• 한국임상수의학회지
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• 제17권2호
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• pp.510-514
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• 2000

A seven-year-old male poodle was presented with multiple non-pruritic draining skin lesions. On physical examination the dog was depressed and had three draining nodules 3.0 to 4.0 cm in diameter on the neck, flank and back. The multifocal sparing of fat lobules, macrophages, and numerous neutrophils were observed in aspiration cytologic examination of nodule. Haematological examination demonstrated a moderate leukocytosis and neutrophilia. An aerobic bacterial culture was undertaken from draining lesions on the flank. But there was no bacterial growth in aerobic culture. Therapy was initiated with oral cephalexin at a dose of 20 mg/kg, body weight three times daily and prednisolone at 1.0 mg/kg twice daily. The (lug returned to normal within 24 hours of treatment and its general attitute and appetite were improved. However, within 1 month new nodules had appeared on the dorsum over the rump, coalescing into a mass of draining nodules and tracts.

• 대한수의학회지
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• 제46권1호
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• pp.77-81
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• 2006

A 1-year and 6-month-old, intact male, Shih-tzu dog was referred to the Konkuk University Veterinary Teaching Hospital, due to ascite, melena, severe anemia, and polyuria/polydipsia. Complete blood count showed moderate leukocytosis, lymphocytosis, monocytosis, and microcytic hypochromic nonregenerative anemia. On serum biochemistry profiles, hypoalbuminemia and hypoproteinemia were observed, and proteinuria was detected on urinalysis. Pleural effusion and mild ascites were noted in radiological findings, and bilateral nephromegaly was noted on ultrasonography. Babesia gibsoni was detected by PCR. Babesiosis and glomerular disease was treated at a time with prednisolone and buparvaquone. This therapeutic regime was very efficacious and clinical sings were rapidly improved. Proteinuria and severe anemia were disappeared following therapy.

• 대한수의학회지
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• 제22권1호
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• pp.63-66
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• 1982

Authors encountered a case of bovine viral leukosis in a young cattle (10 months old) with the following findings; Main clinical symptoms observed were emaciation, digestive disorder, and marked enlargement of superficial lymph nodes. Biopsied specimen of the lymph nodes revealed characteristic histological picture of bovine leukosis. A severe degree of leukocytosis (108,000/cmm) accompanied by marked lympocytosis (96%=103,680/cmm) was detected from the hematological examination of peripheral blood. Most of the lympocytes(94%=101,520) were large-sized, immature, and abnormal in their morphology. In addition, a pronounced anemia (1.78 million/cmm) without regenerative evidence of erythrocyte was noted. The serum of the patient showed positive reaction against gp antigen of bovine leukosis virus in agar-gel diffusion test.

• International journal of thyroidology
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• 제10권1호
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• pp.50-55
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• 2017

Sweet's syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto's thyroiditis but is rare in Graves' disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet's syndrome in a patient with Graves' disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves' disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet's syndrome, supporting that Sweet's syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet's syndrome associated with Graves' disease per se but not PTU or MMI use.

• Neonatal Medicine
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• 제25권4호
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• pp.191-195
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• 2018

Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the gene encoding CD18, which is a constituent of leukocyte integrins. Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections. We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive care unit presented with a septic hip. Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18. This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.

• 한국임상수의학회지
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• 제38권4호
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• pp.210-212
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• 2021

A 10-year-old spayed female beagle referred to the Veterinary Teaching Hospital of Chungnam National University presented with acute diarrhea, depression, anorexia, and emaciation. The laboratory findings of the dog showed leukocytosis, high C-reactive protein, and low albumin levels. Fecal examinations revealed severe infection with Strongyloides (S.) stercoralis, with a high fecal score (6/7). Consequently, the dog was diagnosed with hyperinfection of S. stercoralis, and thus, was treated with fenbendazole and ivermectin after discontinuation of prednisolone treatment. The dog showed negative on the Fecal Dx^® Antigen Panel (IDEXX Laboratories Inc., Westbrook, ME, USA) after treatment, and clinical signs disappeared with normal stool consistency.

• 한국동물위생학회지
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• 제44권4호
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• pp.309-313
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• 2021

A 12-year-old, spayed female, Toy-poodle dog presented in progressive, pruritic carpal mass and mandibular papule. The skin lesions and enlarged superficial lymph nodes were surgically removed. According to histopathology and immunohistochemistry, the patient diagnosed as cutaneous epitheliotropic T-cell lymphoma with lymph node metastasis. Chemotherapy with L-asparaginase, lomustine and prednisolone was initiated. The patient deteriorated despite treatment and was admitted to the hospital. Blood tests revealed significant leukocytosis. Circulating large lymphocytes with convoluted and cerebriform nuclei seen in peripheral blood led to presumption of Sézary cells. Thus, considering skin, lymph nodes and blood involvement, Sézary syndrome was diagnosed.

• 한국임상수의학회지
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• 제38권6호
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• pp.269-273
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• 2021

A dog was presented with a cough, dyspnea, nasal discharge, gagging, and exercise intolerance. The dog showed leukocytosis, peripheral eosinophilia, and an increase C-reactive protein. The radiographic findings noted bronchointerstitial infiltration, intrathoracic lymphadenopathy, and soft tissue opacity mass. Computed tomography findings showed thickening of the bronchus and bronchiole. Also, peri-bronchial consolidation and generalized intrathoracic lymphadenopathy was present. On blind bronchoalveolar lavage and pulmonary cytology, there were significantly increased eosinophils. Canine pulmonary respiratory pathogens from a real-time polymerase chain reaction analysis was negative. Consequently, the dog was diagnosed with eosinophilic bronchopneumopathy. Clinical signs improved significantly within a few days after treatment with an oral corticosteroid.

• Childhood Kidney Diseases
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• 제12권1호
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• pp.62-69
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• 2008

목적 : 배뇨성 방광요도 조영술은 초회 열성 요로감염이 있는 환아에게서 선천성 신장 질환이나 동반된 방광요관 역류를 확인하기 위해 시행한다. 그러나 이 시술은 요로 감염에서 방광 천공까지 다양한 합병증 등이 초래될 수 있으므로 본 연구는 배뇨성 방광요도 조영술 이외에 방광요관 역류의 존재를 예측할 수 있는 인자를 알아보고자 하였다. 방법 : 1998년 5월부터 2005년 11월까지 약 7년간 전북대학교 병원 소아청소년과에 입원하여 소변 배양 검사상 확진된 요로 감염 환아를 대상으로 후향적으로 분석하였다. 각각의 환아들에게서 연령, 성별, 발열, 위장관 증상, 뇨 검사 및 뇨 배양, 말초혈액 백혈구수, ESR, CRP, BUN, 혈청 creatinine과 요로계 초음파 및 DMSA 신스캔 결과와 방관요관 역류의 정도를 표준화된 형식을 통해 기록하였다. 결과 : 총 410명의 환아 중, 방광요관 역류가 없는 그룹은 273명이었고 역류가 있는 그룹은 137명 이었다. 방광요관 역류 존재 유무에 따른 두 그룹 간에는 발열, 농뇨, 말초백혈구수, ESR, CRP의 P 값이 0.001 이하의 의미있는 차이를 나타냈다. 그러나, 방광요관 역류 정도에 따른 비교분석 결과 방광요관 역류가 낮은 군(I-II)과 높은 군(III-V) 사이에는 농뇨, 발열, 말초백혈구수, C-반응단백(CRP) 등에서 의미있는 차이를 보이지 않았다(P<0.05). 역류의 유무에 따른 영상의학적 소견의 차이를 보면, 신장 초음파는 민감도 33%, 특이도 73%를 보였으며 DMSA 신스캔은 민감도 76%, 특이도 65%를 나타내었다. 또한 역류가 심할수록 신장 초음파와 DMSA 신스캔 모두 양성률이 높았다. 결론 : 초회 요로감염 환아 중 발열, 농뇨 및 높은 적혈구 침강속도, C-반응단백를 보이는 경우와 DMSA 신스캔상 이상 소견을 보이는 경우는 방광요관 역류가 있을 가능성이 높으므로, 이 경우에는 반드시 배뇨성 방광요도 조영술을 시행하는 것이 좋을 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제61권5호
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• pp.463-472
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• 2006

연구배경: 농흉을 치료하는데 VATS가 도입된 후 VATS의 유용성에 대해 많은 연구의 결과들이 보고 되고 있으며 실제로 치료 프로토콜에도 변화를 가져왔으나 아직까지는 문헌상의 보고가 양적으로 충분하지 못하며 기존의 치료방법에 비해 VATS의 장점 역시 명확하게 검증되어 있지 못한 상태이다. 방 법: 의무기록과 흉부 방사선 사진을 검토하여 기존의 치료 환자 군과 VATS 환자 군을 비교하였다. 2001년 1월부터 2003년 12월까지 한림대학교 춘천성심병원에 농흉으로 입원하여 기존의 방법으로 치료받은 환자들을 A군으로 하고 2003년 12월부터 2006년 8월까지 농흉으로 흉강경 수술을 받은 환자들을 B군으로 나누어 입원기간, 흉관 유지 기간, 백혈구증가증이 있던 기간, 발열이 있던 기간, 항생제 사용기간을 비교하였다. 그리고 흉막비후, 갈비가로막각이 각각 치료 전후 어떻게 변하였는지 비교하여 보았다. 결 과: A군은 15명으로 남자가 11명, 여자가 4명이었고, 평균 나이는 $58.2{\pm}15.7$세 이었고, B군은 11명으로 남자가 9명, 여자가 2명이었으며 평균 나이는 $51.6{\pm}9.5$세 이었다. B군에서 입원 기간($16.6{\pm}7.4$일, A군은 $33.7{\pm}22.6$일; p=0.014)과 흉관 유지 기간($10.5{\pm}5.7$일, A군은 $19.5{\pm}14.4$일; p=0.039), 백혈구증가기간($6.7{\pm}6.5$일, A군은 $18.8{\pm}13.2$일; p=0.008), 발열 기간($0.8{\pm}1.8$일, A군은 $9.4{\pm}9.2$일; p=0.004), 항생제 사용기간(B군 $14.9{\pm}6.4$일, A군 $25.4{\pm}13.9$일; p=0.018)이 A군에서보다 통계적으로 유의하게 감소하였다. 그러나 흉막비후, 갈비가로막의 둔함의 정도는 통계적으로 유의한 변화는 없었다. 결 론: 농흉에서 흉강경을 이용한 치료를 하면 기존의 방법에 비해 입원 기간, 흉관 유지기간, 백혈구증가증 기간, 발열 기간, 항생제 사용기간을 단축시킬 수 있어 환자의 증상을 더 빨리 개선시키며, 흉관을 조기에 제거할 수 있고 입원기간을 단축시킨다.