• Tuberculosis and Respiratory Diseases
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• 제73권1호
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• pp.61-66
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• 2012

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup of non-Hodgkin's lymphoma. Pulmonary extranodal MZL is a rare entity and accounts for less than 0.5% of primary pulmonary malignancies. Only a few cases of simultaneous occurrence of lung cancer and pulmonary extranodal MZL have been reported. A 60-year-old woman was referred to our hospital with a pulmonary nodule. She was diagnosed with lung adenocarcinoma by percutaneous needle biopsy. The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation. The bronchial lesions were diagnosed as extranodal MZL. Although the patient underwent surgical resection for the lung adenocarcinoma, the pulmonary extranodal MZL was left untreated; it was monitored during follow-up visits. To our knowledge, this is the first report of synchronous lung adenocarcinoma and primary extranodal MZL of the main bronchus.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권5호
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• pp.398-402
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• 2021

Mastoid lymph node inflammation is a rare entity. Pathological conditions in the vicinity of the mastoid processes can be challenging for maxillofacial head-neck surgeons to address. We report a case of suppurative mastoid lymphadenitis in an 18-year-old Caucasian male. To our knowledge, there are no publications that highlight the clinical, ultrasonographic, intra-, and postoperative data for any pathologic process that presented as mastoiditis.

• BMB Reports
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• 제55권12호
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• pp.587-594
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• 2022

A persistent DNA tumor virus infection transforms normal cells into cancer cells by either integrating its genome into host chromosomes or retaining it as an extrachromosomal entity called episome. Viruses have evolved mechanisms for attaching episomes to infected host cell chromatin to efficiently segregate the viral genome during mitosis. It has been reported that viral episome can affect the gene expression of the host chromosomes through interactions between viral episomes and epigenetic regulatory host factors. This mini review summarizes our current knowledge of the tethering sites of viral episomes, such as EBV, KSHV, and HBV, on host chromosomes analyzed by three-dimensional genomic tools.

• International Journal of Computer Science & Network Security
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• 제23권5호
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• pp.212-220
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• 2023

Ontologies are knowledge containers in which information about a specified domain can be shared and reused. An event happens within a specific time and place and in which some actors engage and show specific action features. The fact is that several ontology models are based on events called Event-Based Models, where the event is an individual entity or concept connected with other entities to describe the underlying ontology because the event can be composed of spatiotemporal extents. However, current event-based ontologies are inadequate to bridge the gap between spatiotemporal extents and participants to describe a specific domain event. This paper reviews, describes, and compares the existing event-based ontologies. The paper compares and contrasts various ways of representing the events and how they have been modelled, constructed, and integrated with the ontologies. The primary criterion for comparison is based on the events' ability to represent spatial and temporal extent and the participants in the event.

• Childhood Kidney Diseases
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• 제27권1호
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• pp.11-18
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• 2023

Remarkable advances in genetic diagnosis expanded our knowledge about inherited tubulopathies and other genetic kidney diseases. This review suggests a simple categorization of inherited tubular disease, clarifies the concept of autosomal dominant tubulointerstitial kidney disease (ADTKD), and introduces novel therapies developed for tubulopathies. Facing patients with suspicious tubular disorders, clinicians should first evaluate the status of volume and acid-base. This step helps the clinicians to localize the affected segment and to confirm genetic diagnosis. ADTKD is a recently characterized disease entity involving tubules. The known causative genes are UMOD, MUC1, REN, and HNF1β. Still, only half of ADTKD patients show mutations for these four identified genes. Whole exome sequencing is a suitable diagnostic tool for tubulopathies, especially for ADTKD. Genetic approaches to treat tubulopathies have progressed recently. Despite the practical obstacles, novel therapies targeting inherited tubulopathies are currently in development.

• 정보관리학회지
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• 제33권3호
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• pp.321-343
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• 2016

본 연구의 목적은 1) 소설 속 지명 데이터베이스(DB)를 구축하고, 2) 확장 가능한 지명 DB를 위해 자동으로 지명을 추출하여 데이터베이스를 갱신하며, 3) 데이터베이스 내의 소설지명과 용례를 검색하고 시각화하는 파일럿시스템을 구현하는 데 있다. 특히, 학습자료(training)에 해당하는 말뭉치(corpus)를 확보하기 어려운, 소설지명과 같이 현재 잘 쓰이지 않는 개체명을 자동으로 추출하는 것은 매우 어려운 문제이다. 효과적인 지명 정보 추출용 학습자료 말뭉치 확보 문제를 해결하기 위해 본 논문에서는 이미 수작업으로 구축된 웹 지식(어휘사전)을 활용하여 학습에 필요한 충분한 양의 학습말뭉치를 확보하는 방안을 적용하였다. 이렇게 확보된 학습용 코퍼스와 학습된 자동추출 모듈을 가지고, 새로운 지명 용례를 찾아 추가하는 지명 데이터베이스 확장 도구를 만들었으며, 소설지명을 지도 위에 시각화하는 시스템을 설계하였다. 또한, 시범시스템을 구현함으로써 실험적으로 그 타당성을 입증하였다. 끝으로, 현재 시스템의 보완점을 제시하였다.

• 한국정보과학회논문지:데이타베이스
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• 제32권2호
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• pp.111-119
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• 2005

전자카타로그는 상품에 관한 풍부한 의미를 포함하며 온톨로지가 적용될 여지가 높은 영역이다. 온톨로지는 사물의 본질과 사물간의 관계를 나타내는데, 전자카탈로그를 형식적(formal)인 온톨로지로 표현하는 것은 전자상거래 영역에서 중요하다. DL(Description Logic)은 현재 사용되는 여러 온톨로지 언어의 이론적 기반을 제공한다. 본 논문은 DL 언어를 사용해 전자카타로그를 형식적으로 온톨로지 모델링 한다. 기본적인 모델링 구성요소 집합은 화장 개체 관계(Extended Entity Relationship)로 개념적으로 나타내고, DL 언어로 대응해서 변환한다. EER로 나타낼 수 없는 부가적인 의미적 지식은 직접 DL언어로 표현한다. 논문에서 제시하는 모델링 언어는 언어의 표현력과 복잡도를 고려할 때, 현실적으로 추론에 적합하다고 알려져 있는 SHIQ(d) 언어 범위에 기반하고 있다. 모델링한 온톨로지 e-카타로그의 활용 이해를 돕기 위해 시나리오를 제시하고, 실제 DL 추론 도구를 통해 그 시험적 검증을 한다.

• Interdisciplinary Bio Central
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• 제3권2호
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• pp.7.1-7.6
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• 2011

Background: Published manuscripts are the main source of biological knowledge. Since the manual examination is almost impossible due to the huge volume of literature data (approximately 19 million abstracts in PubMed), intelligent text mining systems are of great utility for knowledge discovery. However, most of current text mining tools have limited applicability because of i) providing abstract-based search rather than sentence-based search, ii) improper use or lack of ontology terms, iii) the design to be used for specific subjects, or iv) slow response time that hampers web services and real time applications. Results: We introduce an advanced text mining system called PubMine that supports intelligent knowledge discovery based on diverse bio-ontologies. PubMine improves query accuracy and flexibility with advanced search capabilities of fuzzy search, wildcard search, proximity search, range search, and the Boolean combinations. Furthermore, PubMine allows users to extract multi-dimensional relationships between genes, diseases, and chemical compounds by using OLAP (On-Line Analytical Processing) techniques. The HUGO gene symbols and the MeSH ontology for diseases, chemical compounds, and anatomy have been included in the current version of PubMine, which is freely available at http://pubmine.kobic.re.kr. Conclusions: PubMine is a unique bio-text mining system that provides flexible searches and analysis of biological entity relationships. We believe that PubMine would serve as a key bioinformatics utility due to its rapid response to enable web services for community and to the flexibility to accommodate general ontology.

• International Journal of Internet, Broadcasting and Communication
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• 제13권2호
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• pp.179-186
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• 2021

We have been developed the smart tourism app and the Instagram and YouTube contents to provide personalized tourism information and travel product information to individual tourists. In this paper, we develop a rule-based smart tourism chatbot with the khaiii (Kakao Hangul Analyzer III) morphological analyzer and Neo4J graph database. In the proposed chatbot system, we use a morpheme analyzer, a proper noun dictionary including tourist destination names, and a general noun dictionary including containing frequently used words in tourist information search to understand the intention of the user's question. The tourism knowledge base built using the Neo4J graph database provides adequate answers to tourists' questions. In this paper, the nodes of Neo4J are Area based on tourist destination address, Contents with property of tourist information, and Service including service attribute data frequently used for search. A Neo4J query is created based on the result of analyzing the intention of a tourist's question with the property of nodes and relationships in Neo4J database. An answer to the question is made by searching in the tourism knowledge base. In this paper, we create the tourism knowledge base using more than 1300 Jeju tourism information used in the smart tourism app. We plan to develop a multilingual smart tour chatbot using the named entity recognition (NER), intention classification using conditional random field(CRF), and transfer learning using the pretrained language models.

• 디지털융복합연구
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• 제19권8호
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• pp.205-217
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• 2021

탈중앙형 SSI(Self Sovereign Identity)가 새로운 디지털 신원 식별 기술의 대안으로 등장하였으나 이는 데이터 거래의 고유 알고리즘 특성으로 인해 효율적인 비식별화 기법이 제안되지 않았다. 본 논문에서는 SSI의 탈중앙형 동작을 보장하기 위해 ZKP(Zero Knowledge Proof)의 검증 결과를 검증인 측에서 외부에 제공 가능한 형태로 재구성함으로써 식별자를 제거하지 않는 비식별 기술을 제안한다. 또한, 이는 검증 참여 각 개체에 대한 차등 주권 관리 개념을 제안하는 것으로 재구성된 비식별 데이터를 정보주체의 동의 없이 제공할 수 있다. 결과적으로 제안 모델은 탈중앙형 SSI 환경에서 국내 개인정보보호법을 만족하고, 안전하며 효율적인 비식별 처리 및 주권 관리를 제공한다.