• Title/Summary/Keyword: life-span effect

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Lifetime Risk Assessment of Lung Cancer Incidence for Nonsmokers in Japan Considering the Joint Effect of Radiation and Smoking Based on the Life Span Study of Atomic Bomb Survivors

  • Shimada, Kazumasa;Kai, Michiaki
    • Journal of Radiation Protection and Research
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    • v.46 no.3
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    • pp.83-97
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    • 2021
  • Background: The lifetime risk of lung cancer incidence due to radiation for nonsmokers is overestimated because of the use of the average cancer baseline risk among a mixed population, including smokers. In recent years, the generalized multiplicative (GM)-excess relative risk (ERR) model has been developed in the life span study of atomic bomb survivors to consider the joint effect of radiation and smoking. Based on this background, this paper discusses the issues of radiation risk assessment considering smoking in two parts. Materials and Methods: In Part 1, we proposed a simple method of estimating the baseline risk for nonsmokers using current smoking data. We performed sensitivity analysis on baseline risk estimation to discuss the birth cohort effects. In Part 2, we applied the GM-ERR model for Japanese smokers to calculate lifetime attributable risk (LAR). We also performed a sensitivity analysis using other ERR models (e.g., simple additive (SA)-ERR model). Results and Discussion: In Part 1, the lifetime baseline risk from mixed population including smokers to nonsmokers decreased by 54% (44%-60%) for males and 24% (18%-29%) for females. In Part 2, comparison of LAR between SA- and GM-ERR models showed that if the radiation dose was ≤200 mGy or less, the difference between these ERR models was within the standard deviation of LAR due to the uncertainty of smoking information. Conclusion: The use of mixed population for baseline risk assessment overestimates the risk for lung cancer due to low-dose radiation exposure in Japanese males.

Optimal Preventive Maintenance Period in Complex Systems in Considering Components Reliability Characteristic (하부 구성품의 신뢰도 특성을 고려한 복합 시스템의 최적 예방정비 주기 산출)

  • Lee, Youn-Ho;Lee, Ik-Do;Lee, Dong-Woo;Sohn, Ki-Hong
    • Journal of Korean Institute of Industrial Engineers
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    • v.37 no.4
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    • pp.390-399
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    • 2011
  • Generally the life-cycle cost of complex systems composed of several sub systems or equipments such as train, aircraft weapon systems is spent much more during operation and maintenance phase than development phase. The maintenance cost for maintaining the availability and extending the life span of systems comprise a large proportion of systems operation cost. The cycle of preventive maintenance affects operation and maintenance cost a lot. In this study we introduce a way minimizing life-cycle cost of systems by calculating more reliable preventive maintenance period than the results of previous study using systems reliability data considered the reliability and failure effect ratio of sub-systems or components. We can solve the preventive maintenance period problem known as NP-Hard as quick as possible by using modified genetic algorithm than using other models introduced in previous study.

Life Cycle of the Perilla Leaf Pyralid Moth, Pyrausta panopealis (Lepidoptera: Pyralidae) and Test of Larvicidal Effect of Some Commercial Natural Products

  • Oh, Hyung-Keun;Kim, Won-Kee;Kang, Ah-Rang;Kim, In-Seon;Lee, Hyang-Burm;Kim, Ik-Soo
    • International Journal of Industrial Entomology and Biomaterials
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    • v.21 no.1
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    • pp.133-137
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    • 2010
  • The perilla leaf pyralid moth, Pyrausta panopealis Walker (Lepidoptera: Pyralidae), is a serious pest damaging to leaf perilla. In order to establish the life parameters of P. panopealis for eventual purpose of control, the developmental span of each stage was investigated under five temperature regimes ($20^{\circ}C{\sim}30^{\circ}C$). The larval period of P. panopealis was longest as 26.8 days at $20^{\circ}C$ and shortened as temperature goes up to $30^{\circ}C$ as 11.3 days. Survivorship of the larval P. panopealis was the highest at $27.5^{\circ}C$ as 82.5%, whereas that of other temperatures ranged from 40% ($20^{\circ}C$) to 60.0% ($30^{\circ}C$), indicating that the P. panopealis appears to favor somewhat higher temperature. In addition to larval period, the duration of egg, prepupal, and pupal period also were shortened sharply as temperature goes up, whereas the duration of adult stage shortened a maximum of only two days as temperature goes up. After the perilla leaf pyralid moths were successfully stabilized in indoor environment the larvicidal efficacy of ten on-the-market environmentfriendly agricultural materials (EFAMs) that were previously selected from the result of other moth species was tested. Seven of the ten tested showed more than 90% of mortality within 12 hrs and reached nearly up to 100% within 24 hrs, but the remaining three showed less than ~70%.

Genetic Mixed Effects Models for Twin Survival Data

  • Ha, Il-Do;Noh, Maengseok;Yoon, Sangchul
    • Communications for Statistical Applications and Methods
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    • v.12 no.3
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    • pp.759-771
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    • 2005
  • Twin studies are one of the most widely used methods for quantifying the influence of genetic and environmental factors on some traits such as a life span or a disease. In this paper we propose a genetic mixed linear model for twin survival time data, which allows us to separate the genetic component from the environmental component. Inferences are based upon the hierarchical likelihood (h-likelihood), which provides a statistically efficient and simple unified framework for various random-effect models. We also propose a simple and fast computation method for analyzing a large data set on twin survival study. The new method is illustrated to the survival data in Swedish Twin Registry. A simulation study is carried out to evaluate the performance.

A Study on Effects of the Elderly Heterosexual Attitudes upon Life Satisfaction - For socioeconomic activists -

  • Jung, Myung-Hee;Jo, Young-Jun
    • The Journal of Industrial Distribution & Business
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    • v.8 no.2
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    • pp.11-20
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    • 2017
  • Purpose - The elderly do not want to know what they want and what happiness is, and have no interest in their society. Thus, many studies have been made to investigate real-life situations and to find a solution. Further studies are needed to investigate the effect of the elderly's dating upon happiness. This study investigated the effects of the elderly's dating upon life satisfaction. Research design, data, and methodology - After coding, SPSS Win18.0 was used. The study was investigated as follows. The subjects were 530 elderly of 3 cities in Chungnam who live without children. A total of 512 questionnaire responses were used after we excluded 18 questionnaire because of incomplete responses. Results - The elderly's date value accounted for 3.22 of 5 in full. In this study, the interviewees (82.3%) said normal or higher level to be satisfied with the date. Conclusions - With the extended life span of the elderly, their chances to retain or make new partners have increased. Considering this trend, social workers and others in senior centers should give health services to the elderly to consult and give educational programs to be free from prejudice and conservative attitudes. Most of the elderly had desire to date but thought that with prejudice and bias.

Investigation of Stress Concentration and Fatigue Life of Axle Drive Shaft with Relief Groove (완화 홈이 가공된 액슬구동축의 응력집중 및 피로수명 평가)

  • Shin, Jae-Myung;Han, Seung-Ho;Han, Dong-Sub
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.11 no.1
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    • pp.88-94
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    • 2012
  • An axle drive shaft with double joint shaft, cross kit and yoke has an important role by transferring power and changing steering angle between axle and wheel in power train system. It has been used widely in the heavy machinery requiring a high reliability in the power train system. At fatigue failures of the axle drive shaft with the long span, a relatively high stress concentration at a snap ring groove on the drive shaft brings to significant fatigue damages under repeated loading condition. As Peterson's suggestions on this study, a relief groove in the vicinity of the snap ring groove is applied by decreasing the stress concentration and improving the fatigue life of axle drive shaft. By using FEM analysis, the decreasing effect of the stress concentration and extended fatigue life are due to the change of design parameters related with size and location of the relief groove. The relief groove with the design parameters such as d/b=2.0 and r/h=1.2 enables to decrease the stress concentration of 22.3% and increase the fatigue life more than 3 times by comparing with no relief groove application.

Effect of building proximity on external and internal pressures under tornado-like flow

  • Sabareesh, G.R.;Cao, Shuyang;Wang, Jin;Matsui, Masahiro;Tamura, Yukio
    • Wind and Structures
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    • v.26 no.3
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    • pp.163-177
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    • 2018
  • Tornadoes are one of the world's deadliest natural phenomena. They are characterized by short life span and danger. It has been observed through post-damage surveys that localities with large numbers of buildings suffer major damage during a tornado attack resulting in huge loss of life and property. Thus,it is important to study interfering buildings exposed to tornado-like vortices. The present study focuses on external and internal pressures developed on building models exposed to translating tornado-like vortices in the presence of an interfering building model. The effects of translating speed and swirl ratio of a tornado-like vortex on external and internal pressures for a principal building in the vicinity of an interfering building are investigated. Results indicate that external and internal pressures are enhanced or reduced depending on the location of the interfering building with respect to the principal building.

Mother-Child Attachment and its Effect on Social Competence; A Life-Span View (3세대를 통해서 본 모-자녀 애착관계와 사회적 능력: 전생애적 접근)

  • 박성연
    • Journal of Families and Better Life
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    • v.13 no.2
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    • pp.86-93
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    • 1995
  • 본 연구는 애착관계를 중심으로 모-자녀간 상호작용의 특성 및 외조모 모, 손녀 3세 대간의 애착관계의 전이와 그것이 반영이 사회적 능력에 미치는 영향을 전생애적 관점에서 파악하고자 하였다 연구대상은 만 14-20개월의 영아와 그 어머니 45쌍 국민학교 1,2,3학년 아동과 그들의 어머니 226쌍 그리고 중.고등학교에 재학중인 여학생과 어머니 외할머니로 구성된 모녀간 3세대 140쌍이었다. 본 연구의 결과 애착관계는 전생애에 걸쳐 비교적 높았 고 상호작용적으로 나타났다 그러나 애착의 특징은 발달단계별로 달라 영아의 어머니에 대 한 애착관계는 어머니의 적절한 양육행동이 아동기는 신뢰감을 주는 양육행동이 청년기에는 애착감정이 그리고 중년기 이후에는 자율성만이 애착관계와 관련이 있었다 3세대간의 애착 관계의 전이는 중년기 이후에만 나타났고 애착과 사회적 능력과의 관계는 아동기, 청년기, 중년기, 노년기까지 관계가 있는 것으로 나타나 애착관계가 전생애적으로 사회적 능력에 중 요함을 보여준다. 이상을 통해 볼 때 본 연구는 전체적으로 전생애적 관점에서의 애착이론 을 지지하였다.

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Effect of Aging on fatigue of Al Clad INVAR Core Wire for High Capacity and Low Sag(STACIR/AW) Conductor ( 1 ) (경년열화가 가공송전선(STACIR/AW)용 강심소재 Al Clad Invar 강선의 피로에 미치는 영향 ( 1 ))

  • Kim Shang-Shu;Kim Byung-Geol;Hyun Suk-Kyu;Sin Goo-Yong;Lee Dong-Il;Min Byung-Uk
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.19 no.1
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    • pp.91-99
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    • 2006
  • Fatigue properties of INVAR/AW wires have been investigated under the heat exposure in order to ensure stable operation and to estimate life span of their power line. In the case of heat exposure for 10000 hr, fatigue life and limit increased. For further heat exposure, fatigue limit decreased due to the decrease in yield strength. The variation fatigue of strand wire was strongly dependent on its amplitude. Also, cracks in wires of 7 strands were caused by stress concentration at the outer surface and fretting between each wire during vibration.

Endogenous retinoic acid mediates the early events in salamander limb regeneration

  • Lee, Eugene;Ju, Bong-Gun;Kim, Won-Sun
    • Animal cells and systems
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    • v.16 no.6
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    • pp.462-468
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    • 2012
  • Urodeles including newt and salamander have remarkable regenerative capacity during the postembryonic life span. Some of the unique features are the formation of the well-developed wound epidermis and the active dedifferentiation process in the early phase of regeneration. These are regarded as key events for the successful regeneration since no further regenerative activity is possible without them. In this study, we investigated the role of retinoic acid (RA) in salamander limb regeneration by blocking RA synthesis using disulfiram, an inhibitor of aldehyde dehydrogenase that oxidizes retinal to RA. Disulfiram treatment resulted in delaying the limb regeneration processes via inhibition of wound epidermis formation and dedifferentiation process. When RA was administered after disulfiram treatment, the inhibitory effect of disulfiram was rescued. In addition, disulfiram treatment after the dedifferentiation stage resulted in the mild retardation of limb regeneration, suggesting that RA might also be involved in the blastema outgrowth. Furthermore, salamander MMP-9 gene expression was also inhibited by disulfiram treatment. Collectively, our findings indicate that endogenous RA may play an important role(s) in the early phase of limb regeneration by regulating the expression of molecules responsible for the modification of intracellular and extracellular environment during salamander limb regeneration.