Browse > Article

A case of protein losing nephropathy in a dog infected with canine Babesia gibsoni  

Kim, Ha-Jung (College of Veterinary Medicine, Konkuk University)
Park, Chul (College of Veterinary Medicine, Konkuk University)
Jung, Dong-In (College of Veterinary Medicine, Konkuk University)
Kang, Byeong-Teck (College of Veterinary Medicine, Konkuk University)
Kim, Ju-Won (College of Veterinary Medicine, Konkuk University)
Lim, Chae-Young (College of Veterinary Medicine, Konkuk University)
Park, Hee-Myung (College of Veterinary Medicine, Konkuk University)
Publication Information
Korean Journal of Veterinary Research / v.46, no.1, 2006 , pp. 77-81 More about this Journal
Abstract
A 1-year and 6-month-old, intact male, Shih-tzu dog was referred to the Konkuk University Veterinary Teaching Hospital, due to ascite, melena, severe anemia, and polyuria/polydipsia. Complete blood count showed moderate leukocytosis, lymphocytosis, monocytosis, and microcytic hypochromic nonregenerative anemia. On serum biochemistry profiles, hypoalbuminemia and hypoproteinemia were observed, and proteinuria was detected on urinalysis. Pleural effusion and mild ascites were noted in radiological findings, and bilateral nephromegaly was noted on ultrasonography. Babesia gibsoni was detected by PCR. Babesiosis and glomerular disease was treated at a time with prednisolone and buparvaquone. This therapeutic regime was very efficacious and clinical sings were rapidly improved. Proteinuria and severe anemia were disappeared following therapy.
Keywords
babesiosis; glomerulonephritis; protein losing nephropathy; proteinuria;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Abuelo JG. Proteinuria: diagnostic principles and procedures. Ann Intern Med 1983, 98, 186-191   DOI   ScienceOn
2 Ettinger SJ, Feldman EC. Glomerular disease. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine: diseases of the dog and cat. 5th ed. pp. 1666-1667, Saunders, Philadelphia, 2000
3 Grauer GF, Thomas CB, Eicker SW. Estimation of quantitative proteinuria in the dog, using the urine protein-to creatinine ratio from a random, voided sample. Am J Vet Res 1985, 46, 2116-2119
4 Morita T, Saeki H, Imai S, Ishii T. Erythrocytocyte oxidation in artificial Babesia gibsoni infection. Vet Parasitol 1996, 63, 1-7   DOI   ScienceOn
5 Moore DJ, Williams MC. Disseminated intravascular coagulation: a complication of Babesia canis infection in the dog. J S Afr Vet Med Assoc 1979, 50, 265-275
6 Reyers F, Leisewitz AL, Lobetti RG, Miller RJ, Jacobson LS, van ZylM. Canine babesiosis in South Africa: more than one disease. Does this serve as a model for falciparum malaria? Ann Trop Med Parasitol 1998, 92, 503-511   DOI
7 DiBartola SP, Spaulding GL, Chew DJ, Lewis RM. Urinary protein excretion and immunopathologic findings in dogs with glomerular disease. J Am Vet Med Assoc 1980, 177, 73-77
8 Malherbe WD. Clinico-pathological studies of Babesia canis infection in dogs. V. The influence of the infection on kidney function. J S Afr Vet Med Assoc 1966, 37, 261-264
9 Wozniak EJ, Barr BC, Thomford JW, Yamane I, McDonough SP, Moore PF, Naydan D, Robinson TW, Conrad PA. Clinical, anatomic, and immunopathologic characterization of Babesia gibsoni infection in the domestic dog (Canis familiaris). J Parasitol 1997, 83, 692-699   DOI   ScienceOn
10 Murase T, Ueda T, Yamato O, Tajima M, Maede Y. Oxidative damage and enhanced erythrophagocytosis in canine erythrocytes infected with Babesia gibsoni. J Vet Med Sci 1996, 58, 259-261   DOI   ScienceOn
11 Center SA, Wilkinson E, Smith CA, Erb H, Lewis RM. 24-Hour urine protein/creatinine ratio in dogs with protein-losing nephropathies. J Am Vet Med Assoc 1985, 187, 820-824
12 Bainbridge J, Elliott J. Proteinuria. In: Bainbridge J, Elliott J (eds.). BSAVA Manual of Canine and Feline Nephrology and Urology. 1st ed. pp. 68-84, British Small Animal Veterinary Association, Cheltenham. 1996
13 Muller-Peddinghaus R, Trauwein G. Spontaneous glomrulonephritis in dogs. II. Correlation of glomerulonephritis with age, chronic interstitial nephritis and extrarenal lesions. Vet Pathol 1977, 14, 121-127   DOI   ScienceOn
14 McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Variation of the TNF-á promoter region associated with susceptibility to cerebral malaria. Nature 1994, 371, 508-510   DOI   ScienceOn