• 한국균학회소식:학술대회논문집
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• 2015.11a
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• pp.35-35
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• 2015

Pleurotus eryngii has recently become a major cultivated mushroom; it uses tetrapolar heterothallism as a part of its reproductive process. Sexual development progresses only when the A and B mating types are compatible. Such mating incompatibility occasionally limits the efficiency of breeding programs in which crossing within loci-shared strains or backcrossing strategies are employed. Therefore, understanding the mating system in edible mushroom fungi will help provide a short cut in the development of new strains. We isolated and identified pheromone and receptor genes in the B3 locus of P. eryngii and performed a functional analysis of the genes in the mating process by transformation. A genomic DNA library was constructed to map the entire mating-type locus. The B3 locus was found to contain four pheromone precursor genes and four receptor genes. Remarkably, receptor PESTE3.3.1 has just 34 amino acid residues in its C-terminal cytoplasmic region; therefore, it seems likely to be a receptor-like gene. Real-time quantitative RT-PCR (real-time qRT-PCR) revealed that most pheromone and receptor genes showed significantly higher expression in monokaryotic cells than dikaryotic cells. The pheromone genes PEphb3.1 and PEphb3.3 and the receptor gene PESTE3.3.1 were transformed into P5 (A3B4). The transformants were mated with a tester strain (A4B4), and the progeny showed clamp connections and a normal fruiting body, which indicates the proposed role of these genes in mating and fruiting processes. This result also confirms that PESTE3.3.1 is a receptor gene. In this study, we identified pheromone and receptor genes in the B3 locus of P. eryngii and found that some of those genes appear to play a role in the mating and fruiting processes. These results might help elucidate the mechanism of fruiting differentiation and improve breeding efficiency.

• Journal of Species Research
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• v.9 no.3
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• pp.233-246
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• 2020

A scientific name is one of changeable terms in biology whenever additional research results of specific taxa is accumulated. The Database of the National Species List of Korea (DBNKo) was developed to manage taxonomic information of Korean species, designed to describe the changeable and complex taxonomical structure and information. A Korean Taxonomical Serial Number (KTSN) was assigned to each taxon, different from the normally used systems that the scientific name was considered as primary key to manage higher rank of taxa systematically. Common names were also treated with the KTSN, reflecting that common name is considered as one type of taxon. Additional taxonomic information (e.g., synonyms, original names, and references) was also added to the database. A web interface with an intuitive dashboard presenting taxonomic hierarchical structure is provided to experts and/or managers of the DBNKo. Currently, several biological databases are available in the National Institute of Biological Resources (NIBR) such as a specimen database, a digital library, a genetic information system, and the shared species data based on the DBNKo. The DBNKo started sharing species information with other institutions such as the Nakdonggang National Institute of Biological Resources. It is an ideal centralized species database to manage standardized information of Korean species.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.2
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• pp.127-135
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• 2017

The computing environment has changed rapidly to enable large-scale finite element models to be analyzed at the PC or workstation level, such as multi-core CPU, optimal math kernel library implementing BLAS and LAPACK, and popularization of direct sparse solvers. In this paper, the design considerations on a parallel finite element code for shared memory based multi-core CPU system are proposed; (1) the use of optimized numerical libraries, (2) the use of latest direct sparse solvers, (3) parallelism using OpenMP for computing element stiffness matrices, and (4) assembly techniques using triplets, which is a type of sparse matrix storage. In addition, the parallelization effect is examined on the time-consuming works through a large scale finite element model.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.4
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• pp.93-112
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• 2020

Objectives: The purpose of this study is to review the clinical research trends of postpartum pelvic organ prolapse and to recognize the efficacy of Korean medicine intervention. Methods: Based on seven domestic and foreign databases, including Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Journal of Korean Obstetric and Gynecology, Cochrane Library Central, Pubmed, China National Knowledge Infrastructure (CNKI) and WangFang Med Online, we analyzed the clinical trials using Korean medicine intervention, which included acupuncture and herbal medicine. Data retrieval was carried out on May 18 to 20, 2020, and a total of 13 papers were included. Results: All papers were published in China and it contains nine randomized controlled trials, three clinical trials, and one case. The most frequently used intervention was herbal medicine, and Bupleuri Radix, Cimicifugae Rhizoma were used. The treatment group treated by Korean medicine intervention was more effective than the control group. Also, there were no significant side effects of Korean medicine. Conclusion: This study shows that Korean medicine can be effective and safe medical alternatives or options for pelvic organ prolapse patients. However, to laying the foundation of clinical guidelines and applying it to the real-world clinical scene, further follow-up research is needed.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.103-110
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• 2017

Objectives: The purpose of this study was to examine trends in duplicate publication in Korean medical articles indexed in the Oriental Medicine Advanced Searching Integrated System(OASIS). Methods: We searched the list of papers published in Korean medical journals by using OASIS. We randomly extracted 10% of total articles (n=1,162). We searched using OASIS by entering keywords from the title and names of the first and last authors of each indexed article. After the librarian selected the candidates of duplicate publication, three authors reviewed the full texts of the articles independently. When their opinions were not in agreement, reconciliation was made by discussion. The patterns of duplicate publication, such as copy, salami slicing (fragmentation), and aggregation (imalas), were also determined. Results: A total of 1162 articles were evaluated, 24 (2.1%) index articles of which were duplicate articles. Among 24 index articles, Two were triple publications and 22 were double publications. The patterns of duplication publication were as follows; (1) copy (n=8, 33.3%); (2) salami (9, 37.5%), (3) imalas (5, 20.8%) (4) others (2, 8.3%). Conclusion: Duplicate publications have appeared in Korean medical journals in a small proportion. Education on publication ethics and authors'ethical awareness is needed.

• Journal of Acupuncture Research
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• v.29 no.3
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• pp.19-28
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• 2012

Objectives : The aim of this study is to evaluate present clinical evidence of oriental medical treatment for cancer in Korea. Method : A search was performed in the Korean Studies Information, Korea Institute of Science and Technology Information, KoreaMed, Oriental Medicine Advanced Searching Integrated System, National Assembly Library, RISS4u, DBPIA, and Oasis using the keyword 'cancer', 'leukemia', 'malignant tumor', 'lymphoma', 'multiple myeloma', 'melanoma'. The search period spanned between Jan 1, 1980~June 30, 2011 and the results were analyzed and evaluated according to the publication date, journal, method of treatment, type of study, and the primary outcome. Randomized clinical trials (RCTs) and Non randomized clinical trial(NRCT) were reviewed separately. Result : The results yielded 133 trials during the period of Jan 1, 1980~June 30, 2011. Most of the trials were concerned with lung cancer and 94 of the trials were simple case studies or case series studies. 61 trials used herbal Formula/herbal medicine as the primary method of treatment. A total of 4 RCTs existed compared to only one NRCT. Conclusion : The use of oriental medicine for the treatment of cancer is gaining popularity in the field of medical scientific research. However most of the studies that have been published up to date are mostly case studies or case series studies, and RCT/NRCT are rare. In order to provide appropriate evidence regarding the effectiveness of oriental medicine in the treatment of cancer, more rigorous and well-designed studies are warranted.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.4
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• pp.551-561
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• 2001

In this paper, the large signal unified model is established for H4O GaAs pHEMT of GEC-Marconi using modified Curtice model. This unified model includes DC characteristic, small signal, and noise characteristic as various bias. Particularly, the model can simply and physically explain trans-conductance $(g_m)$ of pHEMT using modified Curtice model, and can tell the difference $g_m$, $R_ds$ at DC and these at AC through inclusion of internal RF-choke. The results of the established model built up using SDD in HP-Eessof show good agreement to the S/W measured data in DC, small signal, and noise characteristic. This model can also be applied to various computer aided analysis, such as linear simulation, 1-tone harmonic balance simulation, and multi-tone harmonic balance simulation, so the LNA(Low Noise Amplifier), oscillator, and mixer design has been shown using this model library.

• Journal of Korean Academy of Nursing
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• v.50 no.4
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• pp.513-522
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• 2020

Purpose: This study aimed to utilize concept analysis to obtain a better understanding of the concept of "continuity of care" in chronic diseases. Methods: The concept of continuity of care was analyzed using the Walker and Avant method. Covering literature in English from 1930 to 2018, the data sources included CINAHL Complete, Academic Search Complete, MEDLINE, PsyARTICLES, Health Source: Nursing/Academic Edition, Google Scholar, Science Direct, and the Cochrane Library. Results: A comprehensive definition of concept of continuity of care was developed based on a systematic search and synthesis. The key defining attributes were identified as (a) care over time, (b) the relationship between an individual patient and a care team, (c) information transfer, (d) coordination, and (e) meeting changing needs. The antecedents of continuity of care were having a chronic disease, inexperienced with disease management, a poorly coordinated healthcare system, and medical care limitations. The consequences of continuity of care were decreasing hospital admissions, reducing costs, reducing emergency room visits, improving the quality of life, improving patient satisfaction, and delivering good healthcare. Conclusion: The thorough concept analysis provides insight into the nature of "continuity of care" in chronic diseases and also helps ground the concept in healthcare.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.05a
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• pp.257-260
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• 2002

This paper describes a design of cryptographic processor that implements the AES (Advanced Encryption Standard) block cipher algorithm“Rijndael”. To achieve high throughput rate, a sub-pipeline stage is inserted into the round transformation block, resulting that the second half of current round function and the first half of next round function are being simultaneously operated. For area-efficient and low-power implementation the round transformation block is designed to share the hardware resources in encryption and decryption. An efficient scheme for on-the-fly key scheduling, which supports the three master-key lengths of 128-b/192-b/256-b, is devised to generate round keys in the first sub-pipeline stage of each round processing. The cryptoprocessor designed in Verilog-HDL was verified using Xilinx FPGA board and test system. The core synthesized using 0.35-${\mu}{\textrm}{m}$ CMOS cell library consists of about 25,000 gates. Simulation results show that it has a throughput of about 520-Mbits/sec with 220-MHz clock frequency at 2.5-V supply.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.190-192
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• 2018

This paper describes a design of an elliptic curve cryptography (ECC) processor that supports five pseudo-random curves and five Koblitz curves over binary field defined by the NIST standard. The ECC processor adopts the Lopez-Dahab projective coordinate system so that scalar multiplication is computed with modular multiplier and XORs. A word-based Montgomery multiplier of $32-b{\times}32-b$ was designed to implement ECCs of various key lengths using fixed-size hardware. The hardware operation of the ECC processor was verified by FPGA implementation. The ECC processor synthesized using a 0.18-um CMOS cell library occupies 10,674 gate equivalents (GEs) and 9 Kbits RAM at 100 MHz, and the estimated maximum clock frequency is 154 MHz.