• 대한의생명과학회지
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• 제10권2호
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• pp.99-105
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• 2004

Liver and serum rhodanese activities were determined in acute ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD) to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. Liver cytosolic and microsomal rhodanese activities and these Vmax values in CBD ligated rats with acute ethanol intoxication were found to be decreased much more than that in CBD ligation alone. However, the difference of Km value on above hepatic enzyme was not found between the experimental groups. On the other hand, serum rhodanese activity in CBD ligated rats with acute ethanol intoxication was greater increased more than that in CBD ligation alone. These results indicate that the biosynthesis of the hepatic rhodanese decreases and the serum rhodanese activity increases in cholestasis combined with acute ethanol intoxication, reflecting damage of aggravated hapatocytic membrane. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.

• 대한예방한의학회지
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• 제4권2호
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• pp.285-293
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• 2000

Objectives: We have accomplished a clinical research about counteracting the pesticides intoxication using oriental medical method and treatment. And we observed the preventive effect of Gamdu-tang(甘豆湯) to intoxication of Organophosphorus Insecticides. Material and Methods: The subjects were 8 volunteers who were healthy and not taking medications. we observed change of cholinesterase(ChE) activity in serum of them after exposed to pesticides Results and Conclusions : In this study of the preventive effects of Gamdu-tang(甘豆湯) on the intoxication of Organophosphate Insecticides, we evaluated that the decreasing value of ChE activity after spraying insecticides of Gamdu-tang medication group was smaller than non-medication group, but it was less significant(P>0.05 P<0.1). We had a difficult to gather participant in this study, so it's necessary for us to get together more larger group in the next study.

• 대한임상독성학회지
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• 제4권1호
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• pp.61-64
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• 2006

Glufosinate ammonium (GLA), a phosphinic acid derivate of glutamate, is a broad-spectrum contact herbicide. It structurally resembles glutamate, a typical excitatory amino acid in the central nervous system. In korea, the ingestion of GLA for suicidal attempt or accidental event has increased. The neurological complication of GLA intoxication are characterized by loss of consciousness, convulsion, or memory impairment. But, the exact mechanism of GLA toxicity is yet unknown. This report is about a patient with GLA intoxication who showed anterograde amnesia with selective bilateral hip-pocampal lesions supported GLA intoxication with literature reviews supported.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권2호
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• pp.223-225
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• 2008

Grayanotoxin에 의한 중독은 대부분 보존적 치료만으로도 완전히 회복되는 경우가 많기 때문에 이를 감별하는 것이 중요하다. 저자들은 산에서 철쭉꽃을 10송이 넘게 섭취 후 의식저하를 주소로 응급실에 내원한 9세 남자 환자를 진단하고 치료하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국수산과학회지
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• 제37권3호
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• pp.175-178
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• 2004

We here report that the muscle of 'gukmeri-bok' puffer fish (Takifugu vermicularis radiatus) is intoxicated after freezing and thawing processes even though it is not toxic when it is fresh. This study was carried out to investigate the effect of different freezing and thawing conditions as well as the effect of the presence of skin or viscera on the intoxication of muscle of 'gukmeri-bok' puffer during freezing and thawing process. As a result of this investigation, thawing condition, but not freezing conditions or periods played an important role in muscle intoxication. Tetrodotoxin secretory grands exist in the skin of toxic puffer fish, the skin was more responsible for the muscles intoxication than the viscera during the freezing-thawing process. In other words, no toxicity was measured in the muscle of skinned-frozen specimens even when thawed. According to this result, it is recommended that the skin and viscera must be removed before being frozen for edible purpose. Otherwise, when a whole fish should be frozen, alternative half-thawing and removal of skin from frozen specimens is recommended.

• Environmental Analysis Health and Toxicology
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• 제11권3_4호
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• pp.59-63
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• 1996

In present study, we fractionated polysaccharides from Croton tiglium and investigated their hepatoprotective effects on CCl$_4$ intoxication. Polysaccharide fraction of which molecular weight is over 300,000 (HP) showed the most potent hepatoprotective effects on CCl$_4$ intoxication. Lipid peroxidation, sAST and sALT were used as parameters to evaluate the liver damage. Glucose, xylose and arabinose were found to be monosaccharides composing sugar moiety of HP.

• 한국환경보건학회지
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• 제15권2호
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• pp.75-83
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• 1989

To evaluate the effect of Kam Doo-extract (KDE) on organophosphorous (OP)intoxication in mouse, this research was conducted. KDE prescribed with the equal weights of both Padix Glycyrrizae and Simen Glycine was extracted in water at 100$^{\circ}$C for 2hr, and concentrated in a vacuum evaporator. Animmal used in this research was ICR-strained male mice (bodyweight: 20 ~ 25g), and induction material for OP intoxication was DDVP(Dichlovos). Toxicity parameters used to evaluate KDE-preventive effect on DDVP were cholinesterase activity, and protection index of KDE against LDso values of DDVP. As the results, KDE prevented the inhibition of cholinesteranse activity due to DDVP-treatment, and inhanced the protecion index. Consequently our experimental data show the KDE will be useful as an preventive agent in respect that KDE is safe and effective against OP intoxication in mouse.

• 대한임상독성학회지
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• 제1권1호
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• pp.47-50
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• 2003

Endosulfan, one of organochlorine insecticides, is $\gamma$-aminobutyric acid (GABA) antagonist. In sufficient dose, this pesticide lower the seizure threshold and produce CNS stimulation, with resultant seizures, respiratory failure, and death. In patients with endosulfan intoxication, the first manifestation of toxicity is largely a generalized seizure without prodromal signs or symptoms. So the management of airway and seizure control are essential for survival and prognosis of intoxicated patients. We report two cases of acute endosulfan poisoning who manifest 'status epilepticus' similarly, but have different prognosis.

• 한국보건간호학회지
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• 제6권1호
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• pp.62-70
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• 1992

This study was conducted on 334 cases of the acute drug intoxication visited to the emergency room of Gyungsang University Hospital for 3 years from January 1, 1988 to December 31,1990. The results were as follows: 1. The ratio of acute drug intoxicated patients to total patients of the emergency room was $1.9\%$. 2. Male was slightly more than female(1.14 : 1). The highest rate was shown in the age group of 30 years. 3. The monthly incidence was higher at the period from May to September. 4. The suicidal attempts ratio of the patients over 10 years old was $84.9\%$. 5. $74.9\%$ of total cases were intoxicated with pesticides. Among 270 cases who had committed suicide, 220 cases $(81.5\%)$ had ingested pesticides. 6. The fatality rate among cases of pesticides intoxication was $35.2\%$, among chemical intoxication $15.1\%$ and among medical drug intoxication $4.3\%$. 7. 13 cases$(3.9\%)$ of 334 cases showed the psychological problem on chart.

• 대한임상독성학회지
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• 제3권1호
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• pp.52-55
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• 2005

The plant Korean rosebay are members of the Ericaceae(Heath) family and may contain grayanotoxins, which exert toxic effects by binding to sodium channels in cell membranes. We had experience of 2 cases of Korean rose bay intoxication, who exposed to Rhododendron mucronulatum. Patients were presented to our ED with nausea and vomiting, hypotension, and dizziness or depressed mentation. The patients were performed monitoring and supportive treatment and were fully recovered within 48hours. Korean rose bay intoxication should be considered in patients with clinical evidence of gastrointestinal irritation, cardiac arrhythmias, and/or neurologic signs without identifiable causes, especially in spring or early summer.