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http://dx.doi.org/10.5352/JLS.2008.18.3.381

Effect of Deep Sea Water on Phase I, Phase II and Ornithine Decarboxylase.  

Shon, Yun-Hee (Regional Innovation System, Intractable Diseases Research Center, Dongguk University)
Kim, Mee-Kyung (Regional Innovation System, Intractable Diseases Research Center, Dongguk University)
Jang, Jung-Sun (Regional Innovation System, Intractable Diseases Research Center, Dongguk University)
Jung, Eun-Jung (Department of Pharmacology, College of Medicine, Dongguk University)
Nam, Kyung-Soo (Department of Pharmacology, College of Medicine, Dongguk University)
Publication Information
Journal of Life Science / v.18, no.3, 2008 , pp. 381-386 More about this Journal
Abstract
Deep sea water was tested for cancer chemopreventive activity by measuring the activities of ${\beta}-$ naphthoflavone $({\beta}-NF)-induced$ cytochrome P 450 1A2 (CYP 1A2), quinone reductase (QR) and glutathione-S-transferase (GST), glutathione (GSH) levels, and ornithine decarboxylase (ODC) activity. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of $100{\sim}1,000$) showed a hardness-dependent inhibition of CYP 1A2 activity. QR and GST activities were induced about $1.1{\sim}1.2$ fold with the treatment of deep sea water in murine hepatoma Hepa 1clc7 cells. In addition GSH levels were increased $1.3{\sim}1.4$ fold in a hardness range of $100{\sim}1,000$. The deep sea water showed 20.3 and 35.0% inhibition of 12-O- tetradecanoylphorbol-13-a-cetate (TPA)-induced ODC activity at hardness 800 and 1,000, respectively. Therefore, deep sea water is worth further investigation with respect to cancer chemoprevention or therapy.
Keywords
Deep sea water; cytochrome P450 1A2; quinone reductase; glutathione-S-transferase; glutathione; ornithine decarboxylase;
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