• Journal of Life Science
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• v.18 no.3
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• pp.381-386
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• 2008

Deep sea water was tested for cancer chemopreventive activity by measuring the activities of ${\beta}-$ naphthoflavone $({\beta}-NF)-induced$ cytochrome P 450 1A2 (CYP 1A2), quinone reductase (QR) and glutathione-S-transferase (GST), glutathione (GSH) levels, and ornithine decarboxylase (ODC) activity. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of $100{\sim}1,000$) showed a hardness-dependent inhibition of CYP 1A2 activity. QR and GST activities were induced about $1.1{\sim}1.2$ fold with the treatment of deep sea water in murine hepatoma Hepa 1clc7 cells. In addition GSH levels were increased $1.3{\sim}1.4$ fold in a hardness range of $100{\sim}1,000$. The deep sea water showed 20.3 and 35.0% inhibition of 12-O- tetradecanoylphorbol-13-a-cetate (TPA)-induced ODC activity at hardness 800 and 1,000, respectively. Therefore, deep sea water is worth further investigation with respect to cancer chemoprevention or therapy.

• Journal of Chest Surgery
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• v.11 no.3
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• pp.364-367
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• 1978

Embryonal carcinoma of the mediastinum is a very uncommon disease. This is a report of an embryonal carcinoma in the mediastinum found in a 25 years old Korean male patient who had been suffering from chest pain and intractable coughing for 6 months. 5 weeks prior to this admission hemoptysis and high fever were followed. Right exploratory thoracotomy was performed under the impression of a mediastinal tumor, but found to be unresectable. Irradiation therapy was tried, but no response was observed. Patient expired on 78th day postoperatively.

• The Korean Journal of Pain
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• v.4 no.2
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• pp.200-204
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• 1991

Neurolytic splanchnic nerve block is a relatively safe and effective method for the relief of intractable pain caused by upper abdominal cancer. We have experienced a case of severe acute respiratory failure during splanchnic nerve block under control of X-ray fluoroscopy. We think that the most likely cause of the acute respiratory failure was an asthmatic attack due to anxiety and dyspnea from the injury or stimulation of the diaphragm and pleura in this case.

• The Korean Journal of Pain
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• v.5 no.1
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• pp.17-22
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• 1992

Splanchnic nerve block(SNP) is performed to relieve intractable upper abdominal cancer pain. Boas, in a technique using fluoroscopy, was the first to note the difference between transcrural celiac plexus block and retrocrural splanchnic nerve block(SNB). We have experienced 10 cases of SNB at the T12 level under control of fluoroscopy. Our results support this approach as an effective method for upper abdominal cancer pain control.

• Journal of information and communication convergence engineering
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• v.6 no.1
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• pp.86-90
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• 2008

In this paper, I have presented a new approach which can track moving objects in unknown environments. This scheme is important in providing a computationally feasible alternative to complete enumeration of JPDA which is intractable. I have proved that given an artificial measurement and track's configuration, proposed scheme converges to a proper plot in a finite number of iterations. In this light, even if the performance is enhanced by using the relaxation, we also note that the difficulty in tuning the parameters of the relaxation scheme is critical aspect of this suggestion.

• Journal of The Association for Neo Medicine
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• v.2 no.1
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• pp.13-23
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• 1997

Modern medicine can not solve all the problems caused by many intractable, chronic and aging related diseases hence more people have come to recognize the role of foods for the promotion of good health as well as prevention from illness. Further more, controlled diet are proven to be used as effective cures for certain diseases. In this paper, the definition, functional factors and mechanisms of designer(funtional) foods are reviewed. Especially, the biofuntional activities of herbal medicines which also can be treated as designer foods are intensively noted in this paper.

• Korean Journal of Biological Psychiatry
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• v.5 no.2
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• pp.175-183
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• 1998

To consider current concepts of epilepsy further, the brief review begins with a discussion of what is epilepsy, discribes multifactorial nature of epileptic disorders, and ends with a presentation of current classifications. A combination of the standard antiepielptic drugs(AEDs) may be necessary to treat intractable seizures, but no studies have been done to indicate an optimal combination. The new AEDs provide alternative choices, but questions remain about the optimal timing and manner of administration. AEDs selection must individualized, no drug of choice can be named for all patients.

• Journal of the Korean Statistical Society
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• v.32 no.4
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• pp.411-423
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• 2003

In this paper we develop a method for calculating a probability that a particular generalized variance is the smallest of all the K multivariate normal generalized variances. The method gives a way of comparing K multivariate populations in terms of their dispersion or spread, because the generalized variance is a scalar measure of the overall multivariate scatter. Fully parametric frequentist approach for the probability is intractable and thus a Bayesian method is pursued using a variant of weighted Monte Carlo (WMC) sampling based approach. Necessary theory involved in the method and computation is provided.

• Proceedings of the KSLP Conference
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• 2017.04a
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• pp.98-98
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• 2017

• Journal of the Korean Statistical Society
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• v.31 no.1
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• pp.77-91
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• 2002

This paper considers a functional regression model with truncated errors in explanatory variables. We show that the ordinary least squares (OLS) estimators produce bias in regression parameter estimates under misspecified models with ignored errors in the explanatory variable measurements, and then propose methods for analyzing the functional model. Fully parametric frequentist approaches for analyzing the model are intractable and thus Bayesian methods are pursued using a Markov chain Monte Carlo (MCMC) sampling based approach. Necessary theories involved in modeling and computation are provided. Finally, a simulation study is given to illustrate and examine the proposed methods.