 한국초전도ㆍ저온공학회논문지
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• 제1권1호
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• pp.28-32
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• 1999

We have performed an EMTDC simulation for the current limiting effects of a superconducting fault current limiter (SFCL). The fault currents in the 154 kV transmission line between the arbitrary S1 and S2 substations increased up to 54 KA and 60 KA during the line-to-line and three phase faults, respectively. The SFCL with 100$\omega$ of resistance after quench limited the currents to less than 17 KA within a half cycle. This limited current is well below the upper limit of a circuit breaker, suggesting that the resistance of the SFCL in the transmission line is sufficient.

• 한국가금학회지
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• 제42권1호
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• pp.27-32
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• 2015

In this study, we used two breeds of chicken to identify genomic regions corresponding to necrotic enteritis (NE) resistance. We scanned the genomes of a resistant and susceptible line of Fayoumi and White Leghorn chickens (20 birds/line) using a chicken 60 K Illumina SNP panel. A total of 235 loci with divergently fixed alleles were identified across the genome in both breeds; particularly, several clusters of multiple loci with fixed alleles were found in five narrow regions. Moreover, consensus 15-SNP haplotypes that were shared by the resistant lines of both breeds were identified on chromosomes 3, 7 and 9. Genes responsible for NE resistance were identified in chicken lines selected for resistance and susceptibility. Annotation of the regions spanning clustered divergently fixed regions revealed a set of interesting candidate genes such as phosphoinositide-3-kinase, regulatory subunit 5, p101 (PIK3R5) and inositol 1,4,5-trisphosphate receptor 1 (ITPR1), which participate in immune response. Consensus haplotypes were found in regions containing possibly relevant genes, such as myostatin and myosin, which play important roles in muscle development. Thus, genome scans of divergent selection in multiple chicken lines and breeds can be used to identify genomic regions associated with NE resistance.

• 설비공학논문집
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• 제19권7호
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• pp.512-520
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• 2007

The design of a ground-source heat pump system includes specifications for a ground loop heat exchanger where the heat transfer rate depends on the effective thermal conductivity of the ground and the effective thermal resistance of the borehole. To evaluate these heat transfer properties, in-situ thermal response tests on four vertical test boreholes with different grouting materials were conducted by adding a monitored amount of heat to circulating water. The line-source method is applied to the temperature rise in an in-situ test and extended to also give an estimate of borehole effective thermal resistance. The effect of increasing thermal conductivity of the grouting materials from 0.818 to $1.104W/m^{\circ}C$ resulted in overall increases in effective thermal conductivity by 15.8 to 56.3% and reductions in effective thermal resistance by 13.0 to 31.1%.